Field trial with human and equine influenza vaccines in children: protection and antibody titres
Identifieur interne : 000294 ( Pmc/Curation ); précédent : 000293; suivant : 000295Field trial with human and equine influenza vaccines in children: protection and antibody titres
Auteurs : A. Wesselius-De Casparis ; N. Masurel ; K. F. KerrebijnSource :
- Bulletin of the World Health Organization [ 0042-9686 ] ; 1972.
Abstract
A placebo-controlled influenza vaccination trial was carried out on 374 children in the winter of 1967-68. The children were randomly vaccinated with 300 CCA of A2/England/1/1966, 300 CCA of A/equine 2/Miami/1963, or with a placebo. During this winter an influenza outbreak occurred, caused by A2/Nederland/1968. The A2 vaccine yielded a protection rate of 58% (P = 0.02) and the A/equine 2 vaccine a rate of 19% (P = 0.33). Serological data revealed that all influenza infections occurred in subjects who had a pre-epidemic haemagglutination inhibition titre below 150. The antibody response against various human influenza A2 viruses and against the horse strain (A/equine 2) is discussed.
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PubMed: 4555773
PubMed Central: 2480703
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<front><div type="abstract" xml:lang="en"><p>A placebo-controlled influenza vaccination trial was carried out on 374 children in the winter of 1967-68. The children were randomly vaccinated with 300 CCA of A2/England/1/1966, 300 CCA of A/equine 2/Miami/1963, or with a placebo. During this winter an influenza outbreak occurred, caused by A2/Nederland/1968. The A2 vaccine yielded a protection rate of 58% (P = 0.02) and the A/equine 2 vaccine a rate of 19% (P = 0.33). Serological data revealed that all influenza infections occurred in subjects who had a pre-epidemic haemagglutination inhibition titre below 150. The antibody response against various human influenza A2 viruses and against the horse strain (A/equine 2) is discussed.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Bull World Health Organ</journal-id>
<journal-title>Bulletin of the World Health Organization</journal-title>
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<title-group><article-title>Field trial with human and equine influenza vaccines in children: protection and antibody titres</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Wesselius-de Casparis</surname>
<given-names>A.</given-names>
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<contrib contrib-type="author"><name><surname>Masurel</surname>
<given-names>N.</given-names>
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<contrib contrib-type="author"><name><surname>Kerrebijn</surname>
<given-names>K. F.</given-names>
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<pub-date pub-type="ppub"><year>1972</year>
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<volume>46</volume>
<issue>2</issue>
<fpage>151</fpage>
<lpage>157</lpage>
<abstract><p>A placebo-controlled influenza vaccination trial was carried out on 374 children in the winter of 1967-68. The children were randomly vaccinated with 300 CCA of A2/England/1/1966, 300 CCA of A/equine 2/Miami/1963, or with a placebo. During this winter an influenza outbreak occurred, caused by A2/Nederland/1968. The A2 vaccine yielded a protection rate of 58% (P = 0.02) and the A/equine 2 vaccine a rate of 19% (P = 0.33). Serological data revealed that all influenza infections occurred in subjects who had a pre-epidemic haemagglutination inhibition titre below 150. The antibody response against various human influenza A2 viruses and against the horse strain (A/equine 2) is discussed.</p>
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