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Influenza vaccines and vaccinations in Poland – past, present and future

Identifieur interne : 000D99 ( Pmc/Corpus ); précédent : 000D98; suivant : 000E00

Influenza vaccines and vaccinations in Poland – past, present and future

Auteurs : Lidia B. Brydak ; Agnieszka Wo Niak Kosek ; Aneta Nitsch-Osuch

Source :

RBID : PMC:3560607

Abstract

Summary

Influenza causes seasonal infections worldwide that can lead to complications and deaths in every age group. The most effective and cheapest way to combat influenza is through vaccination. In many countries, including Poland, for each age group, the rate of vaccination against influenza is still at a very low level, which generates high social costs, not infrequently family tragedies in the case of irreversible complications of influenza, or death of a loved one. Regular vaccination should be part of good medical practice, as well as an individual’s engagement in their own health and in that of their family. Based on numerous studies, it is estimated that the effectiveness of current inactivated influenza vaccine in reducing morbidity and mortality in high-risk groups ranges from 50–70%. According to data from the National Institute of Public Health-National Institute of Hygiene, the rate of vaccination in children in 2008 in Poland was very low. In the group of children aged from 6 months to 14 years, only 1.1–1.6% were vaccinated. Although influenza vaccination for people aged over 65 years was free of charge in many provinces in this group, only 13.4% of this population was immunized, while in the case of people with chronic diseases, only 11.1% were immunized. The vaccination rate among health care employees is an embarrassing 6.4%. More educational activities addressed to both medical professionals and patients are required in order to increase influenza vaccine coverage in Poland.


Url:
DOI: 10.12659/MSM.883534
PubMed: 23111751
PubMed Central: 3560607

Links to Exploration step

PMC:3560607

Le document en format XML

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<nlm:aff id="af1-medscimonit-18-11-ra166">Department of Influenza Research, National Influenza Center, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland</nlm:aff>
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<affiliation>
<nlm:aff id="af2-medscimonit-18-11-ra166">Department of Immunology, Faculty of Biology, Univesity of Szczecin, Szczecin, Poland</nlm:aff>
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<p>Influenza causes seasonal infections worldwide that can lead to complications and deaths in every age group. The most effective and cheapest way to combat influenza is through vaccination. In many countries, including Poland, for each age group, the rate of vaccination against influenza is still at a very low level, which generates high social costs, not infrequently family tragedies in the case of irreversible complications of influenza, or death of a loved one. Regular vaccination should be part of good medical practice, as well as an individual’s engagement in their own health and in that of their family. Based on numerous studies, it is estimated that the effectiveness of current inactivated influenza vaccine in reducing morbidity and mortality in high-risk groups ranges from 50–70%. According to data from the National Institute of Public Health-National Institute of Hygiene, the rate of vaccination in children in 2008 in Poland was very low. In the group of children aged from 6 months to 14 years, only 1.1–1.6% were vaccinated. Although influenza vaccination for people aged over 65 years was free of charge in many provinces in this group, only 13.4% of this population was immunized, while in the case of people with chronic diseases, only 11.1% were immunized. The vaccination rate among health care employees is an embarrassing 6.4%. More educational activities addressed to both medical professionals and patients are required in order to increase influenza vaccine coverage in Poland.</p>
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<author>
<name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name>
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<author>
<name sortKey="Tauberger, Jk" uniqKey="Tauberger J">JK Tauberger</name>
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<author>
<name sortKey="Borchardt, Ra" uniqKey="Borchardt R">RA Borchardt</name>
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<author>
<name sortKey="Rolston, Kv" uniqKey="Rolston K">KV Rolston</name>
</author>
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<author>
<name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
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<author>
<name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
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<biblStruct>
<analytic>
<author>
<name sortKey="Kissling, E" uniqKey="Kissling E">E Kissling</name>
</author>
<author>
<name sortKey="Valenciano, M" uniqKey="Valenciano M">M Valenciano</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Joshi, Ay" uniqKey="Joshi A">AY Joshi</name>
</author>
<author>
<name sortKey="Iyer, Vn" uniqKey="Iyer V">VN Iyer</name>
</author>
<author>
<name sortKey="Hartz, Mf" uniqKey="Hartz M">MF Hartz</name>
</author>
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<analytic>
<author>
<name sortKey="Janjua, Nz" uniqKey="Janjua N">NZ Janjua</name>
</author>
<author>
<name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name>
</author>
<author>
<name sortKey="De Serres, G" uniqKey="De Serres G">G De Serres</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Marcelin, G" uniqKey="Marcelin G">G Marcelin</name>
</author>
<author>
<name sortKey="Sandbulte, Mr" uniqKey="Sandbulte M">MR Sandbulte</name>
</author>
<author>
<name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
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<author>
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</author>
<author>
<name sortKey="Socquet, J" uniqKey="Socquet J">J Socquet</name>
</author>
</analytic>
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<author>
<name sortKey="Nitsch Osuch, A" uniqKey="Nitsch Osuch A">A Nitsch-Osuch</name>
</author>
<author>
<name sortKey="Brydak, Lb" uniqKey="Brydak L">LB Brydak</name>
</author>
<author>
<name sortKey="Wardyn, Ak" uniqKey="Wardyn A">AK Wardyn</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
<author>
<name sortKey="Shun Shin, M" uniqKey="Shun Shin M">M Shun-Shin</name>
</author>
<author>
<name sortKey="Gill, P" uniqKey="Gill P">P Gill</name>
</author>
</analytic>
</biblStruct>
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<author>
<name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name>
</author>
<author>
<name sortKey="Jones, Ma" uniqKey="Jones M">MA Jones</name>
</author>
<author>
<name sortKey="Doshi, P" uniqKey="Doshi P">P Doshi</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
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<author>
<name sortKey="Ushirogawa, H" uniqKey="Ushirogawa H">H Ushirogawa</name>
</author>
<author>
<name sortKey="Ohuchi, M" uniqKey="Ohuchi M">M Ohuchi</name>
</author>
</analytic>
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<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Med Sci Monit</journal-id>
<journal-id journal-id-type="iso-abbrev">Med. Sci. Monit</journal-id>
<journal-id journal-id-type="publisher-id">Medical Science Monitor</journal-id>
<journal-title-group>
<journal-title>Medical Science Monitor : International Medical Journal of Experimental and Clinical Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">1234-1010</issn>
<issn pub-type="epub">1643-3750</issn>
<publisher>
<publisher-name>International Scientific Literature, Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">23111751</article-id>
<article-id pub-id-type="pmc">3560607</article-id>
<article-id pub-id-type="doi">10.12659/MSM.883534</article-id>
<article-id pub-id-type="publisher-id">883534</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Influenza vaccines and vaccinations in Poland – past, present and future</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Brydak</surname>
<given-names>Lidia B.</given-names>
</name>
<xref ref-type="aff" rid="af1-medscimonit-18-11-ra166">1</xref>
<xref ref-type="aff" rid="af2-medscimonit-18-11-ra166">2</xref>
<xref ref-type="corresp" rid="c1-medscimonit-18-11-ra166"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kosek</surname>
<given-names>Agnieszka WoŸniak</given-names>
</name>
<xref ref-type="aff" rid="af1-medscimonit-18-11-ra166">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nitsch-Osuch</surname>
<given-names>Aneta</given-names>
</name>
<xref ref-type="aff" rid="af3-medscimonit-18-11-ra166">3</xref>
</contrib>
</contrib-group>
<aff id="af1-medscimonit-18-11-ra166">
<label>1</label>
Department of Influenza Research, National Influenza Center, National Institute of Public Health – National Institute of Hygiene, Warsaw, Poland</aff>
<aff id="af2-medscimonit-18-11-ra166">
<label>2</label>
Department of Immunology, Faculty of Biology, Univesity of Szczecin, Szczecin, Poland</aff>
<aff id="af3-medscimonit-18-11-ra166">
<label>3</label>
Department of Family Medicine, Warsaw Medical University, Warsaw, Poland</aff>
<author-notes>
<corresp id="c1-medscimonit-18-11-ra166">Lidia Bernadeta Brydak, Department of Influenza Research, National Influenza Center, National Institute of Public Health-National Institute of Hygiene, Chocimska 24 Str, 00-791 Warsaw, Poland, e-mail:
<email>lbrydak@pzh.gov.pl</email>
and
<email>brydaklidia@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="collection">
<year>2012</year>
</pub-date>
<pub-date pub-type="epub">
<day>01</day>
<month>11</month>
<year>2012</year>
</pub-date>
<volume>18</volume>
<issue>11</issue>
<fpage>RA166</fpage>
<lpage>RA171</lpage>
<history>
<date date-type="received">
<day>05</day>
<month>7</month>
<year>2012</year>
</date>
<date date-type="accepted">
<day>26</day>
<month>8</month>
<year>2012</year>
</date>
</history>
<permissions>
<copyright-statement>© Med Sci Monit, 2012</copyright-statement>
<copyright-year>2012</copyright-year>
<license>
<license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.</license-p>
</license>
</permissions>
<abstract>
<title>Summary</title>
<p>Influenza causes seasonal infections worldwide that can lead to complications and deaths in every age group. The most effective and cheapest way to combat influenza is through vaccination. In many countries, including Poland, for each age group, the rate of vaccination against influenza is still at a very low level, which generates high social costs, not infrequently family tragedies in the case of irreversible complications of influenza, or death of a loved one. Regular vaccination should be part of good medical practice, as well as an individual’s engagement in their own health and in that of their family. Based on numerous studies, it is estimated that the effectiveness of current inactivated influenza vaccine in reducing morbidity and mortality in high-risk groups ranges from 50–70%. According to data from the National Institute of Public Health-National Institute of Hygiene, the rate of vaccination in children in 2008 in Poland was very low. In the group of children aged from 6 months to 14 years, only 1.1–1.6% were vaccinated. Although influenza vaccination for people aged over 65 years was free of charge in many provinces in this group, only 13.4% of this population was immunized, while in the case of people with chronic diseases, only 11.1% were immunized. The vaccination rate among health care employees is an embarrassing 6.4%. More educational activities addressed to both medical professionals and patients are required in order to increase influenza vaccine coverage in Poland.</p>
</abstract>
<kwd-group>
<kwd>influenza</kwd>
<kwd>vaccination</kwd>
<kwd>vaccines</kwd>
<kwd>Poland</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec>
<title>Background</title>
<p>Influenza causes seasonal infections worldwide that can lead to complications and deaths in every age group [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
]. According to information from the WHO, between 330 million and 1.575 billion individuals suffer from influenza and influenza-like virus every year throughout the world, with deaths of between 0.5 and 1 million individuals [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. In many countries, including Poland, for each age group, the rate of vaccination against influenza is still at a very low level, which generates high social costs, not infrequently family tragedies in the case of irreversible complications of influenza, or death of a loved one. The most effective and cheapest way to combat influenza is through vaccination [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
].</p>
<p>Three pandemics caused by 3 different subtypes of the influenza virus occurred in the twentieth century [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
]. The pandemic of 1918–1919, referred to as the
<italic>Spanish flu,</italic>
was caused by the A/H1N1/ virus; the pandemic 1957–1958, known as
<italic>Asian flu,</italic>
was caused by the A/H2N2/ (1–4 million of deaths); and the pandemic known as
<italic>Hong Kong flu</italic>
was caused by the A/H3N2/ (1–4 million of deaths) [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. According to the present data, the 1918–1919 pandemic resulted in 50–100 million deaths [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
]. People who had lived during the pandemic and who had survived, and remembered the spectre of death caused by influenza, did not challenge the validity of vaccination when the 1957–1958
<italic>Asian flu</italic>
pandemic occurred and were eager to undergo vaccination, notwithstanding the lesser quality of vaccines at that time compared with the present [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b4-medscimonit-18-11-ra166">4</xref>
]. During the
<italic>Spanish</italic>
pandemic, the highest incidence was recorded in individuals aged 5–14 years, while the highest mortality rate was recorded in the population aged from 24–40 years [
<xref ref-type="bibr" rid="b4-medscimonit-18-11-ra166">4</xref>
]. Therefore, in order to avoid complications from influenza, and to ensure the appropriate development of children and young people, preventive measures, including regular vaccination against influenza, should be in place [
<xref ref-type="bibr" rid="b5-medscimonit-18-11-ra166">5</xref>
]. This does not mean that other age groups should be omitted from vaccination. The high variability of the influenza virus is a characteristic feature that has been known for many years [
<xref ref-type="bibr" rid="b6-medscimonit-18-11-ra166">6</xref>
]. In each successive seasonal epidemic, the circulation of influenza virus strains can be expected within a population. These strains are genetically and antigenically different from those which caused illness in the past or even in a number of recent epidemics, not only because of mutations, but also due to changes of reassortment resulting from the segmented genome [
<xref ref-type="bibr" rid="b7-medscimonit-18-11-ra166">7</xref>
]. This may in turn, have health and economic impacts associated with the occurrence of epidemic and pandemic influenza. Therefore, regular vaccination is one of the few steps that may be taken to protect people, especially in high-risk groups, from the potential, serious complications of influenza [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
].</p>
</sec>
<sec>
<title>Vaccination Against Influenza</title>
<p>Regular vaccination should be part of good medical practice, as well as people’s engagement in their own health and in that of their family [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b4-medscimonit-18-11-ra166">4</xref>
,
<xref ref-type="bibr" rid="b7-medscimonit-18-11-ra166">7</xref>
]. Based on numerous studies, it is estimated that the effectiveness of current inactivated influenza vaccine in reducing morbidity and mortality in high-risk groups ranges from 50–70% [
<xref ref-type="bibr" rid="b8-medscimonit-18-11-ra166">8</xref>
<xref ref-type="bibr" rid="b12-medscimonit-18-11-ra166">12</xref>
]. We should realize that the flu is a disease in which the continuous evolution of the virus is essential for the occurrence of seasonal epidemics in the human population and, from time to time, as pandemic influenza.</p>
<p>It is known that since 9 May 1997 the A/H5N1/HPAI influenza virus subtype is circulating within the population, creating more and more new mutants, which has resulted in the registration of an approximate mortality of 56.7% among infected individuals [
<xref ref-type="bibr" rid="b13-medscimonit-18-11-ra166">13</xref>
]. The reassortment of the 2 strains of viruses – A/H5N1/ (HPAI), which is very infectious, but does not have the ability of human to human transmission; and A(H1N1)pdm09, a pandemic virus which does have this ability – must be feared. Reassortment could result in the creation of a virus with all of the characteristics of the pandemic virus [
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
]. For example, during the 2010/2011 epidemic season more people died than during the previous year’s influenza pandemic, even though a vaccine was available from 5 different companies, in pharmacies, from the family doctor, or from private medical centres [
<xref ref-type="bibr" rid="b14-medscimonit-18-11-ra166">14</xref>
,
<xref ref-type="bibr" rid="b15-medscimonit-18-11-ra166">15</xref>
].</p>
</sec>
<sec>
<title>Influenza Vaccine Coverage in Poland</title>
<p>According to data from the National Institute of Public Health-National Institute of Hygiene (NIPH-NIH), the rate of vaccination in children in 2008 was very low [
<xref ref-type="bibr" rid="b16-medscimonit-18-11-ra166">16</xref>
]. In the group of children aged 6 months to 14 years, only 1.1–1.6% were vaccinated. Although influenza vaccination for people aged over 65 years was free of charge in many provinces in this group, only 13.4% of this population was immunized, according to the European Centre for Disease Control (ECDC) and the VENICE Network New Integrated Collaboration Effort; while in the case of people with chronic diseases, only 11.1% were immunized (data VENICE ECDC and Network) [
<xref ref-type="bibr" rid="b17-medscimonit-18-11-ra166">17</xref>
,
<xref ref-type="bibr" rid="b18-medscimonit-18-11-ra166">18</xref>
]. The vaccination rate among health care employees is an embarrassing at 6.4% (data VENICE ECDC and Network) [
<xref ref-type="bibr" rid="b17-medscimonit-18-11-ra166">17</xref>
,
<xref ref-type="bibr" rid="b18-medscimonit-18-11-ra166">18</xref>
]. According to the latest data from WHO, the uptake of vaccine places Poland in the penultimate place in Europe (2010) [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. The situation is no better in terms of individuals with different types of insurance within private medical centers. There are over 30 ways to increase of rate of vaccination in Poland [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
].</p>
</sec>
<sec>
<title>Pandemic Influenza Caused by a (H1N1)pdm09 Virus in Poland</title>
<p>The pandemic announced by WHO on 11 June 2009 was caused by the influenza virus subtype A/H1N1/v, which proved to be a reassortment [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. According to data from WHO and ECDC, the mean number of deaths worldwide was about 18,000, which is incomparably less than for seasonal influenza [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. We must not forget that 1 million people throughout the world die from seasonal influenza and influenza-like viruses [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. The global hysteria unleashed because of the purchase of pandemic flu vaccine did not fail to affect Poland. Statements were also made by individuals who had no substantive grounds for doing so. With regard to the issue of vaccination against the pandemic influenza virus A(H1N1)pdm09, the decision taken in Poland should be considered as appropriate when taking into account the type of restrictions imposed on Poland by pandemic vaccine manufacturers, who placed the entire burden of responsibility for vaccine safety onto the state, which is not the practice for seasonal vaccines. Furthermore, in accordance with manufacturers’ requirements, the vaccine could not be made available in pharmacies.</p>
<p>With regard to the Polish position adopted by the Minister of Health, Ewa Kopacz, the Council of Europe voiced its marked appreciation repeatedly. In effect, throughout the world many millions of doses of unused vaccine against pandemic influenza are wasted, representing many millions of Euros. Moreover, additional costs arise from the disposal of the vaccine purchased surplus to need, and it was a shame that these sizeable funds could not be devoted to other public health purposes instead. As we have stated and written many times, and what both then and now continues to give us cause for real concern, is the fact that confidence in the WHO has been undermined, the take-up of all vaccines has decreased, and that there will be a further reduction in the already low take-up of the influenza vaccine, particularly in Poland. Therefore, we deplore the fact that all those individuals who expressed themselves so actively in the press, radio and TV did not take action to increase the rate of vaccination against influenza, particularly since the ternary composition of the vaccine for the 2010/2011 season included the A/H1N1/pdm09 pandemic strain.</p>
<p>Let us present the effects of our casual attitude to vaccination. It is worth emphasizing that those individuals who died in the 2010/2011 epidemic season were in high risk groups, were not vaccinated against influenza, and had infection caused by the virus A(H1N1)pdm09 confirmed by use of molecular biology techniques, which was already a component of the vaccine for this season [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
,
<xref ref-type="bibr" rid="b4-medscimonit-18-11-ra166">4</xref>
].</p>
</sec>
<sec>
<title>Recommendations for Influenza Vaccination</title>
<p>For many years, since the year 2000, the Advisory Committee on Immunization (ACIP) in the U.S. has recommended the routine vaccination against influenza of all individuals above the age of 6 months until late old age [
<xref ref-type="bibr" rid="b19-medscimonit-18-11-ra166">19</xref>
]. Therefore, in the epidemic season, vaccination is recommended for nursing mothers unless they were already vaccinated, and vaccination of household members, caregivers of young children and of individuals who are in close contact with children under the age of 6 months. The recommendations of the Advisory Committee on Immunization (ACIP) are shown in
<xref ref-type="table" rid="t1-medscimonit-18-11-ra166">Table 1</xref>
[
<xref ref-type="bibr" rid="b19-medscimonit-18-11-ra166">19</xref>
].</p>
<p>In the 2010/2011 epidemic season, only 5.0% of the population was vaccinated despite the inclusion of the A/H1N1/pdm09 strain in the ternary composition of the vaccine against influenza [
<xref ref-type="bibr" rid="b14-medscimonit-18-11-ra166">14</xref>
,
<xref ref-type="bibr" rid="b15-medscimonit-18-11-ra166">15</xref>
]. In Poland in 2009,
<italic>split</italic>
inactivated or
<italic>subunit</italic>
vaccines were registered as shown in
<xref ref-type="table" rid="t2-medscimonit-18-11-ra166">Table 2</xref>
.</p>
<p>They can be administered either intramuscularly or intradermally, depending on the type. Vaccines against influenza available in Poland are inactivated (containing fragments of
<italic>killed</italic>
influenza virus), therefore they are not able to multiply in the body and cause disease, but produce a specific immunity directed against the influenza virus. It is worth noting that irrespective of the recommendations of the Advisory Committee on Immunization (ACIP), 14 scientific societies also recommend vaccination against influenza (
<xref ref-type="table" rid="t3-medscimonit-18-11-ra166">Table 3</xref>
) [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
].</p>
<p>Increasingly, the problem of vaccination against influenza is considered in terms of its health and economic aspects, of which we often remain unaware. According to data from the U.S., depending on the influenza epidemic season, the cost impact of influenza infection is between 76–167 billion dollars [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
]. The humoral immune response to influenza vaccination in high-risk groups evaluated in studies undertaken by the Influenza Virus Research Department of the National Centre for Influenza NIPH-NIH in collaboration with clinicians is shown in
<xref ref-type="table" rid="t4-medscimonit-18-11-ra166">Table 4</xref>
[
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
].</p>
<p>We are convinced that the presentation of specific examples will be helpful in promoting prevention, and will encourage health professionals to protect not only their patients, but also their relatives.
<xref ref-type="table" rid="t5-medscimonit-18-11-ra166">Table 5</xref>
includes what in our opinion are the main causes of the low prevalence of influenza vaccination.</p>
</sec>
<sec>
<title>Current Status of Influenza Diagnosis and Treatment in Poland</title>
<p>Diagnostic methods have been available in Poland for decades, beginning with the gold standard for identification of the pathogen in the chicken embryo or tissue culture, by ELISA, immunofluorescence (IF), serological methods, and ending with studies using different combinations of molecular biology methods [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
]. Currently, in Poland and only in the Influenza Virus Research Department of the National Influenza Centre at the NIPH-NIH in Warsaw, 12 respiratory viruses – Influenza type A and B, virus RS type A and B, parainfluenza types 1, 2 and 3, human metapneumovirus (hMPV), adenovirus, rhinovirus, coronavirus, 229E/NL63, and OC43/HKU1 – can be detected from a single sample from the patient, applying the methods of molecular biology [
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
]. However, in the 12 Provincial Sanitary-Epidemiological Stations (PSES) it is possible to diagnose influenza infections using methods of molecular biology, while the remaining 4 PSES perform diagnostics using the immunofluorescence method (IF). The importance of virological diagnosis of respiratory infections, particularly influenza, is high, not only in medical, but also in economic terms. It serves to avoid antibiotics therapy in the absence of indications and also to ensure that appropriate treatment is administered when necessary.</p>
<p>The appropriate use of currently available new influenza virus neuraminidase inhibitors, such as zanamivir (Relenza) and oseltamivir (Tamiflu), and consequently, the simultaneous prevention of appearance of strains resistant to these drugs, reduce the length of hospital stay [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b20-medscimonit-18-11-ra166">20</xref>
<xref ref-type="bibr" rid="b24-medscimonit-18-11-ra166">24</xref>
].</p>
<p>The taking of appropriate measures to prevent the spread of infection refutes those myths associated with vaccination that lead to its avoidance [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
]. One should be aware that, particularly in individuals in high-risk groups (including healthy young children), the effects of influenza in those who are not vaccinated can result in complications, and even death. Therefore, the rapid identification of influenza virus is a priority when considering the possibility of treatment with effective medication.</p>
<p>Currently, 2 influenza antiviral agents have been present on the market for many years – oseltamivir (Tamiflu) and zanamivir (Relenza) – active in the case of infection both with influenza A and B [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
,
<xref ref-type="bibr" rid="b20-medscimonit-18-11-ra166">20</xref>
<xref ref-type="bibr" rid="b24-medscimonit-18-11-ra166">24</xref>
]. The effectiveness of these drugs is dependent on several factors. In the case of seasonal influenza infection, the medication should be given after laboratory confirmation, preferably up to 36 hours from the onset of symptoms [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b20-medscimonit-18-11-ra166">20</xref>
<xref ref-type="bibr" rid="b24-medscimonit-18-11-ra166">24</xref>
]. However, in the event of pandemic influenza, it should be administered on the basis of clinical symptoms, without waiting for the laboratory confirmation of infection. The use of these medicines is indicated not solely for treatment of established infection, but also in prevention, including for post-exposure prophylaxis [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b20-medscimonit-18-11-ra166">20</xref>
<xref ref-type="bibr" rid="b24-medscimonit-18-11-ra166">24</xref>
].</p>
<p>It should be noted that the use of oseltamivir during an epidemic of influenza was recommended from the age of 1 year [
<xref ref-type="bibr" rid="b2-medscimonit-18-11-ra166">2</xref>
]. However, in the situation of a pandemic, both the manufacturer and the European Medicines Agency (EMEA) recommend the use of this medication for those aged less than 1 year, depending on the child’s body weight [
<xref ref-type="bibr" rid="b25-medscimonit-18-11-ra166">25</xref>
]. Oseltamivir (Tamiflu) is available in capsular form, which allows for its use not only in the case of small children, but also in patients who are unable to swallow capsules [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b20-medscimonit-18-11-ra166">20</xref>
<xref ref-type="bibr" rid="b24-medscimonit-18-11-ra166">24</xref>
]. Zanamivir (Relenza) is formulated for inhalation and can be used from the age of 5 years. These drugs are effective for both seasonal influenza infections as well as for subtypes of other influenza type A and B viruses.</p>
<p>According to WHO and Polish data, the new generation of drugs – the neuraminidase inhibitors – have proved effective in infections with the HPAI virus: subtype A/H5N1/, A/H7N7/, pandemic influenza virus subtype A(H1N1)pdm09, as well as in the case of seasonal influenza infection [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b26-medscimonit-18-11-ra166">26</xref>
]. Currently, clinical trials of a new antiviral agent, peramivir, are in progress. Results of preliminary studies of this drug seem promising [
<xref ref-type="bibr" rid="b27-medscimonit-18-11-ra166">27</xref>
].</p>
</sec>
</body>
<back>
<fn-group>
<fn id="fn1-medscimonit-18-11-ra166">
<p>
<bold>Source of support:</bold>
Self financing</p>
</fn>
</fn-group>
<ref-list>
<title>References</title>
<ref id="b1-medscimonit-18-11-ra166">
<label>1</label>
<element-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Brydak</surname>
<given-names>LB</given-names>
</name>
</person-group>
<article-title>Influenza, pandemic flu myth or a real threat?</article-title>
<source>Rhythm</source>
<publisher-loc>Warszawa</publisher-loc>
<year>2008</year>
<fpage>1</fpage>
<lpage>92</lpage>
<comment>[in Polish]</comment>
</element-citation>
</ref>
<ref id="b2-medscimonit-18-11-ra166">
<label>2</label>
<note>
<p>
<ext-link ext-link-type="uri" xlink:href="www.who.int/influenza/en">www.who.int/influenza/en</ext-link>
(avaiable on 12 June 2012)</p>
</note>
</ref>
<ref id="b3-medscimonit-18-11-ra166">
<label>3</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Brydak</surname>
<given-names>LB</given-names>
</name>
</person-group>
<article-title>Influenza disease XXI century</article-title>
<source>Sepsis</source>
<year>2010</year>
<volume>3</volume>
<fpage>301</fpage>
<lpage>64</lpage>
<comment>[in Polish]</comment>
</element-citation>
</ref>
<ref id="b4-medscimonit-18-11-ra166">
<label>4</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Reid</surname>
<given-names>AH</given-names>
</name>
<name>
<surname>Tauberger</surname>
<given-names>JK</given-names>
</name>
</person-group>
<article-title>The origin of the 1918 pandemic influenza virus: a continuing enigma</article-title>
<source>J Gen</source>
<year>2003</year>
<volume>85</volume>
<fpage>2285</fpage>
<lpage>92</lpage>
</element-citation>
</ref>
<ref id="b5-medscimonit-18-11-ra166">
<label>5</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Borchardt</surname>
<given-names>RA</given-names>
</name>
<name>
<surname>Rolston</surname>
<given-names>KV</given-names>
</name>
</person-group>
<article-title>Battling influenza: universal vaccination is the primary weapon</article-title>
<source>JAAPA</source>
<year>2012</year>
<volume>25</volume>
<issue>1</issue>
<fpage>27</fpage>
<lpage>28</lpage>
</element-citation>
</ref>
<ref id="b6-medscimonit-18-11-ra166">
<label>6</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Cox</surname>
<given-names>NJ</given-names>
</name>
<name>
<surname>Subbarao</surname>
<given-names>K</given-names>
</name>
</person-group>
<article-title>Influenza</article-title>
<source>Lancet</source>
<year>1999</year>
<volume>353</volume>
<fpage>1277</fpage>
<lpage>82</lpage>
<pub-id pub-id-type="pmid">10520648</pub-id>
</element-citation>
</ref>
<ref id="b7-medscimonit-18-11-ra166">
<label>7</label>
<element-citation publication-type="book">
<collab>American Academy of Pediatrics</collab>
<article-title>2009 Red book</article-title>
<source>Report of the Committee on Infectious Diseases</source>
<edition>29th ed</edition>
<publisher-loc>ELK Grove Village, IL</publisher-loc>
<publisher-name>American Academy of Pediatrics</publisher-name>
<year>2009</year>
</element-citation>
</ref>
<ref id="b8-medscimonit-18-11-ra166">
<label>8</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kissling</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Valenciano</surname>
<given-names>M</given-names>
</name>
</person-group>
<collab>I-MOVE Case-Control Studies Team</collab>
<article-title>Early estimates of seasonal influenza vaccine effectiveness in Europe among target groups for vaccination: results from the I-MOVE multicentre case-control study, 2011/12</article-title>
<source>Euro Surveill</source>
<year>2012</year>
<volume>7</volume>
<issue>15</issue>
<fpage>20146</fpage>
<pub-id pub-id-type="pmid">22516046</pub-id>
</element-citation>
</ref>
<ref id="b9-medscimonit-18-11-ra166">
<label>9</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Joshi</surname>
<given-names>AY</given-names>
</name>
<name>
<surname>Iyer</surname>
<given-names>VN</given-names>
</name>
<name>
<surname>Hartz</surname>
<given-names>MF</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Effectiveness of trivalent inactivated influenza vaccine in influenza-related hospitalization in children: a case-control study</article-title>
<source>Allergy Asthma Proc</source>
<year>2012</year>
<volume>33</volume>
<issue>2</issue>
<fpage>e23</fpage>
<lpage>27</lpage>
<pub-id pub-id-type="pmid">22525386</pub-id>
</element-citation>
</ref>
<ref id="b10-medscimonit-18-11-ra166">
<label>10</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Janjua</surname>
<given-names>NZ</given-names>
</name>
<name>
<surname>Skowronski</surname>
<given-names>DM</given-names>
</name>
<name>
<surname>De Serres</surname>
<given-names>G</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Estimates of Influenza Vaccine Effectiveness for 2007–2008 From Canada’s Sentinel Surveillance System: Cross-Protection Against Major and Minor Variants</article-title>
<source>J Infect Dis</source>
<year>2012</year>
<volume>205</volume>
<issue>12</issue>
<fpage>1858</fpage>
<lpage>68</lpage>
<pub-id pub-id-type="pmid">22492921</pub-id>
</element-citation>
</ref>
<ref id="b11-medscimonit-18-11-ra166">
<label>11</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Marcelin</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Sandbulte</surname>
<given-names>MR</given-names>
</name>
<name>
<surname>Webby</surname>
<given-names>RJ</given-names>
</name>
</person-group>
<article-title>Contribution of antibody production against neuraminidase to the protection afforded by influenza vaccines</article-title>
<source>Rev Med Virol</source>
<year>2012</year>
<volume>22</volume>
<issue>4</issue>
<fpage>267</fpage>
<lpage>79</lpage>
<pub-id pub-id-type="pmid">22438243</pub-id>
</element-citation>
</ref>
<ref id="b12-medscimonit-18-11-ra166">
<label>12</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Lang</surname>
<given-names>PO</given-names>
</name>
<name>
<surname>Mendes</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Socquet</surname>
<given-names>J</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence</article-title>
<source>Clin Interv Aging</source>
<year>2012</year>
<volume>7</volume>
<fpage>55</fpage>
<lpage>64</lpage>
<pub-id pub-id-type="pmid">22393283</pub-id>
</element-citation>
</ref>
<ref id="b13-medscimonit-18-11-ra166">
<label>13</label>
<note>
<p>
<ext-link ext-link-type="uri" xlink:href="http//www.who.int/influenza/surveillance_monitoring/updates/en/">http//www.who.int/influenza/surveillance_monitoring/updates/en/</ext-link>
(available 3 July 2012)</p>
</note>
</ref>
<ref id="b14-medscimonit-18-11-ra166">
<label>14</label>
<element-citation publication-type="webpage">
<source>Reports on cases of infectious diseases and poisonings in Poland</source>
<year>2010</year>
<comment>
<ext-link ext-link-type="uri" xlink:href="http://www.pzh.gov.pl/oldpage/epimeld/index_a.html">http://www.pzh.gov.pl/oldpage/epimeld/index_a.html</ext-link>
(avaiable 3 July 2012)</comment>
</element-citation>
</ref>
<ref id="b15-medscimonit-18-11-ra166">
<label>15</label>
<element-citation publication-type="webpage">
<source>Reports on cases of infectious diseases and poisonings in Poland</source>
<year>2011</year>
<comment>
<ext-link ext-link-type="uri" xlink:href="http://www.pzh.gov.pl/oldpage/epimeld/index_a.html">http://www.pzh.gov.pl/oldpage/epimeld/index_a.html</ext-link>
(avaiable 3 July 2012)</comment>
</element-citation>
</ref>
<ref id="b16-medscimonit-18-11-ra166">
<label>16</label>
<element-citation publication-type="webpage">
<source>Reports on cases of infectious diseases and poisonings in Poland</source>
<year>2008</year>
<comment>
<ext-link ext-link-type="uri" xlink:href="http://www.pzh.gov.pl/oldpage/epimeld/index_a.html">http://www.pzh.gov.pl/oldpage/epimeld/index_a.html</ext-link>
(avaiable 3 July 2012)</comment>
</element-citation>
</ref>
<ref id="b17-medscimonit-18-11-ra166">
<label>17</label>
<note>
<p>
<ext-link ext-link-type="uri" xlink:href="http//venice.cineca.org/reports.html/">http//venice.cineca.org/reports.html/</ext-link>
(avaiable 2 July 2012)</p>
</note>
</ref>
<ref id="b18-medscimonit-18-11-ra166">
<label>18</label>
<note>
<p>
<ext-link ext-link-type="uri" xlink:href="www.ecdc.eu/en/publications/special_reports/Pages/index.aspx">www.ecdc.eu/en/publications/special_reports/Pages/index.aspx</ext-link>
(avaiable 1 July 2012)</p>
</note>
</ref>
<ref id="b19-medscimonit-18-11-ra166">
<label>19</label>
<element-citation publication-type="journal">
<collab>Prevention and Control of Influenza with Vaccines</collab>
<article-title>Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2011</article-title>
<source>MMWR Morb Mortal Wkly Rep</source>
<year>2011</year>
<volume>60</volume>
<issue>33</issue>
<fpage>1128</fpage>
<lpage>32</lpage>
<pub-id pub-id-type="pmid">21866086</pub-id>
</element-citation>
</ref>
<ref id="b20-medscimonit-18-11-ra166">
<label>20</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Nitsch-Osuch</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Brydak</surname>
<given-names>LB</given-names>
</name>
<name>
<surname>Wardyn</surname>
<given-names>AK</given-names>
</name>
</person-group>
<article-title>Neuraminidase inhibitors in prophylaxis and treatment of influenza]</article-title>
<source>Pol Merk Lek</source>
<year>2008</year>
<volume>25</volume>
<issue>145</issue>
<fpage>67</fpage>
<lpage>73</lpage>
<comment>[in Polish]</comment>
</element-citation>
</ref>
<ref id="b21-medscimonit-18-11-ra166">
<label>21</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wang</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Shun-Shin</surname>
<given-names>M</given-names>
</name>
<name>
<surname>Gill</surname>
<given-names>P</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Neuraminidase inhibitors for preventing and treating influenza in children (published trials only)</article-title>
<source>Cochrane Database Syst Rev</source>
<year>2012</year>
<volume>18</volume>
<volume>4</volume>
<fpage>CD002744</fpage>
</element-citation>
</ref>
<ref id="b22-medscimonit-18-11-ra166">
<label>22</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Jefferson</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Jones</surname>
<given-names>MA</given-names>
</name>
<name>
<surname>Doshi</surname>
<given-names>P</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children</article-title>
<source>Cochrane Database Syst Rev</source>
<year>2012</year>
<volume>18</volume>
<fpage>CD008965</fpage>
<pub-id pub-id-type="pmid">22258996</pub-id>
</element-citation>
</ref>
<ref id="b23-medscimonit-18-11-ra166">
<label>23</label>
<element-citation publication-type="journal">
<collab>Antiviral Agents for the Treatment and Chemoprophylaxis of Influenza</collab>
<article-title>Recommendations of the Advisory Committee on Immunization Practices (ACIP). Center for Disease Control and Prevention</article-title>
<source>MMWR Morb Mortal Wkly Rep</source>
<year>2011</year>
<volume>60</volume>
<issue>RR01</issue>
<fpage>1</fpage>
<lpage>24</lpage>
</element-citation>
</ref>
<ref id="b24-medscimonit-18-11-ra166">
<label>24</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ushirogawa</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Ohuchi</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus</article-title>
<source>Virol J</source>
<year>2011</year>
<volume>8</volume>
<fpage>411</fpage>
<pub-id pub-id-type="pmid">21851647</pub-id>
</element-citation>
</ref>
<ref id="b25-medscimonit-18-11-ra166">
<label>25</label>
<note>
<p>
<ext-link ext-link-type="uri" xlink:href="www.emea.europa.eu">www.emea.europa.eu</ext-link>
(available 27 June 2012)</p>
</note>
</ref>
<ref id="b26-medscimonit-18-11-ra166">
<label>26</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Stoner</surname>
<given-names>TD</given-names>
</name>
<name>
<surname>Krauss</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Turner</surname>
<given-names>JC</given-names>
</name>
<etal></etal>
</person-group>
<article-title>Susceptibility of avian influenza viruses of the N6 subtype to the neuraminidase inhibitor oseltamivir</article-title>
<source>Antiviral Res</source>
<year>2012</year>
<volume>93</volume>
<issue>3</issue>
<fpage>322</fpage>
<lpage>29</lpage>
<pub-id pub-id-type="pmid">22252168</pub-id>
</element-citation>
</ref>
<ref id="b27-medscimonit-18-11-ra166">
<label>27</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Shetty</surname>
<given-names>AK</given-names>
</name>
<name>
<surname>Peek</surname>
<given-names>LA</given-names>
</name>
</person-group>
<article-title>Peramivir for the treatment of influenza</article-title>
<source>Expert Rev Anti Infect Ther</source>
<year>2012</year>
<volume>10</volume>
<issue>2</issue>
<fpage>123</fpage>
<lpage>43</lpage>
<pub-id pub-id-type="pmid">22339187</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
<floats-group>
<table-wrap id="t1-medscimonit-18-11-ra166" position="float">
<label>Table 1</label>
<caption>
<p>Recommendations for vaccination against influenza (ACIP, 2011) [
<xref ref-type="bibr" rid="b19-medscimonit-18-11-ra166">19</xref>
].</p>
</caption>
<table frame="hsides" rules="rows">
<tbody>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">The Advisory Committee on Immunization (ACIP – Advisory Committee on Immunization Practices), together with WHO, each year make recommendations regarding vaccination against influenza. According to them, the indications for the use of inactivated vaccines with
<italic>split virion</italic>
and
<italic>subunit vaccines</italic>
are as follows.</td>
</tr>
<tr>
<td align="center" valign="middle" rowspan="1" colspan="1">
<bold>Clinical indications for influenza vaccination</bold>
<break></break>
High-risk groups particularly vulnerable to the occurrence of complications of influenza</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Currently, it is recommended influenza vaccination for
<bold>all persons, from 6 months old</bold>
. Particular attention is, however, that vaccination should be extended to particular groups as follows:</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>organ transplant individuals </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>all children aged 6 months – 4 years (59 months)</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>all persons aged ≥50 years, because in this group greatly increases the number of people belonging to high risk groups </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>adults and children who have chronic pulmonary(including asthma), or cardiovascular (except isolated hypertension), renal, hepatic, neurological, hematologic or metabolic disorders (including diabetes mellitus);</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>persons who have immunosuppression (including immunosuppression caused by medications or by HIV)</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>women who are or will be pregnant during the influenza season</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>children and adolescents (aged 6 months old - 18 years) who are receiving long-term aspirin therapy and who might be at risk for experiencing Reye syndrome after influenza virus infection;</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>residents of nursing homes, and other long-term- health care facilities </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>persons who are morbidly obese (BMI ≥40) </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="center" valign="middle" rowspan="1" colspan="1">
<bold>Epidemiological indications for influenza vaccination</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Persons who live with or care for person at higher risk for influenza-related complication (persons who can transmit influenza to persons at high risk and healthy people could be a source of infection for these persons):</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>HCP</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>household contacts and caregivers of children aged ≥5 years and adults aged ≥50 years, with particular emphasis on vaccinating of children aged ≥6 months;</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>household contacts and caregivers of person with medical conditions that put them at higher risk for severe complications from influenza</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>All health professionals; doctors, nurses and other staff of hospitals and outpatient centers, emergency services,</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>employees of nursing homes and care facilities who have contact with inmates or patients (including children), as well as persons providing home care to patients with high-risk groups</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>family members of persons belonging to high risk groups </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>cashiers, policemen, soldiers, teachers, kindergarten, journalists, construction workers, shop assistants shops and stores, craft service, etc.</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>people caring for children under the age of 5 years, </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>public service employees, such as conductors, workers, shop and stores, craft service etc</p>
</list-item>
</list>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="t2-medscimonit-18-11-ra166" position="float">
<label>Table 2</label>
<caption>
<p>Influenza vaccines registered in Poland [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
,
<xref ref-type="bibr" rid="b3-medscimonit-18-11-ra166">3</xref>
] (Brydak L.B. 2012).</p>
</caption>
<table frame="hsides" rules="rows">
<tbody>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<bold>Influenza vaccine received in cultured chick embryos:</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<italic>Inactivated influenza vaccine split virion with:</italic>
<list list-type="simple">
<list-item>
<p>– VAXIGRIP (Sanofi Pasteur SA, F)</p>
</list-item>
<list-item>
<p>– Fluarix (GlaxoSmithKline, B)</p>
</list-item>
<list-item>
<p>– Begrivac (Novartis Vaccines and Diagnostics, D)</p>
</list-item>
<list-item>
<p>– ID Flu
<xref ref-type="table-fn" rid="tfn1-medscimonit-18-11-ra166">*</xref>
(Sanofi Pasteur SA, F) </p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<italic>Subunit vaccines containing isolated surface antigens, hemagglutinin and neuraminidase, ie:</italic>
<list list-type="simple">
<list-item>
<p>– Influvac (Abbott, NL)</p>
</list-item>
<list-item>
<p>– Agrippal (Novartis Vaccines and Diagnostics SRL, I)</p>
</list-item>
</list>
<italic>Vaccines wirosomalne:</italic>
<list list-type="simple">
<list-item>
<p>– Inflexal V (Berna Biotech I, S.r.I.)</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<bold>Influenza vaccine received in the MDCK cell culture:</bold>
<break></break>
Inactivated subunit influenza vaccine, containing isolated surface antigens, hemagglutinin and neuraminidase, ie:
<list list-type="simple">
<list-item>
<p>– Optaflu (Novartis Vaccines and Diagnostics, D)</p>
</list-item>
</list>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<bold>Influenza vaccine received in the Vero cell culture:</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Inactivated influenza vaccine with split virion</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Preflucel (Baxter,A)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="tfn1-medscimonit-18-11-ra166">
<label>*</label>
<p>Vaccine administered intradermally.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t3-medscimonit-18-11-ra166" position="float">
<label>Table 3</label>
<caption>
<p>Recommendations of the International Scientific Societies for influenza vaccination [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
] (Brydak L.B. 2008).</p>
</caption>
<table frame="hsides" rules="rows">
<tbody>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="simple">
<list-item>
<p>– Advisory Committee on Immunization (ACIP)</p>
</list-item>
<list-item>
<p>– American Academy of Pediatrics (AAP)</p>
</list-item>
<list-item>
<p>– American Academy of Family Practice (AAFP)</p>
</list-item>
<list-item>
<p>– American Academy of Family Physicians (AAFP)</p>
</list-item>
<list-item>
<p>– Working Party on Preventive Services (USPSTF U.S.)</p>
</list-item>
<list-item>
<p>– American College of Internal Medicine</p>
</list-item>
<list-item>
<p>– American Society of Internal Medicine, U.S.</p>
</list-item>
<list-item>
<p>– American Society for Infectious Diseases (IDSA)</p>
</list-item>
<list-item>
<p>– Canadian Working Group on Periodic Health Research</p>
</list-item>
<list-item>
<p>– American Cancer Society</p>
</list-item>
<list-item>
<p>– American College of Obstetrics and Gynecology</p>
</list-item>
<list-item>
<p>– Executive Director of the Department of Health UK</p>
</list-item>
<list-item>
<p>– American Heart Association/American College of Cardiology</p>
</list-item>
<list-item>
<p>– Global Initiative on Chronic Obstructive Lung Disease (GOLD)</p>
</list-item>
<list-item>
<p>– Global Strategy for Recognition, Treatment and Prevention of Asthma (GINA guidlines) </p>
</list-item>
</list>
</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="t4-medscimonit-18-11-ra166" position="float">
<label>Table 4</label>
<caption>
<p>Studies conducted in the Research Department of influenza viruses, the National Influenza Center, NIPH in collaboration with clinicians in the groups at risk and evaluated the humoral immune response to influenza vaccination [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
] (Brydak L.B. 2008).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="center" valign="middle" rowspan="1" colspan="1">Children</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children aged 6–35 months, 3–8 years of age, 9–12 years 0.13–20 years of age</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with acute lymphoblastic leukemia (ALL), vaccinated at different times after treatment.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with severe haemophilia and mild.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with bronchopulmonary dysplasia.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with glomerulonephritis.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with chronic renal failure subjected to continuous ambulatory peritoneal dialysis, hemodialysis and chronic renal failure vaccinated once and twice.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children infected with HIV.</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children vaccinated after splenectomy in age groups 0–5 years of age, 6–10 years of age, 11–15 years of age, (
<italic>dissertation</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with aplastic anaemia</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with asthma</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Children with inflammatory bowel disease</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="center" valign="middle" rowspan="1" colspan="1">
<bold>Adults</bold>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<hr></hr>
</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Adults aged 1921–1930 years of age, from 1931 to 1940 years of age, from 1941 to 1950 years of age, from 1951 to 1964 years of age, >64 years (
<italic>2 dissertations</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Billeted students of the Military Medical Academy</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients chronically ill</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with acute lymphoblastic leukemia</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with chronic renal failure</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients after renal allograft resipients</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients infected with HIV at various levels of CD4, with symptoms of AIDS and asymptomatic</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with breast cancer</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with cancer of the thyroid</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with asthma (
<italic>part of PhD thesis</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with chronic obstructive pulmonary disease (COPD) (
<italic>part of PhD thesis</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with a group of young and elderly (
<italic>dissertation</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with acute cardiovascular events (
<italic>some of the habilitation thesis</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with malignant lymphomas-Hodgkin’s (
<italic>PhD thesis</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with lupus (
<italic>PhD thesis</italic>
)</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">Patients with primary systemic vascular inflammation: Wegner’s granulomatosis (
<italic>part of the habilitation thesis</italic>
)</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="t5-medscimonit-18-11-ra166" position="float">
<label>Table 5</label>
<caption>
<p>Reasons for low prevalence of influenza vaccination [
<xref ref-type="bibr" rid="b1-medscimonit-18-11-ra166">1</xref>
].</p>
</caption>
<table frame="hsides" rules="rows">
<tbody>
<tr>
<td align="left" valign="middle" rowspan="1" colspan="1">
<list list-type="bullet">
<list-item>
<p>lack of doctors’ greater acceptance for this form of prevention</p>
</list-item>
<list-item>
<p>lack of awareness about the legal obligation of doctors to recommend vaccination</p>
</list-item>
<list-item>
<p>insufficient knowledge about influenza and its complications cost, not only in individual cases, but in the whole country</p>
</list-item>
<list-item>
<p>insufficient knowledge about the types of vaccines</p>
</list-item>
<list-item>
<p>the expectation that vaccination protects against all upper respiratory tract infections (unrealistic, since respiratory viruses are about 200 types)</p>
</list-item>
<list-item>
<p>confuse influenza with the common cold in this example,
<italic>stomach flu</italic>
or other respiratory infections</p>
</list-item>
<list-item>
<p>frequent adverse events after vaccination confusion with influenza complications</p>
</list-item>
<list-item>
<p>the need to repeat vaccination every epidemiologic season </p>
</list-item>
</list>
</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
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