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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Doctrine of Original Antigenic Sin: Separating Good From Evil</title><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Malosh, Ryan E" sort="Malosh, Ryan E" uniqKey="Malosh R" first="Ryan E." last="Malosh">Ryan E. Malosh</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petrie, Joshua G" sort="Petrie, Joshua G" uniqKey="Petrie J" first="Joshua G." last="Petrie">Joshua G. Petrie</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Emily T" sort="Martin, Emily T" uniqKey="Martin E" first="Emily T." last="Martin">Emily T. Martin</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28398521</idno><idno type="pmc">5853211</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853211</idno><idno type="RBID">PMC:5853211</idno><idno type="doi">10.1093/infdis/jix173</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Doctrine of Original Antigenic Sin: Separating Good From Evil</title><author><name sortKey="Monto, Arnold S" sort="Monto, Arnold S" uniqKey="Monto A" first="Arnold S." last="Monto">Arnold S. Monto</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Malosh, Ryan E" sort="Malosh, Ryan E" uniqKey="Malosh R" first="Ryan E." last="Malosh">Ryan E. Malosh</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Petrie, Joshua G" sort="Petrie, Joshua G" uniqKey="Petrie J" first="Joshua G." last="Petrie">Joshua G. Petrie</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author><author><name sortKey="Martin, Emily T" sort="Martin, Emily T" uniqKey="Martin E" first="Emily T." last="Martin">Emily T. Martin</name><affiliation><nlm:aff id="AF0001"><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The term “original antigenic sin” was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza virus strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness (VE). This conclusion was largely dismissed after an experimental study involving sequential administration of then-standard influenza vaccines. Recent observations have provided convincing evidence that reduced VE after sequential influenza vaccination is a real phenomenon. We propose that such reduction in VE be termed “negative antigenic interaction,” given that there is no age cohort effect. In contrast, the potentially positive protective effect of early influenza virus infection later in life continues to be observed. It is essential that we understand better the immunologic factors underlying both original antigenic sin and negative antigenic interaction, to support development of improved influenza vaccines and vaccination strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Francis, T" uniqKey="Francis T">T Francis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name></author><author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M Ambrose</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO 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article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name><publisher-loc>US</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28398521</article-id><article-id pub-id-type="pmc">5853211</article-id><article-id pub-id-type="doi">10.1093/infdis/jix173</article-id><article-id pub-id-type="publisher-id">jix173</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>The Doctrine of Original Antigenic Sin: Separating Good From Evil</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Monto</surname><given-names>Arnold S.</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><pmc-comment>asmonto@umich.edu </pmc-comment>
</contrib><contrib contrib-type="author"><name><surname>Malosh</surname><given-names>Ryan E.</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Petrie</surname><given-names>Joshua G.</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Emily T.</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib></contrib-group><aff id="AF0001"><label>1</label><institution>Department of Epidemiology, University of Michigan School of Public Health</institution>,<addr-line>Ann Arbor</addr-line></aff><author-notes><fn id="fn-0001"><p>Correspondence: A. S. Monto, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI (<email>asmonto@umich.edu</email>).</p></fn></author-notes><pub-date pub-type="ppub"><day>15</day><month>6</month><year>2017</year></pub-date><pub-date pub-type="epub" iso-8601-date="2017-04-07"><day>07</day><month>4</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>4</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<pmc-comment> oupReleaseDelayRemoved from OA Article (10.1093/infdis/jix173jix173ReviewThe Doctrine of Original Antigenic Sin: Separating Good From EvilMontoArnold S.asmonto@umich.eduMaloshRyan E.PetrieJoshua G.MartinEmily T.
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Department of Epidemiology, University of Michigan School of Public Health, Ann ArborCorrespondence: A. S. Monto, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI (asmonto@umich.edu).15062017150620170704201721512178217883101201705042017© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.2017This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comAbstractThe term “original antigenic sin” was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza virus strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness (VE). This conclusion was largely dismissed after an experimental study involving sequential administration of then-standard influenza vaccines. Recent observations have provided convincing evidence that reduced VE after sequential influenza vaccination is a real phenomenon. We propose that such reduction in VE be termed “negative antigenic interaction,” given that there is no age cohort effect. In contrast, the potentially positive protective effect of early influenza virus infection later in life continues to be observed. It is essential that we understand better the immunologic factors underlying both original antigenic sin and negative antigenic interaction, to support development of improved influenza vaccines and vaccination strategies.Influenzaimmune response.World Health Organization10.13039/100004423) </pmc-comment>
<volume>215</volume><issue>12</issue><fpage>1782</fpage><lpage>1788</lpage><history><date date-type="received"><day>31</day><month>1</month><year>2017</year></date><date date-type="accepted"><day>05</day><month>4</month><year>2017</year></date></history><permissions><copyright-statement>© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.</copyright-statement><copyright-year>2017</copyright-year><license license-type="cc-by-nc-nd" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><self-uri xlink:href="jix173.pdf"></self-uri><abstract><title>Abstract</title><p>The term “original antigenic sin” was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza virus strains. Then, approximately 40 years ago, it was observed that sequential influenza vaccination might lead to reduced vaccine effectiveness (VE). This conclusion was largely dismissed after an experimental study involving sequential administration of then-standard influenza vaccines. Recent observations have provided convincing evidence that reduced VE after sequential influenza vaccination is a real phenomenon. We propose that such reduction in VE be termed “negative antigenic interaction,” given that there is no age cohort effect. In contrast, the potentially positive protective effect of early influenza virus infection later in life continues to be observed. It is essential that we understand better the immunologic factors underlying both original antigenic sin and negative antigenic interaction, to support development of improved influenza vaccines and vaccination strategies.</p></abstract><kwd-group><kwd>Influenza</kwd><kwd>immune response.</kwd></kwd-group><funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">World Health Organization</named-content><named-content content-type="funder-identifier">10.13039/100004423</named-content></funding-source></award-group></funding-group><counts><page-count count="7"></page-count></counts></article-meta></front><body><sec id="s1"><title>BACKGROUND OF THE DOCTRINE</title><p>The term “original antigenic sin” (OAS) was coined by Thomas Francis Jr in the late 1950s to describe patterns of antibody response to influenza vaccination [<xref rid="CIT0001" ref-type="bibr">1</xref>]. Francis’ father was a Presbyterian minister, likely a reason he used a theologically charged term to describe a biologic phenomenon. The basic concept was recently summarized as “first flu is forever,” indicating the continued relevance of OAS throughout life [<xref rid="CIT0002" ref-type="bibr">2</xref>]. The authors of this perspective commented on the observation that the first infection in life may predetermine later protection from encounters with avian influenza viruses [<xref rid="CIT0003" ref-type="bibr">3</xref>]. This is exactly the idea that Francis and others were describing in terms of antibodies 60 years ago. The immune response to first infection imprinted itself on subsequent responses to infections and particularly vaccination. The doctrine was based on age cohort–associated antibody patterns observed in sera collected from the community, as well as on differences in antibody responses to vaccination between children and adults. The result could be either positive or negative and could be corrected by vaccination with appropriate antigens, termed the “blessing of induced immunity” [<xref rid="CIT0001" ref-type="bibr">1</xref>]. In addition to being appropriately used to describe imprinting, OAS has also been sometimes inappropriately used to suggest simply that vaccine receipt might be deleterious. It has also been used to describe observations that have little to do with imprinting of early infections, such as when, later in life, vaccination in combination or in sequence does not have the desired response. This phenomenon should be termed instead “antigenic interaction.” With influenza, that interaction has manifested itself in the possible reduced effectiveness of repeat vaccinations. We here review the original observations leading to the doctrine of OAS and how that term has been applied both appropriately and inappropriately to recent events of public health importance. We will confine much of the review to influenza, including the possibility of negative antigenic interaction, even though similar discussions could involve other viruses, particularly flaviviruses and alphaviruses, and the use of various vaccines in sequence.</p></sec><sec id="s2"><title>EARLY INFLUENZA VACCINES AND IMMUNE RECAPITULATION OF OLDER STRAINS</title><p>The discovery that influenza viruses hemagglutinate led both to the ability to concentrate the viruses to produce vaccine and the development of the hemagglutination inhibition (HAI) test to measure antibody response. The first evaluations of today’s inactivated influenza vaccine started in 1943 in conjunction with the US military [<xref rid="CIT0004" ref-type="bibr">4</xref>]. Measurements of antibody titers in those who were vaccinated and those who received placebo showed that the HAI titer correlated with protection, indicating that the response to vaccine at least in part mimicked the response to natural infection. The composition of the 1943 vaccine also indicated recognition, even then, that influenza virus was undergoing antigenic drift. Updates of composition to account for drift continued to be made, but in early 1947, the vaccine stopped being effective, and it was concluded that a new A subtype had evolved [<xref rid="CIT0005" ref-type="bibr">5</xref>]. We now know that this was an example of intrasubtypic reassortment [<xref rid="CIT0006" ref-type="bibr">6</xref>]. Updating the vaccine virus resumed thereafter.</p><p>At the time, with limited molecular techniques available, it was believed that the influenza virus strains that we now term type A(H1N1) viruses comprised 3 independent subtypes: the swine influenza virus subtype (ASw), known to be related to the virus that caused the 1918 pandemic; the A0 subtype, prevalent starting in the 1930s; and the A1 or A prime subtype, postulated when the A0 vaccine stopped being effective in 1946–1947. It was not until 1980 that the current nomenclature was adopted, in which these viruses were designated A(H1N1) strains, meaning in current terms that they would all be considered antigenically drifted variants.</p><p>The concept of OAS was developed first on the basis of detection of residual antibodies from earlier infection with these strains and then by use of experimental vaccination with monovalent vaccines containing these inactivated viruses [<xref rid="CIT0007" ref-type="bibr">7</xref>, <xref rid="CIT0008" ref-type="bibr">8</xref>]. <xref ref-type="fig" rid="F1">Figure 1</xref> is an illustration of antibodies left behind by first infections in life, based on HAI antibodies found in specimens collected before the 1957 pandemic [<xref rid="CIT0001" ref-type="bibr">1</xref>]. ASw antibodies were present in the older individuals, in part from the 1918 pandemic, and they persisted. A0 antibodies were detected in middle-aged individuals but not in the youngest individuals, who only had A1 antibodies. The question was how vaccination would alter these patterns. Experimental monovalent vaccines were used, representing the 3 A variants shown in <xref ref-type="fig" rid="F1">Figure 1</xref>. The individuals receiving the vaccines—before 1957—were children 4–10 years of age, military recruits aged 17–26 years, and persons aged >30 years [<xref rid="CIT0007" ref-type="bibr">7</xref>]. In <xref ref-type="fig" rid="F2">Figure 2</xref>, each panel represents a combination of a vaccine and an antigen used to identify antibody in the HAI test. It was observed that, when the children were vaccinated with 1946–1956 A1 virus vaccines, they produced antibody against these viruses but not antibodies against earlier strains. In contrast, when children were given the PR8-containing 1934 A0 virus monovalent vaccine or the ASw virus monovalent vaccine, they produced antibody not only against the virus specific to each vaccine, but also against the contemporary viruses, and the titer was higher against more-recent strains. When adults were given the vaccine containing a contemporary virus, however, they produced comparable antibody against both contemporary and older strains. Thus, the belief that OAS simply implies a diminished vaccine response to contemporaneous strains is at odds with this description of the phenomenon.</p><fig fig-type="figure" id="F1" orientation="portrait" position="float"><label>Figure 1.</label><caption><p>Prevalence of antibody to type A influenza viruses in unvaccinated individuals to prior to the 1957 influenza A(H2N2) pandemic, demonstrating the absence of antibody in younger individuals to strains that circulated earlier and the persistence of antibody in older individuals. Data are adapted from findings in the report by Francis [<xref rid="CIT0001" ref-type="bibr">1</xref>]. HAI, hemagglutination inhibition.</p></caption><graphic xlink:href="jix17301"></graphic></fig><fig fig-type="figure" id="F2" orientation="portrait" position="float"><label>Figure 2.</label><caption><p>Antibody response to monovalent adjuvant influenza virus vaccine in children, military recruits, and persons aged >30 years. Test antigens in the hemagglutination inhibition (HAI) test are those used in each of the vaccines. Homologous combinations of vaccine and antigen are indicated by an asterisk. Data are adapted from findings in the report by Davenport and Hennessy [<xref rid="CIT0008" ref-type="bibr">8</xref>].</p></caption><graphic xlink:href="jix17302"></graphic></fig><p>The meaning of these findings in terms of the immunologic theory of the time was examined using techniques such as antibody absorption [<xref rid="CIT0009" ref-type="bibr">9</xref>]. This approach was intended to separate antibodies of varying avidity that were specific to the virus, either infecting or immunizing, from antibodies cross-reactive to the 3 strains under study. The results of these studies indicate the importance of using laboratory methods to understand epidemiologic observations [<xref rid="CIT0010" ref-type="bibr">10</xref>, <xref rid="CIT0011" ref-type="bibr">11</xref>]. There was little focus on how well cross-reactive antibodies prevented infection, since vaccination against circulating strains, sometimes with adjuvanted antigens, had previously been demonstrated to be effective, especially in members of the US military who, because of their age, had been first infected with older strains [<xref rid="CIT0012" ref-type="bibr">12</xref>].</p><p>Thus, the conclusion drawn, when OAS was first conceptualized, was that the first infection experience in life “orients” immunologic memory. When discussing the implications, the public health concern at the time was related not to any diminished response to contemporary viruses in different age groups, but to the fact that, although younger individuals did not produce antibody to older viruses, older people did, even in response to current strains. The heightened focus on population immunity to older viruses was rooted in the so-called recycling theory, which posited the existence of a limited number of influenza A virus subtypes that would each appear in succession. The concept was developed in the early 1950s, based in part on the serum survey data shown in <xref ref-type="fig" rid="F1">Figure 1</xref> and the belief that swine (1918), A0 (1934), and A1 (1947) viruses represented different subtypes. Under this theory, if antibodies to prior strains could be induced through vaccination, community spread would be limited when the strains later returned [<xref rid="CIT0001" ref-type="bibr">1</xref>]. Belief in the recycling theory was strengthened following emergence in 1957 of the A(H2N2) viruses, termed at the time Asian influenza viruses [<xref rid="CIT0013" ref-type="bibr">13</xref>]. It was found, first in the Netherlands, that sera collected from individuals ≥60 years of age prior to that pandemic had antibody to the A(H2N2) virus. The gap in antibody prevalence in younger individuals was viewed as increasing their susceptibility to future strains. In his classic article, “On the Doctrine of Original Antigenic Sin” [<xref rid="CIT0001" ref-type="bibr">1</xref>], published after the A(H2N2) pandemic, Francis concluded that these gaps</p><disp-quote><p>in their immunity should be eliminated by providing early in life the antigenic stimuli to meet the known or anticipated recurrent strains. Natural exposures would then serve to enhance the broad immunity laid down by vaccination. It is our hope that such vaccines can be made from pools of chemically purified antigens – or even with strains experimentally devised. In this manner the original sin of infection could be replaced by an initial blessing of induced immunity.</p></disp-quote></sec><sec id="s3"><title>THE HOSKINS PARADOX AND YEARLY VACCINATION</title><p>The issue of OAS remained in the background through the A(H3N2) pandemic of 1968. It was invoked by some as the explanation for what they termed the Hoskins paradox, after the first author of 3 articles on influenza VE, using data from an English boarding school for boys, Christ’s Hospital [<xref rid="CIT0014" ref-type="bibr">14–16</xref>]. The first of these studies reported successful prevention of influenza A/England/42/72(H3N2) infection by an A/Hong Kong/x31/68(H3N2) vaccine. In the second, those protected in the first study were more likely to be infected in a later year. However, questions remained as to how many of those infected in the previously vaccinated group had actually been vaccinated in the current year [<xref rid="CIT0017" ref-type="bibr">17</xref>]. Hoskins et al concluded at that time that prior infection is more effective than vaccination in preventing subsequent infection, an observation that remains undisputed. There was no mention about sequential, repeated vaccination as a concern for future protection.</p><p>It was the final article that concluded that the Christ’s Hospital study found no benefit of revaccination [<xref rid="CIT0016" ref-type="bibr">16</xref>]. The reported attack rates were 13% in those with current-year vaccination only, 22% in those with prior- and current-year vaccination, and 21% in those who were unvaccinated. While these results can be questioned in terms of the role of major antigenic drift of that year’s strain (A/Victoria/3/75[H3N2]) and of use of serologic testing to confirm infection, a method known to introduce bias in vaccinated individuals, they suggest a decreasing effect of prior vaccination on VE [<xref rid="CIT0018" ref-type="bibr">18</xref>, <xref rid="CIT0019" ref-type="bibr">19</xref>]. However, it is also clear that, since most of the boys in question were born in and therefore had their first influenza infections during the A(H2N2) era, the observations cannot be attributed to OAS as originally defined.</p></sec><sec id="s4"><title>REACTION TO THE HOSKINS PARADOX</title><p>The issue of repeat vaccination brought up by the Hoskins articles prompted concern over annual vaccination policies and prompted a number of reviews. Many simply analyzed serologic responses to vaccination, a reflection of the common practice at the time of considering an HAI titer of 1:40 to be seroprotective and treating the presence of HAI antibody as equivalent to actual protection [<xref rid="CIT0020" ref-type="bibr">20</xref>]. A notable exception to this approach was a 5-year experimental investigation by Keitel et al that examined sequential vaccination with licensed whole virus vaccines in adults [<xref rid="CIT0021" ref-type="bibr">21</xref>, <xref rid="CIT0022" ref-type="bibr">22</xref>], with outcomes determined by virus isolation and/or an increase in antibody titer. While year-to-year variation in the actual VE was observed, the overall conclusion was that there was no clear evidence of an effect of repeat vaccination.</p><p>Subsequently, Beyer et al produced an extensive analysis of repeat vaccination, which evaluated the trials that determined actual efficacy in preventing laboratory-confirmed influenza [<xref rid="CIT0023" ref-type="bibr">23</xref>]. While there was heterogeneity in the effect of repeat vaccination, overall there was no consistent negative effect [<xref rid="CIT0023" ref-type="bibr">23</xref>]. Smith et al, in reviewing this meta-analysis, noted the heterogeneity and attributed the variability to antigenic distance between vaccine strains and circulating strains (ie, the greater the antigenic distance the less likely that prior-year vaccination would have an effect on VE) [<xref rid="CIT0024" ref-type="bibr">24</xref>].</p></sec><sec id="s5"><title>RETURN OF THE REPEAT VACCINATION ISSUE</title><p>Despite these cautionary observations, the consensus conclusion for years was that there was no significant prior-year interaction effect reducing VE. Even with the questions raised by Smith et al, this conclusion persisted until recently, when the development of the polymerase chain reaction (PCR) technique made it much easier to confirm that VE estimates were truly specific to influenza. The first clear demonstration of a reduction in VE estimates with prior vaccination was a longitudinal household study using real-time reverse-transcription PCR–defined infection that was conducted during 2010–2011, when there was a minor change in A(H3N2) vaccine composition [<xref rid="CIT0025" ref-type="bibr">25</xref>]. This was followed by confirmation in a larger study using the test-negative design, currently the most common observational design for VE studies, during 2011–2012, a year in which there was no change in vaccine strains from the prior year [<xref rid="CIT0026" ref-type="bibr">26</xref>]. The negative effect of prior-year vaccination has been repeatedly observed in many subsequent years, particularly in years with heavy A(H3N2) circulation [<xref rid="CIT0027" ref-type="bibr">27–29</xref>]. In most studies, even when there was a reduction in VE among those vaccinated over 2 years, the infection risks in that group were lower than among those not vaccinated either year, unlike the report from the study by Hoskins et al. In addition, there was often considerable residual VE in those vaccinated in the prior year only, which may suggest that within-season waning of protection was overstated. The immunologic basis for this phenomenon, including whether it has anything to do with antigenic distance, remains unclear.</p><p>There is a new element that has now been added to the debate on the effects of repeat vaccination. VE estimates for A(H3N2) reported by Skowronski et al for 2014–2015 among those vaccinated in Canada in that year and for 2013–2014 are shown in <xref ref-type="fig" rid="F3">Figure 3</xref>. The A(H3N2) virus circulating in 2014–2015 was a major drift variant of the one contained in that year’s vaccine. The point estimate for those vaccinated in both years was negative (–32%; 95% confidence interval, –75%–0%). This negative VE was interpreted by the authors to indicate that prior influenza vaccination can, in certain situations, produce actual increased susceptibility to infection, not simply a VE that was less than the expected value. This followed a somewhat similar Canadian observation during the 2009 pandemic of increased susceptibility among those who previously received the 2008 trivalent vaccine containing seasonal A(H1N1) [<xref rid="CIT0030" ref-type="bibr">30</xref>]. That observation did not involve subsequent vaccination but was interpreted as increased susceptibility induced by vaccination with previously circulating strains. However, in terms of OAS, none of these studies reported an age cohort effect, which would be necessary for this to be termed OAS. Instead, this seems to be another demonstration of negative antigenic interaction [<xref rid="CIT0029" ref-type="bibr">29</xref>, <xref rid="CIT0030" ref-type="bibr">30</xref>].</p><fig fig-type="figure" id="F3" orientation="portrait" position="float"><label>Figure 3.</label><caption><p>Effect of prior 2013–2014 season influenza vaccine receipt on current 2014–2015 adjusted influenza vaccine effectiveness (VE) for A(H3N2) in Canada, comparing those not vaccinated in either year (reference) to those vaccinated in both years and, separately, those vaccinated in only 1 of 2 years. Data are adapted from findings in the report by Skowronski et al [<xref rid="CIT0029" ref-type="bibr">29</xref>]. Abbreviation: CI, confidence interval.</p></caption><graphic xlink:href="jix17303"></graphic></fig></sec><sec id="s6"><title>OAS IN THE 21ST CENTURY</title><p>Only rarely was the actual concept of OAS with immunologic imprinting considered in the late 20th century, even after the return of the A(H1N1) viruses in 1977, when those >25 years of age were largely protected [<xref rid="CIT0031" ref-type="bibr">31</xref>]. An exception was the work of Powers and Belshe, who, in studying an older population, sought to separate the effects of aging and OAS on immune response [<xref rid="CIT0032" ref-type="bibr">32</xref>]; they were interpreting OAS to mean a possible reduction in antibody response to new viruses among individuals first exposed to older viruses. They examined rises in antibody titer to the original A(H1N1) variants, ASw and A0, after receipt of 1990–1991 seasonal vaccine and their relation to the ages of the individuals involved. Older individuals had smaller responses than younger individuals overall, but both age groups had better responses to newer viruses than to older viruses. Thus, OAS was not responsible for a reduced antibody response in older persons and the problem was attributed to immune senescence.</p><p>Pandemics are generally associated with a revisiting and reexamination of prior concepts. The 2009 A(H1N1) pandemic was no exception. Unlike the situation in 1977, the evidence of overall protection among older individuals was recognized in the context of the effects of prior infection with older A(H1N1) viruses. A commentary entitled “The Wages of Original Antigenic Sin” was written in response to a letter entitled “Original Antigenic Sin and Pandemic (H1N1) 2009” [<xref rid="CIT0033" ref-type="bibr">33</xref>, <xref rid="CIT0034" ref-type="bibr">34</xref>]. As in 1977, nearly all older individuals who had lived through the previous period of A(H1N1) virus circulation were protected [<xref rid="CIT0031" ref-type="bibr">31</xref>, <xref rid="CIT0035" ref-type="bibr">35</xref>, <xref rid="CIT0036" ref-type="bibr">36</xref>]. Response to the 2009 monovalent vaccine was good in all age groups, even in those that did not previously have experience with older strains of A(H1N1) [<xref rid="CIT0037" ref-type="bibr">37</xref>]. A possible exception, cited in several reports, was that those who had previously received seasonal A(H1N1)-containing vaccines had reduced antibody responses to the pandemic vaccine, a phenomenon that also was referred to by the authors as a version of OAS but clearly involved negative antigenic interaction, rather than imprinting [<xref rid="CIT0038" ref-type="bibr">38–41</xref>].</p><p>Recent years have seen a number of reports proposing OAS as an explanation for findings or as motivation for specific studies. A problem of many of these studies was that they were looking for potential negative effects of antigenic interactions, which were said to represent OAS. One of these investigations used sera collected during the 5-year study by Keitel et al, the trial that concluded that there was no deleterious effect of multiyear vaccination [<xref rid="CIT0042" ref-type="bibr">42</xref>]. Amounts and avidities of preexisting antibody and antibody raised by the strains used for vaccination during that investigation were studied, and there were better responses to the vaccine virus itself when that vaccine strain was at greater antigenic distance from the prior one, in support of the hypothesis of Smith et al [<xref rid="CIT0024" ref-type="bibr">24</xref>].</p><p>These results were said to represent OAS, again demonstrating the incorrect use of the term, even though the age of vaccinees was not considered; in response, a follow-up study was designed in mice [<xref rid="CIT0043" ref-type="bibr">43</xref>]. The underlying assumption by Kim et al was that OAS resulted in a “severely diminished” response to the current strains [<xref rid="CIT0043" ref-type="bibr">43</xref>]. The A(H1N1) viruses originally involved in the OAS studies were used after undergoing mouse adaptation for lethal challenge. While the negative effects were modest, the authors concluded that OAS exists.</p><p>In contrast, a more current study, by O’Donnell et al, using older A(H1N1) and 2009 pandemic A(H1N1) viruses, did not report evidence of OAS in ferrets or humans; they too focused on possible deleterious effects [<xref rid="CIT0044" ref-type="bibr">44</xref>]. They explained conflicting findings from previous studies as being due to differences in the definition of what constituted a negative effect. Finding no evidence of deleterious effects agreed with another ferret study designed to explore the suggestion that prior receipt of seasonal trivalent inactivated influenza vaccine (TIV) led to an increased frequency of 2009 pandemic A(H1N1) infection [<xref rid="CIT0030" ref-type="bibr">30</xref>, <xref rid="CIT0045" ref-type="bibr">45</xref>]. In contrast, these authors found actual protection against pandemic A(H1N1) infection in ferrets previously vaccinated with seasonal TIV.</p><p>A recent ferret study by Bodewes et al has extended the issue to heterosubtypic protection. The authors did not use the term OAS, but, unlike the study by O’Donnell et al, their conclusions imply imprinting [<xref rid="CIT0046" ref-type="bibr">46</xref>]. Ferrets were either vaccinated or infected with an A(H3N2) virus (<xref ref-type="table" rid="T1">Table 1</xref>), and all were subsequently challenged with the lethal A(H5N1) virus; ferrets initially infected with A(H3N2) were protected. Those that had only been twice vaccinated but not infected were as susceptible as those that had not received any intervention. Ferrets that were initially vaccinated and then infected with A(H3N2) had intermediate levels of protection, indicating the greater influence of infection on protection, compared with vaccination. The authors generalized these results to critique the US policy of vaccinating children ≥6 months old, speculating that this may negatively affect subsequent development of heterosubtypic immunity through T cells. Although some data have been presented to support the relevance of animal results to the human situation [<xref rid="CIT0047" ref-type="bibr">47</xref>], the debate continues. Nevertheless, there is clearly a need to balance the prevention of severe influenza in young children, who are at high risk of complications, and the possible benefits of allowing the first infection in life to take place without modification by prior vaccination. In contrast, the case for the positive effects of the first seasonal infection, rather than immunization, resulting in heterosubtypic protection against A(H5N1) or A(H7N9) infection through anti– hemagglutinin antibody, was recently made by Gostic et al [<xref rid="CIT0003" ref-type="bibr">3</xref>]. This resulted in the editorial entitled “First Flu Is Forever,” a restatement of OAS [<xref rid="CIT0002" ref-type="bibr">2</xref>].</p><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1.</label><caption><p>Experimental Groups</p></caption><table frame="vsides" rules="groups"><thead><tr><th align="left" valign="bottom" rowspan="1" colspan="1">Group</th><th align="center" valign="bottom" rowspan="1" colspan="1">Vaccination<sup>a</sup></th><th align="center" valign="bottom" rowspan="1" colspan="1">Primary Infection<sup>b</sup></th></tr></thead><tbody><tr><td rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">Mock</td><td align="center" rowspan="1" colspan="1">A/H3N2 virus</td></tr><tr><td rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">A(H3N2) vaccine</td><td align="center" rowspan="1" colspan="1">A/H3N2 virus</td></tr><tr><td rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">A(H3N2) vaccine</td><td align="center" rowspan="1" colspan="1">Mock</td></tr><tr><td rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">Mock</td><td align="center" rowspan="1" colspan="1">Mock</td></tr></tbody></table><table-wrap-foot><fn id="fn-01" fn-type="other"><p>Data are adapted from findings in the report by Bodewes et al [46]. All groups were challenged with influenza A/Indonesia/5/05(H5N1).</p></fn><fn id="fn-02" fn-type="other"><p><sup>a</sup>The A(H3N2) vaccine was a subunit vaccine derived from influenza A/Uruguay/ 716/2007(NYMC X-175-C; H3N2) virus adjuvanted with Titermax Gold adjuvant.</p></fn><fn id="fn-03" fn-type="other"><p><sup>b</sup>The influenza A(H3N2) strain was influenza A/Brisbane/010/07(H3N2).</p></fn></table-wrap-foot></table-wrap></sec><sec id="s7"><title>OAS AND ANTIGENIC INTERACTION: THE NEED FOR A NEW TERM</title><p>At this point, >60 years after the first description of OAS, most would expect that the debate about what it is and whether it exists would be settled. Yet the doctrine is still invoked to explain observations that may but often may not relate to its original description, such as reductions in the response to antigens encountered in sequence later, namely in annual influenza vaccination. This issue has recently attracted much attention, with editorials describing its history and policy implications [<xref rid="CIT0048" ref-type="bibr">48</xref>, <xref rid="CIT0049" ref-type="bibr">49</xref>]. The underlying immune mechanisms involved may be similar to that of OAS, but reductions in the response to a second antigen should not be termed OAS without evidence of a birth cohort effect. Such age specificity is still relevant and seems to be playing a role currently with A(H1N1) vaccine protection, in which there appears to be a cohort effect both overall and with respect to a single mutation [<xref rid="CIT0050" ref-type="bibr">50</xref>]. In the absence of an age effect, we propose use of a modified term when describing a reduced response to repeated vaccination. Smith et al used the term “negative interference” to describe the phenomenon for vaccine strains without sufficient antigenic distance from those in a prior vaccine [<xref rid="CIT0024" ref-type="bibr">24</xref>]. A better term might now be “antigenic interaction,” since it is not clear that interference is occurring.</p><p>The classic description of OAS did not report any “impaired” response to subsequent vaccination, only a strong anamnestic response to the original infecting strain, which was absent in younger individuals not so infected. It was said that the sin of original infection could be remedied by the blessing of vaccination [<xref rid="CIT0001" ref-type="bibr">1</xref>]. That may also apply to modifying the phenomenon that we now refer to as negative antigenic interaction. Before that can happen, we need a better understanding of the immune mechanisms involved, which may vary based on the observed effect. Without that understanding, the remedy will be hard to prescribe. The work will require the use of modern immunologic techniques applied not only to animal models but also to observations in humans. Only by understanding the concept of OAS—now over half a century old—and the new concept of negative antigenic interaction may we be able to improve protection against the ever-changing threat of influenza.</p></sec></body><back><notes id="n1"><title>Notes</title><p><bold><italic>Acknowledgment.</italic></bold> We thank the Centers for Disease Control and Prevention, which provides financial support to the World Health Organization Initiative for Vaccine Research (U50 CK000431).</p><p><bold><italic>Financial support.</italic></bold> This work was support by the Initiative for Vaccine Research, World Health Organization.</p><p><bold><italic>Potential conflicts of interest.</italic></bold> A. S. M. has received grant support from Sanofi Pasteur and consultancy fees from Sanofi, Novartis, and Novavax for work unrelated to this report. R. E. M. and A. S. M. have received grant support from the Multiparty Group for Advice on Science Foundation for work unrelated to this report. E. T. M. has received grant support from Merck and Pfizer for work unrelated to this report. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. 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