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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Implications of segment mismatch for influenza A virus evolution</title><author><name sortKey="White, Maria C" sort="White, Maria C" uniqKey="White M" first="Maria C." last="White">Maria C. White</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lowen, Anice C" sort="Lowen, Anice C" uniqKey="Lowen A" first="Anice C." last="Lowen">Anice C. Lowen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29244017</idno><idno type="pmc">5882089</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882089</idno><idno type="RBID">PMC:5882089</idno><idno type="doi">10.1099/jgv.0.000989</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C87</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Implications of segment mismatch for influenza A virus evolution</title><author><name sortKey="White, Maria C" sort="White, Maria C" uniqKey="White M" first="Maria C." last="White">Maria C. White</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lowen, Anice C" sort="Lowen, Anice C" uniqKey="Lowen A" first="Anice C." last="Lowen">Anice C. Lowen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of General Virology</title><idno type="ISSN">0022-1317</idno><idno type="eISSN">1465-2099</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A virus (IAV) is an RNA virus with a segmented genome. These viral properties allow for the rapid evolution of IAV under selective pressure, due to mutation occurring from error-prone replication and the exchange of gene segments within a co-infected cell, termed reassortment. Both mutation and reassortment give rise to genetic diversity, but constraints shape their impact on viral evolution: just as most mutations are deleterious, most reassortment events result in genetic incompatibilities. The phenomenon of segment mismatch encompasses both RNA- and protein-based incompatibilities between co-infecting viruses and results in the production of progeny viruses with fitness defects. Segment mismatch is an important determining factor of the outcomes of mixed IAV infections and has been addressed in multiple risk assessment studies undertaken to date. However, due to the complexity of genetic interactions among the eight viral gene segments, our understanding of segment mismatch and its underlying mechanisms remain incomplete. Here, we summarize current knowledge regarding segment mismatch and discuss the implications of this phenomenon for IAV reassortment and diversity.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Gen Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Gen. Virol</journal-id><journal-id journal-id-type="publisher-id">JGV</journal-id><journal-title-group><journal-title>The Journal of General Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-1317</issn><issn pub-type="epub">1465-2099</issn><publisher><publisher-name>Microbiology Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29244017</article-id><article-id pub-id-type="pmc">5882089</article-id><article-id pub-id-type="publisher-id">000989</article-id><article-id pub-id-type="doi">10.1099/jgv.0.000989</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject><subj-group subj-group-type="heading"><subject>Animal</subject><subj-group subj-group-type="heading"><subject>Negative-strand RNA Viruses</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Implications of segment mismatch for influenza A virus evolution</article-title><alt-title alt-title-type="recto-page-foot"><ext-link ext-link-type="uri" xlink:href="http://jgv.microbiologyresearch.org">http://jgv.microbiologyresearch.org</ext-link></alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>White</surname><given-names>Maria C.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Lowen</surname><given-names>Anice C.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><aff id="aff1"><institution>Department of Microbiology and Immunology, Emory University School of Medicine</institution>,<addr-line>Atlanta, GA</addr-line>,<country>USA</country></aff></contrib-group><author-notes><corresp id="cor1"><bold>*Correspondence:</bold> Anice C. Lowen, <email xlink:href="anice.lowen@emory.edu">anice.lowen@emory.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>12</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>99</volume><issue>1</issue><fpage>3</fpage><lpage>16</lpage><history><date date-type="received"><day>29</day><month>8</month><year>2017</year></date><date date-type="accepted"><day>03</day><month>12</month><year>2017</year></date></history><permissions><copyright-year>2018</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="jgv-99-3.pdf"></self-uri><abstract><p>Influenza A virus (IAV) is an RNA virus with a segmented genome. These viral properties allow for the rapid evolution of IAV under selective pressure, due to mutation occurring from error-prone replication and the exchange of gene segments within a co-infected cell, termed reassortment. Both mutation and reassortment give rise to genetic diversity, but constraints shape their impact on viral evolution: just as most mutations are deleterious, most reassortment events result in genetic incompatibilities. The phenomenon of segment mismatch encompasses both RNA- and protein-based incompatibilities between co-infecting viruses and results in the production of progeny viruses with fitness defects. Segment mismatch is an important determining factor of the outcomes of mixed IAV infections and has been addressed in multiple risk assessment studies undertaken to date. However, due to the complexity of genetic interactions among the eight viral gene segments, our understanding of segment mismatch and its underlying mechanisms remain incomplete. Here, we summarize current knowledge regarding segment mismatch and discuss the implications of this phenomenon for IAV reassortment and diversity.</p></abstract><kwd-group><kwd>influenza A virus</kwd><kwd>reassortment</kwd><kwd>segment mismatch</kwd><kwd>evolution</kwd><kwd>packaging</kwd><kwd>evolutionary constraint</kwd></kwd-group><funding-group><award-group><funding-source id="sp1">National Institute of Allergy and Infectious Diseases</funding-source><award-id rid="sp1">R01 AI099000</award-id></award-group><award-group><funding-source id="sp2">National Institute of Allergy and Infectious Diseases</funding-source><award-id rid="sp2">R01 AI125268</award-id></award-group><award-group><funding-source id="sp3">National Institute of Allergy and Infectious Diseases</funding-source><award-id rid="sp3">HHSN272201400004C</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>OpenAccessEmbargo</meta-name><meta-value>12</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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