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<title xml:lang="en">Impact of Pollution, Climate, and Sociodemographic Factors on Spatiotemporal Dynamics of Seasonal Respiratory Viruses</title>
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<name sortKey="Sloan, Chantel" sort="Sloan, Chantel" uniqKey="Sloan C" first="Chantel" last="Sloan">Chantel Sloan</name>
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<author>
<name sortKey="Moore, Martin L" sort="Moore, Martin L" uniqKey="Moore M" first="Martin L." last="Moore">Martin L. Moore</name>
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<author>
<name sortKey="Hartert, Tina" sort="Hartert, Tina" uniqKey="Hartert T" first="Tina" last="Hartert">Tina Hartert</name>
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<title xml:lang="en" level="a" type="main">Impact of Pollution, Climate, and Sociodemographic Factors on Spatiotemporal Dynamics of Seasonal Respiratory Viruses</title>
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<name sortKey="Sloan, Chantel" sort="Sloan, Chantel" uniqKey="Sloan C" first="Chantel" last="Sloan">Chantel Sloan</name>
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<name sortKey="Moore, Martin L" sort="Moore, Martin L" uniqKey="Moore M" first="Martin L." last="Moore">Martin L. Moore</name>
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<name sortKey="Hartert, Tina" sort="Hartert, Tina" uniqKey="Hartert T" first="Tina" last="Hartert">Tina Hartert</name>
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<title level="j">Clinical and Translational Science</title>
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<title>Abstract</title>
<p>Seasonal viruses present a major cause of morbidity and mortality in temperate climates. Through major pandemics and smaller annual epidemics, viruses such as influenza, respiratory syncytial virus (RSV) and human rhinovirus (HRV) result in lost school and work days for most that are infected and more serious complications for the immunocompromised. The reasons for these viruses showing strict seasonality include but are not limited to the influence of cold weather and humidity on virus particles, human physiology, and human behavior. The relative importance of each is dependent on what geographic scale is being explored as well as the individual region and time period. Theoretical mathematics has also revealed that climatic changes are likely not the only reasons for strong seasonal cycles, but these are also based in periodic resonance with the natural cycles of immunity and antigenic variance, as well as nationwide synchrony through transportation networks. Investigations of seasonality will aid in understanding disease transmission, and thereby effective prevention strategies. The authors present a review of the literature on seasonal viruses, their annual diffusion through populations, and factors that reduce or enhance their seasonal spread. They also offer suggestions for targeted interventions to reduce the disease burden from seasonal viruses. Clin Trans Sci 2011; Volume 4: 48–54</p>
</div>
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<pmc article-type="review-article">
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<journal-id journal-id-type="nlm-ta">Clin Transl Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin Transl Sci</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1752-8062</journal-id>
<journal-id journal-id-type="publisher-id">CTS</journal-id>
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<journal-title>Clinical and Translational Science</journal-title>
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<issn pub-type="ppub">1752-8054</issn>
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<publisher-name>Blackwell Publishing Inc</publisher-name>
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<subject>Review Articles</subject>
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<article-title>Impact of Pollution, Climate, and Sociodemographic Factors on Spatiotemporal Dynamics of Seasonal Respiratory Viruses</article-title>
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<name>
<surname>Sloan</surname>
<given-names>Chantel</given-names>
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<degrees>Ph.D.</degrees>
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<name>
<surname>Moore</surname>
<given-names>Martin L.</given-names>
</name>
<degrees>Ph.D.</degrees>
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<sup>2</sup>
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<contrib id="cr3" contrib-type="author">
<name>
<surname>Hartert</surname>
<given-names>Tina</given-names>
</name>
<degrees>M.D., M.P.H.</degrees>
<xref ref-type="aff" rid="a1">
<sup>1</sup>
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<label>
<sup>1</sup>
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Vanderbilt University Medical Center, Tennessee, USA</aff>
<aff id="a2">
<label>
<sup>2</sup>
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Emory University School of Medicine, Georgia, USA.</aff>
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<author-notes>
<corresp id="correspondenceTo"> C. Sloan (
<email>chantel.d.sloan@vanderbilt.edu</email>
)</corresp>
</author-notes>
<pub-date pub-type="epub">
<day>23</day>
<month>2</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub">
<month>2</month>
<year>2011</year>
</pub-date>
<volume>4</volume>
<issue>1</issue>
<issue-id pub-id-type="doi">10.1111/cts.2011.4.issue-1</issue-id>
<fpage>48</fpage>
<lpage>54</lpage>
<permissions>
<copyright-statement content-type="article-copyright">© 2011 Wiley Periodicals, Inc.</copyright-statement>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="file:CTS-4-48.pdf"></self-uri>
<abstract>
<title>Abstract</title>
<p>Seasonal viruses present a major cause of morbidity and mortality in temperate climates. Through major pandemics and smaller annual epidemics, viruses such as influenza, respiratory syncytial virus (RSV) and human rhinovirus (HRV) result in lost school and work days for most that are infected and more serious complications for the immunocompromised. The reasons for these viruses showing strict seasonality include but are not limited to the influence of cold weather and humidity on virus particles, human physiology, and human behavior. The relative importance of each is dependent on what geographic scale is being explored as well as the individual region and time period. Theoretical mathematics has also revealed that climatic changes are likely not the only reasons for strong seasonal cycles, but these are also based in periodic resonance with the natural cycles of immunity and antigenic variance, as well as nationwide synchrony through transportation networks. Investigations of seasonality will aid in understanding disease transmission, and thereby effective prevention strategies. The authors present a review of the literature on seasonal viruses, their annual diffusion through populations, and factors that reduce or enhance their seasonal spread. They also offer suggestions for targeted interventions to reduce the disease burden from seasonal viruses. Clin Trans Sci 2011; Volume 4: 48–54</p>
</abstract>
<kwd-group>
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