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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparing Deaths from Influenza H1N1 and Seasonal Influenza A: Main Sociodemographic and Clinical Differences between the Most Prevalent 2009 Viruses</title><author><name sortKey="Fajardo Dolci, German" sort="Fajardo Dolci, German" uniqKey="Fajardo Dolci G" first="German" last="Fajardo-Dolci">German Fajardo-Dolci</name><affiliation><nlm:aff id="I1">Ministry of Health, 06600 Mexico City, DF, Mexico</nlm:aff></affiliation></author><author><name sortKey="Gutierrez, Juan Pablo" sort="Gutierrez, Juan Pablo" uniqKey="Gutierrez J" first="Juan Pablo" last="Gutierrez">Juan Pablo Gutierrez</name><affiliation><nlm:aff id="I2">Center for Evaluation Research and Surveys, National Institute of Public Health, 62100 Cuernavaca, MOR, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Arboleya Casanova, Heberto" sort="Arboleya Casanova, Heberto" uniqKey="Arboleya Casanova H" first="Heberto" last="Arboleya-Casanova">Heberto Arboleya-Casanova</name><affiliation><nlm:aff id="I4">Ixtapaluca Highly Specialized Regional Hospital, Ministry of Health, 56530 Ixtapaluca, MEX, Mexico</nlm:aff></affiliation></author><author><name sortKey="Garcia Saiso, Sebastian" sort="Garcia Saiso, Sebastian" uniqKey="Garcia Saiso S" first="Sebastian" last="Garcia-Saiso">Sebastian Garcia-Saiso</name><affiliation><nlm:aff id="I1">Ministry of Health, 06600 Mexico City, DF, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23346393</idno><idno type="pmc">3546448</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546448</idno><idno type="RBID">PMC:3546448</idno><idno type="doi">10.1155/2012/501784</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000988</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000988</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparing Deaths from Influenza H1N1 and Seasonal Influenza A: Main Sociodemographic and Clinical Differences between the Most Prevalent 2009 Viruses</title><author><name sortKey="Fajardo Dolci, German" sort="Fajardo Dolci, German" uniqKey="Fajardo Dolci G" first="German" last="Fajardo-Dolci">German Fajardo-Dolci</name><affiliation><nlm:aff id="I1">Ministry of Health, 06600 Mexico City, DF, Mexico</nlm:aff></affiliation></author><author><name sortKey="Gutierrez, Juan Pablo" sort="Gutierrez, Juan Pablo" uniqKey="Gutierrez J" first="Juan Pablo" last="Gutierrez">Juan Pablo Gutierrez</name><affiliation><nlm:aff id="I2">Center for Evaluation Research and Surveys, National Institute of Public Health, 62100 Cuernavaca, MOR, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author><author><name sortKey="Arboleya Casanova, Heberto" sort="Arboleya Casanova, Heberto" uniqKey="Arboleya Casanova H" first="Heberto" last="Arboleya-Casanova">Heberto Arboleya-Casanova</name><affiliation><nlm:aff id="I4">Ixtapaluca Highly Specialized Regional Hospital, Ministry of Health, 56530 Ixtapaluca, MEX, Mexico</nlm:aff></affiliation></author><author><name sortKey="Garcia Saiso, Sebastian" sort="Garcia Saiso, Sebastian" uniqKey="Garcia Saiso S" first="Sebastian" last="Garcia-Saiso">Sebastian Garcia-Saiso</name><affiliation><nlm:aff id="I1">Ministry of Health, 06600 Mexico City, DF, Mexico</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Influenza Research and Treatment</title><idno type="ISSN">2090-1380</idno><idno type="eISSN">2090-1399</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. During the 2009 spring epidemic outbreak in Mexico, an important research and policy question faced was related to the differences in clinical profile and population characteristics of those affected by the new H1N1 virus compared with the seasonal virus. <italic>Methods and Findings</italic>. Data from clinical files from all influenza A deaths in Mexico between April 10 and July 13, 2009 were analyzed to describe differences in clinical and socioeconomic profile between H1N1 and non-H1N1 cases. A total of 324 influenza A mortality cases were studied of which 239 presented rt-PCR confirmation for H1N1 virus and 85 for seasonal influenza A. From the differences of means and multivariate logistic regression, it was found that H1N1 deaths occurred in younger and less educated people, and among those who engage in activities where there is increased contact with other unknown persons (OR 4.52, 95% CI 1.56–13.14). Clinical symptoms were similar except for dyspnea, headache, and chest pain that were less frequently found among H1N1 cases. <italic>Conclusions</italic>. Findings suggest that age, education, and occupation are factors that may be useful to identify risk for H1N1 among influenza cases, and also that patients with early dyspnea, headache, and chest pain are more likely to be non-H1N1 cases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martin Daniel, R" uniqKey="Martin Daniel R">R Martin Daniel</name></author><author><name sortKey="Brauner Mark, E" uniqKey="Brauner Mark E">E Brauner Mark</name></author><author><name sortKey="Plouffe Joseph, F" uniqKey="Plouffe Joseph F">F Plouffe Joseph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name></author><author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name></author><author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell </name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunha, B" uniqKey="Cunha B">B Cunha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lavanchy, D" uniqKey="Lavanchy D">D Lavanchy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name></author><author><name sortKey="De La Rosa Zamboni, D" uniqKey="De La Rosa Zamboni D">D de la Rosa-Zamboni</name></author><author><name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce De Leon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name></author><author><name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name></author><author><name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Ar" uniqKey="Lai A">AR Lai</name></author><author><name sortKey="Keet, K" uniqKey="Keet K">K Keet</name></author><author><name sortKey="Yong, Cm" uniqKey="Yong C">CM Yong</name></author><author><name sortKey="Diaz, Jv" uniqKey="Diaz J">JV Diaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigel, Jh" uniqKey="Beigel J">JH Beigel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuite, Ar" uniqKey="Tuite A">AR Tuite</name></author><author><name sortKey="Greer, Al" uniqKey="Greer A">AL Greer</name></author><author><name sortKey="Whelan, M" uniqKey="Whelan M">M Whelan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haro Lopez, C" uniqKey="De Haro Lopez C">C de Haro Lopez</name></author><author><name sortKey="Ferre Roca, R" uniqKey="Ferre Roca R">R Ferre Roca</name></author><author><name sortKey="Velles Daunis, J" uniqKey="Velles Daunis J">J Velles Daunis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fajardo Dolci, G" uniqKey="Fajardo Dolci G">G Fajardo Dolci</name></author><author><name sortKey="Meljem Moctezuma, J" uniqKey="Meljem Moctezuma J">J Meljem Moctezuma</name></author><author><name sortKey="Rodriguez Suarez, J" uniqKey="Rodriguez Suarez J">J Rodriguez Suarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sprenger, Mjw" uniqKey="Sprenger M">MJW Sprenger</name></author><author><name sortKey="Mulder, Pgh" uniqKey="Mulder P">PGH Mulder</name></author><author><name sortKey="Beyer, Wep" uniqKey="Beyer W">WEP Beyer</name></author><author><name sortKey="Van Strik, R" uniqKey="Van Strik R">R Van Strik</name></author><author><name sortKey="Masurel, N" uniqKey="Masurel N">N Masurel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fajardo Dolci, Ge" uniqKey="Fajardo Dolci G">GE Fajardo-Dolci</name></author><author><name sortKey="Hernandez Torres, F" uniqKey="Hernandez Torres F">F Hernández-Torres</name></author><author><name sortKey="Santacruz Varela, J" uniqKey="Santacruz Varela J">J Santacruz-Varela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharvill, Nj" uniqKey="Sharvill N">NJ Sharvill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author><author><name sortKey="Gravenstein, S" uniqKey="Gravenstein S">S Gravenstein</name></author><author><name sortKey="Elliott, M" uniqKey="Elliott M">M Elliott</name></author><author><name sortKey="Colopy, M" uniqKey="Colopy M">M Colopy</name></author><author><name sortKey="Schweinle, J" uniqKey="Schweinle J">J Schweinle</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Res Treat</journal-id><journal-id journal-id-type="iso-abbrev">Influenza Res Treat</journal-id><journal-id journal-id-type="publisher-id">IRT</journal-id><journal-title-group><journal-title>Influenza Research and Treatment</journal-title></journal-title-group><issn pub-type="ppub">2090-1380</issn><issn pub-type="epub">2090-1399</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23346393</article-id><article-id pub-id-type="pmc">3546448</article-id><article-id pub-id-type="doi">10.1155/2012/501784</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Comparing Deaths from Influenza H1N1 and Seasonal Influenza A: Main Sociodemographic and Clinical Differences between the Most Prevalent 2009 Viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">0000-0001-6773-7582</contrib-id><name><surname>Fajardo-Dolci</surname><given-names>German</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gutierrez</surname><given-names>Juan Pablo</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">0000-0002-7940-693X</contrib-id><name><surname>Arboleya-Casanova</surname><given-names>Heberto</given-names></name><xref ref-type="aff" rid="I4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">0000-0003-4455-3080</contrib-id><name><surname>Garcia-Saiso</surname><given-names>Sebastian</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I3"><sup>3</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Ministry of Health, 06600 Mexico City, DF, Mexico</aff><aff id="I2"><sup>2</sup>Center for Evaluation Research and Surveys, National Institute of Public Health, 62100 Cuernavaca, MOR, Mexico</aff><aff id="I3"><sup>3</sup>Health Policy Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK</aff><aff id="I4"><sup>4</sup>Ixtapaluca Highly Specialized Regional Hospital, Ministry of Health, 56530 Ixtapaluca, MEX, Mexico</aff><author-notes><corresp id="cor1">*Sebastian Garcia-Saiso: <email>sebgasa@gmail.com</email></corresp><fn fn-type="other"><p>Academic Editor: Michael L. Perdue</p></fn></author-notes><pub-date pub-type="ppub"><year>2012</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2012</year></pub-date><volume>2012</volume><elocation-id>501784</elocation-id><history><date date-type="received"><day>6</day><month>6</month><year>2012</year></date><date date-type="rev-recd"><day>4</day><month>12</month><year>2012</year></date><date date-type="accepted"><day>11</day><month>12</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012 German Fajardo-Dolci et al.</copyright-statement><copyright-year>2012</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Background</italic>. During the 2009 spring epidemic outbreak in Mexico, an important research and policy question faced was related to the differences in clinical profile and population characteristics of those affected by the new H1N1 virus compared with the seasonal virus. <italic>Methods and Findings</italic>. Data from clinical files from all influenza A deaths in Mexico between April 10 and July 13, 2009 were analyzed to describe differences in clinical and socioeconomic profile between H1N1 and non-H1N1 cases. A total of 324 influenza A mortality cases were studied of which 239 presented rt-PCR confirmation for H1N1 virus and 85 for seasonal influenza A. From the differences of means and multivariate logistic regression, it was found that H1N1 deaths occurred in younger and less educated people, and among those who engage in activities where there is increased contact with other unknown persons (OR 4.52, 95% CI 1.56–13.14). Clinical symptoms were similar except for dyspnea, headache, and chest pain that were less frequently found among H1N1 cases. <italic>Conclusions</italic>. Findings suggest that age, education, and occupation are factors that may be useful to identify risk for H1N1 among influenza cases, and also that patients with early dyspnea, headache, and chest pain are more likely to be non-H1N1 cases.</p></abstract></article-meta></front><body><sec id="sec1"><title>1. Introduction </title><p>Influenza virus is the cause of one of the most common infections worldwide. Its effect on the global population carries important economic, healthcare system, and human suffering consequences [<xref rid="B1" ref-type="bibr">1</xref>]. Influenza virus type A is highly contagious and is the most pathogenic of all human influenza viruses [<xref rid="B1" ref-type="bibr">1</xref>]. </p><p>Human antibodies recognize two antigens (glycoprotein) expressed on the viral surface called hemagglutinin (HA) and neuraminidase (NA). Changes in these glycoprotein represent antigenic variation (antigen drift) that is responsible for the constant changes within the common strains of seasonal influenza. Influenza is classified into 16 HA subtypes and 9 NA subtypes [<xref rid="B1" ref-type="bibr">1</xref>], and as pointed out, influenza comprises “the oldest emerging virus that is still emerging” [<xref rid="B2" ref-type="bibr">2</xref>]. </p><p>Influenza pandemics occur when an influenza virus, that presents an hemagglutinin (HA) molecule for which there is limited or no existing immunity, emerges and efficiently transmits from human to human [<xref rid="B3" ref-type="bibr">3</xref>]. The emergence of a new virus subtype with a new HA is called antigen shift and will condition the lack of immune response to infection by the new virus.</p><p>Despite of pandemics during the last century, this disease generally does not represent an actual concern for the overall population. Several publications [<xref rid="B1" ref-type="bibr">1</xref>, <xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B4" ref-type="bibr">4</xref>–<xref rid="B7" ref-type="bibr">7</xref>], as well as the World Health Organization (WHO) and the American Center of Disease Control (CDC), had repeatedly pointed out that in a manner of time, the world would face a new influenza pandemic that would cause significant figures of global morbidity and mortality.</p><p>Influenza has a fast person-to-person transmission and a high mortality risk when not treated. Among all the major pandemics, influenza A is the only one that may potentially infect a considerable fraction of the world's population in a few months [<xref rid="B2" ref-type="bibr">2</xref>].</p><p>The genomes of the last three pandemic influenza viruses, 1918 (H1N1), 1957 (H2N2), and 1968 (H3N2), originated from nonhuman reservoirs and all HA genes originated from avian influenza viruses [<xref rid="B3" ref-type="bibr">3</xref>].</p><p>There are two mechanisms intervening in the introduction of a virus with new hemagglutinin (HA) subtypes in the human population: recombination and interspecies transmission. The first mechanism of the current Influenza A (H1N1) pandemic comprises recombined viruses of two swine flu types: one of those has a triple recombination strain containing segments originated from the last human seasonal flu H3N2 and the other one originated by avian and swine flu [<xref rid="B4" ref-type="bibr">4</xref>]. </p><p>In early April 2009, cases similar to pneumonia and influenza were notified and reported to the Pan-American Health Organization (PAHO). As research progressed, it was observed that reported Mexican and Californian cases were caused by a similar virus, which triggered the alert of the World Health Organization (WHO) on April 24. On July 11, 2009, the WHO raised its pandemic alert level to 6. </p><p>At the beginning of the outbreak there were a significant number of cases reported as possible new H1N1 influenza that, after the PCR test became widely available in May 2009, were labeled as seasonal influenza A (non-H1N1). The National Commission for Medical Arbitration (CONAMED), as the designated authority to monitor all mortality cases due to influenza, compiled a series of clinical files of all suspicious cases. Since the clinical profile of the new H1N1 virus is not significantly different to that of seasonal influenza A (non-H1N1)—described clinical profiles include cough, rhinorrhea, headache, myalgia, arthralgia, fever, dyspnea, and diarrhea [<xref rid="B8" ref-type="bibr">8</xref>–<xref rid="B13" ref-type="bibr">13</xref>]—many of the initial cases filed by CONAMED were later confirmed by rt-PCR testing as seasonal influenza A (non-H1N1).</p><p>This study describes the main differences between the new influenza H1N1 and seasonal influenza A virus mortality cases in terms of clinical profile and sociodemographic characteristics which may orient clinicians and authorities in decision-making processes.</p></sec><sec id="sec2"><title>2. Methodology</title><p>This is a cross-sectional analysis of secondary data related to deaths due to influenza A infection during the period from April 10 to July 13, 2009. Cases of H1N1 and seasonal influenza A (non H1N1) were identified, as well as information on the clinical and socio-demographic characteristics of individuals. For this study, “case” was considered as any deaths due to influenza type A confirmed by the National Institute of Epidemiologic Diagnosis and Reference (INDRE) through the rt-PCR test for influenza A (H1N1) or seasonal influenza A. The analysis was based on information collected from patients' clinical records and reporting forms from health facilities in Mexico.</p><p>As a first step to analyze the deaths from influenza A H1N1, the necessary coordination with health care institutions and States of Mexico was established in order for them to send records of all patients who had died with clinical diagnosis of influenza across the country to CONAMED [<xref rid="B14" ref-type="bibr">14</xref>]. The influenza working group decided to develop two methods of analysis for such records, a clinical and an epidemiological one. The first in order to identify the individual characteristics of the deceased as well as the process of medical care received, the second to know the general characteristics of the population affected by variables of time, place, and person, and to estimate the rate of mortality and early lethality. In both cases, the primary source document was the clinical file of deceased patients diagnosed with influenza A (H1N1 and non-H1N1) during the period from April 10 to July 13, 2009.</p><p>Once a database including only information from influenza A deceased patients with confirmation of whether it was H1N1 or seasonal A was constructed, variables needed to describe socio-demographic and clinical characteristics were reviewed to check consistency. </p><p>The differences in the socio-demographic profile of the population were analyzed, seeking to identify characteristics that might be associated with a greater likelihood of death from H1N1 compared to influenza type A, that is, trying to identify a profile for these patients. For this purpose, tests for differences of means or proportions were calculated between groups, and further multivariate logistic regression models were carried out.</p><p>To identify possible clinical differences among reported deaths and in order to avoid bias due to differences in socio-demographic characteristics, cases of H1N1 were matched on these socio-demographic characteristics to cases of non-H1N1 using propensity score matching techniques. The propensity score was constructed using age, sex, economic activity, schooling, and marital status. Smoking was included as it was assumed it could be related to the outcomes.</p><p>Estimations were implemented using kernel matching in order to utilize as much information as possible from the available observations. The kernel matching compared a case (H1N1) to the average of the noncases (non H1N1) that had a score in the proximity of the case; in this way, for all cases a match was generated.</p><p>Analysis was implemented with Stata 10. This study was approved by the National Commission for Medical Arbitration Ethics Committee.</p></sec><sec id="sec3"><title>3. Results</title><p>The sample included 324 influenza A cases of which 239 had rt-PCR diagnosis of influenza A H1N1 and 85 of seasonal influenza A (non H1N1). Of the total 53.1% were women and 46.9% men. Within the influenza H1N1 group 50.6% were women and 49.4% men. Within the seasonal influenza A group, 60% were women and 40% men. 41% of deaths within the influenza A H1N1 group occurred in the 20–39-years-old age group and the same age group represented also 41% of the seasonal influenza A group.</p><p>In terms of the general characteristics of individuals within the entire sample, the analysis shows that there are differences by age, education, and type of occupation among those who presented AH1N1 influenza in relation to influenza A non H1N1. Comparing between the two types of influenza, H1N1 deaths would occur from an earlier age, in people with less education, and among those who engage in activities where there is increased contact with other unknown persons (trade or other independent activities) (<xref ref-type="table" rid="tab1">Table 1</xref>).</p><p>Clinical manifestations and outcomes were similar in both types of influenza in most of the indicators but dysnea, headache, and chest pain that were less frequently found among cases with H1N1 compared to non H1N1 (<xref ref-type="table" rid="tab2">Table 2</xref>).</p><p>For the regression analysis, the differences in some socio-demographic indicators were maintained in the multi-variable models. As reported in <xref ref-type="table" rid="tab3">Table 3</xref>, junior high school was associated with lower probability of H1N1 compared to primary school or less and also, having an economic activity related to increased contact with unknown individuals (salespersons or independent professionals) was associated with an increased probability of H1N1 (OR 4.52 95% CI 1.56–13.14) (<xref ref-type="table" rid="tab3">Table 3</xref>).</p><p>To analyze the occurrence of clinical features in deaths, controlling for socio-demographic characteristics of individuals, as described in the methods section, a matched analysis was implemented. After matching, cough was more prevalent among those with H1N1 influenza, while dyspnea, headache, and chest pain were less prevalent among H1N1 compared wit non H1N1. Also, it was found that days from clinical care to death were in average more for those with H1N1. In all other clinical features analyzed, including time elapsed between diagnosis and treatment, and between diagnosis and death, there were no significant differences (<xref ref-type="table" rid="tab4">Table 4</xref>).</p></sec><sec id="sec4"><title>4. Discussion</title><p>The results presented here describe some differences among deceased individuals with influenza H1N1 compared to those with seasonal influenza A (non H1N1). Cases of H1N1 were younger and in average less educated, confirming observations made during the peak of the pandemic [<xref rid="B15" ref-type="bibr">15</xref>]. A contextual factor that could be related to higher exposure is the primary economic activity: cases of H1N1 were individuals that reported in a larger proportion working as salespersons or activities with a higher interaction with unknown individuals, that could result in a larger variety of exposure.</p><p>In a previous study that analyzed the first 120 mortality cases of the new H1N1 virus [<xref rid="B16" ref-type="bibr">16</xref>], it was found that a proportion of 51% were women and 49% were males. 45.1% of cases occurred in patients aged between 20 and 39. The mortality rate was 2.2% and ranged from 0.3% in the 10 to 19 years and 6.3% for 50 to 59 years old group, which coincides with our initial findings. Up to this point the question of which were the main differences between the new influenza H1N1 virus infection and the infection by seasonal A virus was still unanswered.</p><p>Most published case series have shown similarities between infection by both H1N1 and seasonal influenza A, main symptoms being fever, cough, headache, myalgia, and rhinorrhea [<xref rid="B8" ref-type="bibr">8</xref>–<xref rid="B10" ref-type="bibr">10</xref>, <xref rid="B12" ref-type="bibr">12</xref>–<xref rid="B14" ref-type="bibr">14</xref>, <xref rid="B17" ref-type="bibr">17</xref>, <xref rid="B18" ref-type="bibr">18</xref>]. In terms of clinical characteristics that differentiate between the two groups, it was found that cough was more prevalent among those with H1N1 influenza, while dyspnea, headache, and chest pain were less prevalent among H1N1 compared to seasonal A influenza virus. This particular finding is worth noting since these are symptoms which may encourage patients to seek medical care and help physicians diagnose and determine severity of the case as it has been described as signs of progression to more severe disease or complications [<xref rid="B19" ref-type="bibr">19</xref>]. While coughing was more prevalent, which is unspecific for most uncomplicated upper airway infections, symptoms that would alert of a complicated case were not as prevalent, this could be the reason behind the perceived lack of opportune treatment reported by many during the start of the pandemic in June–August 2009 [<xref rid="B14" ref-type="bibr">14</xref>]. </p><p>Also, it was found that days from clinical care to death were in average more for those with infection by H1N1 virus, signaling a relative delay in the evolution of the clinical profile after receiving medical care, which may be related to the H1N1 susceptibility and therefore response to antiviral therapy, although in severe cases only a partial one. It also correlates to longer evolution times and presence of virus for longer periods reported by others [<xref rid="B19" ref-type="bibr">19</xref>].</p><p>The present study shows the main differences in the mortality cases between the new influenza H1N1 and seasonal influenza A virus in terms of clinical profile and socio-demographic characteristics on mortality cases; these differences may prove useful to orient clinicians and authorities in decision making processes.</p><p>At the present time, morbidity and mortality rates from the H1N1 virus have dropped; however, the need to investigate the characteristics of this novel influenza virus along with the epidemiological pattern of the pandemic is still patent. This will increase our understanding of its nature and may help determine future plans to be prepared in case of similar events. 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Pandemic (H1N1) 2009 briefing note 20</article-title><comment>2009, <ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/swineflu/notes/briefing_20091222/en/print.html">http://www.who.int/csr/disease/swineflu/notes/briefing_20091222/en/print.html</ext-link></comment></element-citation></ref></ref-list></back><floats-group><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Sociodemographic characteristics of deceased cases, by type of influenza.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Non-H1N1</th><th align="center" rowspan="1" colspan="1">H1N1</th><th align="center" rowspan="1" colspan="1"><italic>P</italic> value <break></break><italic>t</italic>-test</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Age (means)</td><td align="center" rowspan="1" colspan="1">38.26</td><td align="center" rowspan="1" colspan="1">33.07</td><td align="center" rowspan="1" colspan="1"><bold>0.038</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Sex (men)</td><td align="center" rowspan="1" colspan="1">60%</td><td align="center" rowspan="1" colspan="1">51%</td><td align="center" rowspan="1" colspan="1">0.135</td></tr><tr><td align="left" rowspan="1" colspan="1">Smoking</td><td align="center" rowspan="1" colspan="1">21%</td><td align="center" rowspan="1" colspan="1">15%</td><td align="center" rowspan="1" colspan="1">0.259</td></tr><tr><td align="left" rowspan="1" colspan="1">Have a partner</td><td align="center" rowspan="1" colspan="1">60%</td><td align="center" rowspan="1" colspan="1">49%</td><td align="center" rowspan="1" colspan="1">0.090</td></tr><tr><td align="left" rowspan="1" colspan="1">Primary school or less</td><td align="center" rowspan="1" colspan="1">54%</td><td align="center" rowspan="1" colspan="1">60%</td><td align="center" rowspan="1" colspan="1">0.331</td></tr><tr><td align="left" rowspan="1" colspan="1">Junior high school</td><td align="center" rowspan="1" colspan="1">26%</td><td align="center" rowspan="1" colspan="1">13%</td><td align="center" rowspan="1" colspan="1"><bold>0.018</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">High school or higher level</td><td align="center" rowspan="1" colspan="1">20%</td><td align="center" rowspan="1" colspan="1">26%</td><td align="center" rowspan="1" colspan="1">0.224</td></tr><tr><td align="left" rowspan="1" colspan="1">Housewife</td><td align="center" rowspan="1" colspan="1">33%</td><td align="center" rowspan="1" colspan="1">23%</td><td align="center" rowspan="1" colspan="1">0.079</td></tr><tr><td align="left" rowspan="1" colspan="1">Unemployed or retiree</td><td align="center" rowspan="1" colspan="1">14%</td><td align="center" rowspan="1" colspan="1">8%</td><td align="center" rowspan="1" colspan="1">0.134</td></tr><tr><td align="left" rowspan="1" colspan="1">Student</td><td align="center" rowspan="1" colspan="1">11%</td><td align="center" rowspan="1" colspan="1">20%</td><td align="center" rowspan="1" colspan="1"><bold>0.036</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Independent worker, salesperson</td><td align="center" rowspan="1" colspan="1">8%</td><td align="center" rowspan="1" colspan="1">25%</td><td align="center" rowspan="1" colspan="1"><bold>0.000</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Employee</td><td align="center" rowspan="1" colspan="1">33%</td><td align="center" rowspan="1" colspan="1">24%</td><td align="center" rowspan="1" colspan="1">0.124</td></tr></tbody></table></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Clinical characteristics of deceased cases, by type of influenza.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Non-H1N1</th><th align="center" rowspan="1" colspan="1">H1N1</th><th align="center" rowspan="1" colspan="1"><italic>P</italic> value <break></break><italic>t</italic>-test</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Pneumonia</td><td align="center" rowspan="1" colspan="1">33%</td><td align="center" rowspan="1" colspan="1">43%</td><td align="center" rowspan="1" colspan="1">0.125</td></tr><tr><td align="left" rowspan="1" colspan="1">Fever</td><td align="center" rowspan="1" colspan="1">84%</td><td align="center" rowspan="1" colspan="1">85%</td><td align="center" rowspan="1" colspan="1">0.826</td></tr><tr><td align="left" rowspan="1" colspan="1">Cough</td><td align="center" rowspan="1" colspan="1">81%</td><td align="center" rowspan="1" colspan="1">87%</td><td align="center" rowspan="1" colspan="1">0.229</td></tr><tr><td align="left" rowspan="1" colspan="1">Dyspnea</td><td align="center" rowspan="1" colspan="1">88%</td><td align="center" rowspan="1" colspan="1">73%</td><td align="center" rowspan="1" colspan="1"><bold>0.001</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Expectoration</td><td align="center" rowspan="1" colspan="1">50%</td><td align="center" rowspan="1" colspan="1">48%</td><td align="center" rowspan="1" colspan="1">0.721</td></tr><tr><td align="left" rowspan="1" colspan="1">Myalgia</td><td align="center" rowspan="1" colspan="1">38%</td><td align="center" rowspan="1" colspan="1">31%</td><td align="center" rowspan="1" colspan="1">0.239</td></tr><tr><td align="left" rowspan="1" colspan="1">Rhinorrhea</td><td align="center" rowspan="1" colspan="1">28%</td><td align="center" rowspan="1" colspan="1">26%</td><td align="center" rowspan="1" colspan="1">0.769</td></tr><tr><td align="left" rowspan="1" colspan="1">Cyanosis</td><td align="center" rowspan="1" colspan="1">26%</td><td align="center" rowspan="1" colspan="1">25%</td><td align="center" rowspan="1" colspan="1">0.869</td></tr><tr><td align="left" rowspan="1" colspan="1">Headache</td><td align="center" rowspan="1" colspan="1">52%</td><td align="center" rowspan="1" colspan="1">29%</td><td align="center" rowspan="1" colspan="1"><bold>0.000</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Chest pain</td><td align="center" rowspan="1" colspan="1">37%</td><td align="center" rowspan="1" colspan="1">15%</td><td align="center" rowspan="1" colspan="1"><bold>0.000</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Nasal obstruction</td><td align="center" rowspan="1" colspan="1">5%</td><td align="center" rowspan="1" colspan="1">9%</td><td align="center" rowspan="1" colspan="1">0.196</td></tr><tr><td align="left" rowspan="1" colspan="1">Vomiting</td><td align="center" rowspan="1" colspan="1">6%</td><td align="center" rowspan="1" colspan="1">10%</td><td align="center" rowspan="1" colspan="1">0.189</td></tr><tr><td align="left" rowspan="1" colspan="1">Diarrhea</td><td align="center" rowspan="1" colspan="1">9%</td><td align="center" rowspan="1" colspan="1">9%</td><td align="center" rowspan="1" colspan="1">0.945</td></tr><tr><td align="left" rowspan="1" colspan="1">Days from symptoms start to care</td><td align="center" rowspan="1" colspan="1">6.86</td><td align="center" rowspan="1" colspan="1">6.30</td><td align="center" rowspan="1" colspan="1">0.582</td></tr><tr><td align="left" rowspan="1" colspan="1">Days from care to death</td><td align="center" rowspan="1" colspan="1">6.86</td><td align="center" rowspan="1" colspan="1">7.79</td><td align="center" rowspan="1" colspan="1">0.304</td></tr><tr><td align="left" rowspan="1" colspan="1">Days from symptoms start to death</td><td align="center" rowspan="1" colspan="1">13.96</td><td align="center" rowspan="1" colspan="1">14.03</td><td align="center" rowspan="1" colspan="1">0.962</td></tr></tbody></table></table-wrap><table-wrap id="tab3" orientation="portrait" position="float"><label>Table 3</label><caption><p>Regression analysis.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">OR (95% CI)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Sex (women)</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1">Sex (men)</td><td align="center" rowspan="1" colspan="1">0.762 <break></break>(0.389–1.494)</td></tr><tr><td align="left" rowspan="1" colspan="1">Age</td><td align="center" rowspan="1" colspan="1">0.989 <break></break>(0.971–1.007)</td></tr><tr><td align="left" rowspan="1" colspan="1">Have a partner</td><td align="center" rowspan="1" colspan="1">0.789<break></break>(0.430–1.448)</td></tr><tr><td align="left" rowspan="1" colspan="1">Smoking</td><td align="center" rowspan="1" colspan="1">0.722<break></break>(0.350–1.489)</td></tr><tr><td align="left" rowspan="1" colspan="1">Primary school or less</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1">Junior high school</td><td align="center" rowspan="1" colspan="1"><bold>0.391</bold>
<break></break><bold>(0.189–0.809)</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">High school or higher level</td><td align="center" rowspan="1" colspan="1">1.651 <break></break>(0.766–3.559)</td></tr><tr><td align="left" rowspan="1" colspan="1">Housewife</td><td align="center" rowspan="1" colspan="1">1</td></tr><tr><td align="left" rowspan="1" colspan="1">Unemployed or retiree</td><td align="center" rowspan="1" colspan="1">0.674<break></break>(0.242–1.878)</td></tr><tr><td align="left" rowspan="1" colspan="1">Student</td><td align="center" rowspan="1" colspan="1">1.165<break></break>(0.359–3.778)</td></tr><tr><td align="left" rowspan="1" colspan="1">Independent worker, salesperson</td><td align="center" rowspan="1" colspan="1"><bold>4.523</bold>
<break></break><bold>(1.556–13.144)</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Employee</td><td align="center" rowspan="1" colspan="1">0.664<break></break>(0.280–1.574)</td></tr></tbody></table></table-wrap><table-wrap id="tab4" orientation="portrait" position="float"><label>Table 4</label><caption><p>Average differences after matching (H1N1 as exposure).</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th><th align="center" rowspan="1" colspan="1">Matched difference</th><th align="center" rowspan="1" colspan="1"><italic>t</italic>-stat</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Pneumonia</td><td align="center" rowspan="1" colspan="1">0.0804</td><td align="center" rowspan="1" colspan="1">1.02</td></tr><tr><td align="left" rowspan="1" colspan="1">Fever</td><td align="center" rowspan="1" colspan="1">−0.0303</td><td align="center" rowspan="1" colspan="1">−0.54</td></tr><tr><td align="left" rowspan="1" colspan="1">Cough</td><td align="center" rowspan="1" colspan="1">0.1138</td><td align="center" rowspan="1" colspan="1"><bold>1.78</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Dyspnea</td><td align="center" rowspan="1" colspan="1">−0.1318</td><td align="center" rowspan="1" colspan="1">−<bold>2.30</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Expectoration</td><td align="center" rowspan="1" colspan="1">−0.0469</td><td align="center" rowspan="1" colspan="1">−0.58</td></tr><tr><td align="left" rowspan="1" colspan="1">Myalgia</td><td align="center" rowspan="1" colspan="1">−0.0704</td><td align="center" rowspan="1" colspan="1">−0.91</td></tr><tr><td align="left" rowspan="1" colspan="1">Rhinorrhea</td><td align="center" rowspan="1" colspan="1">−0.0560</td><td align="center" rowspan="1" colspan="1">−0.79</td></tr><tr><td align="left" rowspan="1" colspan="1">Cyanosis</td><td align="center" rowspan="1" colspan="1">−0.0117</td><td align="center" rowspan="1" colspan="1">−0.16</td></tr><tr><td align="left" rowspan="1" colspan="1">Headache</td><td align="center" rowspan="1" colspan="1">−0.0210</td><td align="center" rowspan="1" colspan="1">−<bold>2.51</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Chest pain</td><td align="center" rowspan="1" colspan="1">−0.1591</td><td align="center" rowspan="1" colspan="1">−<bold>2.09</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Nasal obstruction</td><td align="center" rowspan="1" colspan="1">0.0512</td><td align="center" rowspan="1" colspan="1">1.46</td></tr><tr><td align="left" rowspan="1" colspan="1">Vomiting</td><td align="center" rowspan="1" colspan="1">0.0212</td><td align="center" rowspan="1" colspan="1">0.50</td></tr><tr><td align="left" rowspan="1" colspan="1">Diarrhea</td><td align="center" rowspan="1" colspan="1">0.0083</td><td align="center" rowspan="1" colspan="1">0.17</td></tr><tr><td align="left" rowspan="1" colspan="1">Days from symptoms start to care</td><td align="center" rowspan="1" colspan="1">0.2744</td><td align="center" rowspan="1" colspan="1">0.20</td></tr><tr><td align="left" rowspan="1" colspan="1">Days from care to death</td><td align="center" rowspan="1" colspan="1">1.8296</td><td align="center" rowspan="1" colspan="1"><bold>1.63</bold></td></tr><tr><td align="left" rowspan="1" colspan="1">Days from symptoms start to death</td><td align="center" rowspan="1" colspan="1">1.8925</td><td align="center" rowspan="1" colspan="1">1.05</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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