Clinical Management of Pandemic 2009 Influenza A(H1N1) Infection
Identifieur interne : 000937 ( Pmc/Corpus ); précédent : 000936; suivant : 000938Clinical Management of Pandemic 2009 Influenza A(H1N1) Infection
Auteurs : David S. Hui ; Nelson Lee ; Paul K. S. ChanSource :
- Chest [ 0012-3692 ] ; 2010.
Abstract
Antiviral therapy and vaccination are important strategies for controlling pandemic 2009 influenza A(H1N1) but efficacy depends on the timing of administration and is often limited by supply shortage. Patients with dyspnea, tachypnea, evidence of hypoxemia, and pulmonary infiltrates on chest radiograph should be hospitalized. Patients with severe illness or underlying medical conditions that increase the risk of more severe disease should be treated with oseltamivir or zanamivir as soon as possible, without waiting for the results of laboratory tests. Lung-protective ventilation strategy with a low tidal volume and adequate pressure, in addition to a conservative fluid management approach, is recommended when treating adult patients with ARDS. Extracorporeal membrane oxygenation has emerged as an important rescue therapy for critically ill patients. Use of systemic steroids was associated with delayed viral clearance in severe acute respiratory syndrome and H3N2 infection. Low-dose corticosteroids may be considered in the treatment of refractory septic shock. Passive immunotherapy in the form of convalescent plasma or hyperimmune globulin may be explored as rescue therapy. More data are needed to explore the potential role of IV gamma globulin and other drugs with immunomodulating properties, such as statins, gemfibrozil, and
Url:
DOI: 10.1378/chest.09-2344
PubMed: 20022969
PubMed Central: 7094244
Links to Exploration step
PMC:7094244Le document en format XML
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<affiliation><nlm:aff id="aff2">Stanley Ho Center for Emerging Infectious Diseases, School of Public Health & Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</nlm:aff>
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<author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name>
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<author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name>
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<front><div type="abstract" xml:lang="en"><p>Antiviral therapy and vaccination are important strategies for controlling pandemic 2009 influenza A(H1N1) but efficacy depends on the timing of administration and is often limited by supply shortage. Patients with dyspnea, tachypnea, evidence of hypoxemia, and pulmonary infiltrates on chest radiograph should be hospitalized. Patients with severe illness or underlying medical conditions that increase the risk of more severe disease should be treated with oseltamivir or zanamivir as soon as possible, without waiting for the results of laboratory tests. Lung-protective ventilation strategy with a low tidal volume and adequate pressure, in addition to a conservative fluid management approach, is recommended when treating adult patients with ARDS. Extracorporeal membrane oxygenation has emerged as an important rescue therapy for critically ill patients. Use of systemic steroids was associated with delayed viral clearance in severe acute respiratory syndrome and H3N2 infection. Low-dose corticosteroids may be considered in the treatment of refractory septic shock. Passive immunotherapy in the form of convalescent plasma or hyperimmune globulin may be explored as rescue therapy. More data are needed to explore the potential role of IV gamma globulin and other drugs with immunomodulating properties, such as statins, gemfibrozil, and <italic>N</italic>
-acetyl-cysteine. Health-care workers must apply strict standard and droplet precautions when dealing with suspected and confirmed case and upgrade to airborne precautions when performing aerosol-generating procedures. Nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, good community hygiene, and restrictions on travel are useful measures in controlling an influenza pandemic at its early phase.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name>
</author>
<author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name>
</author>
<author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trifonov, V" uniqKey="Trifonov V">V Trifonov</name>
</author>
<author><name sortKey="Khiabanian, H" uniqKey="Khiabanian H">H Khiabanian</name>
</author>
<author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shinde, V" uniqKey="Shinde V">V Shinde</name>
</author>
<author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name>
</author>
<author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Davis, Ct" uniqKey="Davis C">CT Davis</name>
</author>
<author><name sortKey="Russell, Ca" uniqKey="Russell C">CA Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name>
</author>
<author><name sortKey="Jayaraman, A" uniqKey="Jayaraman A">A Jayaraman</name>
</author>
<author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khan, K" uniqKey="Khan K">K Khan</name>
</author>
<author><name sortKey="Arino, J" uniqKey="Arino J">J Arino</name>
</author>
<author><name sortKey="Hu, W" uniqKey="Hu W">W Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author><name sortKey="Novel Swine Origin Influenza A H1n1 Virus Investigation Team" uniqKey="Novel Swine Origin Influenza A H1n1 Virus Investigation Team">Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name>
</author>
<author><name sortKey="De La Rosa Zamboni, D" uniqKey="De La Rosa Zamboni D">D de la Rosa-Zamboni</name>
</author>
<author><name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce de Leon</name>
</author>
<author><name sortKey="Iner Working Group On Influenza" uniqKey="Iner Working Group On Influenza">INER Working Group on Influenza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author><name sortKey="Kamimoto, L" uniqKey="Kamimoto L">L Kamimoto</name>
</author>
<author><name sortKey="Bramley, Am" uniqKey="Bramley A">AM Bramley</name>
</author>
<author><name sortKey="2009 Pandemic Influenza A H1n1 Virus Hospitalizations Investigation Team" uniqKey="2009 Pandemic Influenza A H1n1 Virus Hospitalizations Investigation Team">2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webb, Sa" uniqKey="Webb S">SA Webb</name>
</author>
<author><name sortKey="Pettil, V" uniqKey="Pettil V">V Pettilä</name>
</author>
<author><name sortKey="Seppelt, I" uniqKey="Seppelt I">I Seppelt</name>
</author>
<author><name sortKey="Anzic Influenza Investigators" uniqKey="Anzic Influenza Investigators">ANZIC Influenza Investigators</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name>
</author>
<author><name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R Zarychanski</name>
</author>
<author><name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name>
</author>
<author><name sortKey="Canadian Critical Care Trials Group H1n1 Collaborative" uniqKey="Canadian Critical Care Trials Group H1n1 Collaborative">Canadian Critical Care Trials Group H1N1 Collaborative</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name>
</author>
<author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia Garcia, L" uniqKey="Garcia Garcia L">L Garcia-Garcia</name>
</author>
<author><name sortKey="Valdespino G Mez, Jl" uniqKey="Valdespino G Mez J">JL Valdespino-Gómez</name>
</author>
<author><name sortKey="Lazcano Ponce, E" uniqKey="Lazcano Ponce E">E Lazcano-Ponce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mauad, T" uniqKey="Mauad T">T Mauad</name>
</author>
<author><name sortKey="Hajjar, La" uniqKey="Hajjar L">LA Hajjar</name>
</author>
<author><name sortKey="Callegari, Gd" uniqKey="Callegari G">GD Callegari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name>
</author>
<author><name sortKey="Lau, Yk" uniqKey="Lau Y">YK Lau</name>
</author>
<author><name sortKey="Lee, Kl" uniqKey="Lee K">KL Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaufman, Ma" uniqKey="Kaufman M">MA Kaufman</name>
</author>
<author><name sortKey="Duke, Gj" uniqKey="Duke G">GJ Duke</name>
</author>
<author><name sortKey="Mcgain, F" uniqKey="Mcgain F">F McGain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birnkrant, D" uniqKey="Birnkrant D">D Birnkrant</name>
</author>
<author><name sortKey="Cox, E" uniqKey="Cox E">E Cox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glaxosmithkline Gsk And Fda Alert" uniqKey="Glaxosmithkline Gsk And Fda Alert">GlaxoSmithKline (GSK) and FDA alert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="The Acute Respiratory Distress Syndrome Network" uniqKey="The Acute Respiratory Distress Syndrome Network">The Acute Respiratory Distress Syndrome Network</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wiedemann, Hp" uniqKey="Wiedemann H">HP Wiedemann</name>
</author>
<author><name sortKey="Wheeler, Ap" uniqKey="Wheeler A">AP Wheeler</name>
</author>
<author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name>
</author>
<author><name sortKey="National Heart Lung And Blood Institute Acute Respiratory Distress Syndrome Ards Clinical Trials Network" uniqKey="National Heart Lung And Blood Institute Acute Respiratory Distress Syndrome Ards Clinical Trials Network">National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davies, A" uniqKey="Davies A">A Davies</name>
</author>
<author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name>
</author>
<author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name>
</author>
<author><name sortKey="Australia And New Zealand Extracorporeal Membrane Oxygenation Anz Ecmo Influenza Investigators" uniqKey="Australia And New Zealand Extracorporeal Membrane Oxygenation Anz Ecmo Influenza Investigators">Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rello, J" uniqKey="Rello J">J Rello</name>
</author>
<author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodríguez</name>
</author>
<author><name sortKey="Iba Ez, P" uniqKey="Iba Ez P">P Ibañez</name>
</author>
<author><name sortKey="H1n1 Semicyuc Working Group" uniqKey="H1n1 Semicyuc Working Group">H1N1 SEMICYUC Working Group</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annane, D" uniqKey="Annane D">D Annane</name>
</author>
<author><name sortKey="Bellissant, E" uniqKey="Bellissant E">E Bellissant</name>
</author>
<author><name sortKey="Bollaert, Pe" uniqKey="Bollaert P">PE Bollaert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Bm" uniqKey="Tang B">BM Tang</name>
</author>
<author><name sortKey="Craig, Jc" uniqKey="Craig J">JC Craig</name>
</author>
<author><name sortKey="Eslick, Gd" uniqKey="Eslick G">GD Eslick</name>
</author>
<author><name sortKey="Seppelt, I" uniqKey="Seppelt I">I Seppelt</name>
</author>
<author><name sortKey="Mclean, As" uniqKey="Mclean A">AS McLean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quispe Laime, Am" uniqKey="Quispe Laime A">AM Quispe-Laime</name>
</author>
<author><name sortKey="Bracco, Jd" uniqKey="Bracco J">JD Bracco</name>
</author>
<author><name sortKey="Barberio, Pa" uniqKey="Barberio P">PA Barberio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Allen Chan, Kc" uniqKey="Allen Chan K">KC Allen Chan</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Kang, W" uniqKey="Kang W">W Kang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Griffith, Jf" uniqKey="Griffith J">JF Griffith</name>
</author>
<author><name sortKey="Antonio, Ge" uniqKey="Antonio G">GE Antonio</name>
</author>
<author><name sortKey="Kumta, Sm" uniqKey="Kumta S">SM Kumta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yap, Fh" uniqKey="Yap F">FH Yap</name>
</author>
<author><name sortKey="Gomersall, Cd" uniqKey="Gomersall C">CD Gomersall</name>
</author>
<author><name sortKey="Fung, Ks" uniqKey="Fung K">KS Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luke, Tc" uniqKey="Luke T">TC Luke</name>
</author>
<author><name sortKey="Kilbane, Em" uniqKey="Kilbane E">EM Kilbane</name>
</author>
<author><name sortKey="Jackson, Jl" uniqKey="Jackson J">JL Jackson</name>
</author>
<author><name sortKey="Hoffman, Sl" uniqKey="Hoffman S">SL Hoffman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="Pan, X" uniqKey="Pan X">X Pan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanson, Bj" uniqKey="Hanson B">BJ Hanson</name>
</author>
<author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name>
</author>
<author><name sortKey="Lim, Ap" uniqKey="Lim A">AP Lim</name>
</author>
<author><name sortKey="Webb, A" uniqKey="Webb A">A Webb</name>
</author>
<author><name sortKey="Ooi, Ee" uniqKey="Ooi E">EE Ooi</name>
</author>
<author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name>
</author>
<author><name sortKey="Simmons, Cp" uniqKey="Simmons C">CP Simmons</name>
</author>
<author><name sortKey="Thanh, Tt" uniqKey="Thanh T">TT Thanh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dinarello, Ca" uniqKey="Dinarello C">CA Dinarello</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bone, Rc" uniqKey="Bone R">RC Bone</name>
</author>
<author><name sortKey="Grodzin, Cj" uniqKey="Grodzin C">CJ Grodzin</name>
</author>
<author><name sortKey="Balk, Ra" uniqKey="Balk R">RA Balk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kwak, B" uniqKey="Kwak B">B Kwak</name>
</author>
<author><name sortKey="Mulhaupt, F" uniqKey="Mulhaupt F">F Mulhaupt</name>
</author>
<author><name sortKey="Myit, S" uniqKey="Myit S">S Myit</name>
</author>
<author><name sortKey="Mach, F" uniqKey="Mach F">F Mach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS Fedson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lew, Tw" uniqKey="Lew T">TW Lew</name>
</author>
<author><name sortKey="Kwek, Tk" uniqKey="Kwek T">TK Kwek</name>
</author>
<author><name sortKey="Tai, D" uniqKey="Tai D">D Tai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, Py" uniqKey="Chong P">PY Chong</name>
</author>
<author><name sortKey="Chui, P" uniqKey="Chui P">P Chui</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Umapathi, T" uniqKey="Umapathi T">T Umapathi</name>
</author>
<author><name sortKey="Kor, Ac" uniqKey="Kor A">AC Kor</name>
</author>
<author><name sortKey="Venketasubramanian, N" uniqKey="Venketasubramanian N">N Venketasubramanian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, Sn" uniqKey="Han S">SN Han</name>
</author>
<author><name sortKey="Meydani, Sn" uniqKey="Meydani S">SN Meydani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akaike, T" uniqKey="Akaike T">T Akaike</name>
</author>
<author><name sortKey="Ando, M" uniqKey="Ando M">M Ando</name>
</author>
<author><name sortKey="Oda, T" uniqKey="Oda T">T Oda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knobil, K" uniqKey="Knobil K">K Knobil</name>
</author>
<author><name sortKey="Choi, Am" uniqKey="Choi A">AM Choi</name>
</author>
<author><name sortKey="Weigand, Gw" uniqKey="Weigand G">GW Weigand</name>
</author>
<author><name sortKey="Jacoby, Db" uniqKey="Jacoby D">DB Jacoby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Geiler, J" uniqKey="Geiler J">J Geiler</name>
</author>
<author><name sortKey="Michaelis, M" uniqKey="Michaelis M">M Michaelis</name>
</author>
<author><name sortKey="Naczk, P" uniqKey="Naczk P">P Naczk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Friel, H" uniqKey="Friel H">H Friel</name>
</author>
<author><name sortKey="Lederman, H" uniqKey="Lederman H">H Lederman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, It" uniqKey="Yu I">IT Yu</name>
</author>
<author><name sortKey="Xie, Zh" uniqKey="Xie Z">ZH Xie</name>
</author>
<author><name sortKey="Tsoi, Kk" uniqKey="Tsoi K">KK Tsoi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lo, Jy" uniqKey="Lo J">JY Lo</name>
</author>
<author><name sortKey="Tsang, Th" uniqKey="Tsang T">TH Tsang</name>
</author>
<author><name sortKey="Leung, Yh" uniqKey="Leung Y">YH Leung</name>
</author>
<author><name sortKey="Yeung, Ey" uniqKey="Yeung E">EY Yeung</name>
</author>
<author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name>
</author>
<author><name sortKey="Lim, Ww" uniqKey="Lim W">WW Lim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loeb, M" uniqKey="Loeb M">M Loeb</name>
</author>
<author><name sortKey="Dafoe, N" uniqKey="Dafoe N">N Dafoe</name>
</author>
<author><name sortKey="Mahony, J" uniqKey="Mahony J">J Mahony</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Df" uniqKey="Johnson D">DF Johnson</name>
</author>
<author><name sortKey="Druce, Jd" uniqKey="Druce J">JD Druce</name>
</author>
<author><name sortKey="Birch, C" uniqKey="Birch C">C Birch</name>
</author>
<author><name sortKey="Grayson, Ml" uniqKey="Grayson M">ML Grayson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Chow, Bk" uniqKey="Chow B">BK Chow</name>
</author>
<author><name sortKey="Ng, Ss" uniqKey="Ng S">SS Ng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Chow, Bk" uniqKey="Chow B">BK Chow</name>
</author>
<author><name sortKey="Chu, Lc" uniqKey="Chu L">LC Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Hall, Sd" uniqKey="Hall S">SD Hall</name>
</author>
<author><name sortKey="Chan, Mt" uniqKey="Chan M">MT Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name>
</author>
<author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name>
</author>
<author><name sortKey="Cajka, Jc" uniqKey="Cajka J">JC Cajka</name>
</author>
<author><name sortKey="Cooley, Pc" uniqKey="Cooley P">PC Cooley</name>
</author>
<author><name sortKey="Burke, Ds" uniqKey="Burke D">DS Burke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Sugimoto, Jd" uniqKey="Sugimoto J">JD Sugimoto</name>
</author>
<author><name sortKey="Halloran, Me" uniqKey="Halloran M">ME Halloran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="National Center For Immunization And Respiratory Diseases" uniqKey="National Center For Immunization And Respiratory Diseases">National Center for Immunization and Respiratory Diseases</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chest</journal-id>
<journal-id journal-id-type="iso-abbrev">Chest</journal-id>
<journal-title-group><journal-title>Chest</journal-title>
</journal-title-group>
<issn pub-type="ppub">0012-3692</issn>
<issn pub-type="epub">1931-3543</issn>
<publisher><publisher-name>The American College of Chest Physicians. Published by Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20022969</article-id>
<article-id pub-id-type="pmc">7094244</article-id>
<article-id pub-id-type="publisher-id">S0012-3692(10)60198-5</article-id>
<article-id pub-id-type="doi">10.1378/chest.09-2344</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Clinical Management of Pandemic 2009 Influenza A(H1N1) Infection</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au1"><name><surname>Hui</surname>
<given-names>David S.</given-names>
</name>
<degrees>MD, FCCP</degrees>
<email>dschui@cuhk.edu.hk</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="cor1" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author" id="au2"><name><surname>Lee</surname>
<given-names>Nelson</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au3"><name><surname>Chan</surname>
<given-names>Paul K.S.</given-names>
</name>
<degrees>MD</degrees>
<xref rid="aff2" ref-type="aff">b</xref>
<xref rid="aff3" ref-type="aff">c</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</aff>
<aff id="aff2"><label>b</label>
Stanley Ho Center for Emerging Infectious Diseases, School of Public Health & Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</aff>
<aff id="aff3"><label>c</label>
Department of Microbiology (Dr Chan), The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>Correspondence to:</bold>
David S Hui, MD, FCCP, Division of Respiratory Medicine, The Chinese University of Hong Kong, 9/F, Prince of Wales Hospital, 30-32 Ngan Shing St, Shatin, New Territories, Hong Kong <email>dschui@cuhk.edu.hk</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>16</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>16</day>
<month>12</month>
<year>2015</year>
</pub-date>
<volume>137</volume>
<issue>4</issue>
<fpage>916</fpage>
<lpage>925</lpage>
<history><date date-type="received"><day>3</day>
<month>10</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>12</day>
<month>12</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© 2010 The American College of Chest Physicians</copyright-statement>
<copyright-year>2010</copyright-year>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="abs1"><p>Antiviral therapy and vaccination are important strategies for controlling pandemic 2009 influenza A(H1N1) but efficacy depends on the timing of administration and is often limited by supply shortage. Patients with dyspnea, tachypnea, evidence of hypoxemia, and pulmonary infiltrates on chest radiograph should be hospitalized. Patients with severe illness or underlying medical conditions that increase the risk of more severe disease should be treated with oseltamivir or zanamivir as soon as possible, without waiting for the results of laboratory tests. Lung-protective ventilation strategy with a low tidal volume and adequate pressure, in addition to a conservative fluid management approach, is recommended when treating adult patients with ARDS. Extracorporeal membrane oxygenation has emerged as an important rescue therapy for critically ill patients. Use of systemic steroids was associated with delayed viral clearance in severe acute respiratory syndrome and H3N2 infection. Low-dose corticosteroids may be considered in the treatment of refractory septic shock. Passive immunotherapy in the form of convalescent plasma or hyperimmune globulin may be explored as rescue therapy. More data are needed to explore the potential role of IV gamma globulin and other drugs with immunomodulating properties, such as statins, gemfibrozil, and <italic>N</italic>
-acetyl-cysteine. Health-care workers must apply strict standard and droplet precautions when dealing with suspected and confirmed case and upgrade to airborne precautions when performing aerosol-generating procedures. Nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, good community hygiene, and restrictions on travel are useful measures in controlling an influenza pandemic at its early phase.</p>
</abstract>
</article-meta>
</front>
<body><sec id="cenucl250"><title>Abbreviations</title>
<def-list><def-item><term id="defterm1">ECMO</term>
<def><p id="para1">extracorporeal membrane oxygenation</p>
</def>
</def-item>
<def-item><term id="defterm2">HCW</term>
<def><p id="para2">health-care worker</p>
</def>
</def-item>
<def-item><term id="defterm3">IMV</term>
<def><p id="para3">invasive mechanical ventilation</p>
</def>
</def-item>
<def-item><term id="defterm4">MRSA</term>
<def><p id="para4">methicillin-resistant <italic>Staphylococcus aureus</italic>
</p>
</def>
</def-item>
<def-item><term id="defterm5">NAC</term>
<def><p id="para5"><italic>N</italic>
-acetyl-<sc>L</sc>
-cysteine</p>
</def>
</def-item>
<def-item><term id="defterm6">NPPV</term>
<def><p id="para6">noninvasive positive pressure ventilation</p>
</def>
</def-item>
<def-item><term id="defterm7">pandemic A(H1N1)</term>
<def><p id="para7">pandemic 2009 influenza A(H1N1)</p>
</def>
</def-item>
<def-item><term id="defterm8">ROS</term>
<def><p id="para8">reactive oxygen species</p>
</def>
</def-item>
<def-item><term id="defterm9">RT-PCR</term>
<def><p id="para9">reverse transcription-polymerase chain reaction</p>
</def>
</def-item>
<def-item><term id="defterm10">SARS</term>
<def><p id="para10">severe acute respiratory syndrome</p>
</def>
</def-item>
<def-item><term id="defterm11">WHO</term>
<def><p id="para11">World Health Organization</p>
</def>
</def-item>
</def-list>
</sec>
<sec><p id="para12">Influenza A virus belongs to the genus <italic>Orthomyxovirus</italic>
under the family Orthomyxoviridae. The enveloped virion contains eight segments of single, negative-stranded RNA genome, encoding the surface glycoproteins of hemagglutinin and neuraminidase, RNA polymerase (PA, PB1, PB2), nucleoprotein, matrix protein, and nonstructural protein. There are 16 hemagglutinin subtypes and nine neuraminidase subtypes based on the antigenic characteristics. Introduction of a new subtype into humans can result in a large-scale pandemic with high morbidity and mortality due to the naïve immunity and the absence of an effective vaccine in the initial phase of outbreak. Three influenza pandemics occurred in the 20th century. The most severe influenza pandemic of “Spanish flu” A(H1N1) occurred in 1918 to 1919, with a global mortality of 20 to 25 million. It was estimated that 50% of the global population became infected, of whom half suffered clinical illnesses. The A(H2N2) pandemic that occurred in 1957 to 1958 caused about 70,000 deaths in the United States. In 1968, another new type A(H3N2) emerged and remains in circulation today.<xref rid="bib1" ref-type="bibr">1</xref>
, <xref rid="bib2" ref-type="bibr">2</xref>
</p>
<p id="para13">Pandemic 2009 influenza A(H1N1) [A(H1N1)] is a new strain of influenza virus that was first identified in Mexico and the United States in March and April 2009, respectively. The pandemic A(H1N1) virus originated from the triple-reassortment swine influenza (H1) virus circulating in North American pigs.<xref rid="bib3" ref-type="bibr">3</xref>
, <xref rid="bib4" ref-type="bibr">4</xref>
Complete genome sequencing has shown that the known molecular markers of pathogenicity (PB1-F2 and nonstructural-1 proteins) are not expressed in the pandemic A(H1N1) virus.<xref rid="bib5" ref-type="bibr"><sup>5</sup>
</xref>
Animal studies have shown that the novel influenza virus caused increased morbidity, replicated to higher titers in lung tissue, and was recovered from the intestinal tract of intranasally inoculated ferrets in contrast to seasonal influenza H1N1 virus.<xref rid="bib6" ref-type="bibr">6</xref>
, <xref rid="bib7" ref-type="bibr">7</xref>
, <xref rid="bib8" ref-type="bibr">8</xref>
This may explain why the novel virus is relatively more pathogenic than seasonal influenza viruses in its capacity to invade the lower respiratory tract and cause rapidly progressive pneumonia in humans because of our lack of background immunity to the former. Within several weeks from onset, the novel virus has spread throughout the world through international air travel and resulted in an influenza pandemic.<xref rid="bib9" ref-type="bibr"><sup>9</sup>
</xref>
The World Health Organization (WHO) has raised the level of influenza pandemic alert from phase 5 to phase 6 since June 11, 2009.<xref rid="bib10" ref-type="bibr"><sup>10</sup>
</xref>
</p>
<p id="para14">As of November 29, 2009, there have been > 622,482 laboratory-confirmed cases of pandemic A(H1N1) and 8,768 deaths in 207 countries and territories reported to the WHO. As more and more countries have stopped counting individual cases, particularly of milder illness, the case count is significantly lower than the actual number of cases that have occurred.<xref rid="bib11" ref-type="bibr"><sup>11</sup>
</xref>
</p>
<sec id="cesec1"><title>Clinical and Laboratory Features of Severe Cases</title>
<p id="para15">The majority of patients with pandemic A(H1N1) infection develop mild upper respiratory tract symptoms similar to seasonal influenza, but gastrointestinal symptoms seem more common in the former. In a study of 642 confirmed cases during the early outbreak in the United States in April 2009, 60% of patients were ≤ 18 years of age. Among those with available data, 18% had history of recent travel to Mexico, whereas 16% were identified from school outbreaks. The most common presenting symptoms were fever (94%), cough (92%), and sore throat (66%); 25% of patients had diarrhea, and 25% had vomiting. Of the 399 patients for whom hospitalization status was known, 36 (9%) required hospitalization and two died.<xref rid="bib12" ref-type="bibr"><sup>12</sup>
</xref>
In a study of 863 confirmed cases in Ontario, Canada, cough, fever, sore throat, and gastrointestinal symptoms were reported in 92%, 91%, 41%, and 24% of patients, respectively, with a hospitalization rate of 3.6% and a case fatality ratio of 0.2%.<xref rid="bib13" ref-type="bibr"><sup>13</sup>
</xref>
</p>
<p id="para16">Patients with more severe disease present with fever, cough, dyspnea or respiratory distress, increased serum lactate dehydrogenase levels, and bilateral patchy pneumonia (<xref rid="fig1" ref-type="fig">Figs 1A–C</xref>
). Other common findings were an increased creatinine kinase level and lymphopenia.<xref rid="bib14" ref-type="bibr"><sup>14</sup>
</xref>
The WHO has outlined the warning signs for more severe disease as listed in <xref rid="tbl1" ref-type="table">Table 1</xref>
.<xref rid="bib15" ref-type="bibr"><sup>15</sup>
</xref>
Although severe disease may occur in otherwise well and young subjects, there are often risk factors for developing more severe disease (<xref rid="tbl2" ref-type="table">Table 2</xref>
).<xref rid="bib14" ref-type="bibr">14</xref>
, <xref rid="bib16" ref-type="bibr">16</xref>
, <xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
<fig id="fig1"><label>Figure 1</label>
<caption><p>(<italic>A</italic>
) Chest radiograph of an obese, 23-year-old woman (BMI 31 kg/m<sup>2</sup>
). She had influenza symptom onset on July 8, 2009, and was treated by a general practitioner with antibiotics. A chest radiograph taken on July 15, 2009, showed bilateral mid and lower zone patchy infiltrates. Reverse transcription-polymerase chain reaction (RT-PCR) from the nasopharyngeal aspirate was positive for the pandemic A(H1N1) virus. Oseltamivir 150 mg bid was started on July 15, 2009. (<italic>B</italic>
) Despite treatment with high-dose oseltamivir and supplemental oxygen, her condition deteriorated, and a chest radiograph taken on July 18, 2009, showed bilateral and extensive consolidation. She required invasive mechanical ventilation (IMV) on July 18, 2009, with lung-protective ventilation strategy and conservative fluid management. (<italic>C</italic>
) Her condition improved following intensive care support and high-dose oseltamivir for 10 days. She was extubated on July 24, 2009. Chest radiograph taken on July 29, 2009, showed marked clearing of the lung consolidation.</p>
</caption>
<graphic xlink:href="gr1_lrg"></graphic>
</fig>
<table-wrap position="float" id="tbl1"><label>Table 1</label>
<caption><p>Warning Signs Indicating More Severe Disease<xref rid="bib15" ref-type="bibr"><sup>15</sup>
</xref>
</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left">Dyspnea, either during physical activity or while resting</td>
</tr>
<tr><td align="left">Cyanosis</td>
</tr>
<tr><td align="left">Bloody or colored sputum</td>
</tr>
<tr><td align="left">Chest pain</td>
</tr>
<tr><td align="left">Altered mental status</td>
</tr>
<tr><td align="left">High fever that persists beyond 3 d</td>
</tr>
<tr><td align="left">Hypotension</td>
</tr>
<tr><td align="left">In children, danger signs include tachypnea or dyspnea, drowsiness, and little or no desire to play</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap position="float" id="tbl2"><label>Table 2</label>
<caption><p>Risk Factors for Developing More Severe Disease<xref rid="bib14" ref-type="bibr">14</xref>
, <xref rid="bib16" ref-type="bibr">16</xref>
, <xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left">Chronic respiratory diseases (eg, asthma, COPD, bronchiectasis, lung surgery)</td>
</tr>
<tr><td align="left">Obesity</td>
</tr>
<tr><td align="left">Pregnancy</td>
</tr>
<tr><td align="left">Smoking</td>
</tr>
<tr><td align="left">Diabetes mellitus</td>
</tr>
<tr><td align="left">Chronic cardiovascular diseases</td>
</tr>
<tr><td align="left">Renal diseases</td>
</tr>
<tr><td align="left">Immunosuppression (such as blood disorders, malignancy)</td>
</tr>
<tr><td align="left">Delay in presentation to hospital (and hence delay in initiating antiviral therapy)</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
<p id="para17">In contrast to seasonal influenza, most severe pandemic A(H1N1) disease and its related mortality have occurred among children and adults aged < 60 years, whereas about 40% of patients who have required hospitalization or died were previously healthy.<xref rid="bib16" ref-type="bibr">16</xref>
, <xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
The number of ICU admissions due to pandemic A(H1N1) infection was 15 times the number due to viral pneumonitis in recent years in Australia and New Zealand.<xref rid="bib17" ref-type="bibr"><sup>17</sup>
</xref>
The elderly (> 65 years) are less frequently infected by the novel virus,<xref rid="bib16" ref-type="bibr">16</xref>
, <xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
, <xref rid="bib19" ref-type="bibr">19</xref>
probably because of some pre-existing cross-reacting immunity against the virus due to their past exposure to previous circulating seasonal influenza A(H1N1) strains similar to the current pandemic A(H1N1) virus.<xref rid="bib20" ref-type="bibr"><sup>20</sup>
</xref>
However, it is controversial if the seasonal influenza vaccine antigen components confer any cross-immunity against the pandemic strain.<xref rid="bib20" ref-type="bibr">20</xref>
, <xref rid="bib21" ref-type="bibr">21</xref>
</p>
<p id="para18">Autopsy findings have shown three distinct pulmonary histologic patterns: diffuse alveolar damage, necrotizing bronchiolitis, and diffuse alveolar damage with intense alveolar hemorrhage. There is also evidence of ongoing pulmonary aberrant immune response.<xref rid="bib22" ref-type="bibr"><sup>22</sup>
</xref>
Pulmonary emboli were noted, whereas secondary bacterial or fungal pneumonia were reported in 7/50 (14%) fatal cases in California.<xref rid="bib23" ref-type="bibr"><sup>23</sup>
</xref>
A fatal case with coinfection with community-acquired methicillin-resistant <italic>Staphylococcus aureus</italic>
(MRSA) occurred in a Filipino sailor who died in Hong Kong.<xref rid="bib24" ref-type="bibr"><sup>24</sup>
</xref>
In a study of 77 American patients with fatal cases of confirmed pandemic A(H1N1) infection,<xref rid="bib25" ref-type="bibr"><sup>25</sup>
</xref>
evidence of concurrent bacterial infection was found in 22 (29%) patients, including 10 with <italic>Streptococcus pneumoniae</italic>
, six with <italic>Streptococcus pyogenes</italic>
, seven with <italic>S aureus</italic>
, two with <italic>Streptococcus mitis</italic>
, and one with <italic>Haemophilus influenzae</italic>
; four cases involved multiple pathogens. The median age of the 22 patients was 31 years and median duration of illness was 6 days. These findings confirm that bacterial lung infections are occurring among patients with fatal cases of pandemic A(H1N1) infection and underscore both the need for early recognition/treatment of bacterial pneumonia in patients with influenza and the importance of pneumococcal vaccination for persons at increased risk for pneumococcal pneumonia.<xref rid="bib25" ref-type="bibr"><sup>25</sup>
</xref>
The indications for hospitalization are listed in <xref rid="tbl3" ref-type="table">Table 3</xref>
.<xref rid="bib26" ref-type="bibr"><sup>26</sup>
</xref>
<table-wrap position="float" id="tbl3"><label>Table 3</label>
<caption><p>Indications for Hospital Admission<xref rid="bib26" ref-type="bibr"><sup>26</sup>
</xref>
</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left">Patients with influenza symptoms should be hospitalized if there is evidence of: hypoxemia (Sp<sc>O</sc>
<sub>2</sub>
< 95%), tachypnea (respiratory rate > 24 breaths/min), or pulmonary infiltrates on chest radiograph.</td>
</tr>
<tr><td align="left">Patients should be referred for ICU assessment if: F<sc>IO</sc>
<sub>2</sub>
of > 0.5 or oxygen at a rate of > 10 L/min is required to maintain the Sp<sc>O</sc>
<sub>2</sub>
at 92%.</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>Sp<sc>O</sc>
<sub>2</sub>
= oxygen saturation.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
</sec>
<sec id="cesec2"><title>Diagnostic Tests</title>
<p id="para19">Nasal swabs with nasal secretions (from the anterior turbinate area) or nasopharyngeal aspirates or swabs are appropriate specimens for detecting human influenza A and B. Although the rapid influenza diagnostic tests were capable of detecting novel A(H1N1) virus from respiratory specimens containing high levels of virus, the overall sensitivity was low (40%-69%) among all specimens tested and declined substantially as virus levels decreased. Patients with illnesses compatible with pandemic A(H1N1) virus infection but with negative rapid influenza diagnostic test results should be treated empirically based on the level of clinical suspicion, underlying medical conditions, severity of illness, and risk for complications. If a more definitive determination of infection with influenza virus is required, testing with real-time reverse transcription-polymerase chain reaction (RT-PCR) or virus isolation should be performed.<xref rid="bib27" ref-type="bibr"><sup>27</sup>
</xref>
In patients who require invasive mechanical ventilation (IMV), tracheal aspirates may offer higher diagnostic yield than nasopharyngeal flocked swab (<xref rid="fig2" ref-type="fig">Fig 2</xref>
). Sequential sampling is important because it increases opportunities for positive diagnosis and facilitates understanding of viral load/clearance during illness course, in addition to monitoring development of antiviral resistance.<fig id="fig2"><label>Figure 2</label>
<caption><p>Virus-shedding profile of the same 23-year-old obese woman as shown in <xref rid="fig1" ref-type="fig">Figure 1</xref>
with pandemic A(H1N1) infection. Although the concentration of virus shed from the upper respiratory tract decreased after a few days of antiviral therapy, very high viral loads were detected from the lower respiratory tract specimens (tracheal aspirates) from July 18-22, 2009. Viral copy numbers were determined by real-time RT-PCR targeting the matrix protein gene. Specimens with undetectable viral copy number (lower detection limit = 62.6 viral copies/μL) were plotted at zero. Dotted line represents virus concentrations detected from upper respiratory tract specimens, and solid line represents virus concentrations detected from lower respiratory tract specimens. See <xref rid="fig1" ref-type="fig">Figure 1</xref>
legend for definition of abbreviation.</p>
</caption>
<graphic xlink:href="gr2_lrg"></graphic>
</fig>
</p>
</sec>
<sec id="cesec3"><title>Antiviral Therapy</title>
<p id="para20">The pandemic virus is currently susceptible to the neuraminidase inhibitors, but resistant to the matrix protein-2 inhibitors. Most patients infected with the pandemic virus experience typical influenza symptoms and fully recover within a week, even without any form of medical treatment. Healthy patients with uncomplicated illness need not be treated with antivirals. For patients who initially present with severe illness or whose condition begins to deteriorate, treatment with oseltamivir should commence as soon as possible and antiviral treatment should be provided even if started later than 48 h. If oseltamivir is unavailable or cannot be used for any reason, zanamivir may be given. This recommendation applies to all patient groups, including pregnant women, and all age groups, including young children and infants.<xref rid="bib15" ref-type="bibr"><sup>15</sup>
</xref>
The Food and Drug Administration in the United States has approved emergency use of intravenous peramivir for treatment of severe cases,<xref rid="bib28" ref-type="bibr"><sup>28</sup>
</xref>
whereas zanamivir dry powder should not be administered by nebulization as the lactose sugar in this formulation can obstruct proper functioning of mechanical ventilator equipment.<xref rid="bib29" ref-type="bibr"><sup>29</sup>
</xref>
</p>
<p id="para21">For patients with underlying medical conditions that increase the risk of more severe disease, the WHO recommends treatment with either oseltamivir or zanamivir as soon as possible after symptom onset, without waiting for the results of laboratory tests. About 30% to 40% of severe cases globally have occurred in previously healthy children and adults, usually under the age of 50 years. Some of these patients experience a sudden and very rapid deterioration in their clinical condition, usually on day 5 or 6 following the onset of symptoms. Clinical deterioration is characterized by primary viral pneumonia and failure of multiple organs, including the heart, kidneys, and liver. These patients require management in the ICU. In cases of severe or deteriorating illness, clinicians may consider using higher doses of oseltamivir and for a longer duration (eg, 150 mg bid for 10 days for adults) than is normally prescribed.<xref rid="bib15" ref-type="bibr">15</xref>
, <xref rid="bib30" ref-type="bibr">30</xref>
</p>
<p id="para22">Cases of oseltamivir-resistant viruses continue to be sporadic and infrequent, with no evidence that oseltamivir-resistant pandemic A(H1N1) viruses are circulating within communities or worldwide. All of these viruses show the same H275Y (N1 nomenclature) mutation that confers resistance to the antiviral oseltamivir, but not to the antiviral zanamivir. Thus zanamivir remains a treatment option in symptomatic patients with severe or deteriorating illness due to oseltamivir-resistant virus.<xref rid="bib31" ref-type="bibr"><sup>31</sup>
</xref>
</p>
<p id="para23">The risk of resistance is considered higher in patients with severely compromised or suppressed immune systems who have prolonged illness, have received oseltamivir treatment (especially for an extended duration), but still have evidence of persistent viral replication. The risk of resistance is also considered higher in people who receive oseltamivir for postexposure prophylaxis following exposure to another person with influenza and who then develop illness despite taking oseltamivir. In general, it is not recommended to use antiviral drugs for prophylactic purposes. An alternative option is close monitoring for symptoms in people who have had exposure to an infected person and are at a higher risk of developing severe or complicated illness, followed by prompt early antiviral treatment should symptoms develop.<xref rid="bib30" ref-type="bibr">30</xref>
, <xref rid="bib31" ref-type="bibr">31</xref>
</p>
</sec>
<sec id="cesec4"><title>Respiratory Support for Critically Ill Patients</title>
<p id="para24">About 1% to 10% of patients with clinical illness due to the novel infection have required hospitalization and the overall case fatality ratio has been estimated as < 0.5%.<xref rid="bib19" ref-type="bibr"><sup>19</sup>
</xref>
Rapidly progressive respiratory failure is relatively common and about 10% to 30% of hospitalized patients have required ICU admission.<xref rid="bib30" ref-type="bibr"><sup>30</sup>
</xref>
IMV, with a lung-protective ventilation strategy, is recommended as the initial approach for managing patients with pandemic A(H1N1) infection complicated by ARDS.<xref rid="bib26" ref-type="bibr">26</xref>
, <xref rid="bib30" ref-type="bibr">30</xref>
The recommendation is based on the ARDSNet trial demonstrating a relative risk reduction of mortality by 22% in patients with ARDS ventilated with the lower tidal volume (eg, goal of maximum tidal volume 6 mL/kg of predicted body weight with plateau pressures up to maximum 30 cm H<sub>2</sub>
O).<xref rid="bib32" ref-type="bibr"><sup>32</sup>
</xref>
Furthermore, it is prudent to adopt a conservative fluid management approach for patients with ARDS/acute lung injury, as this has been shown to increase ventilator-free days and improve oxygenation when compared with a fluid liberal strategy.<xref rid="bib33" ref-type="bibr"><sup>33</sup>
</xref>
</p>
<p id="para25">In ICUs where expertise and technology are available, extracorporeal membrane oxygenation (ECMO), high-frequency oscillation ventilation, prone positioning, and inhaled nitric oxide have been reported as useful rescue therapies for critically ill patients.<xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
, <xref rid="bib34" ref-type="bibr">34</xref>
The median duration for IMV was 8 days; 12% of the ventilated patients with severe respiratory failure in Australia and New Zealand received ECMO support, with a survival rate of 70% in this subgroup.<xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib34" ref-type="bibr">34</xref>
The overall ICU mortality rate for the critically ill cases was close to 17%.<xref rid="bib17" ref-type="bibr">17</xref>
, <xref rid="bib18" ref-type="bibr">18</xref>
Factors that were independently associated with death in the hospital included requirement of IMV at ICU admission, any coexisting condition, and older age.<xref rid="bib17" ref-type="bibr"><sup>17</sup>
</xref>
</p>
<p id="para26">Noninvasive positive pressure ventilation (NPPV) was applied to a small number of critically ill patients with pandemic A(H1N1) infection complicated by respiratory failure, but most patients subsequently required IMV support.<xref rid="bib26" ref-type="bibr">26</xref>
, <xref rid="bib35" ref-type="bibr">35</xref>
NPPV is generally not recommended for patients with the novel influenza infection complicated by pneumonia and ARDS. NPPV temporarily improves oxygenation and reduces the work of breathing, but does not necessarily alter the course of the disease. The need for NPPV is an indication of severe disease and the likelihood of IMV.<xref rid="bib26" ref-type="bibr"><sup>26</sup>
</xref>
In addition, hemodynamic instability and multiorgan failure are contraindications to application of NPPV. The WHO interim guidelines on prevention and control of acute respiratory diseases in health care have included NPPV among those aerosol-generating procedures in which there is possibly increased risk of respiratory pathogen transmission.<xref rid="bib36" ref-type="bibr"><sup>36</sup>
</xref>
Low-dose heparin should be started prophylactically for critically ill patients who require ICU treatment in view of the reports of pulmonary embolism, especially among the critically ill obese patients with pandemic A(H1N1) infection.<xref rid="bib23" ref-type="bibr"><sup>23</sup>
</xref>
</p>
</sec>
<sec id="cesec5"><title>Systemic Corticosteroids</title>
<p id="para27">High-dose corticosteroids have not been shown to be beneficial in ARDS and septic shock unrelated to A(H1N1) virus infection in reducing mortality. However, stress-dose corticosteroids (hydrocortisone 200-300 mg/d) may be beneficial in improving hospital mortality and morbidity outcomes.<xref rid="bib37" ref-type="bibr">37</xref>
, <xref rid="bib38" ref-type="bibr">38</xref>
Although low-dose corticosteroids may be considered in the management of refractory septic shock, the precise role of systemic steroids in the setting of ARDS and refractory shock due to severe influenza pneumonitis requires further investigation as metaanalyses to date have mainly derived from data related to bacterial-induced sepsis,<xref rid="bib37" ref-type="bibr">37</xref>
, <xref rid="bib38" ref-type="bibr">38</xref>
and data specific for pandemic A(H1N1) are limited.<xref rid="bib39" ref-type="bibr"><sup>39</sup>
</xref>
</p>
<p id="para28">It is important to use systemic corticosteroids with caution in the treatment of respiratory viral diseases. Early use of corticosteroids might prolong viral replication in severe acute respiratory syndrome (SARS)<xref rid="bib40" ref-type="bibr"><sup>40</sup>
</xref>
and H3N2 influenza.<xref rid="bib41" ref-type="bibr"><sup>41</sup>
</xref>
In addition, prolonged use of systemic corticosteroids in SARS led to severe adverse effects, including fatal disseminated <italic>Aspergillus</italic>
infection<xref rid="bib42" ref-type="bibr"><sup>42</sup>
</xref>
and osteonecrosis.<xref rid="bib43" ref-type="bibr"><sup>43</sup>
</xref>
During the SARS period in the ICU, the use of systemic steroids was associated with an increase in the rate of isolation of MRSA, <italic>Stenotrophomonas</italic>
and <italic>Candida</italic>
species. The ventilator-associated pneumonia rate was high, at 36.5 episodes per 1,000 ventilator-days, and 47% of episodes were caused by MRSA. The MRSA acquisition rate also increased from 3.53% during the pre-SARS period to 25.30% during the SARS period.<xref rid="bib44" ref-type="bibr"><sup>44</sup>
</xref>
The use of systemic steroids for acute exacerbation of COPD due to pandemic A(H1N1) infection may potentially prolong viral shedding (<xref rid="fig3" ref-type="fig">Fig 3</xref>
).<fig id="fig3"><label>Figure 3</label>
<caption><p>Virus-shedding profile of a 68-year-old man who was hospitalized with acute exacerbation of COPD on July 6, 2009, with a 2-day history of cough, fever, and increased dyspnea. His chest radiograph showed no consolidation. He was given prednisolone 30 mg daily for 10 days and amoxicillin-clavulanate 1 g bid for acute exacerbation of COPD. RT-PCR from his nasopharyngeal aspirate taken on July 6, 2009, was positive for the pandemic A(H1N1) virus. Oseltamivir 75 mg bid was started on July 7, 2009, for 5 days. He developed hypercapnic respiratory failure on July 8, 2009, and required noninvasive positive pressure ventilation (NPPV) support for 2 days in a negative pressure isolation room. His nasopharyngeal flocked swab was still positive by RT-PCR on July 16, 2009, although clinically he was well. The use of systemic steroid for COPD might have prolonged his viral shedding. He was discharged from hospital well on July 26, 2009. Viral copy numbers were determined by real-time RT-PCR targeting the matrix protein gene. Specimens with undetectable viral copy number (lower detection limit = 62.6 viral copies/μL) were plotted at zero. See <xref rid="fig1" ref-type="fig">Figure 1</xref>
legend for definition of abbreviation.</p>
</caption>
<graphic xlink:href="gr3_lrg"></graphic>
</fig>
</p>
</sec>
<sec id="cesec6"><title>Passive Immunotherapy</title>
<p id="para29">A metaanalysis has suggested that early administration of convalescent blood products might have reduced the risk for death in patients with Spanish influenza pneumonia during the 1918 pandemic.<xref rid="bib45" ref-type="bibr"><sup>45</sup>
</xref>
Convalescent plasma was used as rescue therapy with seemingly favorable response in a 31-year-old male patient in severe A(H5N1) infection complicated by multiorgan failure despite treatment with oseltamivir,<xref rid="bib46" ref-type="bibr"><sup>46</sup>
</xref>
although it is difficult to judge the efficacy of convalescent plasma without any randomized controlled study. There is, however, experimental evidence in animal models that administration of anti-H5N1-specific antibodies in the form of neutralizing monoclonal antibodies or polyclonal sera (convalescent or postimmunization) is effective in treating influenza A(H5N1) disease.<xref rid="bib47" ref-type="bibr">47</xref>
, <xref rid="bib48" ref-type="bibr">48</xref>
Thus passive immunotherapy, including in the form of hyperimmune globulin made from convalescent plasma, is a potential option for treatment of pandemic A(H1N1) infection.</p>
</sec>
<sec id="cesec7"><title>Other Immunomodulating Agents</title>
<sec id="cesec8"><title>Statins</title>
<p id="para30">High viral load and the resulting intense inflammatory response have been hypothesized as causing the organ damage and severe morbidity/mortality of A(H5N1) disease.<xref rid="bib49" ref-type="bibr"><sup>49</sup>
</xref>
Cytokine dysregulation has also been invoked in the pathogenesis of sepsis and septic shock.<xref rid="bib50" ref-type="bibr">50</xref>
, <xref rid="bib51" ref-type="bibr">51</xref>
Statins have antiinflammatory and immunomodulatory effects (eg, by repressing induction of major histocompatibility complex-II by interferon-γ and subsequent T-lymphocyte activation).<xref rid="bib52" ref-type="bibr"><sup>52</sup>
</xref>
Statins have been proposed to play a potential role for treatment and prophylaxis of pandemic influenza based on observational studies showing the survival benefits in patients receiving statins who developed bacteremia, sepsis, or pneumonia.<xref rid="bib53" ref-type="bibr"><sup>53</sup>
</xref>
</p>
<p id="para31">In H5N1-, H3N2-, and H1N1-infected BALB/c mice, 50 μg statin/200 μg caffeine effectively ameliorated lung damage and inhibited viral replication and was at least as effective as oseltamivir and ribavirin. The statins/caffeine combination also appeared to be more effective when administered preventatively rather than as treatment. These findings provide justification for further research into this novel antiviral formulation.<xref rid="bib54" ref-type="bibr"><sup>54</sup>
</xref>
</p>
</sec>
<sec id="cesec9"><title>IV Ig</title>
<p id="para32">IV Ig may be considered as a treatment option for its immunomodulating effects in influenza with active systemic inflammation.<xref rid="bib55" ref-type="bibr"><sup>55</sup>
</xref>
IV Ig was used for treatment of SARS, but there were thromboembolic events, such as pulmonary embolism and ischemic stroke, despite use of prophylactic low-molecular-weight heparin.<xref rid="bib56" ref-type="bibr">56</xref>
, <xref rid="bib57" ref-type="bibr">57</xref>
, <xref rid="bib58" ref-type="bibr">58</xref>
Thus, it is important to monitor for the complications of IV Ig, especially vascular thrombotic events.</p>
</sec>
<sec id="cesec10"><title>N-acetyl-l-cysteine</title>
<p id="para33">Production of reactive oxygen species (ROS) has been shown to contribute to pulmonary damage caused by influenza virus infection.<xref rid="bib59" ref-type="bibr"><sup>59</sup>
</xref>
Different sources of ROS have been suggested in influenza A virus-infected lungs. Leukocytes may be activated and primed by influenza A virus infection and produce ROS.<xref rid="bib60" ref-type="bibr"><sup>60</sup>
</xref>
Moreover, increased xanthine oxidase levels were found in influenza A virus-infected lungs.<xref rid="bib60" ref-type="bibr"><sup>60</sup>
</xref>
Epithelial cells of the lungs may also be a source of ROS since influenza A virus infection induced oxidant stress response in cultured airway epithelial cells.<xref rid="bib61" ref-type="bibr"><sup>61</sup>
</xref>
The antioxidant <italic>N</italic>
-acetyl-<sc>L</sc>
-cysteine (NAC) has been shown to inhibit replication of seasonal human influenza A viruses. NAC inhibits H5N1 replication and H5N1-induced production of proinflammatory molecules.<xref rid="bib62" ref-type="bibr"><sup>62</sup>
</xref>
Therefore, antioxidants like NAC represent a potential additional treatment option that could be considered in the case of severe influenza infection. Other compounds with immunomodulating properties, such as macrolides, gemfibrozil, glitazone,<xref rid="bib53" ref-type="bibr"><sup>53</sup>
</xref>
and nutritional supplements,<xref rid="bib63" ref-type="bibr"><sup>63</sup>
</xref>
have been proposed as adjunct treatments, but these would require further investigation with controlled clinical trials.</p>
</sec>
</sec>
<sec id="cesec11"><title>Prevention and Infection Control Aspects</title>
<p id="para34">There are some infection control lessons from SARS that have important clinical implications for infection control against human influenza pandemic. A case-control study involving 124 medical wards in 26 hospitals in Guangzhou and Hong Kong has identified six independent risk factors of super-spreading nosocomial outbreaks of SARS: minimum distance between beds < 1 m, performance of resuscitation, staff working while experience symptoms, and SARS patients requiring oxygen therapy or NPPV, whereas availability of washing or changing facilities for staff was a protective factor.<xref rid="bib64" ref-type="bibr"><sup>64</sup>
</xref>
Good hand and respiratory hygiene in 2003 led to significant reduction of common respiratory viral infections in the community in Hong Kong.<xref rid="bib65" ref-type="bibr"><sup>65</sup>
</xref>
</p>
<p id="para35">Several measures are recommended by the WHO in the context of pandemic A(H1N1) and other epidemics. These include maintaining standard and droplet precautions among the health-care workers (HCWs) at all levels of health care, emphasizing respiratory etiquette and hand hygiene, cohorting, adequate room ventilation, and separating a minimum distance of ≥ 1 m between patients when providing routine care to patients infected with pandemic H1N1 influenza and those with influenza-like symptoms.<xref rid="bib30" ref-type="bibr">30</xref>
, <xref rid="bib66" ref-type="bibr">66</xref>
Recent data suggest that surgical masks are as effective as N95 masks for respiratory protection of HCWs in the routine care of hospitalized patients during seasonal influenza.<xref rid="bib67" ref-type="bibr">67</xref>
, <xref rid="bib68" ref-type="bibr">68</xref>
It is also important to limit the number of HCWs/family members/visitors exposed to the patient with pandemic A(H1N1), in addition to implementing triage, early recognition, and reporting of pandemic A(H1N1) infection. In addition, it is important to monitor health of HCWs exposed to patients with pandemic A(H1N1), whereas HCWs with symptoms should stay at home. Vulnerable groups at high risk for complications of pandemic A(H1N1) infection should carefully follow recommended infection-control measures. In addition, alternatives such as reassignment to other duties should be considered. Antiviral prophylaxis should follow local policy.<xref rid="bib66" ref-type="bibr"><sup>66</sup>
</xref>
</p>
<p id="para36">When performing aerosol-generating procedures (eg, aspiration of respiratory tract, intubation, resuscitation, bronchoscopy, autopsy), HCWs should be aware that these procedures have been associated with increased risk of infection transmission and should upgrade to airborne infection control precautions, including the use of N95 mask (<xref rid="tbl4" ref-type="table">Table 4</xref>
).<xref rid="bib66" ref-type="bibr"><sup>66</sup>
</xref>
It is important to note that substantial exposure to exhaled air occurs within 0.4-m and 1-m radius of patients receiving oxygen therapy via Hudson mask and during application of NPPV, respectively.<xref rid="bib69" ref-type="bibr">69</xref>
, <xref rid="bib70" ref-type="bibr">70</xref>
, <xref rid="bib71" ref-type="bibr">71</xref>
Geographically targeted nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, and restrictions on travel, are useful measures in controlling an influenza pandemic at its early phase.<xref rid="bib72" ref-type="bibr"><sup>72</sup>
</xref>
<table-wrap position="float" id="tbl4"><label>Table 4</label>
<caption><p>Airborne Precautions To Be Followed When Performing Aerosol-Generating Procedures<xref rid="bib66" ref-type="bibr"><sup>66</sup>
</xref>
</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left">Wear a facial particulate respirator (eg, EU FFP2, US NIOSH-certified N95), eye protection (ie, goggles or a face shield); a clean, nonsterile, long-sleeved gown; and gloves (some of these procedures require sterile gloves)</td>
</tr>
<tr><td align="left">Perform procedures in an adequately ventilated room (> 12 air changes per h)</td>
</tr>
<tr><td align="left">Avoid permitting unnecessary individuals into the room</td>
</tr>
<tr><td align="left">Perform hand hygiene before and after patient contact and after removal of personal protective equipment</td>
</tr>
<tr><td align="left">EU FFP2 = European Union Filtering Face-Piece Class 2; NIOSH = National Institute for Occupational Safety and Health.</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
<p id="para37">Pandemic vaccine is an important strategy for control of pandemic A(H1N1) disease but the efficacy of this modality is limited by shortage of supply due to limited production capacity. If vaccines were available soon enough, it has been estimated that vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic.<xref rid="bib73" ref-type="bibr"><sup>73</sup>
</xref>
The priority groups to receive the pandemic vaccine are listed in <xref rid="tbl5" ref-type="table">Table 5</xref>
.<xref rid="bib74" ref-type="bibr"><sup>74</sup>
</xref>
Because the pandemic virus is new, both nonclinical and clinical trials are being conducted to gain essential information on immune response and safety. Outcomes of trials completed to date suggest that pandemic vaccines are as safe as seasonal influenza vaccines. The WHO advises all countries administering pandemic vaccines to conduct intensive monitoring for safety and to report adverse events.<xref rid="bib75" ref-type="bibr"><sup>75</sup>
</xref>
<table-wrap position="float" id="tbl5"><label>Table 5</label>
<caption><p>Priority Groups for Receiving the Pandemic A(H1N1) Vaccine as Recommended by the US Centers for Disease Control and Prevention<xref rid="bib74" ref-type="bibr"><sup>74</sup>
</xref>
</p>
</caption>
<table frame="hsides" rules="groups"><tbody><tr><td align="left">Pregnant women</td>
</tr>
<tr><td align="left">Household contacts of infants younger than 6 mo</td>
</tr>
<tr><td align="left">Health-care and emergency services personnel</td>
</tr>
<tr><td align="left">Individuals between 6 mo and 24 y</td>
</tr>
<tr><td align="left">Those aged 25 y or older with underlying conditions that put them at high risk of complications from influenza</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
<p id="para38">In summary, antiviral agents and pandemic vaccines are important modalities in the control of a pandemic, but their efficacy is limited by timing of administration and supply. Oxygen therapy and NPPV should be applied in health-care facilities with good ventilation and respiratory protection for the HCWs, but most patients with severe respiratory failure will require IMV. A lung-protective ventilation strategy and a conservative fluid management approach are recommended for patients with ARDS. Rescue therapies, including ECMO, may be considered only after application of standard ICU management practices. Low-dose systemic steroids may be considered for patients with refractory septic shock. The role of passive immunotherapy and immunomodulating agents, such as IV Ig, statins, gemfibrozil, and NAC, requires further investigations. Nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, good community hygiene, and restrictions on travel, are useful measures in controlling an influenza pandemic during the early phase.</p>
</sec>
</sec>
</body>
<back><ref-list id="fread1"><title>References</title>
<ref id="bib1"><label>1</label>
<element-citation publication-type="book" id="sbref1"><person-group person-group-type="author"><name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
<name><surname>Chan</surname>
<given-names>PK</given-names>
</name>
</person-group>
<chapter-title>Viral pneumonia</chapter-title>
<person-group person-group-type="editor"><name><surname>Laurent</surname>
<given-names>GJ</given-names>
</name>
<name><surname>Shapiro</surname>
<given-names>SD</given-names>
</name>
</person-group>
<source>Encyclopaedia of Respiratory Medicine</source>
<year>2006</year>
<publisher-name>Elsevier</publisher-name>
<publisher-loc>Amsterdam, The Netherlands</publisher-loc>
<fpage>456</fpage>
<lpage>466</lpage>
</element-citation>
</ref>
<ref id="bib2"><label>2</label>
<element-citation publication-type="journal" id="sbref2"><person-group person-group-type="author"><name><surname>Smith</surname>
<given-names>GJ</given-names>
</name>
<name><surname>Bahl</surname>
<given-names>J</given-names>
</name>
<name><surname>Vijaykrishna</surname>
<given-names>D</given-names>
</name>
</person-group>
<article-title>Dating the emergence of pandemic influenza viruses</article-title>
<source>Proc Natl Acad Sci U S A</source>
<volume>106</volume>
<issue>28</issue>
<year>2009</year>
<fpage>11709</fpage>
<lpage>11712</lpage>
<pub-id pub-id-type="pmid">19597152</pub-id>
</element-citation>
</ref>
<ref id="bib3"><label>3</label>
<element-citation publication-type="journal" id="sbref3"><person-group person-group-type="author"><name><surname>Trifonov</surname>
<given-names>V</given-names>
</name>
<name><surname>Khiabanian</surname>
<given-names>H</given-names>
</name>
<name><surname>Rabadan</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>2</issue>
<year>2009</year>
<fpage>115</fpage>
<lpage>119</lpage>
<pub-id pub-id-type="pmid">19474418</pub-id>
</element-citation>
</ref>
<ref id="bib4"><label>4</label>
<element-citation publication-type="journal" id="sbref4"><person-group person-group-type="author"><name><surname>Shinde</surname>
<given-names>V</given-names>
</name>
<name><surname>Bridges</surname>
<given-names>CB</given-names>
</name>
<name><surname>Uyeki</surname>
<given-names>TM</given-names>
</name>
</person-group>
<article-title>Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009</article-title>
<source>N Engl J Med</source>
<volume>360</volume>
<issue>25</issue>
<year>2009</year>
<fpage>2616</fpage>
<lpage>2625</lpage>
<pub-id pub-id-type="pmid">19423871</pub-id>
</element-citation>
</ref>
<ref id="bib5"><label>5</label>
<element-citation publication-type="journal" id="sbref5"><person-group person-group-type="author"><name><surname>Garten</surname>
<given-names>RJ</given-names>
</name>
<name><surname>Davis</surname>
<given-names>CT</given-names>
</name>
<name><surname>Russell</surname>
<given-names>CA</given-names>
</name>
</person-group>
<article-title>Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans</article-title>
<source>Science</source>
<volume>325</volume>
<issue>5937</issue>
<year>2009</year>
<fpage>197</fpage>
<lpage>201</lpage>
<pub-id pub-id-type="pmid">19465683</pub-id>
</element-citation>
</ref>
<ref id="bib6"><label>6</label>
<element-citation publication-type="journal" id="sbref6"><person-group person-group-type="author"><name><surname>Maines</surname>
<given-names>TR</given-names>
</name>
<name><surname>Jayaraman</surname>
<given-names>A</given-names>
</name>
<name><surname>Belser</surname>
<given-names>JA</given-names>
</name>
</person-group>
<article-title>Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice</article-title>
<source>Science</source>
<volume>325</volume>
<issue>5939</issue>
<year>2009</year>
<fpage>484</fpage>
<lpage>487</lpage>
<pub-id pub-id-type="pmid">19574347</pub-id>
</element-citation>
</ref>
<ref id="bib7"><label>7</label>
<element-citation publication-type="journal" id="sbref7"><person-group person-group-type="author"><name><surname>Munster</surname>
<given-names>VJ</given-names>
</name>
<name><surname>de Wit</surname>
<given-names>E</given-names>
</name>
<name><surname>van den Brand</surname>
<given-names>JM</given-names>
</name>
</person-group>
<article-title>Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets</article-title>
<source>Science</source>
<volume>325</volume>
<issue>5939</issue>
<year>2009</year>
<fpage>481</fpage>
<lpage>483</lpage>
<pub-id pub-id-type="pmid">19574348</pub-id>
</element-citation>
</ref>
<ref id="bib8"><label>8</label>
<element-citation publication-type="journal" id="sbref8"><person-group person-group-type="author"><name><surname>Itoh</surname>
<given-names>Y</given-names>
</name>
<name><surname>Shinya</surname>
<given-names>K</given-names>
</name>
<name><surname>Kiso</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses</article-title>
<source>Nature</source>
<volume>460</volume>
<issue>7258</issue>
<year>2009</year>
<fpage>1021</fpage>
<lpage>1025</lpage>
<pub-id pub-id-type="pmid">19672242</pub-id>
</element-citation>
</ref>
<ref id="bib9"><label>9</label>
<element-citation publication-type="journal" id="sbref9"><person-group person-group-type="author"><name><surname>Khan</surname>
<given-names>K</given-names>
</name>
<name><surname>Arino</surname>
<given-names>J</given-names>
</name>
<name><surname>Hu</surname>
<given-names>W</given-names>
</name>
</person-group>
<article-title>Spread of a novel influenza A (H1N1) virus via global airline transportation</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>2</issue>
<year>2009</year>
<fpage>212</fpage>
<lpage>214</lpage>
<pub-id pub-id-type="pmid">19564630</pub-id>
</element-citation>
</ref>
<ref id="bib10"><label>10</label>
<element-citation publication-type="other" id="sbref10"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>What is phase 6?</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/swineflu/frequently_asked_questions/levels_pandemic_alert/en/index.html" id="interref2">http://www.who.int/csr/disease/swineflu/frequently_asked_questions/levels_pandemic_alert/en/index.html</ext-link>
<comment>Accessed Sept 20, 2009.</comment>
</element-citation>
</ref>
<ref id="bib11"><label>11</label>
<element-citation publication-type="other" id="sbref11"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Pandemic (H1N1 2009 —update 77</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/don/2009_12_04/en/index.html" id="interref3">http://www.who.int/csr/don/2009_12_04/en/index.html</ext-link>
<comment>Accessed Dec 8, 2009.</comment>
</element-citation>
</ref>
<ref id="bib12"><label>12</label>
<element-citation publication-type="journal" id="sbref12"><person-group person-group-type="author"><name><surname>Dawood</surname>
<given-names>FS</given-names>
</name>
<name><surname>Jain</surname>
<given-names>S</given-names>
</name>
<name><surname>Finelli</surname>
<given-names>L</given-names>
</name>
<name><surname>Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team</surname>
</name>
</person-group>
<article-title>Emergence of a novel swine-origin influenza A (H1N1) virus in humans</article-title>
<source>N Engl J Med</source>
<volume>360</volume>
<issue>25</issue>
<year>2009</year>
<fpage>2605</fpage>
<lpage>2615</lpage>
<pub-id pub-id-type="pmid">19423869</pub-id>
</element-citation>
</ref>
<ref id="bib13"><label>13</label>
<element-citation publication-type="journal" id="sbref13"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Epidemiological summary of pandemic influenza A (H1N1) 2009 virus—Ontario, Canada, June 2009</article-title>
<source>Wkly Epidemiol Rec</source>
<volume>84</volume>
<issue>47</issue>
<year>2009</year>
<fpage>485</fpage>
<lpage>491</lpage>
<pub-id pub-id-type="pmid">19928301</pub-id>
</element-citation>
</ref>
<ref id="bib14"><label>14</label>
<element-citation publication-type="journal" id="sbref14"><person-group person-group-type="author"><name><surname>Perez-Padilla</surname>
<given-names>R</given-names>
</name>
<name><surname>de la Rosa-Zamboni</surname>
<given-names>D</given-names>
</name>
<name><surname>Ponce de Leon</surname>
<given-names>S</given-names>
</name>
<name><surname>INER Working Group on Influenza</surname>
</name>
</person-group>
<article-title>Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>7</issue>
<year>2009</year>
<fpage>680</fpage>
<lpage>689</lpage>
<pub-id pub-id-type="pmid">19564631</pub-id>
</element-citation>
</ref>
<ref id="bib15"><label>15</label>
<element-citation publication-type="other" id="sbref15"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Recommended use of antivirals. Pandemic (H1N1 2009 briefing note 8</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/swineflu/notes/h1n1_use_antivirals_20090820/en/index.html" id="interref4">http://www.who.int/csr/disease/swineflu/notes/h1n1_use_antivirals_20090820/en/index.html</ext-link>
<comment>Accessed September 1, 2009.</comment>
</element-citation>
</ref>
<ref id="bib16"><label>16</label>
<element-citation publication-type="journal" id="sbref16"><person-group person-group-type="author"><name><surname>Jain</surname>
<given-names>S</given-names>
</name>
<name><surname>Kamimoto</surname>
<given-names>L</given-names>
</name>
<name><surname>Bramley</surname>
<given-names>AM</given-names>
</name>
<name><surname>2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team</surname>
</name>
</person-group>
<article-title>Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>20</issue>
<year>2009</year>
<fpage>1935</fpage>
<lpage>1944</lpage>
<pub-id pub-id-type="pmid">19815859</pub-id>
</element-citation>
</ref>
<ref id="bib17"><label>17</label>
<element-citation publication-type="journal" id="sbref17"><person-group person-group-type="author"><name><surname>Webb</surname>
<given-names>SA</given-names>
</name>
<name><surname>Pettilä</surname>
<given-names>V</given-names>
</name>
<name><surname>Seppelt</surname>
<given-names>I</given-names>
</name>
<name><surname>ANZIC Influenza Investigators</surname>
</name>
</person-group>
<article-title>Critical care services and 2009 H1N1 influenza in Australia and New Zealand</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>20</issue>
<year>2009</year>
<fpage>1925</fpage>
<lpage>1934</lpage>
<pub-id pub-id-type="pmid">19815860</pub-id>
</element-citation>
</ref>
<ref id="bib18"><label>18</label>
<element-citation publication-type="journal" id="sbref18"><person-group person-group-type="author"><name><surname>Kumar</surname>
<given-names>A</given-names>
</name>
<name><surname>Zarychanski</surname>
<given-names>R</given-names>
</name>
<name><surname>Pinto</surname>
<given-names>R</given-names>
</name>
<name><surname>Canadian Critical Care Trials Group H1N1 Collaborative</surname>
</name>
</person-group>
<article-title>Critically ill patients with 2009 influenza A(H1N1) infection in Canada</article-title>
<source>JAMA</source>
<volume>302</volume>
<issue>17</issue>
<year>2009</year>
<fpage>1872</fpage>
<lpage>1879</lpage>
<pub-id pub-id-type="pmid">19822627</pub-id>
</element-citation>
</ref>
<ref id="bib19"><label>19</label>
<element-citation publication-type="journal" id="sbref19"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Human infection with pandemic A (H1N1 2009 influenza virus: clinical observations in hospitalized patients, Americas, July 2009 update</article-title>
<source>Weekly Epidemiological Record on Pandemic H1N1 2009</source>
<volume>84</volume>
<issue>30</issue>
<year>2009</year>
<fpage>305</fpage>
<lpage>308</lpage>
</element-citation>
</ref>
<ref id="bib20"><label>20</label>
<element-citation publication-type="journal" id="sbref20"><person-group person-group-type="author"><name><surname>Hancock</surname>
<given-names>K</given-names>
</name>
<name><surname>Veguilla</surname>
<given-names>V</given-names>
</name>
<name><surname>Lu</surname>
<given-names>X</given-names>
</name>
</person-group>
<article-title>Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>20</issue>
<year>2009</year>
<fpage>1945</fpage>
<lpage>1952</lpage>
<pub-id pub-id-type="pmid">19745214</pub-id>
</element-citation>
</ref>
<ref id="bib21"><label>21</label>
<element-citation publication-type="journal" id="sbref21"><person-group person-group-type="author"><name><surname>Garcia-Garcia</surname>
<given-names>L</given-names>
</name>
<name><surname>Valdespino-Gómez</surname>
<given-names>JL</given-names>
</name>
<name><surname>Lazcano-Ponce</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City</article-title>
<source>BMJ</source>
<volume>339</volume>
<year>2009</year>
<fpage>b3928</fpage>
<pub-id pub-id-type="pmid">19808768</pub-id>
</element-citation>
</ref>
<ref id="bib22"><label>22</label>
<element-citation publication-type="journal" id="sbref22"><person-group person-group-type="author"><name><surname>Mauad</surname>
<given-names>T</given-names>
</name>
<name><surname>Hajjar</surname>
<given-names>LA</given-names>
</name>
<name><surname>Callegari</surname>
<given-names>GD</given-names>
</name>
</person-group>
<article-title>Lung pathology in fatal novel human influenza A (H1N1) infection</article-title>
<source>Am J Respir Crit Care Med</source>
<volume>181</volume>
<issue>1</issue>
<year>2010</year>
<fpage>72</fpage>
<lpage>79</lpage>
<pub-id pub-id-type="pmid">19875682</pub-id>
</element-citation>
</ref>
<ref id="bib23"><label>23</label>
<element-citation publication-type="journal" id="sbref23"><person-group person-group-type="author"><name><surname>Centers for Disease Control and Prevention (CDC)</surname>
</name>
</person-group>
<article-title>Intensive-care patients with severe novel influenza A (H1N1) virus infection—Michigan, June 2009</article-title>
<source>MMWR Morb Mortal Wkly Rep</source>
<volume>58</volume>
<issue>27</issue>
<year>2009</year>
<fpage>749</fpage>
<lpage>752</lpage>
<pub-id pub-id-type="pmid">19609249</pub-id>
</element-citation>
</ref>
<ref id="bib24"><label>24</label>
<element-citation publication-type="journal" id="sbref24"><person-group person-group-type="author"><name><surname>Cheng</surname>
<given-names>VC</given-names>
</name>
<name><surname>Lau</surname>
<given-names>YK</given-names>
</name>
<name><surname>Lee</surname>
<given-names>KL</given-names>
</name>
</person-group>
<article-title>Fatal co-infection with swine origin influenza virus A/H1N1 and community-acquired methicillin-resistant Staphylococcus aureus</article-title>
<source>J Infect</source>
<volume>59</volume>
<issue>5</issue>
<year>2009</year>
<fpage>366</fpage>
<lpage>370</lpage>
<pub-id pub-id-type="pmid">19747506</pub-id>
</element-citation>
</ref>
<ref id="bib25"><label>25</label>
<element-citation publication-type="journal" id="sbref25"><person-group person-group-type="author"><name><surname>Centers for Disease Control and Prevention (CDC)</surname>
</name>
</person-group>
<article-title>Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A(H1N1)—United States, May-August 2009</article-title>
<source>MMWR Morb Mortal Wkly Rep</source>
<volume>58</volume>
<issue>38</issue>
<year>2009</year>
<fpage>1071</fpage>
<lpage>1074</lpage>
<pub-id pub-id-type="pmid">19798021</pub-id>
</element-citation>
</ref>
<ref id="bib26"><label>26</label>
<element-citation publication-type="journal" id="sbref26"><person-group person-group-type="author"><name><surname>Kaufman</surname>
<given-names>MA</given-names>
</name>
<name><surname>Duke</surname>
<given-names>GJ</given-names>
</name>
<name><surname>McGain</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Life-threatening respiratory failure from H1N1 influenza 09 (human swine influenza)</article-title>
<source>Med J Aust</source>
<volume>191</volume>
<issue>3</issue>
<year>2009</year>
<fpage>154</fpage>
<lpage>156</lpage>
<pub-id pub-id-type="pmid">19645645</pub-id>
</element-citation>
</ref>
<ref id="bib27"><label>27</label>
<element-citation publication-type="journal" id="sbref27"><person-group person-group-type="author"><name><surname>Centers for Disease Control and Prevention (CDC)</surname>
</name>
</person-group>
<article-title>Evaluation of rapid influenza diagnostic tests for detection of novel influenza A (H1N1) virus—United States, 2009</article-title>
<source>MMWR Morb Mortal Wkly Rep</source>
<volume>58</volume>
<issue>30</issue>
<year>2009</year>
<fpage>826</fpage>
<lpage>829</lpage>
<pub-id pub-id-type="pmid">19661856</pub-id>
</element-citation>
</ref>
<ref id="bib28"><label>28</label>
<element-citation publication-type="journal" id="sbref28"><person-group person-group-type="author"><name><surname>Birnkrant</surname>
<given-names>D</given-names>
</name>
<name><surname>Cox</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza</article-title>
<source>N Engl J Med</source>
<volume>361</volume>
<issue>23</issue>
<year>2009</year>
<fpage>2204</fpage>
<lpage>2207</lpage>
<pub-id pub-id-type="pmid">19884645</pub-id>
</element-citation>
</ref>
<ref id="bib29"><label>29</label>
<element-citation publication-type="other" id="sbref29"><person-group person-group-type="author"><name><surname>GlaxoSmithKline (GSK) and FDA alert</surname>
</name>
</person-group>
<article-title>Relenza (zanamivir) inhalation powder</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm186081.htm" id="interref5">http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm186081.htm</ext-link>
<comment>Accessed October 10, 2009.</comment>
</element-citation>
</ref>
<ref id="bib30"><label>30</label>
<element-citation publication-type="other" id="sbref30"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Clinical management of human infection with pandemic (H1N1 2009 revised guidance</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/resources/publications/swineflu/clinical_management_h1n1.pdf" id="interref6">http://www.who.int/csr/resources/publications/swineflu/clinical_management_h1n1.pdf</ext-link>
<comment>Accessed November 15, 2009.</comment>
</element-citation>
</ref>
<ref id="bib31"><label>31</label>
<element-citation publication-type="other" id="sbref31"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Antiviral use and the risk of drug resistance. Pandemic (H1N1 2009 briefing note 12</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.html" id="interref7">http://www.who.int/csr/disease/swineflu/notes/h1n1_antiviral_use_20090925/en/index.html</ext-link>
<comment>Accessed October 2, 2009.</comment>
</element-citation>
</ref>
<ref id="bib32"><label>32</label>
<element-citation publication-type="journal" id="sbref32"><person-group person-group-type="author"><name><surname>The Acute Respiratory Distress Syndrome Network</surname>
</name>
</person-group>
<article-title>Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome</article-title>
<source>N Engl J Med</source>
<volume>342</volume>
<issue>18</issue>
<year>2000</year>
<fpage>1301</fpage>
<lpage>1308</lpage>
<pub-id pub-id-type="pmid">10793162</pub-id>
</element-citation>
</ref>
<ref id="bib33"><label>33</label>
<element-citation publication-type="journal" id="sbref33"><person-group person-group-type="author"><name><surname>Wiedemann</surname>
<given-names>HP</given-names>
</name>
<name><surname>Wheeler</surname>
<given-names>AP</given-names>
</name>
<name><surname>Bernard</surname>
<given-names>GR</given-names>
</name>
<name><surname>National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network</surname>
</name>
</person-group>
<article-title>Comparison of two fluid-management strategies in acute lung injury</article-title>
<source>N Engl J Med</source>
<volume>354</volume>
<issue>24</issue>
<year>2006</year>
<fpage>2564</fpage>
<lpage>2575</lpage>
<pub-id pub-id-type="pmid">16714767</pub-id>
</element-citation>
</ref>
<ref id="bib34"><label>34</label>
<element-citation publication-type="journal" id="sbref34"><person-group person-group-type="author"><name><surname>Davies</surname>
<given-names>A</given-names>
</name>
<name><surname>Jones</surname>
<given-names>D</given-names>
</name>
<name><surname>Bailey</surname>
<given-names>M</given-names>
</name>
<name><surname>Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators</surname>
</name>
</person-group>
<article-title>Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome</article-title>
<source>JAMA</source>
<volume>302</volume>
<issue>17</issue>
<year>2009</year>
<fpage>1888</fpage>
<lpage>1895</lpage>
<pub-id pub-id-type="pmid">19822628</pub-id>
</element-citation>
</ref>
<ref id="bib35"><label>35</label>
<element-citation publication-type="journal" id="sbref35"><person-group person-group-type="author"><name><surname>Rello</surname>
<given-names>J</given-names>
</name>
<name><surname>Rodríguez</surname>
<given-names>A</given-names>
</name>
<name><surname>Ibañez</surname>
<given-names>P</given-names>
</name>
<name><surname>H1N1 SEMICYUC Working Group</surname>
</name>
</person-group>
<article-title>Intensive care adult patients with severe respiratory failure caused by influenza A (H1N1) in Spain</article-title>
<source>Crit Care</source>
<volume>13</volume>
<issue>5</issue>
<year>2009</year>
<fpage>R148</fpage>
<pub-id pub-id-type="pmid">19747383</pub-id>
</element-citation>
</ref>
<ref id="bib36"><label>36</label>
<element-citation publication-type="other" id="sbref36"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Infection and control of epidemic- and pandemic-prone acute respiratory diseases in health care. WHO interim guidelines. World Health Organization 2007</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/resources/publications/WHO_CD_EPR_2007_6/en/" id="interref8">http://www.who.int/csr/resources/publications/WHO_CD_EPR_2007_6/en/</ext-link>
<comment>Accessed Mar 19, 2009.</comment>
</element-citation>
</ref>
<ref id="bib37"><label>37</label>
<element-citation publication-type="journal" id="sbref37"><person-group person-group-type="author"><name><surname>Annane</surname>
<given-names>D</given-names>
</name>
<name><surname>Bellissant</surname>
<given-names>E</given-names>
</name>
<name><surname>Bollaert</surname>
<given-names>PE</given-names>
</name>
</person-group>
<article-title>Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review</article-title>
<source>JAMA</source>
<volume>301</volume>
<issue>22</issue>
<year>2009</year>
<fpage>2362</fpage>
<lpage>2375</lpage>
<pub-id pub-id-type="pmid">19509383</pub-id>
</element-citation>
</ref>
<ref id="bib38"><label>38</label>
<element-citation publication-type="journal" id="sbref38"><person-group person-group-type="author"><name><surname>Tang</surname>
<given-names>BM</given-names>
</name>
<name><surname>Craig</surname>
<given-names>JC</given-names>
</name>
<name><surname>Eslick</surname>
<given-names>GD</given-names>
</name>
<name><surname>Seppelt</surname>
<given-names>I</given-names>
</name>
<name><surname>McLean</surname>
<given-names>AS</given-names>
</name>
</person-group>
<article-title>Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis</article-title>
<source>Crit Care Med</source>
<volume>37</volume>
<issue>5</issue>
<year>2009</year>
<fpage>1594</fpage>
<lpage>1603</lpage>
<pub-id pub-id-type="pmid">19325471</pub-id>
</element-citation>
</ref>
<ref id="bib39"><label>39</label>
<element-citation publication-type="journal" id="sbref39"><person-group person-group-type="author"><name><surname>Quispe-Laime</surname>
<given-names>AM</given-names>
</name>
<name><surname>Bracco</surname>
<given-names>JD</given-names>
</name>
<name><surname>Barberio</surname>
<given-names>PA</given-names>
</name>
</person-group>
<article-title>H1N1 influenza A virus-associated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment</article-title>
<source>Intensive Care Med</source>
<volume>36</volume>
<issue>1</issue>
<year>2010</year>
<fpage>33</fpage>
<lpage>41</lpage>
<pub-id pub-id-type="pmid">19924393</pub-id>
</element-citation>
</ref>
<ref id="bib40"><label>40</label>
<element-citation publication-type="journal" id="sbref40"><person-group person-group-type="author"><name><surname>Lee</surname>
<given-names>N</given-names>
</name>
<name><surname>Allen Chan</surname>
<given-names>KC</given-names>
</name>
<name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
</person-group>
<article-title>Effects of early corticosteroid treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients</article-title>
<source>J Clin Virol</source>
<volume>31</volume>
<issue>4</issue>
<year>2004</year>
<fpage>304</fpage>
<lpage>309</lpage>
<pub-id pub-id-type="pmid">15494274</pub-id>
</element-citation>
</ref>
<ref id="bib41"><label>41</label>
<element-citation publication-type="journal" id="sbref41"><person-group person-group-type="author"><name><surname>Lee</surname>
<given-names>N</given-names>
</name>
<name><surname>Chan</surname>
<given-names>PK</given-names>
</name>
<name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
</person-group>
<article-title>Viral loads and duration of viral shedding in adult patients hospitalized with influenza</article-title>
<source>J Infect Dis</source>
<volume>200</volume>
<issue>4</issue>
<year>2009</year>
<fpage>492</fpage>
<lpage>500</lpage>
<pub-id pub-id-type="pmid">19591575</pub-id>
</element-citation>
</ref>
<ref id="bib42"><label>42</label>
<element-citation publication-type="journal" id="sbref42"><person-group person-group-type="author"><name><surname>Wang</surname>
<given-names>H</given-names>
</name>
<name><surname>Ding</surname>
<given-names>Y</given-names>
</name>
<name><surname>Li</surname>
<given-names>X</given-names>
</name>
<name><surname>Yang</surname>
<given-names>L</given-names>
</name>
<name><surname>Zhang</surname>
<given-names>W</given-names>
</name>
<name><surname>Kang</surname>
<given-names>W</given-names>
</name>
</person-group>
<article-title>Fatal aspergillosis in a patient with SARS who was treated with corticosteroids</article-title>
<source>N Engl J Med</source>
<volume>349</volume>
<issue>5</issue>
<year>2003</year>
<fpage>507</fpage>
<lpage>508</lpage>
<pub-id pub-id-type="pmid">12890854</pub-id>
</element-citation>
</ref>
<ref id="bib43"><label>43</label>
<element-citation publication-type="journal" id="sbref43"><person-group person-group-type="author"><name><surname>Griffith</surname>
<given-names>JF</given-names>
</name>
<name><surname>Antonio</surname>
<given-names>GE</given-names>
</name>
<name><surname>Kumta</surname>
<given-names>SM</given-names>
</name>
</person-group>
<article-title>Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids</article-title>
<source>Radiology</source>
<volume>235</volume>
<issue>1</issue>
<year>2005</year>
<fpage>168</fpage>
<lpage>175</lpage>
<pub-id pub-id-type="pmid">15703312</pub-id>
</element-citation>
</ref>
<ref id="bib44"><label>44</label>
<element-citation publication-type="journal" id="sbref44"><person-group person-group-type="author"><name><surname>Yap</surname>
<given-names>FH</given-names>
</name>
<name><surname>Gomersall</surname>
<given-names>CD</given-names>
</name>
<name><surname>Fung</surname>
<given-names>KS</given-names>
</name>
</person-group>
<article-title>Increase in methicillin-resistant Staphylococcus aureus acquisition rate and change in pathogen pattern associated with an outbreak of severe acute respiratory syndrome</article-title>
<source>Clin Infect Dis</source>
<volume>39</volume>
<issue>4</issue>
<year>2004</year>
<fpage>511</fpage>
<lpage>516</lpage>
<pub-id pub-id-type="pmid">15356814</pub-id>
</element-citation>
</ref>
<ref id="bib45"><label>45</label>
<element-citation publication-type="journal" id="sbref45"><person-group person-group-type="author"><name><surname>Luke</surname>
<given-names>TC</given-names>
</name>
<name><surname>Kilbane</surname>
<given-names>EM</given-names>
</name>
<name><surname>Jackson</surname>
<given-names>JL</given-names>
</name>
<name><surname>Hoffman</surname>
<given-names>SL</given-names>
</name>
</person-group>
<article-title>Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?</article-title>
<source>Ann Intern Med</source>
<volume>145</volume>
<issue>8</issue>
<year>2006</year>
<fpage>599</fpage>
<lpage>609</lpage>
<pub-id pub-id-type="pmid">16940336</pub-id>
</element-citation>
</ref>
<ref id="bib46"><label>46</label>
<element-citation publication-type="journal" id="sbref46"><person-group person-group-type="author"><name><surname>Zhou</surname>
<given-names>B</given-names>
</name>
<name><surname>Zhong</surname>
<given-names>NS</given-names>
</name>
<name><surname>Guan</surname>
<given-names>Y</given-names>
</name>
</person-group>
<article-title>Treatment with convalescent plasma for influenza A (H5N1) infection</article-title>
<source>N Engl J Med</source>
<volume>357</volume>
<issue>14</issue>
<year>2007</year>
<fpage>1450</fpage>
<lpage>1451</lpage>
<pub-id pub-id-type="pmid">17914053</pub-id>
</element-citation>
</ref>
<ref id="bib47"><label>47</label>
<element-citation publication-type="journal" id="sbref47"><person-group person-group-type="author"><name><surname>Lu</surname>
<given-names>J</given-names>
</name>
<name><surname>Guo</surname>
<given-names>Z</given-names>
</name>
<name><surname>Pan</surname>
<given-names>X</given-names>
</name>
</person-group>
<article-title>Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab′)2 in mice</article-title>
<source>Respir Res</source>
<volume>7</volume>
<year>2006</year>
<fpage>43</fpage>
<pub-id pub-id-type="pmid">16553963</pub-id>
</element-citation>
</ref>
<ref id="bib48"><label>48</label>
<element-citation publication-type="journal" id="sbref48"><person-group person-group-type="author"><name><surname>Hanson</surname>
<given-names>BJ</given-names>
</name>
<name><surname>Boon</surname>
<given-names>AC</given-names>
</name>
<name><surname>Lim</surname>
<given-names>AP</given-names>
</name>
<name><surname>Webb</surname>
<given-names>A</given-names>
</name>
<name><surname>Ooi</surname>
<given-names>EE</given-names>
</name>
<name><surname>Webby</surname>
<given-names>RJ</given-names>
</name>
</person-group>
<article-title>Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice</article-title>
<source>Respir Res</source>
<volume>7</volume>
<year>2006</year>
<fpage>126</fpage>
<pub-id pub-id-type="pmid">17040574</pub-id>
</element-citation>
</ref>
<ref id="bib49"><label>49</label>
<element-citation publication-type="journal" id="sbref49"><person-group person-group-type="author"><name><surname>de Jong</surname>
<given-names>MD</given-names>
</name>
<name><surname>Simmons</surname>
<given-names>CP</given-names>
</name>
<name><surname>Thanh</surname>
<given-names>TT</given-names>
</name>
</person-group>
<article-title>Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia</article-title>
<source>Nat Med</source>
<volume>12</volume>
<issue>10</issue>
<year>2006</year>
<fpage>1203</fpage>
<lpage>1207</lpage>
<pub-id pub-id-type="pmid">16964257</pub-id>
</element-citation>
</ref>
<ref id="bib50"><label>50</label>
<element-citation publication-type="journal" id="sbref50"><person-group person-group-type="author"><name><surname>Dinarello</surname>
<given-names>CA</given-names>
</name>
</person-group>
<article-title>Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock</article-title>
<source>Chest</source>
<volume>112</volume>
<issue>suppl 6</issue>
<year>1997</year>
<fpage>321S</fpage>
<lpage>329S</lpage>
<pub-id pub-id-type="pmid">9400897</pub-id>
</element-citation>
</ref>
<ref id="bib51"><label>51</label>
<element-citation publication-type="journal" id="sbref51"><person-group person-group-type="author"><name><surname>Bone</surname>
<given-names>RC</given-names>
</name>
<name><surname>Grodzin</surname>
<given-names>CJ</given-names>
</name>
<name><surname>Balk</surname>
<given-names>RA</given-names>
</name>
</person-group>
<article-title>Sepsis: a new hypothesis for pathogenesis of the disease process</article-title>
<source>Chest</source>
<volume>112</volume>
<issue>1</issue>
<year>1997</year>
<fpage>235</fpage>
<lpage>243</lpage>
<pub-id pub-id-type="pmid">9228382</pub-id>
</element-citation>
</ref>
<ref id="bib52"><label>52</label>
<element-citation publication-type="journal" id="sbref52"><person-group person-group-type="author"><name><surname>Kwak</surname>
<given-names>B</given-names>
</name>
<name><surname>Mulhaupt</surname>
<given-names>F</given-names>
</name>
<name><surname>Myit</surname>
<given-names>S</given-names>
</name>
<name><surname>Mach</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Statins as a newly recognized type of immunomodulator</article-title>
<source>Nat Med</source>
<volume>6</volume>
<issue>12</issue>
<year>2000</year>
<fpage>1399</fpage>
<lpage>1402</lpage>
<pub-id pub-id-type="pmid">11100127</pub-id>
</element-citation>
</ref>
<ref id="bib53"><label>53</label>
<element-citation publication-type="journal" id="sbref53"><person-group person-group-type="author"><name><surname>Fedson</surname>
<given-names>DS</given-names>
</name>
</person-group>
<article-title>Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: why they are needed and how they might work</article-title>
<source>Influenza Other Respi Viruses</source>
<volume>3</volume>
<issue>4</issue>
<year>2009</year>
<fpage>129</fpage>
<lpage>142</lpage>
</element-citation>
</ref>
<ref id="bib54"><label>54</label>
<element-citation publication-type="journal" id="sbref54"><person-group person-group-type="author"><name><surname>Liu</surname>
<given-names>Z</given-names>
</name>
<name><surname>Guo</surname>
<given-names>Z</given-names>
</name>
<name><surname>Wang</surname>
<given-names>G</given-names>
</name>
</person-group>
<article-title>Evaluation of the efficacy and safety of a statin/caffeine combination against H5N1, H3N2 and H1N1 virus infection in BALB/c mice</article-title>
<source>Eur J Pharm Sci</source>
<volume>38</volume>
<issue>3</issue>
<year>2009</year>
<fpage>215</fpage>
<lpage>223</lpage>
<pub-id pub-id-type="pmid">19616097</pub-id>
</element-citation>
</ref>
<ref id="bib55"><label>55</label>
<element-citation publication-type="other" id="sbref55"><article-title>Clinical management of human infection with avian influenza A (H5N1) virus. WHO updated advice 15 Aug 2007</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/avian_influenza/guidelines/clinicalmanage07/en/index.html" id="interref9">http://www.who.int/csr/disease/avian_influenza/guidelines/clinicalmanage07/en/index.html</ext-link>
<comment>Accessed Dec 18, 2007.</comment>
</element-citation>
</ref>
<ref id="bib56"><label>56</label>
<element-citation publication-type="journal" id="sbref56"><person-group person-group-type="author"><name><surname>Lew</surname>
<given-names>TW</given-names>
</name>
<name><surname>Kwek</surname>
<given-names>TK</given-names>
</name>
<name><surname>Tai</surname>
<given-names>D</given-names>
</name>
</person-group>
<article-title>Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome</article-title>
<source>JAMA</source>
<volume>290</volume>
<issue>3</issue>
<year>2003</year>
<fpage>374</fpage>
<lpage>380</lpage>
<pub-id pub-id-type="pmid">12865379</pub-id>
</element-citation>
</ref>
<ref id="bib57"><label>57</label>
<element-citation publication-type="journal" id="sbref57"><person-group person-group-type="author"><name><surname>Chong</surname>
<given-names>PY</given-names>
</name>
<name><surname>Chui</surname>
<given-names>P</given-names>
</name>
<name><surname>Ling</surname>
<given-names>AE</given-names>
</name>
</person-group>
<article-title>Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis</article-title>
<source>Arch Pathol Lab Med</source>
<volume>128</volume>
<issue>2</issue>
<year>2004</year>
<fpage>195</fpage>
<lpage>204</lpage>
<pub-id pub-id-type="pmid">14736283</pub-id>
</element-citation>
</ref>
<ref id="bib58"><label>58</label>
<element-citation publication-type="journal" id="sbref58"><person-group person-group-type="author"><name><surname>Umapathi</surname>
<given-names>T</given-names>
</name>
<name><surname>Kor</surname>
<given-names>AC</given-names>
</name>
<name><surname>Venketasubramanian</surname>
<given-names>N</given-names>
</name>
</person-group>
<article-title>Large artery ischaemic stroke in severe acute respiratory syndrome (SARS)</article-title>
<source>J Neurol</source>
<volume>251</volume>
<issue>10</issue>
<year>2004</year>
<fpage>1227</fpage>
<lpage>1231</lpage>
<pub-id pub-id-type="pmid">15503102</pub-id>
</element-citation>
</ref>
<ref id="bib59"><label>59</label>
<element-citation publication-type="journal" id="sbref59"><person-group person-group-type="author"><name><surname>Han</surname>
<given-names>SN</given-names>
</name>
<name><surname>Meydani</surname>
<given-names>SN</given-names>
</name>
</person-group>
<article-title>Antioxidants, cytokines, and influenza infection in aged mice and elderly humans</article-title>
<source>J Infect Dis</source>
<volume>182</volume>
<issue>Suppl 1</issue>
<year>2000</year>
<fpage>S74</fpage>
<lpage>S80</lpage>
<pub-id pub-id-type="pmid">10944487</pub-id>
</element-citation>
</ref>
<ref id="bib60"><label>60</label>
<element-citation publication-type="journal" id="sbref60"><person-group person-group-type="author"><name><surname>Akaike</surname>
<given-names>T</given-names>
</name>
<name><surname>Ando</surname>
<given-names>M</given-names>
</name>
<name><surname>Oda</surname>
<given-names>T</given-names>
</name>
</person-group>
<article-title>Dependence on O2-generation by xanthine oxidase of pathogenesis of influenza virus infection in mice</article-title>
<source>J Clin Invest</source>
<volume>85</volume>
<issue>3</issue>
<year>1990</year>
<fpage>739</fpage>
<lpage>745</lpage>
<pub-id pub-id-type="pmid">2155924</pub-id>
</element-citation>
</ref>
<ref id="bib61"><label>61</label>
<element-citation publication-type="journal" id="sbref61"><person-group person-group-type="author"><name><surname>Knobil</surname>
<given-names>K</given-names>
</name>
<name><surname>Choi</surname>
<given-names>AM</given-names>
</name>
<name><surname>Weigand</surname>
<given-names>GW</given-names>
</name>
<name><surname>Jacoby</surname>
<given-names>DB</given-names>
</name>
</person-group>
<article-title>Role of oxidants in influenza virus-induced gene expression</article-title>
<source>Am J Physiol</source>
<volume>274</volume>
<issue>1 Pt 1</issue>
<year>1998</year>
<fpage>L134</fpage>
<lpage>L142</lpage>
<pub-id pub-id-type="pmid">9458811</pub-id>
</element-citation>
</ref>
<ref id="bib62"><label>62</label>
<element-citation publication-type="journal" id="sbref62"><person-group person-group-type="author"><name><surname>Geiler</surname>
<given-names>J</given-names>
</name>
<name><surname>Michaelis</surname>
<given-names>M</given-names>
</name>
<name><surname>Naczk</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title><italic>N</italic>
-acetyl-<sc>L</sc>
-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus</article-title>
<source>Biochem Pharmacol</source>
<volume>79</volume>
<issue>3</issue>
<year>2010</year>
<fpage>413</fpage>
<lpage>420</lpage>
<pub-id pub-id-type="pmid">19732754</pub-id>
</element-citation>
</ref>
<ref id="bib63"><label>63</label>
<element-citation publication-type="journal" id="sbref63"><person-group person-group-type="author"><name><surname>Friel</surname>
<given-names>H</given-names>
</name>
<name><surname>Lederman</surname>
<given-names>H</given-names>
</name>
</person-group>
<article-title>A nutritional supplement formula for influenza A (H5N1) infection in humans</article-title>
<source>Med Hypotheses</source>
<volume>67</volume>
<issue>3</issue>
<year>2006</year>
<fpage>578</fpage>
<lpage>587</lpage>
<pub-id pub-id-type="pmid">16624496</pub-id>
</element-citation>
</ref>
<ref id="bib64"><label>64</label>
<element-citation publication-type="journal" id="sbref64"><person-group person-group-type="author"><name><surname>Yu</surname>
<given-names>IT</given-names>
</name>
<name><surname>Xie</surname>
<given-names>ZH</given-names>
</name>
<name><surname>Tsoi</surname>
<given-names>KK</given-names>
</name>
</person-group>
<article-title>Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others?</article-title>
<source>Clin Infect Dis</source>
<volume>44</volume>
<issue>8</issue>
<year>2007</year>
<fpage>1017</fpage>
<lpage>1025</lpage>
<pub-id pub-id-type="pmid">17366443</pub-id>
</element-citation>
</ref>
<ref id="bib65"><label>65</label>
<element-citation publication-type="journal" id="sbref65"><person-group person-group-type="author"><name><surname>Lo</surname>
<given-names>JY</given-names>
</name>
<name><surname>Tsang</surname>
<given-names>TH</given-names>
</name>
<name><surname>Leung</surname>
<given-names>YH</given-names>
</name>
<name><surname>Yeung</surname>
<given-names>EY</given-names>
</name>
<name><surname>Wu</surname>
<given-names>T</given-names>
</name>
<name><surname>Lim</surname>
<given-names>WW</given-names>
</name>
</person-group>
<article-title>Respiratory infections during SARS outbreak, Hong Kong, 2003</article-title>
<source>Emerg Infect Dis</source>
<volume>11</volume>
<issue>11</issue>
<year>2005</year>
<fpage>1738</fpage>
<lpage>1741</lpage>
<pub-id pub-id-type="pmid">16318726</pub-id>
</element-citation>
</ref>
<ref id="bib66"><label>66</label>
<element-citation publication-type="other" id="sbref66"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Infection prevention and control in health care for confirmed or suspected cases of pandemic (H1N1) 2009 and influenza-like illnesses. Interim guidance. June 25, 2009 (originally published April 29 2009</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/resources/publications/swineflu/swineinfinfcont/en/index.html" id="interref10">http://www.who.int/csr/resources/publications/swineflu/swineinfinfcont/en/index.html</ext-link>
<comment>Accessed Sept 28, 2009.</comment>
</element-citation>
</ref>
<ref id="bib67"><label>67</label>
<element-citation publication-type="journal" id="sbref67"><person-group person-group-type="author"><name><surname>Loeb</surname>
<given-names>M</given-names>
</name>
<name><surname>Dafoe</surname>
<given-names>N</given-names>
</name>
<name><surname>Mahony</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial</article-title>
<source>JAMA</source>
<volume>302</volume>
<issue>17</issue>
<year>2009</year>
<fpage>1865</fpage>
<lpage>1871</lpage>
<pub-id pub-id-type="pmid">19797474</pub-id>
</element-citation>
</ref>
<ref id="bib68"><label>68</label>
<element-citation publication-type="journal" id="sbref68"><person-group person-group-type="author"><name><surname>Johnson</surname>
<given-names>DF</given-names>
</name>
<name><surname>Druce</surname>
<given-names>JD</given-names>
</name>
<name><surname>Birch</surname>
<given-names>C</given-names>
</name>
<name><surname>Grayson</surname>
<given-names>ML</given-names>
</name>
</person-group>
<article-title>A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection</article-title>
<source>Clin Infect Dis</source>
<volume>49</volume>
<issue>2</issue>
<year>2009</year>
<fpage>275</fpage>
<lpage>277</lpage>
<pub-id pub-id-type="pmid">19522650</pub-id>
</element-citation>
</ref>
<ref id="bib69"><label>69</label>
<element-citation publication-type="journal" id="sbref69"><person-group person-group-type="author"><name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
<name><surname>Chow</surname>
<given-names>BK</given-names>
</name>
<name><surname>Ng</surname>
<given-names>SS</given-names>
</name>
</person-group>
<article-title>Exhaled air dispersion distances during noninvasive ventilation via different Respironics face masks</article-title>
<source>Chest</source>
<volume>136</volume>
<issue>4</issue>
<year>2009</year>
<fpage>998</fpage>
<lpage>1005</lpage>
<pub-id pub-id-type="pmid">19411297</pub-id>
</element-citation>
</ref>
<ref id="bib70"><label>70</label>
<element-citation publication-type="journal" id="sbref70"><person-group person-group-type="author"><name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
<name><surname>Chow</surname>
<given-names>BK</given-names>
</name>
<name><surname>Chu</surname>
<given-names>LC</given-names>
</name>
</person-group>
<article-title>Exhaled air and aerosolized droplet dispersion during application of a jet nebulizer</article-title>
<source>Chest</source>
<volume>135</volume>
<issue>3</issue>
<year>2009</year>
<fpage>648</fpage>
<lpage>654</lpage>
<pub-id pub-id-type="pmid">19265085</pub-id>
</element-citation>
</ref>
<ref id="bib71"><label>71</label>
<element-citation publication-type="journal" id="sbref71"><person-group person-group-type="author"><name><surname>Hui</surname>
<given-names>DS</given-names>
</name>
<name><surname>Hall</surname>
<given-names>SD</given-names>
</name>
<name><surname>Chan</surname>
<given-names>MT</given-names>
</name>
</person-group>
<article-title>Exhaled air dispersion during oxygen delivery via a simple oxygen mask</article-title>
<source>Chest</source>
<volume>132</volume>
<issue>2</issue>
<year>2007</year>
<fpage>540</fpage>
<lpage>546</lpage>
<pub-id pub-id-type="pmid">17573505</pub-id>
</element-citation>
</ref>
<ref id="bib72"><label>72</label>
<element-citation publication-type="journal" id="sbref72"><person-group person-group-type="author"><name><surname>Ferguson</surname>
<given-names>NM</given-names>
</name>
<name><surname>Cummings</surname>
<given-names>DA</given-names>
</name>
<name><surname>Fraser</surname>
<given-names>C</given-names>
</name>
<name><surname>Cajka</surname>
<given-names>JC</given-names>
</name>
<name><surname>Cooley</surname>
<given-names>PC</given-names>
</name>
<name><surname>Burke</surname>
<given-names>DS</given-names>
</name>
</person-group>
<article-title>Strategies for mitigating an influenza pandemic</article-title>
<source>Nature</source>
<volume>442</volume>
<issue>7101</issue>
<year>2006</year>
<fpage>448</fpage>
<lpage>452</lpage>
<pub-id pub-id-type="pmid">16642006</pub-id>
</element-citation>
</ref>
<ref id="bib73"><label>73</label>
<element-citation publication-type="journal" id="sbref73"><person-group person-group-type="author"><name><surname>Yang</surname>
<given-names>Y</given-names>
</name>
<name><surname>Sugimoto</surname>
<given-names>JD</given-names>
</name>
<name><surname>Halloran</surname>
<given-names>ME</given-names>
</name>
</person-group>
<article-title>The transmissibility and control of pandemic influenza A (H1N1) virus</article-title>
<source>Science</source>
<volume>326</volume>
<issue>5953</issue>
<year>2009</year>
<fpage>729</fpage>
<lpage>733</lpage>
<pub-id pub-id-type="pmid">19745114</pub-id>
</element-citation>
</ref>
<ref id="bib74"><label>74</label>
<element-citation publication-type="journal" id="sbref74"><person-group person-group-type="author"><name><surname>National Center for Immunization and Respiratory Diseases</surname>
</name>
</person-group>
<article-title>CDC; Centers for Disease Control and Prevention (CDC). Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009</article-title>
<source>MMWR Recomm Rep</source>
<volume>58</volume>
<issue>RR–10</issue>
<year>2009</year>
<fpage>1</fpage>
<lpage>8</lpage>
</element-citation>
</ref>
<ref id="bib75"><label>75</label>
<element-citation publication-type="other" id="sbref75"><person-group person-group-type="author"><name><surname>World Health Organization</surname>
</name>
</person-group>
<article-title>Experts advise WHO on pandemic vaccine policies and strategies. Pandemic (H1N1 2009 briefing note 14</article-title>
<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/swineflu/notes/briefing_20091030/en/index.html" id="interref11">http://www.who.int/csr/disease/swineflu/notes/briefing_20091030/en/index.html</ext-link>
<comment>Accessed November 26, 2009.</comment>
</element-citation>
</ref>
</ref-list>
<ack id="ack1"><title>Acknowledgments</title>
<p><bold>Financial/nonfinancial disclosures:</bold>
The authors have reported to <italic>CHEST</italic>
that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.</p>
</ack>
<fn-group><fn id="d32e993"><p id="cenotep1">Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (<ext-link ext-link-type="uri" xlink:href="http://www.chestpubs.org/site/misc/reprints.xhtml" id="interref1">www.chestpubs.org/site/misc/reprints.xhtml</ext-link>
).</p>
</fn>
</fn-group>
</back>
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