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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Broad protection against influenza infection by vectored immunoprophylaxis in mice</title><author><name sortKey="Balazs, Alejandro B" sort="Balazs, Alejandro B" uniqKey="Balazs A" first="Alejandro B." last="Balazs">Alejandro B. Balazs</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bloom, Jesse D" sort="Bloom, Jesse D" uniqKey="Bloom J" first="Jesse D." last="Bloom">Jesse D. Bloom</name><affiliation><nlm:aff id="A2">Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hong, Christin M" sort="Hong, Christin M" uniqKey="Hong C" first="Christin M." last="Hong">Christin M. Hong</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dinesh S" sort="Rao, Dinesh S" uniqKey="Rao D" first="Dinesh S." last="Rao">Dinesh S. Rao</name><affiliation><nlm:aff id="A3">Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Baltimore, David" sort="Baltimore, David" uniqKey="Baltimore D" first="David" last="Baltimore">David Baltimore</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23728362</idno><idno type="pmc">4030719</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030719</idno><idno type="RBID">PMC:4030719</idno><idno type="doi">10.1038/nbt.2618</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000889</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000889</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Broad protection against influenza infection by vectored immunoprophylaxis in mice</title><author><name sortKey="Balazs, Alejandro B" sort="Balazs, Alejandro B" uniqKey="Balazs A" first="Alejandro B." last="Balazs">Alejandro B. Balazs</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author><author><name sortKey="Bloom, Jesse D" sort="Bloom, Jesse D" uniqKey="Bloom J" first="Jesse D." last="Bloom">Jesse D. Bloom</name><affiliation><nlm:aff id="A2">Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</nlm:aff></affiliation></author><author><name sortKey="Hong, Christin M" sort="Hong, Christin M" uniqKey="Hong C" first="Christin M." last="Hong">Christin M. Hong</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author><author><name sortKey="Rao, Dinesh S" sort="Rao, Dinesh S" uniqKey="Rao D" first="Dinesh S." last="Rao">Dinesh S. Rao</name><affiliation><nlm:aff id="A3">Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA</nlm:aff></affiliation></author><author><name sortKey="Baltimore, David" sort="Baltimore, David" uniqKey="Baltimore D" first="David" last="Baltimore">David Baltimore</name><affiliation><nlm:aff id="A1">Division of Biology, California Institute of Technology, Pasadena, California, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature biotechnology</title><idno type="ISSN">1087-0156</idno><idno type="eISSN">1546-1696</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Neutralizing antibodies that target epitopes conserved among many strains of influenza virus have been recently isolated from humans. Here we demonstrate that adeno-associated viruses (AAV) encoding two such broadly neutralizing antibodies are protective against diverse influenza strains. Serum from mice that received a single intramuscular AAV injection efficiently neutralized all H1, H2 and H5 influenza strains tested. After infection with diverse strains of H1N1 influenza, treated mice showed minimal weight loss and lung inflammation. Protection lasted for at least 11 months after AAV injection. Notably, even immunodeficient and older mice were protected by this method, suggesting that expression of a monoclonal antibody alone is sufficient to protect mice from illness. If translated to humans, this prophylactic approach may be uniquely capable of protecting immunocompromised or elderly patient populations not reliably protected by existing vaccines.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9604648</journal-id><journal-id journal-id-type="pubmed-jr-id">20305</journal-id><journal-id journal-id-type="nlm-ta">Nat Biotechnol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Biotechnol.</journal-id><journal-title-group><journal-title>Nature biotechnology</journal-title></journal-title-group><issn pub-type="ppub">1087-0156</issn><issn pub-type="epub">1546-1696</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23728362</article-id><article-id pub-id-type="pmc">4030719</article-id><article-id pub-id-type="doi">10.1038/nbt.2618</article-id><article-id pub-id-type="manuscript">NIHMS566395</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Broad protection against influenza infection by vectored immunoprophylaxis in mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balazs</surname><given-names>Alejandro B.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bloom</surname><given-names>Jesse D.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hong</surname><given-names>Christin M.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Dinesh S.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Baltimore</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Biology, California Institute of Technology, Pasadena, California, USA</aff><aff id="A2"><label>2</label>Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA</aff><aff id="A3"><label>3</label>Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA</aff><author-notes><corresp id="FN1">Correspondence should be addressed to: D.B. (<email>baltimo@caltech.edu</email>)</corresp><fn id="FN4" fn-type="conflict"><p><bold>COMPETING FINANCIAL INTERESTS</bold></p><p>The authors declare no competing financial interests.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>02</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>5</month><year>2014</year></pub-date><volume>31</volume><issue>7</issue><fpage>647</fpage><lpage>652</lpage><pmc-comment>elocation-id from pubmed: 10.1038/nbt.2618</pmc-comment>
<permissions><copyright-statement>© 2013 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Neutralizing antibodies that target epitopes conserved among many strains of influenza virus have been recently isolated from humans. Here we demonstrate that adeno-associated viruses (AAV) encoding two such broadly neutralizing antibodies are protective against diverse influenza strains. Serum from mice that received a single intramuscular AAV injection efficiently neutralized all H1, H2 and H5 influenza strains tested. After infection with diverse strains of H1N1 influenza, treated mice showed minimal weight loss and lung inflammation. Protection lasted for at least 11 months after AAV injection. Notably, even immunodeficient and older mice were protected by this method, suggesting that expression of a monoclonal antibody alone is sufficient to protect mice from illness. If translated to humans, this prophylactic approach may be uniquely capable of protecting immunocompromised or elderly patient populations not reliably protected by existing vaccines.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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