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<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Parkinsonism and Neurological Manifestations of Influenza Throughout the 20
<sup>th</sup>
and 21
<sup>st</sup>
Centuries</title>
<author>
<name sortKey="Henry, Julie" sort="Henry, Julie" uniqKey="Henry J" first="Julie" last="Henry">Julie Henry</name>
</author>
<author>
<name sortKey="Smeyne, Richard J" sort="Smeyne, Richard J" uniqKey="Smeyne R" first="Richard J." last="Smeyne">Richard J. Smeyne</name>
</author>
<author>
<name sortKey="Jang, Haeman" sort="Jang, Haeman" uniqKey="Jang H" first="Haeman" last="Jang">Haeman Jang</name>
</author>
<author>
<name sortKey="Miller, Bayard" sort="Miller, Bayard" uniqKey="Miller B" first="Bayard" last="Miller">Bayard Miller</name>
</author>
<author>
<name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">20650672</idno>
<idno type="pmc">4684089</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684089</idno>
<idno type="RBID">PMC:4684089</idno>
<idno type="doi">10.1016/j.parkreldis.2010.06.012</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000886</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000886</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Parkinsonism and Neurological Manifestations of Influenza Throughout the 20
<sup>th</sup>
and 21
<sup>st</sup>
Centuries</title>
<author>
<name sortKey="Henry, Julie" sort="Henry, Julie" uniqKey="Henry J" first="Julie" last="Henry">Julie Henry</name>
</author>
<author>
<name sortKey="Smeyne, Richard J" sort="Smeyne, Richard J" uniqKey="Smeyne R" first="Richard J." last="Smeyne">Richard J. Smeyne</name>
</author>
<author>
<name sortKey="Jang, Haeman" sort="Jang, Haeman" uniqKey="Jang H" first="Haeman" last="Jang">Haeman Jang</name>
</author>
<author>
<name sortKey="Miller, Bayard" sort="Miller, Bayard" uniqKey="Miller B" first="Bayard" last="Miller">Bayard Miller</name>
</author>
<author>
<name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name>
</author>
</analytic>
<series>
<title level="j">Parkinsonism & related disorders</title>
<idno type="ISSN">1353-8020</idno>
<idno type="eISSN">1873-5126</idno>
<imprint>
<date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec id="S1">
<title>Purpose</title>
<p id="P1">Given the recent paper by Jang et al. on “A Highly Pathogenic H5N1 Influenza Virus” which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20
<sup>th</sup>
and 21
<sup>st</sup>
century literature on parkinsonism and neurological manifestations of influenza.</p>
</sec>
<sec id="S2">
<title>Scope</title>
<p id="P2">There were at least twelve major flu pandemics reported in the literature in the 20
<sup>th</sup>
and 21
<sup>st</sup>
century. Neurological manifestations most prevalent during the pandemics included delirium, encephalitis, ocular abnormalities, amyotrophy, myelopathy, radiculopathy, ataxia and seizures. Very little parkinsonism was reported with the exception of the 1917 cases originally described by von Economo.</p>
</sec>
<sec id="S3">
<title>Conclusions</title>
<p id="P3">To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9513583</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21522</journal-id>
<journal-id journal-id-type="nlm-ta">Parkinsonism Relat Disord</journal-id>
<journal-id journal-id-type="iso-abbrev">Parkinsonism Relat. Disord.</journal-id>
<journal-title-group>
<journal-title>Parkinsonism & related disorders</journal-title>
</journal-title-group>
<issn pub-type="ppub">1353-8020</issn>
<issn pub-type="epub">1873-5126</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">20650672</article-id>
<article-id pub-id-type="pmc">4684089</article-id>
<article-id pub-id-type="doi">10.1016/j.parkreldis.2010.06.012</article-id>
<article-id pub-id-type="manuscript">NIHMS744017</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Parkinsonism and Neurological Manifestations of Influenza Throughout the 20
<sup>th</sup>
and 21
<sup>st</sup>
Centuries</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Henry</surname>
<given-names>Julie</given-names>
</name>
<degrees>B.S.</degrees>
<aff id="A1">Department of Neurology, University of Florida Movement Disorders Center, Gainesville FL</aff>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Smeyne</surname>
<given-names>Richard J.</given-names>
</name>
<degrees>PhD.</degrees>
<aff id="A2">Department of Developmental Neurobiology Saint Jude Children's Research Hospital, Memphis TN</aff>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jang</surname>
<given-names>Haeman</given-names>
</name>
<degrees>PhD.</degrees>
<aff id="A3">Department of Developmental Neurobiology Saint Jude Children's Research Hospital, Memphis TN</aff>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Miller</surname>
<given-names>Bayard</given-names>
</name>
<degrees>M.D.</degrees>
<aff id="A4">Department of Neurology, University of Florida, Gainesville FL</aff>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Okun</surname>
<given-names>Michael S.</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="corresp" rid="CR1">*</xref>
<aff id="A5">Departments of Neurology and Neurosurgery, University of Florida Movement Disorders Center, Gainesville FL</aff>
</contrib>
</contrib-group>
<author-notes>
<corresp id="CR1">
<label>*</label>
Corresponding Author: Michael S. Okun, M.D., 101 S Newell Dr., Rm L3-101, Gainesville FL 32611; Phone: 352-273-5550; Fax 352-273-5575;
<email>okun@neurology.ufl.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>11</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>21</day>
<month>7</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<month>11</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>18</day>
<month>12</month>
<year>2015</year>
</pub-date>
<volume>16</volume>
<issue>9</issue>
<fpage>566</fpage>
<lpage>571</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.parkreldis.2010.06.012</pmc-comment>
<abstract>
<sec id="S1">
<title>Purpose</title>
<p id="P1">Given the recent paper by Jang et al. on “A Highly Pathogenic H5N1 Influenza Virus” which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20
<sup>th</sup>
and 21
<sup>st</sup>
century literature on parkinsonism and neurological manifestations of influenza.</p>
</sec>
<sec id="S2">
<title>Scope</title>
<p id="P2">There were at least twelve major flu pandemics reported in the literature in the 20
<sup>th</sup>
and 21
<sup>st</sup>
century. Neurological manifestations most prevalent during the pandemics included delirium, encephalitis, ocular abnormalities, amyotrophy, myelopathy, radiculopathy, ataxia and seizures. Very little parkinsonism was reported with the exception of the 1917 cases originally described by von Economo.</p>
</sec>
<sec id="S3">
<title>Conclusions</title>
<p id="P3">To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks.</p>
</sec>
</abstract>
<kwd-group>
<kwd>neurological</kwd>
<kwd>complications</kwd>
<kwd>adverse events</kwd>
<kwd>flu</kwd>
<kwd>influenza</kwd>
<kwd>parkinson’s disease</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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