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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development</title><author><name sortKey="Zhang, Jiantao" sort="Zhang, Jiantao" uniqKey="Zhang J" first="Jiantao" last="Zhang">Jiantao Zhang</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Hu, Yanmei" sort="Hu, Yanmei" uniqKey="Hu Y" first="Yanmei" last="Hu">Yanmei Hu</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Musharrafieh, Rami" sort="Musharrafieh, Rami" uniqKey="Musharrafieh R" first="Rami" last="Musharrafieh">Rami Musharrafieh</name><affiliation><nlm:aff id="A2">Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Yin, Hang" sort="Yin, Hang" uniqKey="Yin H" first="Hang" last="Yin">Hang Yin</name><affiliation><nlm:aff id="A3">Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, United States</nlm:aff></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A4">BIO5 Institute, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29984646</idno><idno type="pmc">6426683</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426683</idno><idno type="RBID">PMC:6426683</idno><idno type="doi">10.2174/0929867325666180706112940</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000882</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000882</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development</title><author><name sortKey="Zhang, Jiantao" sort="Zhang, Jiantao" uniqKey="Zhang J" first="Jiantao" last="Zhang">Jiantao Zhang</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Hu, Yanmei" sort="Hu, Yanmei" uniqKey="Hu Y" first="Yanmei" last="Hu">Yanmei Hu</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Musharrafieh, Rami" sort="Musharrafieh, Rami" uniqKey="Musharrafieh R" first="Rami" last="Musharrafieh">Rami Musharrafieh</name><affiliation><nlm:aff id="A2">Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author><author><name sortKey="Yin, Hang" sort="Yin, Hang" uniqKey="Yin H" first="Hang" last="Yin">Hang Yin</name><affiliation><nlm:aff id="A3">Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, United States</nlm:aff></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation><nlm:aff id="A1">Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation><affiliation><nlm:aff id="A4">BIO5 Institute, The University of Arizona, Tucson, Arizona 85721, United States</nlm:aff></affiliation></author></analytic><series><title level="j">Current medicinal chemistry</title><idno type="ISSN">0929-8673</idno><idno type="eISSN">1875-533X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current influenza vaccines, as well as emerging drug resistance from small molecule antiviral drugs, there is a clear need to develop new antivirals with novel mechanisms of action. The influenza virus polymerase complex has become a promising target for the development of the next-generation of antivirals for several reasons. Firstly, the influenza virus polymerase, which forms a heterotrimeric complex that consists of PA, PB1, and PB2 subunits, is highly conserved. Secondly, both individual polymerase subunit (PA, PB1, and PB2) and inter-subunit interactions (PA-PB1, PB1-PB2) represent promising drug targets. Lastly, growing insight into the structure and function of the polymerase complex has spearheaded the structure-guided design of new polymerase inhibitors. In this review, we highlight recent progress in drug discovery and assay development targeting the influenza virus polymerase complex and discuss their therapeutic potentials.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9440157</journal-id><journal-id journal-id-type="pubmed-jr-id">20806</journal-id><journal-id journal-id-type="nlm-ta">Curr Med Chem</journal-id><journal-id journal-id-type="iso-abbrev">Curr. Med. Chem.</journal-id><journal-title-group><journal-title>Current medicinal chemistry</journal-title></journal-title-group><issn pub-type="ppub">0929-8673</issn><issn pub-type="epub">1875-533X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">29984646</article-id><article-id pub-id-type="pmc">6426683</article-id><article-id pub-id-type="doi">10.2174/0929867325666180706112940</article-id><article-id pub-id-type="manuscript">NIHMS1016978</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Jiantao</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Yanmei</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Musharrafieh</surname><given-names>Rami</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Yin</surname><given-names>Hang</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jun</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A4">d</xref><xref rid="CR1" ref-type="corresp">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States</aff><aff id="A2"><label>b</label>Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States</aff><aff id="A3"><label>c</label>Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado, Boulder, Colorado 80309, United States</aff><aff id="A4"><label>d</label>BIO5 Institute, The University of Arizona, Tucson, Arizona 85721, United States</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author: Jun Wang, Ph.D., Room 423, 1657 E. Helen St., BIO5 Institute, Tucson, Arizona 85721, United States. Phone: 520-626-1366; <email>junwang@pharmacy.arizona.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>3</month><year>2019</year></pub-date><pub-date pub-type="ppub"><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2020</year></pub-date><volume>26</volume><issue>13</issue><fpage>2243</fpage><lpage>2263</lpage><pmc-comment>elocation-id from pubmed: 10.2174/0929867325666180706112940</pmc-comment>
<abstract id="ABS1"><p id="P1">Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current influenza vaccines, as well as emerging drug resistance from small molecule antiviral drugs, there is a clear need to develop new antivirals with novel mechanisms of action. The influenza virus polymerase complex has become a promising target for the development of the next-generation of antivirals for several reasons. Firstly, the influenza virus polymerase, which forms a heterotrimeric complex that consists of PA, PB1, and PB2 subunits, is highly conserved. Secondly, both individual polymerase subunit (PA, PB1, and PB2) and inter-subunit interactions (PA-PB1, PB1-PB2) represent promising drug targets. Lastly, growing insight into the structure and function of the polymerase complex has spearheaded the structure-guided design of new polymerase inhibitors. In this review, we highlight recent progress in drug discovery and assay development targeting the influenza virus polymerase complex and discuss their therapeutic potentials.</p></abstract><kwd-group><kwd>Influenza</kwd><kwd>polymerase</kwd><kwd>ribonucleoprotein</kwd><kwd>PA</kwd><kwd>PB1</kwd><kwd>PB2</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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