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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Animal models for influenza virus pathogenesis, transmission, and immunology</title><author><name sortKey="Thangavel, Rajagowthamee R" sort="Thangavel, Rajagowthamee R" uniqKey="Thangavel R" first="Rajagowthamee R." last="Thangavel">Rajagowthamee R. Thangavel</name><affiliation><nlm:aff id="A1">Department of Microbiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation></author><author><name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name><affiliation><nlm:aff id="A1">Department of Microbiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24709389</idno><idno type="pmc">4163064</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163064</idno><idno type="RBID">PMC:4163064</idno><idno type="doi">10.1016/j.jim.2014.03.023</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000839</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Animal models for influenza virus pathogenesis, transmission, and immunology</title><author><name sortKey="Thangavel, Rajagowthamee R" sort="Thangavel, Rajagowthamee R" uniqKey="Thangavel R" first="Rajagowthamee R." last="Thangavel">Rajagowthamee R. Thangavel</name><affiliation><nlm:aff id="A1">Department of Microbiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation></author><author><name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name><affiliation><nlm:aff id="A1">Department of Microbiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of immunological methods</title><idno type="ISSN">0022-1759</idno><idno type="eISSN">1872-7905</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">In humans, infection with an influenza A or B virus manifests typically as an acute and self-limited upper respiratory tract illness characterized by fever, cough, sore throat, and malaise. However, influenza can present along a broad spectrum of disease, ranging from sub-clinical or even asymptomatic infection to a severe primary viral pneumonia requiring advanced medical supportive care. Disease severity depends upon the virulence of the influenza virus strain and the immune competence and previous influenza exposures of the patient. Animal models are used in influenza research not only to elucidate the viral and host factors that affect influenza disease outcomes in and spread among susceptible hosts, but also to evaluate interventions designed to prevent or reduce influenza morbidity and mortality in man. This review will focus on the three animal models currently used most frequently in influenza virus research -- mice, ferrets, and guinea pigs -- and discuss the advantages and disadvantages of each.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">1305440</journal-id><journal-id journal-id-type="pubmed-jr-id">4818</journal-id><journal-id journal-id-type="nlm-ta">J Immunol Methods</journal-id><journal-id journal-id-type="iso-abbrev">J. Immunol. Methods</journal-id><journal-title-group><journal-title>Journal of immunological methods</journal-title></journal-title-group><issn pub-type="ppub">0022-1759</issn><issn pub-type="epub">1872-7905</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24709389</article-id><article-id pub-id-type="pmc">4163064</article-id><article-id pub-id-type="doi">10.1016/j.jim.2014.03.023</article-id><article-id pub-id-type="manuscript">NIHMS583155</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Animal models for influenza virus pathogenesis, transmission, and immunology</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thangavel</surname><given-names>Rajagowthamee R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bouvier</surname><given-names>Nicole M.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Microbiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</aff><aff id="A2"><label>2</label>Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA.</aff><author-notes><corresp id="cor1"><label>*</label>Corresponding author: <email>nicole.bouvier@mssm.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>5</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>4</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2015</year></pub-date><volume>0</volume><fpage>60</fpage><lpage>79</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.jim.2014.03.023</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">In humans, infection with an influenza A or B virus manifests typically as an acute and self-limited upper respiratory tract illness characterized by fever, cough, sore throat, and malaise. However, influenza can present along a broad spectrum of disease, ranging from sub-clinical or even asymptomatic infection to a severe primary viral pneumonia requiring advanced medical supportive care. Disease severity depends upon the virulence of the influenza virus strain and the immune competence and previous influenza exposures of the patient. Animal models are used in influenza research not only to elucidate the viral and host factors that affect influenza disease outcomes in and spread among susceptible hosts, but also to evaluate interventions designed to prevent or reduce influenza morbidity and mortality in man. This review will focus on the three animal models currently used most frequently in influenza virus research -- mice, ferrets, and guinea pigs -- and discuss the advantages and disadvantages of each.</p></abstract><kwd-group><kwd>influenza virus</kwd><kwd>animal model</kwd><kwd>mouse</kwd><kwd>ferret</kwd><kwd>guinea pig</kwd><kwd>pathogenicity</kwd><kwd>transmission</kwd><kwd>immunology</kwd><kwd>influenza vaccine</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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