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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza A Virus Infection, Innate Immunity, and Childhood</title><author><name sortKey="Coates, Bria M" sort="Coates, Bria M" uniqKey="Coates B" first="Bria M." last="Coates">Bria M. Coates</name></author><author><name sortKey="Staricha, Kelly L" sort="Staricha, Kelly L" uniqKey="Staricha K" first="Kelly L." last="Staricha">Kelly L. Staricha</name></author><author><name sortKey="Wiese, Kristin M" sort="Wiese, Kristin M" uniqKey="Wiese K" first="Kristin M." last="Wiese">Kristin M. Wiese</name></author><author><name sortKey="Ridge, Karen M" sort="Ridge, Karen M" uniqKey="Ridge K" first="Karen M." last="Ridge">Karen M. Ridge</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26237589</idno><idno type="pmc">4765914</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765914</idno><idno type="RBID">PMC:4765914</idno><idno type="doi">10.1001/jamapediatrics.2015.1387</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000835</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000835</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Influenza A Virus Infection, Innate Immunity, and Childhood</title><author><name sortKey="Coates, Bria M" sort="Coates, Bria M" uniqKey="Coates B" first="Bria M." last="Coates">Bria M. Coates</name></author><author><name sortKey="Staricha, Kelly L" sort="Staricha, Kelly L" uniqKey="Staricha K" first="Kelly L." last="Staricha">Kelly L. Staricha</name></author><author><name sortKey="Wiese, Kristin M" sort="Wiese, Kristin M" uniqKey="Wiese K" first="Kristin M." last="Wiese">Kristin M. Wiese</name></author><author><name sortKey="Ridge, Karen M" sort="Ridge, Karen M" uniqKey="Ridge K" first="Karen M." last="Ridge">Karen M. Ridge</name></author></analytic><series><title level="j">JAMA pediatrics</title><idno type="ISSN">2168-6203</idno><idno type="eISSN">2168-6211</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Infection with influenza A virus is responsible for considerable morbidity and mortality in children worldwide. While it is apparent that adequate activation of the innate immune system is essential for pathogen clearance and host survival, an excessive inflammatory response to infection is detrimental to the young host. A review of the literature indicates that innate immune responses change throughout childhood. Whether these changes are genetically programmed or triggered by environmental cues is unknown. The objectives of this review are to summarize the role of innate immunity in influenza A virus infection in the young child and to highlight possible differences between children and adults that may make children more susceptible to severe influenza A infection. A better understanding of age-related differences in innate immune signaling will be essential to improve care for this high-risk population.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101589544</journal-id><journal-id journal-id-type="pubmed-jr-id">40868</journal-id><journal-id journal-id-type="nlm-ta">JAMA Pediatr</journal-id><journal-id journal-id-type="iso-abbrev">JAMA Pediatr</journal-id><journal-title-group><journal-title>JAMA pediatrics</journal-title></journal-title-group><issn pub-type="ppub">2168-6203</issn><issn pub-type="epub">2168-6211</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26237589</article-id><article-id pub-id-type="pmc">4765914</article-id><article-id pub-id-type="doi">10.1001/jamapediatrics.2015.1387</article-id><article-id pub-id-type="manuscript">NIHMS758883</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Influenza A Virus Infection, Innate Immunity, and Childhood</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coates</surname><given-names>Bria M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Staricha</surname><given-names>Kelly L.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wiese</surname><given-names>Kristin M.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Ridge</surname><given-names>Karen M.</given-names></name><degrees>PhD</degrees></contrib><aff id="A1">Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois (Coates, Staricha); Division of Critical Care Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois (Coates); Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois (Wiese, Ridge); Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois (Ridge).</aff></contrib-group><author-notes><corresp id="cor1">Corresponding Author: Bria M., Coates, MD, Division of Critical Care, Medicine, Ann & Robert H. Lurie, Children’s Hospital of Chicago, 225 E, Chicago Ave, Campus Box 43,, Chicago, IL 60611, (<email>b-coates@northwestern.edu</email>)</corresp><fn id="FN2" fn-type="conflict"><p id="P35"><bold>Conflict of Interest Disclosures:</bold> None reported.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>2</month><year>2016</year></pub-date><volume>169</volume><issue>10</issue><fpage>956</fpage><lpage>963</lpage><pmc-comment>elocation-id from pubmed: 10.1001/jamapediatrics.2015.1387</pmc-comment>
<abstract><p id="P1">Infection with influenza A virus is responsible for considerable morbidity and mortality in children worldwide. While it is apparent that adequate activation of the innate immune system is essential for pathogen clearance and host survival, an excessive inflammatory response to infection is detrimental to the young host. A review of the literature indicates that innate immune responses change throughout childhood. Whether these changes are genetically programmed or triggered by environmental cues is unknown. The objectives of this review are to summarize the role of innate immunity in influenza A virus infection in the young child and to highlight possible differences between children and adults that may make children more susceptible to severe influenza A infection. A better understanding of age-related differences in innate immune signaling will be essential to improve care for this high-risk population.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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