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<title xml:lang="en">Animal models for influenza virus transmission studies: A historical perspective</title>
<author>
<name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name>
<affiliation>
<nlm:aff id="A1">Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA</nlm:aff>
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<affiliation>
<nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA</nlm:aff>
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<idno type="pmid">26126082</idno>
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<idno type="doi">10.1016/j.coviro.2015.06.002</idno>
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<title xml:lang="en" level="a" type="main">Animal models for influenza virus transmission studies: A historical perspective</title>
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<name sortKey="Bouvier, Nicole M" sort="Bouvier, Nicole M" uniqKey="Bouvier N" first="Nicole M." last="Bouvier">Nicole M. Bouvier</name>
<affiliation>
<nlm:aff id="A1">Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA</nlm:aff>
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<title level="j">Current opinion in virology</title>
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<p id="P1">Animal models are used to simulate, under experimental conditions, the complex interactions among host, virus, and environment that affect the person-to-person spread of influenza viruses. The three species that have been most frequently employed, both past and present, as influenza virus transmission models -- ferrets, mice, and guinea pigs -- have each provided unique insights into the factors governing the efficiency with which these viruses pass from an infected host to a susceptible one. This review will highlight a few of these noteworthy discoveries, with a particular focus on the historical contexts in which each model was developed and the advantages and disadvantages of each species with regard to the study of influenza virus transmission among mammals.</p>
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<journal-id journal-id-type="nlm-journal-id">101560941</journal-id>
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<journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id>
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<article-title>Animal models for influenza virus transmission studies: A historical perspective</article-title>
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<name>
<surname>Bouvier</surname>
<given-names>Nicole M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
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Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA</aff>
<aff id="A2">
<label>2</label>
Department of Microbiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA</aff>
<author-notes>
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<label>*</label>
Corresponding author:
<email>nicole.bouvier@mssm.edu</email>
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<pub-date pub-type="nihms-submitted">
<day>8</day>
<month>7</month>
<year>2015</year>
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<pub-date pub-type="epub">
<day>28</day>
<month>6</month>
<year>2015</year>
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<pub-date pub-type="ppub">
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>8</month>
<year>2016</year>
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<volume>13</volume>
<fpage>101</fpage>
<lpage>108</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.coviro.2015.06.002</pmc-comment>
<abstract>
<p id="P1">Animal models are used to simulate, under experimental conditions, the complex interactions among host, virus, and environment that affect the person-to-person spread of influenza viruses. The three species that have been most frequently employed, both past and present, as influenza virus transmission models -- ferrets, mice, and guinea pigs -- have each provided unique insights into the factors governing the efficiency with which these viruses pass from an infected host to a susceptible one. This review will highlight a few of these noteworthy discoveries, with a particular focus on the historical contexts in which each model was developed and the advantages and disadvantages of each species with regard to the study of influenza virus transmission among mammals.</p>
</abstract>
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</front>
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