Influenza virus hemagglutinin stalk-based antibodies and vaccines
Identifieur interne : 000829 ( Pmc/Corpus ); précédent : 000828; suivant : 000830Influenza virus hemagglutinin stalk-based antibodies and vaccines
Auteurs : Florian Krammer ; Peter PaleseSource :
- Current opinion in virology [ 1879-6257 ] ; 2013.
Abstract
Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Due to the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, e.g. chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.
Url:
DOI: 10.1016/j.coviro.2013.07.007
PubMed: 23978327
PubMed Central: 3804342
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PMC:3804342Le document en format XML
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<affiliation><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</nlm:aff>
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<author><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</nlm:aff>
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<affiliation><nlm:aff id="A2">Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P2">Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Due to the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, e.g. chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101560941</journal-id>
<journal-id journal-id-type="pubmed-jr-id">39304</journal-id>
<journal-id journal-id-type="nlm-ta">Curr Opin Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">Curr Opin Virol</journal-id>
<journal-title-group><journal-title>Current opinion in virology</journal-title>
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<article-id pub-id-type="manuscript">NIHMS514313</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Influenza virus hemagglutinin stalk-based antibodies and vaccines</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Krammer</surname>
<given-names>Florian</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Palese</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
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<aff id="A3">One Gustave L. Levy Place, New York, 10029 NY, USA</aff>
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<aff id="A1"><label>1</label>
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA</aff>
<aff id="A2"><label>2</label>
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA</aff>
<author-notes><fn id="FN2"><p id="P1"><email>Florian.Krammer@mssm.edu</email>
and <email>Peter.Palese@mssm.edu</email>
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<pub-date pub-type="nihms-submitted"><day>20</day>
<month>9</month>
<year>2013</year>
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<pub-date pub-type="epub"><day>24</day>
<month>8</month>
<year>2013</year>
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<pub-date pub-type="ppub"><month>10</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>3</volume>
<issue>5</issue>
<fpage>521</fpage>
<lpage>530</lpage>
<permissions><copyright-statement>© 2013 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p id="P2">Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Due to the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, e.g. chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>P01 AI097092 || AI</award-id>
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