Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia
Identifieur interne : 000824 ( Pmc/Corpus ); précédent : 000823; suivant : 000825Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia
Auteurs : Patrick J. Blair ; Shannon D. Putnam ; Whitney S. Krueger ; Channimol Chum ; Thomas F. Wierzba ; Gary L. Heil ; Chadwick Y. Yasuda ; Maya Williams ; Matthew R. Kasper ; John A. Friary ; Ana W. Capuano ; Vonthanak Saphonn ; Malik Peiris ; Hongxia Shao ; Daniel R. Perez ; Gregory C. GraySource :
- Journal of infection and public health [ 1876-0341 ] ; 2013.
Abstract
Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.
In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.
Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.
Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.
Url:
DOI: 10.1016/j.jiph.2012.11.005
PubMed: 23537819
PubMed Central: 3612269
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Krueger</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Chum, Channimol" sort="Chum, Channimol" uniqKey="Chum C" first="Channimol" last="Chum">Channimol Chum</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L." last="Heil">Gary L. Heil</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Williams, Maya" sort="Williams, Maya" uniqKey="Williams M" first="Maya" last="Williams">Maya Williams</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Friary, John A" sort="Friary, John A" uniqKey="Friary J" first="John A." last="Friary">John A. Friary</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Capuano, Ana W" sort="Capuano, Ana W" uniqKey="Capuano A" first="Ana W." last="Capuano">Ana W. Capuano</name><affiliation><nlm:aff id="A3">College of Public Health, University of Iowa, Iowa City, Iowa, USA</nlm:aff></affiliation></author><author><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><affiliation><nlm:aff id="A4">National Institute of Public Health/Ministry of Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation><nlm:aff id="A5">Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name><affiliation><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R." last="Perez">Daniel R. Perez</name><affiliation><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C." last="Gray">Gregory C. Gray</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23537819</idno><idno type="pmc">3612269</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612269</idno><idno type="RBID">PMC:3612269</idno><idno type="doi">10.1016/j.jiph.2012.11.005</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000824</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000824</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia</title><author><name sortKey="Blair, Patrick J" sort="Blair, Patrick J" uniqKey="Blair P" first="Patrick J." last="Blair">Patrick J. Blair</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Putnam, Shannon D" sort="Putnam, Shannon D" uniqKey="Putnam S" first="Shannon D." last="Putnam">Shannon D. Putnam</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Krueger, Whitney S" sort="Krueger, Whitney S" uniqKey="Krueger W" first="Whitney S." last="Krueger">Whitney S. Krueger</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Chum, Channimol" sort="Chum, Channimol" uniqKey="Chum C" first="Channimol" last="Chum">Channimol Chum</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Wierzba, Thomas F" sort="Wierzba, Thomas F" uniqKey="Wierzba T" first="Thomas F." last="Wierzba">Thomas F. Wierzba</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Heil, Gary L" sort="Heil, Gary L" uniqKey="Heil G" first="Gary L." last="Heil">Gary L. Heil</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Yasuda, Chadwick Y" sort="Yasuda, Chadwick Y" uniqKey="Yasuda C" first="Chadwick Y." last="Yasuda">Chadwick Y. Yasuda</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Williams, Maya" sort="Williams, Maya" uniqKey="Williams M" first="Maya" last="Williams">Maya Williams</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Kasper, Matthew R" sort="Kasper, Matthew R" uniqKey="Kasper M" first="Matthew R." last="Kasper">Matthew R. Kasper</name><affiliation><nlm:aff id="A1">Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Friary, John A" sort="Friary, John A" uniqKey="Friary J" first="John A." last="Friary">John A. Friary</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Capuano, Ana W" sort="Capuano, Ana W" uniqKey="Capuano A" first="Ana W." last="Capuano">Ana W. Capuano</name><affiliation><nlm:aff id="A3">College of Public Health, University of Iowa, Iowa City, Iowa, USA</nlm:aff></affiliation></author><author><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><affiliation><nlm:aff id="A4">National Institute of Public Health/Ministry of Health, Phnom Penh, Cambodia</nlm:aff></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation><nlm:aff id="A5">Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name><affiliation><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R." last="Perez">Daniel R. Perez</name><affiliation><nlm:aff id="A6">VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</nlm:aff></affiliation></author><author><name sortKey="Gray, Gregory C" sort="Gray, Gregory C" uniqKey="Gray G" first="Gregory C." last="Gray">Gregory C. Gray</name><affiliation><nlm:aff id="A2">College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of infection and public health</title><idno type="ISSN">1876-0341</idno><idno type="eISSN">1876-035X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.</p></sec><sec id="S2"><title>Methods</title><p id="P2">In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.</p></sec><sec id="S3"><title>Results</title><p id="P3">Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101487384</journal-id><journal-id journal-id-type="pubmed-jr-id">37890</journal-id><journal-id journal-id-type="nlm-ta">J Infect Public Health</journal-id><journal-id journal-id-type="iso-abbrev">J Infect Public Health</journal-id><journal-title-group><journal-title>Journal of infection and public health</journal-title></journal-title-group><issn pub-type="ppub">1876-0341</issn><issn pub-type="epub">1876-035X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23537819</article-id><article-id pub-id-type="pmc">3612269</article-id><article-id pub-id-type="doi">10.1016/j.jiph.2012.11.005</article-id><article-id pub-id-type="manuscript">NIHMS436432</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Evidence for Avian H9N2 Influenza Virus Infections among Rural Villagers in Cambodia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Blair</surname><given-names>Patrick J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Putnam</surname><given-names>Shannon D.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Krueger</surname><given-names>Whitney S.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chum</surname><given-names>Channimol</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wierzba</surname><given-names>Thomas F.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Heil</surname><given-names>Gary L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yasuda</surname><given-names>Chadwick Y.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Williams</surname><given-names>Maya</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kasper</surname><given-names>Matthew R.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Friary</surname><given-names>John A.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Capuano</surname><given-names>Ana W.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Saphonn</surname><given-names>Vonthanak</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Peiris</surname><given-names>Malik</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Shao</surname><given-names>Hongxia</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Perez</surname><given-names>Daniel R.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gray</surname><given-names>Gregory C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Naval Medical Research Unit #2 / National Institute of Public Health, Phnom Penh, Cambodia</aff><aff id="A2"><label>2</label>College of Public Health and Health Professions and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA</aff><aff id="A3"><label>3</label>College of Public Health, University of Iowa, Iowa City, Iowa, USA</aff><aff id="A4"><label>4</label>National Institute of Public Health/Ministry of Health, Phnom Penh, Cambodia</aff><aff id="A5"><label>5</label>Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong, China</aff><aff id="A6"><label>6</label>VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA</aff><author-notes><corresp id="cor1">Address correspondence to: Gregory C. Gray, MD, MPH, FIDSA, Professor and Chair, Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, P.O. Box 100188, Gainesville Florida 32610, Tel 352-273-9188, Fax 352-273-6070, <email>gcgray@phhp.ufl.edu</email></corresp><fn id="FN4" fn-type="conflict"><p id="P39"><bold>Conflicts of Interest</bold></p><p id="P40">None to declare.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>01</day><month>2</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>4</month><year>2014</year></pub-date><volume>6</volume><issue>2</issue><fpage>69</fpage><lpage>79</lpage><permissions><copyright-statement>© 2012 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Limited. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P1">Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur.</p></sec><sec id="S2"><title>Methods</title><p id="P2">In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains.</p></sec><sec id="S3"><title>Results</title><p id="P3">Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.</p></sec></abstract><kwd-group><kwd>influenza A virus, avian</kwd><kwd>zoonoses</kwd><kwd>occupational exposure</kwd><kwd>communicable diseases, emerging</kwd><kwd>cohort studies</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>R01 AI068803 || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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