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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia</title><author><name sortKey="Mcauley, Julie L" sort="Mcauley, Julie L" uniqKey="Mcauley J" first="Julie L." last="Mcauley">Julie L. Mcauley</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Hornung, Felicita" sort="Hornung, Felicita" uniqKey="Hornung F" first="Felicita" last="Hornung">Felicita Hornung</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. Boyd</name><affiliation><nlm:aff id="A3"> Animal Resources Center, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Smith, Amber M" sort="Smith, Amber M" uniqKey="Smith A" first="Amber M." last="Smith">Amber M. Smith</name><affiliation><nlm:aff id="A4"> Department of Mathematics, University of Utah, Salt Lake City, UT 84112</nlm:aff></affiliation></author><author><name sortKey="Mckeon, Raelene" sort="Mckeon, Raelene" uniqKey="Mckeon R" first="Raelene" last="Mckeon">Raelene Mckeon</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Bennink, Jack" sort="Bennink, Jack" uniqKey="Bennink J" first="Jack" last="Bennink">Jack Bennink</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. Yewdell</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18005742</idno><idno type="pmc">2083255</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083255</idno><idno type="RBID">PMC:2083255</idno><idno type="doi">10.1016/j.chom.2007.09.001</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000821</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000821</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia</title><author><name sortKey="Mcauley, Julie L" sort="Mcauley, Julie L" uniqKey="Mcauley J" first="Julie L." last="Mcauley">Julie L. Mcauley</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Hornung, Felicita" sort="Hornung, Felicita" uniqKey="Hornung F" first="Felicita" last="Hornung">Felicita Hornung</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. Boyd</name><affiliation><nlm:aff id="A3"> Animal Resources Center, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Smith, Amber M" sort="Smith, Amber M" uniqKey="Smith A" first="Amber M." last="Smith">Amber M. Smith</name><affiliation><nlm:aff id="A4"> Department of Mathematics, University of Utah, Salt Lake City, UT 84112</nlm:aff></affiliation></author><author><name sortKey="Mckeon, Raelene" sort="Mckeon, Raelene" uniqKey="Mckeon R" first="Raelene" last="Mckeon">Raelene Mckeon</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author><author><name sortKey="Bennink, Jack" sort="Bennink, Jack" uniqKey="Bennink J" first="Jack" last="Bennink">Jack Bennink</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Yewdell, Jonathan W" sort="Yewdell, Jonathan W" uniqKey="Yewdell J" first="Jonathan W." last="Yewdell">Jonathan W. Yewdell</name><affiliation><nlm:aff id="A2"> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><affiliation><nlm:aff id="A1"> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</nlm:aff></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="ISSN">1931-3128</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101302316</journal-id><journal-id journal-id-type="pubmed-jr-id">33345</journal-id><journal-id journal-id-type="nlm-ta">Cell Host Microbe</journal-id><journal-title>Cell host & microbe</journal-title><issn pub-type="ppub">1931-3128</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18005742</article-id><article-id pub-id-type="pmc">2083255</article-id><article-id pub-id-type="doi">10.1016/j.chom.2007.09.001</article-id><article-id pub-id-type="manuscript">NIHMS32644</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viral and Secondary Bacterial Pneumonia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>McAuley</surname><given-names>Julie L.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Hornung</surname><given-names>Felicita</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Boyd</surname><given-names>Kelli L.</given-names></name><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Amber M.</given-names></name><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>McKeon</surname><given-names>Raelene</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Bennink</surname><given-names>Jack</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Yewdell</surname><given-names>Jonathan W.</given-names></name><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>McCullers</surname><given-names>Jonathan A.</given-names></name><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN</aff><aff id="A3"><label>3</label> Animal Resources Center, St. Jude Children’s Research Hospital, Memphis, TN</aff><aff id="A2"><label>2</label> Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892</aff><aff id="A4"><label>4</label> Department of Mathematics, University of Utah, Salt Lake City, UT 84112</aff><author-notes><corresp id="FN1">Corresponding Author: Jonathan A. McCullers, Department of Infectious Diseases, St. Jude Children’s Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794 (901) 495-3486, FAX: (901) 495-3099, <email>jon.mccullers@stjude.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>10</month><year>2007</year></pub-date><pub-date pub-type="ppub"><day>11</day><month>10</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>10</month><year>2008</year></pub-date><volume>2</volume><issue>4</issue><fpage>240</fpage><lpage>249</lpage><abstract><p id="P2">Secondary bacterial pneumonia frequently claimed the lives of victims during the devastating 1918 influenza A virus pandemic. Little is known about the viral factors contributing to the lethality of the 1918 pandemic. Here we show that expression of the viral accessory protein PB1-F2 enhances inflammation during primary viral infection of mice and increases both the frequency and severity of secondary bacterial pneumonia. The priming effect of PB1-F2 on bacterial pneumonia could be recapitulated in mice by intranasal delivery of a synthetic peptide derived from the C-terminal portion of the PB1-F2. Relative to its isogenic parent, an influenza virus engineered to express a PB1-F2 with coding changes matching the 1918 pandemic strain was more virulent in mice, induced more pulmonary immunopathology, and led to more severe secondary bacterial pneumonia. These findings help explain both the unparalleled virulence of the 1918 strain and the high incidence of fatal pneumonia during the pandemic.</p></abstract><contract-num rid="AI1">R01 AI066349-03</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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