Reassortment in segmented RNA viruses: mechanisms and outcomes
Identifieur interne : 000813 ( Pmc/Corpus ); précédent : 000812; suivant : 000814Reassortment in segmented RNA viruses: mechanisms and outcomes
Auteurs : Sarah M. Mcdonald ; Martha I. Nelson ; Paul E. Turner ; John T. PattonSource :
- Nature reviews. Microbiology [ 1740-1526 ] ; 2016.
Abstract
Segmented RNA viruses are widespread in nature and include important human, animal and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA virus genome segmentation remains elusive, a major consequence of this genome structure is the capacity for reassortment to occur during co-infection, whereby segments are exchanged among different viral strains. Therefore, reassortment can create viral progeny that contain genes that are derived from more than one parent, potentially conferring important fitness advantages or disadvantages to the progeny virus. However, for segmented RNA viruses that package their multiple genome segments into a single virion particle, reassortment also requires genetic compatibility between parental strains, which occurs in the form of conserved packaging signals, and the maintenance of RNA and protein interactions. In this Review, we discuss recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families —
Url:
DOI: 10.1038/nrmicro.2016.46
PubMed: 27211789
PubMed Central: 5119462
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PMC:5119462Le document en format XML
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<author><name sortKey="Mcdonald, Sarah M" sort="Mcdonald, Sarah M" uniqKey="Mcdonald S" first="Sarah M." last="Mcdonald">Sarah M. Mcdonald</name>
<affiliation><nlm:aff id="A1">Virginia Tech Carilion School of Medicine and Research Institute, 2 Riverside Circle, Roanoke, Virginia 24016, USA</nlm:aff>
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<affiliation><nlm:aff id="A2">Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA</nlm:aff>
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<author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name>
<affiliation><nlm:aff id="A3">Fogarty International Center, National Institutes of Health, 31 Center Drive, MSC 2220, Bethesda, Maryland 20892, USA</nlm:aff>
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<author><name sortKey="Turner, Paul E" sort="Turner, Paul E" uniqKey="Turner P" first="Paul E." last="Turner">Paul E. Turner</name>
<affiliation><nlm:aff id="A4">Department of Ecology and Evolutionary Biology, Yale University, Osborn Memorial Labs, 165 Prospect Street, P. O. Box 208106, New Haven, Connecticut 06520, USA</nlm:aff>
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<author><name sortKey="Patton, John T" sort="Patton, John T" uniqKey="Patton J" first="John T." last="Patton">John T. Patton</name>
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<affiliation><nlm:aff id="A2">Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA</nlm:aff>
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<author><name sortKey="Turner, Paul E" sort="Turner, Paul E" uniqKey="Turner P" first="Paul E." last="Turner">Paul E. Turner</name>
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<series><title level="j">Nature reviews. Microbiology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Segmented RNA viruses are widespread in nature and include important human, animal and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA virus genome segmentation remains elusive, a major consequence of this genome structure is the capacity for reassortment to occur during co-infection, whereby segments are exchanged among different viral strains. Therefore, reassortment can create viral progeny that contain genes that are derived from more than one parent, potentially conferring important fitness advantages or disadvantages to the progeny virus. However, for segmented RNA viruses that package their multiple genome segments into a single virion particle, reassortment also requires genetic compatibility between parental strains, which occurs in the form of conserved packaging signals, and the maintenance of RNA and protein interactions. In this Review, we discuss recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families — <italic>Cystoviridae</italic>
, <italic>Orthomyxoviridae</italic>
and <italic>Reoviridae</italic>
— and discuss how these findings provide new perspectives on the replication and evolution of segmented RNA viruses.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101190261</journal-id>
<journal-id journal-id-type="pubmed-jr-id">31733</journal-id>
<journal-id journal-id-type="nlm-ta">Nat Rev Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Nat. Rev. Microbiol.</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Reassortment in segmented RNA viruses: mechanisms and outcomes</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>McDonald</surname>
<given-names>Sarah M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Nelson</surname>
<given-names>Martha I.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Turner</surname>
<given-names>Paul E.</given-names>
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<xref ref-type="aff" rid="A4">4</xref>
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<contrib contrib-type="author"><name><surname>Patton</surname>
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<aff id="A1"><label>1</label>
Virginia Tech Carilion School of Medicine and Research Institute, 2 Riverside Circle, Roanoke, Virginia 24016, USA</aff>
<aff id="A2"><label>2</label>
Department of Biomedical Sciences and Pathobiology, Virginia–Maryland College of Veterinary Medicine, 205 Duck Pond Drive, Blacksburg, Virginia 24061, USA</aff>
<aff id="A3"><label>3</label>
Fogarty International Center, National Institutes of Health, 31 Center Drive, MSC 2220, Bethesda, Maryland 20892, USA</aff>
<aff id="A4"><label>4</label>
Department of Ecology and Evolutionary Biology, Yale University, Osborn Memorial Labs, 165 Prospect Street, P. O. Box 208106, New Haven, Connecticut 06520, USA</aff>
<aff id="A5"><label>5</label>
Virginia–Maryland College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, Maryland 20742, USA</aff>
<author-notes><corresp id="FN1">Correspondence to S.M.M. <email>mcdonaldsa@vtc.vt.edu</email>
</corresp>
<fn fn-type="COI-statement" id="FN2"><p><bold>Competing interests statement</bold>
</p>
<p>The authors declare no competing interests.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>11</month>
<year>2016</year>
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<pub-date pub-type="epub"><day>23</day>
<month>5</month>
<year>2016</year>
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<pub-date pub-type="ppub"><month>7</month>
<year>2016</year>
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<pub-date pub-type="pmc-release"><day>22</day>
<month>11</month>
<year>2016</year>
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<volume>14</volume>
<issue>7</issue>
<fpage>448</fpage>
<lpage>460</lpage>
<pmc-comment>elocation-id from pubmed: 10.1038/nrmicro.2016.46</pmc-comment>
<abstract><p id="P1">Segmented RNA viruses are widespread in nature and include important human, animal and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA virus genome segmentation remains elusive, a major consequence of this genome structure is the capacity for reassortment to occur during co-infection, whereby segments are exchanged among different viral strains. Therefore, reassortment can create viral progeny that contain genes that are derived from more than one parent, potentially conferring important fitness advantages or disadvantages to the progeny virus. However, for segmented RNA viruses that package their multiple genome segments into a single virion particle, reassortment also requires genetic compatibility between parental strains, which occurs in the form of conserved packaging signals, and the maintenance of RNA and protein interactions. In this Review, we discuss recent studies that examined the mechanisms and outcomes of reassortment for three well-studied viral families — <italic>Cystoviridae</italic>
, <italic>Orthomyxoviridae</italic>
and <italic>Reoviridae</italic>
— and discuss how these findings provide new perspectives on the replication and evolution of segmented RNA viruses.</p>
</abstract>
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</front>
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