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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Innate immune responses to influenza A H5N1: friend or foe?</title>
<author><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheung, Cy" sort="Cheung, Cy" uniqKey="Cheung C" first="Cy" last="Cheung">Cy Cheung</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leung, Cyh" sort="Leung, Cyh" uniqKey="Leung C" first="Cyh" last="Leung">Cyh Leung</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name>
<affiliation><nlm:aff id="A2">Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19864182</idno>
<idno type="pmc">5068224</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068224</idno>
<idno type="RBID">PMC:5068224</idno>
<idno type="doi">10.1016/j.it.2009.09.004</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000807</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000807</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Innate immune responses to influenza A H5N1: friend or foe?</title>
<author><name sortKey="Peiris, Jsm" sort="Peiris, Jsm" uniqKey="Peiris J" first="Jsm" last="Peiris">Jsm Peiris</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cheung, Cy" sort="Cheung, Cy" uniqKey="Cheung C" first="Cy" last="Cheung">Cy Cheung</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leung, Cyh" sort="Leung, Cyh" uniqKey="Leung C" first="Cyh" last="Leung">Cyh Leung</name>
<affiliation><nlm:aff id="A1">Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicholls, Jm" sort="Nicholls, Jm" uniqKey="Nicholls J" first="Jm" last="Nicholls">Jm Nicholls</name>
<affiliation><nlm:aff id="A2">Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Trends in immunology</title>
<idno type="ISSN">1471-4906</idno>
<idno type="eISSN">1471-4981</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Avian influenza A H5N1 remains unusual in its virulence for humans. While infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia leading to acute respiratory distress syndrome and death but its pathogenesis remains an enigma. Comparisons in the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and in relevant primary human cell cultures remains instructive. While the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to the pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100966032</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22039</journal-id>
<journal-id journal-id-type="nlm-ta">Trends Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Trends Immunol.</journal-id>
<journal-title-group><journal-title>Trends in immunology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1471-4906</issn>
<issn pub-type="epub">1471-4981</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19864182</article-id>
<article-id pub-id-type="pmc">5068224</article-id>
<article-id pub-id-type="doi">10.1016/j.it.2009.09.004</article-id>
<article-id pub-id-type="manuscript">NIHMS145861</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Innate immune responses to influenza A H5N1: friend or foe?</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Peiris</surname>
<given-names>JSM</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cheung</surname>
<given-names>CY</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leung</surname>
<given-names>CYH</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nicholls</surname>
<given-names>JM</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</aff>
<aff id="A2"><label>2</label>
Department of Pathology, The University of Hong Kong, Hong Kong Special Administrative Region, PR China</aff>
<aff id="A3"><label>3</label>
HKU-Pasteur Research Centre, Hong Kong Special Administrative Region, PR China</aff>
<author-notes><corresp id="cor1">Corresponding author: JSM Peiris, Department of Microbiology, University Pathology Building, Queen Mary Hospital, Pokfulam, Hong Kong SAR., Phone (852)-2855-4888, <email>malik@hkucc.hku.hk</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>19</day>
<month>5</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>26</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>18</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>30</volume>
<issue>12</issue>
<fpage>574</fpage>
<lpage>584</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.it.2009.09.004</pmc-comment>
<abstract><p id="P1">Avian influenza A H5N1 remains unusual in its virulence for humans. While infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia leading to acute respiratory distress syndrome and death but its pathogenesis remains an enigma. Comparisons in the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and in relevant primary human cell cultures remains instructive. While the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to the pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.</p>
</abstract>
<kwd-group><kwd>influenza</kwd>
<kwd>H5N1</kwd>
<kwd>pandemic</kwd>
<kwd>innate immune response</kwd>
<kwd>cytokine</kwd>
<kwd>macrophage</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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