Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 virus</title>
<author><name sortKey="Linster, Martin" sort="Linster, Martin" uniqKey="Linster M" first="Martin" last="Linster">Martin Linster</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Boheemen, Sander" sort="Van Boheemen, Sander" uniqKey="Van Boheemen S" first="Sander" last="Van Boheemen">Sander Van Boheemen</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schrauwen, Eefje J A" sort="Schrauwen, Eefje J A" uniqKey="Schrauwen E" first="Eefje J. A." last="Schrauwen">Eefje J. A. Schrauwen</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lexmond, Pascal" sort="Lexmond, Pascal" uniqKey="Lexmond P" first="Pascal" last="Lexmond">Pascal Lexmond</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Nz, Benjamin" sort="M Nz, Benjamin" uniqKey="M Nz B" first="Benjamin" last="M Nz">Benjamin M Nz</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M." last="Bestebroer">Theo M. Bestebroer</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baumann, Jan" sort="Baumann, Jan" uniqKey="Baumann J" first="Jan" last="Baumann">Jan Baumann</name>
<affiliation><nlm:aff id="A2">Institute of Virology, Philipps-University, 35043 Marburg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
<affiliation><nlm:aff id="A2">Institute of Virology, Philipps-University, 35043 Marburg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24725402</idno>
<idno type="pmc">4003409</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003409</idno>
<idno type="RBID">PMC:4003409</idno>
<idno type="doi">10.1016/j.cell.2014.02.040</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000803</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000803</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 virus</title>
<author><name sortKey="Linster, Martin" sort="Linster, Martin" uniqKey="Linster M" first="Martin" last="Linster">Martin Linster</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Boheemen, Sander" sort="Van Boheemen, Sander" uniqKey="Van Boheemen S" first="Sander" last="Van Boheemen">Sander Van Boheemen</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Graaf, Miranda" sort="De Graaf, Miranda" uniqKey="De Graaf M" first="Miranda" last="De Graaf">Miranda De Graaf</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schrauwen, Eefje J A" sort="Schrauwen, Eefje J A" uniqKey="Schrauwen E" first="Eefje J. A." last="Schrauwen">Eefje J. A. Schrauwen</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lexmond, Pascal" sort="Lexmond, Pascal" uniqKey="Lexmond P" first="Pascal" last="Lexmond">Pascal Lexmond</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Nz, Benjamin" sort="M Nz, Benjamin" uniqKey="M Nz B" first="Benjamin" last="M Nz">Benjamin M Nz</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M." last="Bestebroer">Theo M. Bestebroer</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baumann, Jan" sort="Baumann, Jan" uniqKey="Baumann J" first="Jan" last="Baumann">Jan Baumann</name>
<affiliation><nlm:aff id="A2">Institute of Virology, Philipps-University, 35043 Marburg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Riel, Debby" sort="Van Riel, Debby" uniqKey="Van Riel D" first="Debby" last="Van Riel">Debby Van Riel</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
<affiliation><nlm:aff id="A2">Institute of Virology, Philipps-University, 35043 Marburg, Germany</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name>
<affiliation><nlm:aff id="A1">Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell</title>
<idno type="ISSN">0092-8674</idno>
<idno type="eISSN">1097-4172</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>SUMMARY</title>
<p id="P3">Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus replication. One substitution increased HA thermostability and lowered the pH of membrane fusion. Two substitutions independently changed HA binding preference from α2,3 linked to α2,6 linked sialic acid receptors. The loss of a glycosylation site in HA enhanced overall binding to receptors. The acquired substitutions emerged early during ferret passage as minor variants and became dominant rapidly. Identification of substitutions that are essential for airborne transmission of avian influenza viruses between ferrets and their associated phenotypes advances our fundamental understanding of virus transmission and will increase the value of future surveillance programs and public health risk assessments.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0413066</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2830</journal-id>
<journal-id journal-id-type="nlm-ta">Cell</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell</journal-id>
<journal-title-group><journal-title>Cell</journal-title>
</journal-title-group>
<issn pub-type="ppub">0092-8674</issn>
<issn pub-type="epub">1097-4172</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24725402</article-id>
<article-id pub-id-type="pmc">4003409</article-id>
<article-id pub-id-type="doi">10.1016/j.cell.2014.02.040</article-id>
<article-id pub-id-type="manuscript">NIHMS571565</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 virus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Linster</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">§</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Boheemen</surname>
<given-names>Sander</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">§</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Graaf</surname>
<given-names>Miranda</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schrauwen</surname>
<given-names>Eefje J. A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lexmond</surname>
<given-names>Pascal</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mänz</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bestebroer</surname>
<given-names>Theo M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baumann</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Riel</surname>
<given-names>Debby</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rimmelzwaan</surname>
<given-names>Guus F.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Osterhaus</surname>
<given-names>Albert D.M.E.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Matrosovich</surname>
<given-names>Mikhail</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fouchier</surname>
<given-names>Ron A. M.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Herfst</surname>
<given-names>Sander</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands</aff>
<aff id="A2"><label>2</label>
Institute of Virology, Philipps-University, 35043 Marburg, Germany</aff>
<author-notes><corresp id="FN1"><label>*</label>
corresponding author: <email>r.fouchier@erasmusmc.nl</email>
</corresp>
<fn id="FN2" fn-type="equal"><label>§</label>
<p>authors contributed equally to this work</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><day>10</day>
<month>4</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>4</month>
<year>2015</year>
</pub-date>
<volume>157</volume>
<issue>2</issue>
<fpage>329</fpage>
<lpage>339</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.cell.2014.02.040</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><title>SUMMARY</title>
<p id="P3">Recently, A/H5N1 influenza viruses were shown to acquire airborne transmissibility between ferrets upon targeted mutagenesis and virus passage. The critical genetic changes in airborne A/Indonesia/5/05 were not yet identified. Here, five substitutions proved to be sufficient to determine this airborne transmission phenotype. Substitutions in PB1 and PB2 collectively caused enhanced transcription and virus replication. One substitution increased HA thermostability and lowered the pH of membrane fusion. Two substitutions independently changed HA binding preference from α2,3 linked to α2,6 linked sialic acid receptors. The loss of a glycosylation site in HA enhanced overall binding to receptors. The acquired substitutions emerged early during ferret passage as minor variants and became dominant rapidly. Identification of substitutions that are essential for airborne transmission of avian influenza viruses between ferrets and their associated phenotypes advances our fundamental understanding of virus transmission and will increase the value of future surveillance programs and public health risk assessments.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000803 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000803 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |