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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model</title><author><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Korenkov, Daniil" sort="Korenkov, Daniil" uniqKey="Korenkov D" first="Daniil" last="Korenkov">Daniil Korenkov</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Smolonogina, Tatiana" sort="Smolonogina, Tatiana" uniqKey="Smolonogina T" first="Tatiana" last="Smolonogina">Tatiana Smolonogina</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Tretiak, Tatiana" sort="Tretiak, Tatiana" uniqKey="Tretiak T" first="Tatiana" last="Tretiak">Tatiana Tretiak</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Donina, Svetlana" sort="Donina, Svetlana" uniqKey="Donina S" first="Svetlana" last="Donina">Svetlana Donina</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Rekstin, Andrey" sort="Rekstin, Andrey" uniqKey="Rekstin A" first="Andrey" last="Rekstin">Andrey Rekstin</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Naykhin, Anatoly" sort="Naykhin, Anatoly" uniqKey="Naykhin A" first="Anatoly" last="Naykhin">Anatoly Naykhin</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Shcherbik, Svetlana" sort="Shcherbik, Svetlana" uniqKey="Shcherbik S" first="Svetlana" last="Shcherbik">Svetlana Shcherbik</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Pearce, Nicholas" sort="Pearce, Nicholas" uniqKey="Pearce N" first="Nicholas" last="Pearce">Nicholas Pearce</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Bousse, Tatiana" sort="Bousse, Tatiana" uniqKey="Bousse T" first="Tatiana" last="Bousse">Tatiana Bousse</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27829176</idno><idno type="pmc">5127729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127729</idno><idno type="RBID">PMC:5127729</idno><idno type="doi">10.1016/j.virol.2016.10.027</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000790</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000790</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model</title><author><name sortKey="Isakova Sivak, Irina" sort="Isakova Sivak, Irina" uniqKey="Isakova Sivak I" first="Irina" last="Isakova-Sivak">Irina Isakova-Sivak</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Korenkov, Daniil" sort="Korenkov, Daniil" uniqKey="Korenkov D" first="Daniil" last="Korenkov">Daniil Korenkov</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Smolonogina, Tatiana" sort="Smolonogina, Tatiana" uniqKey="Smolonogina T" first="Tatiana" last="Smolonogina">Tatiana Smolonogina</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Tretiak, Tatiana" sort="Tretiak, Tatiana" uniqKey="Tretiak T" first="Tatiana" last="Tretiak">Tatiana Tretiak</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Donina, Svetlana" sort="Donina, Svetlana" uniqKey="Donina S" first="Svetlana" last="Donina">Svetlana Donina</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Rekstin, Andrey" sort="Rekstin, Andrey" uniqKey="Rekstin A" first="Andrey" last="Rekstin">Andrey Rekstin</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Naykhin, Anatoly" sort="Naykhin, Anatoly" uniqKey="Naykhin A" first="Anatoly" last="Naykhin">Anatoly Naykhin</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author><author><name sortKey="Shcherbik, Svetlana" sort="Shcherbik, Svetlana" uniqKey="Shcherbik S" first="Svetlana" last="Shcherbik">Svetlana Shcherbik</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Pearce, Nicholas" sort="Pearce, Nicholas" uniqKey="Pearce N" first="Nicholas" last="Pearce">Nicholas Pearce</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Bousse, Tatiana" sort="Bousse, Tatiana" uniqKey="Bousse T" first="Tatiana" last="Bousse">Tatiana Bousse</name><affiliation><nlm:aff id="A2">Centers for Disease Control and Prevention, Atlanta, GA, USA</nlm:aff></affiliation></author><author><name sortKey="Rudenko, Larisa" sort="Rudenko, Larisa" uniqKey="Rudenko L" first="Larisa" last="Rudenko">Larisa Rudenko</name><affiliation><nlm:aff id="A1">Institute of Experimental Medicine, Saint Petersburg, Russia</nlm:aff></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6:2 (NP from MDV) and 5:3 (NP from wild-type virus) genome compositions were compared with regard to their growth characteristics, induction of humoral and cellular immune responses in mice, and ability to protect mice against homologous and heterologous challenge viruses. Although, in general, the 6:2 reassortant induced greater cell-mediated immunity in C57BL6 mice than the 5:3 vaccine, mice immunized with the 5:3 LAIV were better protected against heterologous challenge. The 5:3 LAIV-induced CTLs also had better <italic>in vivo</italic> killing activity against target cells loaded with the NP<sub>366</sub> epitope of recent influenza viruses. Modification of the genome of reassortant vaccine viruses by incorporating the NP gene from wild-type viruses represents a simple strategy to improve the immunogenicity and cross-protection of influenza vaccines.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id><journal-id journal-id-type="pubmed-jr-id">8015</journal-id><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27829176</article-id><article-id pub-id-type="pmc">5127729</article-id><article-id pub-id-type="doi">10.1016/j.virol.2016.10.027</article-id><article-id pub-id-type="manuscript">HHSPA830165</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Isakova-Sivak</surname><given-names>Irina</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="FN1">1</xref></contrib><contrib contrib-type="author"><name><surname>Korenkov</surname><given-names>Daniil</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="author-notes" rid="FN1">1</xref></contrib><contrib contrib-type="author"><name><surname>Smolonogina</surname><given-names>Tatiana</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Tretiak</surname><given-names>Tatiana</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Donina</surname><given-names>Svetlana</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Rekstin</surname><given-names>Andrey</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Naykhin</surname><given-names>Anatoly</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Shcherbik</surname><given-names>Svetlana</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Pearce</surname><given-names>Nicholas</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Li-Mei</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Bousse</surname><given-names>Tatiana</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Rudenko</surname><given-names>Larisa</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Institute of Experimental Medicine, Saint Petersburg, Russia</aff><aff id="A2"><label>b</label>Centers for Disease Control and Prevention, Atlanta, GA, USA</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Leading Researcher, Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street, Saint Petersburg 197376, Russia., <email>isakova.sivak@gmail.com</email> (I. Isakova-Sivak)</corresp><fn id="FN1" fn-type="equal"><label>1</label><p id="P1">these authors contributed equally to this work.</p></fn><fn fn-type="COI-statement" id="FN2"><p id="P43"><bold>Conflict of interest statement</bold></p><p id="P44">All the authors have declared that have no conflict of interest.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>17</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>6</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>1</month><year>2017</year></pub-date><volume>500</volume><fpage>209</fpage><lpage>217</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.virol.2016.10.027</pmc-comment>
<abstract><p id="P2">This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6:2 (NP from MDV) and 5:3 (NP from wild-type virus) genome compositions were compared with regard to their growth characteristics, induction of humoral and cellular immune responses in mice, and ability to protect mice against homologous and heterologous challenge viruses. Although, in general, the 6:2 reassortant induced greater cell-mediated immunity in C57BL6 mice than the 5:3 vaccine, mice immunized with the 5:3 LAIV were better protected against heterologous challenge. The 5:3 LAIV-induced CTLs also had better <italic>in vivo</italic> killing activity against target cells loaded with the NP<sub>366</sub> epitope of recent influenza viruses. Modification of the genome of reassortant vaccine viruses by incorporating the NP gene from wild-type viruses represents a simple strategy to improve the immunogenicity and cross-protection of influenza vaccines.</p></abstract><kwd-group><kwd>Live attenuated influenza vaccine</kwd><kwd>Nucleoprotein</kwd><kwd>Immunogenicity</kwd><kwd>Cell-mediated immunity</kwd><kwd>Cross-protection</kwd><kwd>Mouse model</kwd><kwd>Immunodominant epitope</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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