Transmission of Influenza A Viruses
Identifieur interne : 000789 ( Pmc/Corpus ); précédent : 000788; suivant : 000790Transmission of Influenza A Viruses
Auteurs : Gabriele Neumann ; Yoshihiro KawaokaSource :
- Virology [ 0042-6822 ] ; 2015.
Abstract
Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Widespread outbreaks (pandemics) are attributable to ‘novel’ viruses that possess a viral hemagglutinin (HA) gene to which humans lack immunity. After a pandemic, these novel viruses form stable virus lineages in humans and circulate until they are replaced by other novel viruses. The factors and mechanisms that facilitate virus transmission among hosts and the establishment of novel lineages are not completely understood, but the HA and basic polymerase 2 (PB2) proteins are thought to play essential roles in these processes by enabling avian influenza viruses to infect mammals and replicate efficiently in their new host. Here, we summarize our current knowledge of the contributions of HA, PB2, and other viral components to virus transmission and the formation of new virus lineages.
Url:
DOI: 10.1016/j.virol.2015.03.009
PubMed: 25812763
PubMed Central: 4424116
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<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id><journal-id journal-id-type="pubmed-jr-id">8015</journal-id><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25812763</article-id><article-id pub-id-type="pmc">4424116</article-id><article-id pub-id-type="doi">10.1016/j.virol.2015.03.009</article-id><article-id pub-id-type="manuscript">NIHMS675203</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Transmission of Influenza A Viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Neumann</surname><given-names>Gabriele</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA</aff><aff id="A2"><label>b</label>Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding Author. Tel.: +1 608 265 4925; fax: +1 608 265 5622 Address for correspondence: Influenza Research Institute, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711. <email>kawaokay@svm.vetmed.wisc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>24</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2016</year></pub-date><volume>0</volume><fpage>234</fpage><lpage>246</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.virol.2015.03.009</pmc-comment>
<permissions><copyright-statement>© 2015 Published by Elsevier Inc.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p id="P1">Influenza A viruses cause respiratory infections that range from asymptomatic to deadly in humans. Widespread outbreaks (pandemics) are attributable to ‘novel’ viruses that possess a viral hemagglutinin (HA) gene to which humans lack immunity. After a pandemic, these novel viruses form stable virus lineages in humans and circulate until they are replaced by other novel viruses. The factors and mechanisms that facilitate virus transmission among hosts and the establishment of novel lineages are not completely understood, but the HA and basic polymerase 2 (PB2) proteins are thought to play essential roles in these processes by enabling avian influenza viruses to infect mammals and replicate efficiently in their new host. Here, we summarize our current knowledge of the contributions of HA, PB2, and other viral components to virus transmission and the formation of new virus lineages.</p></abstract><kwd-group><kwd>Influenza virus</kwd><kwd>transmission</kwd><kwd>virus lineage</kwd><kwd>HA</kwd><kwd>PB2</kwd><kwd>NA</kwd><kwd>receptor-binding</kwd><kwd>gain-of-function</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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