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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children</title>
<author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thomas, Stephen J" sort="Thomas, Stephen J" uniqKey="Thomas S" first="Stephen J." last="Thomas">Stephen J. Thomas</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jarman, Richard G" sort="Jarman, Richard G" uniqKey="Jarman R" first="Richard G." last="Jarman">Richard G. Jarman</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rungrojcharoenkit, Kamonthip" sort="Rungrojcharoenkit, Kamonthip" uniqKey="Rungrojcharoenkit K" first="Kamonthip" last="Rungrojcharoenkit">Kamonthip Rungrojcharoenkit</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fernandez, Stefan" sort="Fernandez, Stefan" uniqKey="Fernandez S" first="Stefan" last="Fernandez">Stefan Fernandez</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buddhari, Darunee" sort="Buddhari, Darunee" uniqKey="Buddhari D" first="Darunee" last="Buddhari">Darunee Buddhari</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25141276</idno>
<idno type="pmc">4183906</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183906</idno>
<idno type="RBID">PMC:4183906</idno>
<idno type="doi">10.1089/vim.2014.0061</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000777</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000777</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children</title>
<author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thomas, Stephen J" sort="Thomas, Stephen J" uniqKey="Thomas S" first="Stephen J." last="Thomas">Stephen J. Thomas</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jarman, Richard G" sort="Jarman, Richard G" uniqKey="Jarman R" first="Richard G." last="Jarman">Richard G. Jarman</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rungrojcharoenkit, Kamonthip" sort="Rungrojcharoenkit, Kamonthip" uniqKey="Rungrojcharoenkit K" first="Kamonthip" last="Rungrojcharoenkit">Kamonthip Rungrojcharoenkit</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fernandez, Stefan" sort="Fernandez, Stefan" uniqKey="Fernandez S" first="Stefan" last="Fernandez">Stefan Fernandez</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yoon, In Kyu" sort="Yoon, In Kyu" uniqKey="Yoon I" first="In-Kyu" last="Yoon">In-Kyu Yoon</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buddhari, Darunee" sort="Buddhari, Darunee" uniqKey="Buddhari D" first="Darunee" last="Buddhari">Darunee Buddhari</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Viral Immunology</title>
<idno type="ISSN">0882-8245</idno>
<idno type="eISSN">1557-8976</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of cell-free virus by antibodies to hemagglutinin and interference of virus release from infected cells by antibodies to neuraminidase, influenza virus-specific antibodies specifically can bind to infected cells and lyse virus-infected cells through the activation of complement or natural killer (NK) cells, via antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent lysis (CDL). We evaluated preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection. Though both preexisting HAI and CDL antibodies were associated with protection against clinical influenza, our data suggested that CDL was not a better correlate than HAI. We found that ADCC antibodies behaved differently from HAI and CDL antibodies. Unlike HAI and CDL antibodies, preexisting ADCC antibodies did not correlate with protection against clinical influenza. In fact, ADCC antibodies were detected more frequently in the clinical influenza group than the subclinical group. In addition, in contrast to HAI and CDL antibodies, HAI and the ADCC antibodies titers did not correlate. We also found that ADCC, but not CDL or HAI antibodies, positively correlated with the ages of the children.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Viral Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Viral Immunol</journal-id>
<journal-id journal-id-type="publisher-id">vim</journal-id>
<journal-title-group><journal-title>Viral Immunology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0882-8245</issn>
<issn pub-type="epub">1557-8976</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25141276</article-id>
<article-id pub-id-type="pmc">4183906</article-id>
<article-id pub-id-type="publisher-id">10.1089/vim.2014.0061</article-id>
<article-id pub-id-type="doi">10.1089/vim.2014.0061</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Relationship of Preexisting Influenza Hemagglutination Inhibition, Complement-Dependent Lytic, and Antibody-Dependent Cellular Cytotoxicity Antibodies to the Development of Clinical Illness in a Prospective Study of A(H1N1)pdm09 Influenza in Children</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Co</surname>
<given-names>Mary Dawn T.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Terajima</surname>
<given-names>Masanori</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thomas</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jarman</surname>
<given-names>Richard G.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rungrojcharoenkit</surname>
<given-names>Kamonthip</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fernandez</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yoon</surname>
<given-names>In-Kyu</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buddhari</surname>
<given-names>Darunee</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cruz</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ennis</surname>
<given-names>Francis A.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Department of Medicine,<institution>University of Massachusetts Medical School</institution>
, Worcester, Massachusetts.</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
Viral Diseases Branch,<institution>Walter Reed Army Institute of Research</institution>
, Silver Spring, Maryland.</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Department of Virology,<institution>Armed Forces Research Institute of Medical Sciences</institution>
, Bangkok,<country>Thailand</country>
.</aff>
</contrib-group>
<author-notes><corresp><addr-line>Address correspondence to:</addr-line>
<addr-line><italic>Dr. Mary Dawn T. Co</italic>
</addr-line>
<institution><italic>University of Massachusetts Medical School</italic>
</institution>
<addr-line><italic>55 Lake Avenue North</italic>
</addr-line>
<addr-line><italic>Worcester, MA 01655</italic>
</addr-line>
<italic>E-mail:</italic>
<email xlink:href="mailto:mary.co@umassmed.edu">mary.co@umassmed.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>10</month>
<year>2014</year>
<pmc-comment>string-date: October 2014</pmc-comment>
</pub-date>
<volume>27</volume>
<issue>8</issue>
<fpage>375</fpage>
<lpage>382</lpage>
<permissions><copyright-statement>Copyright 2014, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="vim.2014.0061.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of cell-free virus by antibodies to hemagglutinin and interference of virus release from infected cells by antibodies to neuraminidase, influenza virus-specific antibodies specifically can bind to infected cells and lyse virus-infected cells through the activation of complement or natural killer (NK) cells, via antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent lysis (CDL). We evaluated preexisting HAI, CDL, and ADCC antibodies in young children enrolled in a prospective cohort study of dengue during the epidemic with influenza A(H1N1)pdm09 virus to determine associations between preexisting antibodies and the occurrence of clinical or subclinical influenza virus infection. Though both preexisting HAI and CDL antibodies were associated with protection against clinical influenza, our data suggested that CDL was not a better correlate than HAI. We found that ADCC antibodies behaved differently from HAI and CDL antibodies. Unlike HAI and CDL antibodies, preexisting ADCC antibodies did not correlate with protection against clinical influenza. In fact, ADCC antibodies were detected more frequently in the clinical influenza group than the subclinical group. In addition, in contrast to HAI and CDL antibodies, HAI and the ADCC antibodies titers did not correlate. We also found that ADCC, but not CDL or HAI antibodies, positively correlated with the ages of the children.</p>
</abstract>
<counts><fig-count count="4"></fig-count>
<table-count count="2"></table-count>
<ref-count count="30"></ref-count>
<page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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