Influenza, Immune System, and Pregnancy
Identifieur interne : 000769 ( Pmc/Corpus ); précédent : 000768; suivant : 000770Influenza, Immune System, and Pregnancy
Auteurs : Renju S. Raj ; Elizabeth A. Bonney ; Mark PhillippeSource :
- Reproductive Sciences [ 1933-7191 ] ; 2014.
Abstract
Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.
Url:
DOI: 10.1177/1933719114537720
PubMed: 24899469
PubMed Central: 4231130
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Reprod Sci</journal-id><journal-id journal-id-type="iso-abbrev">Reprod Sci</journal-id><journal-id journal-id-type="publisher-id">RSX</journal-id><journal-id journal-id-type="hwp">sprsx</journal-id><journal-title-group><journal-title>Reproductive Sciences</journal-title></journal-title-group><issn pub-type="ppub">1933-7191</issn><issn pub-type="epub">1933-7205</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage CA: Los Angeles, CA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24899469</article-id><article-id pub-id-type="pmc">4231130</article-id><article-id pub-id-type="doi">10.1177/1933719114537720</article-id><article-id pub-id-type="publisher-id">10.1177_1933719114537720</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Influenza, Immune System, and Pregnancy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Raj</surname><given-names>Renju S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-1933719114537720">1</xref></contrib><contrib contrib-type="author"><name><surname>Bonney</surname><given-names>Elizabeth A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1-1933719114537720">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Phillippe</surname><given-names>Mark</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff2-1933719114537720">2</xref><xref ref-type="corresp" rid="corresp1-1933719114537720"></xref></contrib></contrib-group><aff id="aff1-1933719114537720"><label>1</label>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, VT, USA</aff><aff id="aff2-1933719114537720"><label>2</label>Department of Obstetrics & Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA</aff><author-notes><corresp id="corresp1-1933719114537720">Mark Phillippe, Department of Obstetrics & Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Founders Bldg 520-A, Boston, MA 02114, USA. Email: <email>mphillippe@mgh.harvard.edu</email></corresp><fn fn-type="conflict" id="fn1-1933719114537720"><p><bold>Declaration of Conflicting Interests:</bold> The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.</p></fn></author-notes><pub-date pub-type="epub-ppub"><month>12</month><year>2014</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>21</volume><issue>12</issue><fpage>1434</fpage><lpage>1451</lpage><permissions><copyright-statement>© The Author(s) 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder content-type="society">Society for Gynecologic Investigation</copyright-holder></permissions><abstract><p>Influenza is a major health problem worldwide. Both seasonal influenza and pandemics take a major toll on the health and economy of our country. The present review focuses on the virology and complex immunology of this RNA virus in general and in relation to pregnancy. The goal is to attempt to explain the increased morbidity and mortality seen in infection during pregnancy. We discuss elements of innate and adaptive immunity as well as placental cellular responses to infection. In addition, we delineate findings in animal models as well as human disease. Increased knowledge of maternal and fetal immunologic responses to influenza is needed. However, enhanced understanding of nonimmune, pregnancy-specific factors influencing direct interaction of the virus with host cells is also important for the development of more effective prevention and treatment options in the future.</p></abstract><kwd-group><kwd>influenza</kwd><kwd>pregnancy</kwd><kwd>innate immunity</kwd><kwd>adaptive immunity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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