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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses</title><author><name sortKey="Sandbulte, Matthew R" sort="Sandbulte, Matthew R" uniqKey="Sandbulte M" first="Matthew R." last="Sandbulte">Matthew R. Sandbulte</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author><author><name sortKey="Westgeest, Kim B" sort="Westgeest, Kim B" uniqKey="Westgeest K" first="Kim B." last="Westgeest">Kim B. Westgeest</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author><author><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name><affiliation><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I." last="Klimov">Alexander I. Klimov</name><affiliation><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Burke, David F" sort="Burke, David F" uniqKey="Burke D" first="David F." last="Burke">David F. Burke</name><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22143798</idno><idno type="pmc">3251064</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251064</idno><idno type="RBID">PMC:3251064</idno><idno type="doi">10.1073/pnas.1113801108</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000753</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000753</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses</title><author><name sortKey="Sandbulte, Matthew R" sort="Sandbulte, Matthew R" uniqKey="Sandbulte M" first="Matthew R." last="Sandbulte">Matthew R. Sandbulte</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author><author><name sortKey="Westgeest, Kim B" sort="Westgeest, Kim B" uniqKey="Westgeest K" first="Kim B." last="Westgeest">Kim B. Westgeest</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Gao, Jin" sort="Gao, Jin" uniqKey="Gao J" first="Jin" last="Gao">Jin Gao</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author><author><name sortKey="Xu, Xiyan" sort="Xu, Xiyan" uniqKey="Xu X" first="Xiyan" last="Xu">Xiyan Xu</name><affiliation><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Klimov, Alexander I" sort="Klimov, Alexander I" uniqKey="Klimov A" first="Alexander I." last="Klimov">Alexander I. Klimov</name><affiliation><nlm:aff id="aff3">Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Russell, Colin A" sort="Russell, Colin A" uniqKey="Russell C" first="Colin A." last="Russell">Colin A. Russell</name><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Burke, David F" sort="Burke, David F" uniqKey="Burke D" first="David F." last="Burke">David F. Burke</name><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Smith, Derek J" sort="Smith, Derek J" uniqKey="Smith D" first="Derek J." last="Smith">Derek J. Smith</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff4">Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff5">Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation><nlm:aff id="aff2">Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</nlm:aff></affiliation></author><author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers and antigenic cartography. As previously shown for HA, genetic changes in NA did not always lead to an antigenic change. The noncontinuous pattern of NA drift did not correspond closely with HA drift in either subtype. Although NA drift was demonstrated using ferret sera, we show that these changes also impact recognition by NA-inhibiting antibodies in human sera. Remarkably, a single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains. These data underscore the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22143798</article-id><article-id pub-id-type="pmc">3251064</article-id><article-id pub-id-type="publisher-id">201113801</article-id><article-id pub-id-type="doi">10.1073/pnas.1113801108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Microbiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sandbulte</surname><given-names>Matthew R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Westgeest</surname><given-names>Kim B.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Jin</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Xiyan</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Klimov</surname><given-names>Alexander I.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Russell</surname><given-names>Colin A.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Burke</surname><given-names>David F.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Derek J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fouchier</surname><given-names>Ron A. M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Eichelberger</surname><given-names>Maryna C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>a</sup>Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>, Bethesda, MD 20892;</aff><aff id="aff2"><sup>b</sup>Department of Virology,<institution>Erasmus Medical Center</institution>, 3000 CA, Rotterdam,<country>The Netherlands</country>;</aff><aff id="aff3"><sup>c</sup>Influenza Division, National Center for Immunization and Respiratory Diseases,<institution>Centers for Disease Control and Prevention</institution>, Atlanta, GA 30333;</aff><aff id="aff4"><sup>d</sup>Department of Zoology,<institution>University of Cambridge</institution>, Cambridge CB2 3EJ,<country>United Kingdom</country>; and</aff><aff id="aff5"><sup>e</sup>Fogarty International Center,<institution>National Institutes of Health</institution>, Bethesda, MD 20892</aff></contrib-group><author-notes><corresp id="cor1"><sup>1</sup>To whom correspondence should be addressed. E-mail: <email>maryna.eichelberger@fda.hhs.gov</email>.</corresp><fn fn-type="edited-by"><p>Edited by Peter Palese, Mount Sinai School of Medicine, New York, NY, and approved November 8, 2011 (received for review August 23, 2011)</p></fn><fn fn-type="con"><p>Author contributions: M.R.S. and M.C.E. designed research; M.R.S., K.B.W., J.G., and M.C.E. performed research; X.X., A.I.K., D.J.S., and R.A.M.F. contributed new reagents/analytic tools; M.R.S., K.B.W., C.A.R., D.F.B., D.J.S., and R.A.M.F. analyzed data; and M.R.S., K.B.W., R.A.M.F., and M.C.E. wrote the paper.</p></fn><fn fn-type="conflict"><p>The authors declare no conflict of interest.</p></fn></author-notes><pub-date pub-type="ppub"><day>20</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>5</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>12</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>108</volume><issue>51</issue><fpage>20748</fpage><lpage>20753</lpage><permissions><license license-type="open-access"><license-p>Freely available online through the PNAS open access option.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="pnas.201113801.pdf"></self-uri><abstract><p>Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity. Antigenic drift is a feature of not only the hemagglutinin (HA), but also of neuraminidase (NA). We have evaluated the antigenic evolution of each protein in H1N1 and H3N2 viruses used in vaccine formulations during the last 15 y by analysis of HA and NA inhibition titers and antigenic cartography. As previously shown for HA, genetic changes in NA did not always lead to an antigenic change. The noncontinuous pattern of NA drift did not correspond closely with HA drift in either subtype. Although NA drift was demonstrated using ferret sera, we show that these changes also impact recognition by NA-inhibiting antibodies in human sera. Remarkably, a single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains. These data underscore the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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