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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model</title><author><name sortKey="Kimble, J Brian" sort="Kimble, J Brian" uniqKey="Kimble J" first="J. Brian" last="Kimble">J. Brian Kimble</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Sorrell, Erin" sort="Sorrell, Erin" uniqKey="Sorrell E" first="Erin" last="Sorrell">Erin Sorrell</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Martin, Philip L" sort="Martin, Philip L" uniqKey="Martin P" first="Philip L." last="Martin">Philip L. Martin</name><affiliation><nlm:aff id="aff2">Center for Advanced Preclinical Research,<institution>Science Applications International Corporation/National Cancer Institute</institution>, Frederick, MD 21702</nlm:aff></affiliation></author><author><name sortKey="Perez, Daniel Roberto" sort="Perez, Daniel Roberto" uniqKey="Perez D" first="Daniel Roberto" last="Perez">Daniel Roberto Perez</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21730147</idno><idno type="pmc">3141953</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141953</idno><idno type="RBID">PMC:3141953</idno><idno type="doi">10.1073/pnas.1108058108</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000751</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000751</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model</title><author><name sortKey="Kimble, J Brian" sort="Kimble, J Brian" uniqKey="Kimble J" first="J. Brian" last="Kimble">J. Brian Kimble</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Sorrell, Erin" sort="Sorrell, Erin" uniqKey="Sorrell E" first="Erin" last="Sorrell">Erin Sorrell</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author><author><name sortKey="Martin, Philip L" sort="Martin, Philip L" uniqKey="Martin P" first="Philip L." last="Martin">Philip L. Martin</name><affiliation><nlm:aff id="aff2">Center for Advanced Preclinical Research,<institution>Science Applications International Corporation/National Cancer Institute</institution>, Frederick, MD 21702</nlm:aff></affiliation></author><author><name sortKey="Perez, Daniel Roberto" sort="Perez, Daniel Roberto" uniqKey="Perez D" first="Daniel Roberto" last="Perez">Daniel Roberto Perez</name><affiliation><nlm:aff wicri:cut="; and" id="aff1">Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 2009, a novel H1N1 influenza (pH1N1) virus caused the first influenza pandemic in 40 y. The virus was identified as a triple reassortant between avian, swine, and human influenza viruses, highlighting the importance of reassortment in the generation of viruses with pandemic potential. Previously, we showed that a reassortant virus composed of wild-type avian H9N2 surface genes in a seasonal human H3N2 backbone could gain efficient respiratory droplet transmission in the ferret model. Here we determine the ability of the H9N2 surface genes in the context of the internal genes of a pH1N1 virus to efficiently transmit via respiratory droplets in ferrets. We generated reassorted viruses carrying the HA gene alone or in combination with the NA gene of a prototypical H9N2 virus in the background of a pH1N1 virus. Four reassortant viruses were generated, with three of them showing efficient respiratory droplet transmission. Differences in replication efficiency were observed for these viruses; however, the results clearly indicate that H9N2 avian influenza viruses and pH1N1 viruses, both of which have occasionally infected pigs, have the potential to reassort and generate novel viruses with respiratory transmission potential in mammals.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21730147</article-id><article-id pub-id-type="pmc">3141953</article-id><article-id pub-id-type="publisher-id">201108058</article-id><article-id pub-id-type="doi">10.1073/pnas.1108058108</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Microbiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kimble</surname><given-names>J. Brian</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sorrell</surname><given-names>Erin</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shao</surname><given-names>Hongxia</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Philip L.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Perez</surname><given-names>Daniel Roberto</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><sup>a</sup>Department of Veterinary Medicine,<institution>University of Maryland</institution>, College Park and Virginia-Maryland Regional College of Veterinary Medicine, College Park, MD 20742; and</aff><aff id="aff2"><sup>b</sup>Center for Advanced Preclinical Research,<institution>Science Applications International Corporation/National Cancer Institute</institution>, Frederick, MD 21702</aff></contrib-group><author-notes><corresp id="cor1"><sup>1</sup>To whom correspondence should be addressed. E-mail: <email>dperez1@umd.edu</email>.</corresp><fn fn-type="edited-by"><p>Edited by Peter Palese, Mount Sinai School of Medicine, New York, NY, and approved June 10, 2011 (received for review May 19, 2011)</p></fn><fn fn-type="con"><p>Author contributions: J.B.K., E.S., and D.R.P. designed research; J.B.K., E.S., H.S., and P.L.M. performed research; H.S. contributed new reagents/analytic tools; J.B.K., E.S., H.S., P.L.M., and D.R.P. analyzed data; and J.B.K., E.S., and D.R.P. wrote the paper.</p></fn><fn fn-type="conflict"><p>The authors declare no conflict of interest.</p></fn></author-notes><pub-date pub-type="ppub"><day>19</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>5</day><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>7</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>108</volume><issue>29</issue><fpage>12084</fpage><lpage>12088</lpage><permissions><license license-type="open-access"><license-p>Freely available online through the PNAS open access option.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="pnas.201108058.pdf"></self-uri><abstract><p>In 2009, a novel H1N1 influenza (pH1N1) virus caused the first influenza pandemic in 40 y. The virus was identified as a triple reassortant between avian, swine, and human influenza viruses, highlighting the importance of reassortment in the generation of viruses with pandemic potential. Previously, we showed that a reassortant virus composed of wild-type avian H9N2 surface genes in a seasonal human H3N2 backbone could gain efficient respiratory droplet transmission in the ferret model. Here we determine the ability of the H9N2 surface genes in the context of the internal genes of a pH1N1 virus to efficiently transmit via respiratory droplets in ferrets. We generated reassorted viruses carrying the HA gene alone or in combination with the NA gene of a prototypical H9N2 virus in the background of a pH1N1 virus. Four reassortant viruses were generated, with three of them showing efficient respiratory droplet transmission. Differences in replication efficiency were observed for these viruses; however, the results clearly indicate that H9N2 avian influenza viruses and pH1N1 viruses, both of which have occasionally infected pigs, have the potential to reassort and generate novel viruses with respiratory transmission potential in mammals.</p></abstract><kwd-group><kwd>TRIG cassette</kwd><kwd>preparedness</kwd><kwd>infection</kwd><kwd>pathology</kwd><kwd>ecology</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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