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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility</title><author><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A." last="Belser">Jessica A. Belser</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff2">Emory University, Atlanta, GA 30322</nlm:aff></affiliation></author><author><name sortKey="Blixt, Ola" sort="Blixt, Ola" uniqKey="Blixt O" first="Ola" last="Blixt">Ola Blixt</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Pappas, Claudia" sort="Pappas, Claudia" uniqKey="Pappas C" first="Claudia" last="Pappas">Claudia Pappas</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R." last="Maines">Taronna R. Maines</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Donis, Ruben" sort="Donis, Ruben" uniqKey="Donis R" first="Ruben" last="Donis">Ruben Donis</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Busch, Julia" sort="Busch, Julia" uniqKey="Busch J" first="Julia" last="Busch">Julia Busch</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Mcbride, Ryan" sort="Mcbride, Ryan" uniqKey="Mcbride R" first="Ryan" last="Mcbride">Ryan Mcbride</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C." last="Paulson">James C. Paulson</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18508975</idno><idno type="pmc">2396559</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396559</idno><idno type="RBID">PMC:2396559</idno><idno type="doi">10.1073/pnas.0801259105</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000744</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000744</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility</title><author><name sortKey="Belser, Jessica A" sort="Belser, Jessica A" uniqKey="Belser J" first="Jessica A." last="Belser">Jessica A. Belser</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut="; and" id="aff2">Emory University, Atlanta, GA 30322</nlm:aff></affiliation></author><author><name sortKey="Blixt, Ola" sort="Blixt, Ola" uniqKey="Blixt O" first="Ola" last="Blixt">Ola Blixt</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Chen, Li Mei" sort="Chen, Li Mei" uniqKey="Chen L" first="Li-Mei" last="Chen">Li-Mei Chen</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Pappas, Claudia" sort="Pappas, Claudia" uniqKey="Pappas C" first="Claudia" last="Pappas">Claudia Pappas</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Maines, Taronna R" sort="Maines, Taronna R" uniqKey="Maines T" first="Taronna R." last="Maines">Taronna R. Maines</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Van Hoeven, Neal" sort="Van Hoeven, Neal" uniqKey="Van Hoeven N" first="Neal" last="Van Hoeven">Neal Van Hoeven</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Donis, Ruben" sort="Donis, Ruben" uniqKey="Donis R" first="Ruben" last="Donis">Ruben Donis</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Busch, Julia" sort="Busch, Julia" uniqKey="Busch J" first="Julia" last="Busch">Julia Busch</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Mcbride, Ryan" sort="Mcbride, Ryan" uniqKey="Mcbride R" first="Ryan" last="Mcbride">Ryan Mcbride</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Paulson, James C" sort="Paulson, James C" uniqKey="Paulson J" first="James C." last="Paulson">James C. Paulson</name><affiliation><nlm:aff id="aff3">Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</nlm:aff></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author><author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name><affiliation><nlm:aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Avian H7 influenza viruses from both the Eurasian and North American lineage have caused outbreaks in poultry since 2002, with confirmed human infection occurring during outbreaks in The Netherlands, British Columbia, and the United Kingdom. The majority of H7 infections have resulted in self-limiting conjunctivitis, whereas probable human-to-human transmission has been rare. Here, we used glycan microarray technology to determine the receptor-binding preference of Eurasian and North American lineage H7 influenza viruses and their transmissibility in the ferret model. We found that highly pathogenic H7N7 viruses from The Netherlands in 2003 maintained the classic avian-binding preference for α2–3-linked sialic acids (SA) and are not readily transmissible in ferrets, as observed previously for highly pathogenic H5N1 viruses. However, H7N3 viruses isolated from Canada in 2004 and H7N2 viruses from the northeastern United States isolated in 2002–2003 possessed an HA with increased affinity toward α2–6-linked SA, the linkage type found prominently on human tracheal epithelial cells. We identified a low pathogenic H7N2 virus isolated from a man in New York in 2003, A/NY/107/03, which replicated efficiently in the upper respiratory tract of ferrets and was capable of transmission in this species by direct contact. These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="hwp">pnas</journal-id><journal-id journal-id-type="pmc">pnas</journal-id><journal-id journal-id-type="publisher-id">PNAS</journal-id><journal-title-group><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title></journal-title-group><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18508975</article-id><article-id pub-id-type="pmc">2396559</article-id><article-id pub-id-type="publisher-id">0365</article-id><article-id pub-id-type="doi">10.1073/pnas.0801259105</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Microbiology</subject></subj-group></subj-group></article-categories><title-group><article-title>Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Belser</surname><given-names>Jessica A.</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="aff" rid="aff2"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Blixt</surname><given-names>Ola</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Li-Mei</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Pappas</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Maines</surname><given-names>Taronna R.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Van Hoeven</surname><given-names>Neal</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Donis</surname><given-names>Ruben</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Busch</surname><given-names>Julia</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>McBride</surname><given-names>Ryan</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Paulson</surname><given-names>James C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>‡</sup></xref></contrib><contrib contrib-type="author"><name><surname>Katz</surname><given-names>Jacqueline M.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Tumpey</surname><given-names>Terrence M.</given-names></name><xref ref-type="aff" rid="aff1">*</xref><xref ref-type="corresp" rid="cor1"><sup>§</sup></xref></contrib><aff id="aff1">*Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333;</aff><aff id="aff2"><sup>†</sup>Emory University, Atlanta, GA 30322; and</aff><aff id="aff3"><sup>‡</sup>Departments of Physiological Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037</aff></contrib-group><author-notes><corresp id="cor1"><sup>§</sup>To whom correspondence should be addressed. E-mail: <email>tft9@cdc.gov</email></corresp><fn fn-type="edited-by"><p>Edited by Peter Palese, Mount Sinai School of Medicine, New York, NY, and approved March 21, 2008</p></fn><fn fn-type="con"><p>Author contributions: J.A.B., T.R.M., J.C.P., J.M.K., and T.M.T. designed research; J.A.B., O.B., C.P., T.R.M., N.V.H., J.B., and R.M. performed research; L.-M.C., R.D., and J.C.P. contributed new reagents/analytic tools; J.A.B., O.B., T.R.M., J.C.P., J.M.K., and T.M.T. analyzed data; and J.A.B., J.C.P., J.M.K., and T.M.T. wrote the paper.</p></fn><fn fn-type="conflict"><p>The authors declare no conflict of interest.</p></fn></author-notes><pub-date pub-type="ppub"><day>27</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>27</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>27</day><month>5</month><year>2008</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
epub date downloaded from Highwire. </pmc-comment>
<volume>105</volume><issue>21</issue><fpage>7558</fpage><lpage>7563</lpage><history><date date-type="received"><day>7</day><month>2</month><year>2008</year></date></history><permissions><copyright-statement>© 2008 by The National Academy of Sciences of the USA</copyright-statement><license license-type="open-access"><license-p>Freely available online through the PNAS open access option.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zpq02108007558.pdf"></self-uri><abstract><p>Avian H7 influenza viruses from both the Eurasian and North American lineage have caused outbreaks in poultry since 2002, with confirmed human infection occurring during outbreaks in The Netherlands, British Columbia, and the United Kingdom. The majority of H7 infections have resulted in self-limiting conjunctivitis, whereas probable human-to-human transmission has been rare. Here, we used glycan microarray technology to determine the receptor-binding preference of Eurasian and North American lineage H7 influenza viruses and their transmissibility in the ferret model. We found that highly pathogenic H7N7 viruses from The Netherlands in 2003 maintained the classic avian-binding preference for α2–3-linked sialic acids (SA) and are not readily transmissible in ferrets, as observed previously for highly pathogenic H5N1 viruses. However, H7N3 viruses isolated from Canada in 2004 and H7N2 viruses from the northeastern United States isolated in 2002–2003 possessed an HA with increased affinity toward α2–6-linked SA, the linkage type found prominently on human tracheal epithelial cells. We identified a low pathogenic H7N2 virus isolated from a man in New York in 2003, A/NY/107/03, which replicated efficiently in the upper respiratory tract of ferrets and was capable of transmission in this species by direct contact. These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals.</p></abstract><kwd-group><kwd>hemagglutinin</kwd><kwd>transmission</kwd><kwd>receptor binding</kwd><kwd>animal model</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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