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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structural and Molecular Characterization of the Hemagglutinin from the Fifth-Epidemic-Wave A(H7N9) Influenza Viruses</title><author><name sortKey="Yang, Hua" sort="Yang, Hua" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Carney, Paul J" sort="Carney, Paul J" uniqKey="Carney P" first="Paul J." last="Carney">Paul J. Carney</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Chang, Jessie C" sort="Chang, Jessie C" uniqKey="Chang J" first="Jessie C." last="Chang">Jessie C. Chang</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Zhu" sort="Guo, Zhu" uniqKey="Guo Z" first="Zhu" last="Guo">Zhu Guo</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29848588</idno><idno type="pmc">6069181</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069181</idno><idno type="RBID">PMC:6069181</idno><idno type="doi">10.1128/JVI.00375-18</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000704</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000704</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structural and Molecular Characterization of the Hemagglutinin from the Fifth-Epidemic-Wave A(H7N9) Influenza Viruses</title><author><name sortKey="Yang, Hua" sort="Yang, Hua" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Carney, Paul J" sort="Carney, Paul J" uniqKey="Carney P" first="Paul J." last="Carney">Paul J. Carney</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Chang, Jessie C" sort="Chang, Jessie C" uniqKey="Chang J" first="Jessie C." last="Chang">Jessie C. Chang</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Guo, Zhu" sort="Guo, Zhu" uniqKey="Guo Z" first="Zhu" last="Guo">Zhu Guo</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Stevens, James" sort="Stevens, James" uniqKey="Stevens J" first="James" last="Stevens">James Stevens</name><affiliation><nlm:aff id="aff1">Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The A(H7N9) viruses circulating in China are of great public health concern. Here, we report a molecular and structural study of the major surface proteins from several recent A(H7N9) influenza viruses. Our results improve the understanding of these evolving viruses and provide important information on their receptor preference that is central to ongoing pandemic risk assessment.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29848588</article-id><article-id pub-id-type="pmc">6069181</article-id><article-id pub-id-type="publisher-id">00375-18</article-id><article-id pub-id-type="doi">10.1128/JVI.00375-18</article-id><article-categories><subj-group subj-group-type="heading"><subject>Structure and Assembly</subject></subj-group><subj-group subj-group-type="editorial-class"><subject>Spotlight</subject></subj-group></article-categories><title-group><article-title>Structural and Molecular Characterization of the Hemagglutinin from the Fifth-Epidemic-Wave A(H7N9) Influenza Viruses</article-title><alt-title alt-title-type="running-head">Fifth-Wave A(H7N9) Hemagglutinins</alt-title><alt-title alt-title-type="short-authors">Yang et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Hua</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Carney</surname><given-names>Paul J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Jessie C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Zhu</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Stevens</surname><given-names>James</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Williams</surname><given-names>Bryan R. G.</given-names></name><role>Editor</role><aff>Hudson Institute of Medical Research</aff></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to James Stevens, <email>fwb4@cdc.gov</email>.</corresp><fn fn-type="other"><p><bold>Citation</bold> Yang H, Carney PJ, Chang JC, Guo Z, Stevens J. 2018. Structural and molecular characterization of the hemagglutinin from the fifth-epidemic-wave A(H7N9) influenza viruses. J Virol 92:e00375-18. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/JVI.00375-18">https://doi.org/10.1128/JVI.00375-18</ext-link>.</p></fn></author-notes><pub-date pub-type="epreprint"><day>30</day><month>5</month><year>2018</year></pub-date><pub-date pub-type="epub"><day>31</day><month>7</month><year>2018</year></pub-date><pub-date pub-type="collection"><day>15</day><month>8</month><year>2018</year></pub-date><volume>92</volume><issue>16</issue><elocation-id>e00375-18</elocation-id><history><date date-type="received"><day>5</day><month>3</month><year>2018</year></date><date date-type="accepted"><day>22</day><month>5</month><year>2018</year></date></history><permissions><copyright-statement>This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.</copyright-statement></permissions><self-uri content-type="pdf" xlink:href="zjv016183748001.pdf"></self-uri><abstract abstract-type="precis"><p>The A(H7N9) viruses circulating in China are of great public health concern. Here, we report a molecular and structural study of the major surface proteins from several recent A(H7N9) influenza viruses. Our results improve the understanding of these evolving viruses and provide important information on their receptor preference that is central to ongoing pandemic risk assessment.</p></abstract><abstract><title>ABSTRACT</title><p>The avian influenza A(H7N9) virus continues to cause human infections in China and is a major ongoing public health concern. Five epidemic waves of A(H7N9) infection have occurred since 2013, and the recent fifth epidemic wave saw the emergence of two distinct lineages with elevated numbers of human infection cases and broader geographic distribution of viral diseases compared to the first four epidemic waves. Moreover, highly pathogenic avian influenza (HPAI) A(H7N9) viruses were also isolated during the fifth epidemic wave. Here, we present a detailed structural and biochemical analysis of the surface hemagglutinin (HA) antigen from viruses isolated during this recent epidemic wave. Results highlight that, compared to the 2013 virus HAs, the fifth-wave virus HAs remained a weak binder to human glycan receptor analogs. We also studied three mutations, V177K-K184T-G219S, that were recently reported to switch a 2013 A(H7N9) HA to human-type receptor specificity. Our results indicate that these mutations could also switch the H7 HA receptor preference to a predominantly human binding specificity for both fifth-wave H7 HAs analyzed in this study.</p><p><bold>IMPORTANCE</bold> The A(H7N9) viruses circulating in China are of great public health concern. Here, we report a molecular and structural study of the major surface proteins from several recent A(H7N9) influenza viruses. Our results improve the understanding of these evolving viruses and provide important information on their receptor preference that is central to ongoing pandemic risk assessment.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>A(H7N9)</kwd><kwd>receptor binding</kwd><kwd>glycan array</kwd><kwd>A(H7N9)</kwd><kwd>hemagglutinin</kwd></kwd-group><funding-group><award-group id="award1"><funding-source id="gs1"><institution-wrap><institution>HHS | Centers for Disease Control and Prevention (CDC)</institution><institution-id>https://doi.org/10.13039/100000030</institution-id></institution-wrap></funding-source><principal-award-recipient><name><surname>Yang</surname><given-names>Hua</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>Carney</surname><given-names>Paul</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>Chang</surname><given-names>Jessie C.</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>Guo</surname><given-names>Zhu</given-names></name></principal-award-recipient><principal-award-recipient><name><surname>Stevens</surname><given-names>James</given-names></name></principal-award-recipient></award-group></funding-group><counts><fig-count count="6"></fig-count><table-count count="3"></table-count><equation-count count="0"></equation-count><ref-count count="53"></ref-count><page-count count="16"></page-count><word-count count="8824"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>August 2018</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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