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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques</title><author><name sortKey="Jegaskanda, Sinthujan" sort="Jegaskanda, Sinthujan" uniqKey="Jegaskanda S" first="Sinthujan" last="Jegaskanda">Sinthujan Jegaskanda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Amarasena, Thakshila H" sort="Amarasena, Thakshila H" uniqKey="Amarasena T" first="Thakshila H." last="Amarasena">Thakshila H. Amarasena</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Laurie, Karen L" sort="Laurie, Karen L" uniqKey="Laurie K" first="Karen L." last="Laurie">Karen L. Laurie</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Tan, Hyon Xhi" sort="Tan, Hyon Xhi" uniqKey="Tan H" first="Hyon-Xhi" last="Tan">Hyon-Xhi Tan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Butler, Jeff" sort="Butler, Jeff" uniqKey="Butler J" first="Jeff" last="Butler">Jeff Butler</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Parsons, Matthew S" sort="Parsons, Matthew S" uniqKey="Parsons M" first="Matthew S." last="Parsons">Matthew S. Parsons</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alcantara, Sheilajen" sort="Alcantara, Sheilajen" uniqKey="Alcantara S" first="Sheilajen" last="Alcantara">Sheilajen Alcantara</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Petravic, Janka" sort="Petravic, Janka" uniqKey="Petravic J" first="Janka" last="Petravic">Janka Petravic</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Davenport, Miles P" sort="Davenport, Miles P" uniqKey="Davenport M" first="Miles P." last="Davenport">Miles P. Davenport</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24109221</idno><idno type="pmc">3838265</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838265</idno><idno type="RBID">PMC:3838265</idno><idno type="doi">10.1128/JVI.01666-13</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000673</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000673</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques</title><author><name sortKey="Jegaskanda, Sinthujan" sort="Jegaskanda, Sinthujan" uniqKey="Jegaskanda S" first="Sinthujan" last="Jegaskanda">Sinthujan Jegaskanda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Amarasena, Thakshila H" sort="Amarasena, Thakshila H" uniqKey="Amarasena T" first="Thakshila H." last="Amarasena">Thakshila H. Amarasena</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Laurie, Karen L" sort="Laurie, Karen L" uniqKey="Laurie K" first="Karen L." last="Laurie">Karen L. Laurie</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Tan, Hyon Xhi" sort="Tan, Hyon Xhi" uniqKey="Tan H" first="Hyon-Xhi" last="Tan">Hyon-Xhi Tan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Butler, Jeff" sort="Butler, Jeff" uniqKey="Butler J" first="Jeff" last="Butler">Jeff Butler</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Parsons, Matthew S" sort="Parsons, Matthew S" uniqKey="Parsons M" first="Matthew S." last="Parsons">Matthew S. Parsons</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Alcantara, Sheilajen" sort="Alcantara, Sheilajen" uniqKey="Alcantara S" first="Sheilajen" last="Alcantara">Sheilajen Alcantara</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Petravic, Janka" sort="Petravic, Janka" uniqKey="Petravic J" first="Janka" last="Petravic">Janka Petravic</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Davenport, Miles P" sort="Davenport, Miles P" uniqKey="Davenport M" first="Miles P." last="Davenport">Miles P. Davenport</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Reading, Patrick C" sort="Reading, Patrick C" uniqKey="Reading P" first="Patrick C." last="Reading">Patrick C. Reading</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Yearly vaccination with the trivalent inactivated influenza vaccine (TIV) is recommended, since current vaccines induce little cross neutralization to divergent influenza strains. Whether the TIV can induce antibody-dependent cellular cytotoxicity (ADCC) responses that can cross-recognize divergent influenza virus strains is unknown. We immunized 6 influenza-naive pigtail macaques twice with the 2011–2012 season TIV and then challenged the macaques, along with 12 control macaques, serially with H1N1 and H3N2 viruses. We measured ADCC responses in plasma to a panel of H1 and H3 hemagglutinin (HA) proteins and influenza virus-specific CD8 T cell (CTL) responses using a sensitive major histocompatibility complex (MHC) tetramer reagent. The TIV was weakly immunogenic and, although binding antibodies were detected by enzyme-linked immunosorbent assay (ELISA), did not induce detectable influenza virus-specific ADCC or CTL responses. The H1N1 challenge elicited robust ADCC to both homologous and heterologous H1 HA proteins, but not influenza virus HA proteins from different subtypes (H2 to H7). There was no anamnestic influenza virus-specific ADCC or CTL response in vaccinated animals. The subsequent H3N2 challenge did not induce or boost ADCC either to H1 HA proteins or to divergent H3 proteins but did boost CTL responses. ADCC or CTL responses were not induced by TIV vaccination in influenza-naive macaques. There was a marked difference in the ability of infection compared to that of vaccination to induce cross-reactive ADCC and CTL responses. Improved vaccination strategies are needed to induce broad-based ADCC immunity to influenza.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24109221</article-id><article-id pub-id-type="pmc">3838265</article-id><article-id pub-id-type="publisher-id">01666-13</article-id><article-id pub-id-type="doi">10.1128/JVI.01666-13</article-id><article-categories><subj-group subj-group-type="heading"><subject>Vaccines and Antiviral Agents</subject></subj-group></article-categories><title-group><article-title>Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jegaskanda</surname><given-names>Sinthujan</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Amarasena</surname><given-names>Thakshila H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Laurie</surname><given-names>Karen L.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>Hyon-Xhi</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Butler</surname><given-names>Jeff</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Parsons</surname><given-names>Matthew S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alcantara</surname><given-names>Sheilajen</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Petravic</surname><given-names>Janka</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Davenport</surname><given-names>Miles P.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hurt</surname><given-names>Aeron C.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reading</surname><given-names>Patrick C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kent</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1">Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia<label>a</label></aff><aff id="aff2">WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, North Melbourne, Victoria, Australia<label>b</label></aff><aff id="aff3">Centre for Vascular Research, University of New South Wales, NSW, Australia<label>c</label></aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to Stephen J. Kent, <email>skent@unimelb.edu.au</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2013</year></pub-date><volume>87</volume><issue>24</issue><fpage>13706</fpage><lpage>13718</lpage><history><date date-type="received"><day>18</day><month>6</month><year>2013</year></date><date date-type="accepted"><day>2</day><month>10</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv02413013706.pdf"></self-uri><abstract><p>Yearly vaccination with the trivalent inactivated influenza vaccine (TIV) is recommended, since current vaccines induce little cross neutralization to divergent influenza strains. Whether the TIV can induce antibody-dependent cellular cytotoxicity (ADCC) responses that can cross-recognize divergent influenza virus strains is unknown. We immunized 6 influenza-naive pigtail macaques twice with the 2011–2012 season TIV and then challenged the macaques, along with 12 control macaques, serially with H1N1 and H3N2 viruses. We measured ADCC responses in plasma to a panel of H1 and H3 hemagglutinin (HA) proteins and influenza virus-specific CD8 T cell (CTL) responses using a sensitive major histocompatibility complex (MHC) tetramer reagent. The TIV was weakly immunogenic and, although binding antibodies were detected by enzyme-linked immunosorbent assay (ELISA), did not induce detectable influenza virus-specific ADCC or CTL responses. The H1N1 challenge elicited robust ADCC to both homologous and heterologous H1 HA proteins, but not influenza virus HA proteins from different subtypes (H2 to H7). There was no anamnestic influenza virus-specific ADCC or CTL response in vaccinated animals. The subsequent H3N2 challenge did not induce or boost ADCC either to H1 HA proteins or to divergent H3 proteins but did boost CTL responses. ADCC or CTL responses were not induced by TIV vaccination in influenza-naive macaques. There was a marked difference in the ability of infection compared to that of vaccination to induce cross-reactive ADCC and CTL responses. Improved vaccination strategies are needed to induce broad-based ADCC immunity to influenza.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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