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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses</title><author><name sortKey="Mahallawi, Waleed H" sort="Mahallawi, Waleed H" uniqKey="Mahallawi W" first="Waleed H." last="Mahallawi">Waleed H. Mahallawi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kasbekar, Anand V" sort="Kasbekar, Anand V" uniqKey="Kasbekar A" first="Anand V." last="Kasbekar">Anand V. Kasbekar</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mccormick, Maxwell S" sort="Mccormick, Maxwell S" uniqKey="Mccormick M" first="Maxwell S." last="Mccormick">Maxwell S. Mccormick</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hoschler, Katja" sort="Hoschler, Katja" uniqKey="Hoschler K" first="Katja" last="Hoschler">Katja Hoschler</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Leong, Samuel C" sort="Leong, Samuel C" uniqKey="Leong S" first="Samuel C." last="Leong">Samuel C. Leong</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Beer, Helen" sort="Beer, Helen" uniqKey="Beer H" first="Helen" last="Beer">Helen Beer</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ferrara, Francesca" sort="Ferrara, Francesca" uniqKey="Ferrara F" first="Francesca" last="Ferrara">Francesca Ferrara</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Mcnamara, Paul S" sort="Mcnamara, Paul S" uniqKey="Mcnamara P" first="Paul S." last="Mcnamara">Paul S. Mcnamara</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Qibo" sort="Zhang, Qibo" uniqKey="Zhang Q" first="Qibo" last="Zhang">Qibo Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23468498</idno><idno type="pmc">3648155</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648155</idno><idno type="RBID">PMC:3648155</idno><idno type="doi">10.1128/JVI.03547-12</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000664</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses</title><author><name sortKey="Mahallawi, Waleed H" sort="Mahallawi, Waleed H" uniqKey="Mahallawi W" first="Waleed H." last="Mahallawi">Waleed H. Mahallawi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kasbekar, Anand V" sort="Kasbekar, Anand V" uniqKey="Kasbekar A" first="Anand V." last="Kasbekar">Anand V. Kasbekar</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Mccormick, Maxwell S" sort="Mccormick, Maxwell S" uniqKey="Mccormick M" first="Maxwell S." last="Mccormick">Maxwell S. Mccormick</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hoschler, Katja" sort="Hoschler, Katja" uniqKey="Hoschler K" first="Katja" last="Hoschler">Katja Hoschler</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Temperton, Nigel" sort="Temperton, Nigel" uniqKey="Temperton N" first="Nigel" last="Temperton">Nigel Temperton</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Leong, Samuel C" sort="Leong, Samuel C" uniqKey="Leong S" first="Samuel C." last="Leong">Samuel C. Leong</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Beer, Helen" sort="Beer, Helen" uniqKey="Beer H" first="Helen" last="Beer">Helen Beer</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ferrara, Francesca" sort="Ferrara, Francesca" uniqKey="Ferrara F" first="Francesca" last="Ferrara">Francesca Ferrara</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Mcnamara, Paul S" sort="Mcnamara, Paul S" uniqKey="Mcnamara P" first="Paul S." last="Mcnamara">Paul S. Mcnamara</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Qibo" sort="Zhang, Qibo" uniqKey="Zhang Q" first="Qibo" last="Zhang">Qibo Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza is a highly contagious mucosal infection in the respiratory tract. The 2009 pandemic H1N1 (pH1N1) influenza virus infection resulted in substantial morbidity and mortality in humans. Little is known on whether immunological memory develops following pH1N1 infection and whether it provides protection against other virus subtypes. An enzyme-linked immunosorbent spot assay was used to analyze hemagglutinin (HA)-specific memory B cell responses after virus antigen stimulation in nose-associated lymphoid tissues (NALT) from children and adults. Individuals with serological evidence of previous exposure to pH1N1 showed significant cross-reactive HA-specific memory B cell responses to pH1N1, seasonal H1N1 (sH1N1), and avian H5N1 (aH5N1) viruses upon pH1N1 virus stimulation. pH1N1 virus antigen elicited stronger cross-reactive memory B cell responses than sH1N1 virus. Intriguingly, aH5N1 virus also activated cross-reactive memory responses to sH1N1 and pH1N1 HAs in those who had previous pH1N1 exposure, and that correlated well with the memory response stimulated by pH1N1 virus antigen. These memory B cell responses resulted in cross-reactive neutralizing antibodies against sH1N1, 1918 H1N1, and aH5N1 viruses. The 2009 pH1N1 infection appeared to have primed human host with B cell memory in NALT that offers cross-protective mucosal immunity to not only H1N1 but also aH5N1 viruses. These findings may have important implications for future vaccination strategies against influenza. It will be important to induce and/or enhance such cross-protective mucosal memory B cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23468498</article-id><article-id pub-id-type="pmc">3648155</article-id><article-id pub-id-type="publisher-id">03547-12</article-id><article-id pub-id-type="doi">10.1128/JVI.03547-12</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cellular Response to Infection</subject></subj-group></article-categories><title-group><article-title>Infection with 2009 H1N1 Influenza Virus Primes for Immunological Memory in Human Nose-Associated Lymphoid Tissue, Offering Cross-Reactive Immunity to H1N1 and Avian H5N1 Viruses</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mahallawi</surname><given-names>Waleed H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kasbekar</surname><given-names>Anand V.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>McCormick</surname><given-names>Maxwell S.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hoschler</surname><given-names>Katja</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><name><surname>Temperton</surname><given-names>Nigel</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Leong</surname><given-names>Samuel C.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Beer</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferrara</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>McNamara</surname><given-names>Paul S.</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Zhang</surname><given-names>Qibo</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1">Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom<label>a</label></aff><aff id="aff2">ENT Department, Alder Hey Children's Hospital, Liverpool, United Kingdom<label>b</label></aff><aff id="aff3">ENT Department, Royal Liverpool University Hospital, Liverpool, United Kingdom<label>c</label></aff><aff id="aff4">Respiratory Virus Unit, Health Protection Agency, London, United Kingdom<label>d</label></aff><aff id="aff5">Viral Pseudotype Unit, School of Pharmacy, University of Kent, Kent, United Kingdom<label>e</label></aff><aff id="aff6">Institute of Child Health, University of Liverpool, Liverpool, United Kingdom<label>f</label></aff></contrib-group><author-notes><corresp>Address correspondence to Qibo Zhang, <email>qibo.zhang@liv.ac.uk</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>5</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>87</volume><issue>10</issue><fpage>5331</fpage><lpage>5339</lpage><history><date date-type="received"><day>25</day><month>12</month><year>2012</year></date><date date-type="accepted"><day>28</day><month>2</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder><license license-type="open-access"><license-p>The authors have paid a fee to allow immediate free access to this article.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv01013005331.pdf"></self-uri><abstract><p>Influenza is a highly contagious mucosal infection in the respiratory tract. The 2009 pandemic H1N1 (pH1N1) influenza virus infection resulted in substantial morbidity and mortality in humans. Little is known on whether immunological memory develops following pH1N1 infection and whether it provides protection against other virus subtypes. An enzyme-linked immunosorbent spot assay was used to analyze hemagglutinin (HA)-specific memory B cell responses after virus antigen stimulation in nose-associated lymphoid tissues (NALT) from children and adults. Individuals with serological evidence of previous exposure to pH1N1 showed significant cross-reactive HA-specific memory B cell responses to pH1N1, seasonal H1N1 (sH1N1), and avian H5N1 (aH5N1) viruses upon pH1N1 virus stimulation. pH1N1 virus antigen elicited stronger cross-reactive memory B cell responses than sH1N1 virus. Intriguingly, aH5N1 virus also activated cross-reactive memory responses to sH1N1 and pH1N1 HAs in those who had previous pH1N1 exposure, and that correlated well with the memory response stimulated by pH1N1 virus antigen. These memory B cell responses resulted in cross-reactive neutralizing antibodies against sH1N1, 1918 H1N1, and aH5N1 viruses. The 2009 pH1N1 infection appeared to have primed human host with B cell memory in NALT that offers cross-protective mucosal immunity to not only H1N1 but also aH5N1 viruses. These findings may have important implications for future vaccination strategies against influenza. It will be important to induce and/or enhance such cross-protective mucosal memory B cells.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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