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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Priming with H1N1 Influenza Viruses of Variable Antigenic Distances on Challenge with 2009 Pandemic H1N1 Virus</title><author><name sortKey="O Donnell, Christopher D" sort="O Donnell, Christopher D" uniqKey="O Donnell C" first="Christopher D." last="O'Donnell">Christopher D. O'Donnell</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Wright, Amber" sort="Wright, Amber" uniqKey="Wright A" first="Amber" last="Wright">Amber Wright</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Vogel, Leatrice N" sort="Vogel, Leatrice N" uniqKey="Vogel L" first="Leatrice N." last="Vogel">Leatrice N. Vogel</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Wei, Chih Jen" sort="Wei, Chih Jen" uniqKey="Wei C" first="Chih-Jen" last="Wei">Chih-Jen Wei</name><affiliation><nlm:aff id="aff2">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J." last="Nabel">Gary J. Nabel</name><affiliation><nlm:aff id="aff2">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22674976</idno><idno type="pmc">3421718</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421718</idno><idno type="RBID">PMC:3421718</idno><idno type="doi">10.1128/JVI.00147-12</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000649</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Priming with H1N1 Influenza Viruses of Variable Antigenic Distances on Challenge with 2009 Pandemic H1N1 Virus</title><author><name sortKey="O Donnell, Christopher D" sort="O Donnell, Christopher D" uniqKey="O Donnell C" first="Christopher D." last="O'Donnell">Christopher D. O'Donnell</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Wright, Amber" sort="Wright, Amber" uniqKey="Wright A" first="Amber" last="Wright">Amber Wright</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Vogel, Leatrice N" sort="Vogel, Leatrice N" uniqKey="Vogel L" first="Leatrice N." last="Vogel">Leatrice N. Vogel</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author><author><name sortKey="Wei, Chih Jen" sort="Wei, Chih Jen" uniqKey="Wei C" first="Chih-Jen" last="Wei">Chih-Jen Wei</name><affiliation><nlm:aff id="aff2">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J." last="Nabel">Gary J. Nabel</name><affiliation><nlm:aff id="aff2">Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Compared to seasonal influenza viruses, the 2009 pandemic H1N1 (pH1N1) virus caused greater morbidity and mortality in children and young adults. People over 60 years of age showed a higher prevalence of cross-reactive pH1N1 antibodies, suggesting that they were previously exposed to an influenza virus or vaccine that was antigenically related to the pH1N1 virus. To define the basis for this cross-reactivity, ferrets were infected with H1N1 viruses of variable antigenic distance that circulated during different decades from the 1930s (Alaska/35), 1940s (Fort Monmouth/47), 1950s (Fort Warren/50), and 1990s (New Caledonia/99) and challenged with 2009 pH1N1 virus 6 weeks later. Ferrets primed with the homologous CA/09 or New Jersey/76 (NJ/76) virus served as a positive control, while the negative control was an influenza B virus that should not cross-protect against influenza A virus infection. Significant protection against challenge virus replication in the respiratory tract was observed in ferrets primed with AK/35, FM/47, and NJ/76; FW/50-primed ferrets showed reduced protection, and NC/99-primed ferrets were not protected. The hemagglutinins (HAs) of AK/35, FM/47, and FW/50 differ in the presence of glycosylation sites. We found that the loss of protective efficacy observed with FW/50 was associated with the presence of a specific glycosylation site. Our results suggest that changes in the HA occurred between 1947 and 1950, such that prior infection could no longer protect against 2009 pH1N1 infection. This provides a mechanistic understanding of the nature of serological cross-protection observed in people over 60 years of age during the 2009 H1N1 pandemic.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22674976</article-id><article-id pub-id-type="pmc">3421718</article-id><article-id pub-id-type="publisher-id">00147-12</article-id><article-id pub-id-type="doi">10.1128/JVI.00147-12</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Effect of Priming with H1N1 Influenza Viruses of Variable Antigenic Distances on Challenge with 2009 Pandemic H1N1 Virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>O'Donnell</surname><given-names>Christopher D.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Amber</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Vogel</surname><given-names>Leatrice N.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Chih-Jen</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nabel</surname><given-names>Gary J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label>Laboratory of Infectious Diseases</aff><aff id="aff2"><label>b</label>Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA</aff></contrib-group><author-notes><corresp>Address correspondence to K. Subbarao, <email>ksubbarao@niaid.nih.gov</email>.</corresp><fn id="FN1" fn-type="present-address"><label>*</label><p>Present address: A. Wright, NIEHS Microarray Group, Research Triangle Park, North Carolina, USA.</p></fn></author-notes><pub-date pub-type="ppub"><month>8</month><year>2012</year></pub-date><volume>86</volume><issue>16</issue><fpage>8625</fpage><lpage>8633</lpage><history><date date-type="received"><day>18</day><month>1</month><year>2012</year></date><date date-type="accepted"><day>22</day><month>5</month><year>2012</year></date></history><permissions><copyright-statement>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv01612008625.pdf"></self-uri><abstract><p>Compared to seasonal influenza viruses, the 2009 pandemic H1N1 (pH1N1) virus caused greater morbidity and mortality in children and young adults. People over 60 years of age showed a higher prevalence of cross-reactive pH1N1 antibodies, suggesting that they were previously exposed to an influenza virus or vaccine that was antigenically related to the pH1N1 virus. To define the basis for this cross-reactivity, ferrets were infected with H1N1 viruses of variable antigenic distance that circulated during different decades from the 1930s (Alaska/35), 1940s (Fort Monmouth/47), 1950s (Fort Warren/50), and 1990s (New Caledonia/99) and challenged with 2009 pH1N1 virus 6 weeks later. Ferrets primed with the homologous CA/09 or New Jersey/76 (NJ/76) virus served as a positive control, while the negative control was an influenza B virus that should not cross-protect against influenza A virus infection. Significant protection against challenge virus replication in the respiratory tract was observed in ferrets primed with AK/35, FM/47, and NJ/76; FW/50-primed ferrets showed reduced protection, and NC/99-primed ferrets were not protected. The hemagglutinins (HAs) of AK/35, FM/47, and FW/50 differ in the presence of glycosylation sites. We found that the loss of protective efficacy observed with FW/50 was associated with the presence of a specific glycosylation site. Our results suggest that changes in the HA occurred between 1947 and 1950, such that prior infection could no longer protect against 2009 pH1N1 infection. This provides a mechanistic understanding of the nature of serological cross-protection observed in people over 60 years of age during the 2009 H1N1 pandemic.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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