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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses</title>
<author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name>
<affiliation><nlm:aff id="aff6">Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J." last="Huffman">Chelsey J. Huffman</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L." last="Blum">David L. Blum</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Medicine, Division of Infectious Diseases</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Medicine, Division of Infectious Diseases</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22457520</idno>
<idno type="pmc">3372199</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372199</idno>
<idno type="RBID">PMC:3372199</idno>
<idno type="doi">10.1128/JVI.07158-11</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000647</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000647</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses</title>
<author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tsibane, Tshidi" sort="Tsibane, Tshidi" uniqKey="Tsibane T" first="Tshidi" last="Tsibane">Tshidi Tsibane</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name>
<affiliation><nlm:aff id="aff6">Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Huffman, Chelsey J" sort="Huffman, Chelsey J" uniqKey="Huffman C" first="Chelsey J." last="Huffman">Chelsey J. Huffman</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albrecht, Randy" sort="Albrecht, Randy" uniqKey="Albrecht R" first="Randy" last="Albrecht">Randy Albrecht</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blum, David L" sort="Blum, David L" uniqKey="Blum D" first="David L." last="Blum">David L. Blum</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ramos, Irene" sort="Ramos, Irene" uniqKey="Ramos I" first="Irene" last="Ramos">Irene Ramos</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fernandez Sesma, Ana" sort="Fernandez Sesma, Ana" uniqKey="Fernandez Sesma A" first="Ana" last="Fernandez-Sesma">Ana Fernandez-Sesma</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Medicine, Division of Infectious Diseases</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Medicine, Division of Infectious Diseases</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
<affiliation><nlm:aff id="aff3">Department of Microbiology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name>
<affiliation><nlm:aff id="aff1">Departments of Pediatrics</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V<sub>H</sub>
1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22457520</article-id>
<article-id pub-id-type="pmc">3372199</article-id>
<article-id pub-id-type="publisher-id">07158-11</article-id>
<article-id pub-id-type="doi">10.1128/JVI.07158-11</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Influenza Viruses</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Krause</surname>
<given-names>Jens C.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tsibane</surname>
<given-names>Tshidi</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tumpey</surname>
<given-names>Terrence M.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>f</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huffman</surname>
<given-names>Chelsey J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Albrecht</surname>
<given-names>Randy</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>e</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blum</surname>
<given-names>David L.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ramos</surname>
<given-names>Irene</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fernandez-Sesma</surname>
<given-names>Ana</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>d</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>e</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Edwards</surname>
<given-names>Kathryn M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>García-Sastre</surname>
<given-names>Adolfo</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>d</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>e</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Basler</surname>
<given-names>Christopher F.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>c</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Crowe</surname>
<given-names>James E.</given-names>
<suffix>Jr.</suffix>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<aff id="aff1"><label>a</label>
Departments of Pediatrics</aff>
<aff id="aff2">of<label>b</label>
Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA</aff>
<aff id="aff3"><label>c</label>
Department of Microbiology</aff>
<aff id="aff4"><label>d</label>
Department of Medicine, Division of Infectious Diseases</aff>
<aff id="aff5"><label>e</label>
Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, USA</aff>
<aff id="aff6"><label>f</label>
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA</aff>
</contrib-group>
<author-notes><corresp>Address correspondence to James E. Crowe, Jr., <email>james.crowe@vanderbilt.edu</email>
.</corresp>
<fn fn-type="equal"><p>J.C.K. and T.T. contributed equally to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2012</year>
</pub-date>
<volume>86</volume>
<issue>11</issue>
<fpage>6334</fpage>
<lpage>6340</lpage>
<history><date date-type="received"><day>19</day>
<month>12</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>19</day>
<month>3</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv01112006334.pdf"></self-uri>
<abstract><p>Investigation of the human antibody response to the 1957 pandemic H2N2 influenza A virus has been largely limited to serologic studies. We generated five influenza virus hemagglutinin (HA)-reactive human monoclonal antibodies (MAbs) by hybridoma technology from the peripheral blood of healthy donors who were born between 1950 and 1968. Two MAbs reacted with the pandemic H2N2 virus, two recognized the pandemic H3N2 virus, and remarkably, one reacted with both the pandemic H2N2 and H3N2 viruses. Each of these five naturally occurring MAbs displayed hemagglutination inhibition activity, suggesting specificity for the globular head domain of influenza virus HA. When incubated with virus, MAbs 8F8, 8M2, and 2G1 each elicited H2N2 escape mutations immediately adjacent to the receptor-binding domain on the HA globular head in embryonated chicken eggs. All H2N2-specific MAbs were able to inhibit a 2006 swine H2N3 influenza virus. MAbs 8M2 and 2G1 shared the V<sub>H</sub>
1-69 germ line gene, but these antibodies were otherwise not genetically related. Each antibody was able to protect mice in a lethal H2N2 virus challenge. Thus, even 43 years after circulation of H2N2 viruses, these subjects possessed peripheral blood B cells encoding potent inhibiting antibodies specific for a conserved region on the globular head of the pandemic H2 HA.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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