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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Receptor Binding Specificity of the Live Attenuated Influenza H2 and H6 Vaccine Viruses Contributes to Vaccine Immunogenicity and Protection in Ferrets</title><author><name sortKey="Chen, Zhongying" sort="Chen, Zhongying" uniqKey="Chen Z" first="Zhongying" last="Chen">Zhongying Chen</name></author><author><name sortKey="Zhou, Helen" sort="Zhou, Helen" uniqKey="Zhou H" first="Helen" last="Zhou">Helen Zhou</name></author><author><name sortKey="Kim, Lomi" sort="Kim, Lomi" uniqKey="Kim L" first="Lomi" last="Kim">Lomi Kim</name></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22190726</idno><idno type="pmc">3302243</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302243</idno><idno type="RBID">PMC:3302243</idno><idno type="doi">10.1128/JVI.06219-11</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000643</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000643</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Receptor Binding Specificity of the Live Attenuated Influenza H2 and H6 Vaccine Viruses Contributes to Vaccine Immunogenicity and Protection in Ferrets</title><author><name sortKey="Chen, Zhongying" sort="Chen, Zhongying" uniqKey="Chen Z" first="Zhongying" last="Chen">Zhongying Chen</name></author><author><name sortKey="Zhou, Helen" sort="Zhou, Helen" uniqKey="Zhou H" first="Helen" last="Zhou">Helen Zhou</name></author><author><name sortKey="Kim, Lomi" sort="Kim, Lomi" uniqKey="Kim L" first="Lomi" last="Kim">Lomi Kim</name></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To prepare for influenza pandemics that may be caused by the H2 and H6 subtype influenza viruses, live attenuated influenza virus (LAIV) H2 and H6 vaccines are being developed and evaluated. The H2 and H6 vaccine candidates with different receptor binding preferences specified by amino acid substitutions at residues 226 and 228 were generated and evaluated for their growth in embryonated chicken eggs and their immunogenicity and protection against wild-type virus challenge in the ferret model. The viruses containing Q226 and G228 in the hemagglutinin (HA) protein bound to the avian-like α2,3-sialic acid (SA) receptor and replicated efficiently in chicken eggs. The viruses with L226 and G228 bound preferentially to the human-like α2,6-SA receptor. The viruses containing L226 and S228 displayed dual binding to both α2,3-SA and α2,6-SA receptors and replicated efficiently in eggs. The strains containing L226/G228 or L226/S228 that preferentially bound to α2,6-SA receptors replicated efficiently in the upper respiratory tract of ferrets, induced high levels of neutralizing antibody, and conferred a high level of protection against wild-type virus challenge infection compared to the strain with the Q226/G228 residues. Our data suggest that pandemic vaccines with receptor binding preference to both avian- and human-like receptors might be desired for efficient viral replication in eggs and for inducing protective immune responses in humans.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22190726</article-id><article-id pub-id-type="pmc">3302243</article-id><article-id pub-id-type="publisher-id">06219-11</article-id><article-id pub-id-type="doi">10.1128/JVI.06219-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Vaccines and Antiviral Agents</subject></subj-group></article-categories><title-group><article-title>The Receptor Binding Specificity of the Live Attenuated Influenza H2 and H6 Vaccine Viruses Contributes to Vaccine Immunogenicity and Protection in Ferrets</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Zhongying</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Helen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Lomi</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Jin</surname><given-names>Hong</given-names></name></contrib><aff>MedImmune LLC, Mountain View, California, USA</aff></contrib-group><author-notes><corresp>Address correspondence to Hong Jin, <email>jinh@medimmune.com</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2012</year></pub-date><volume>86</volume><issue>5</issue><fpage>2780</fpage><lpage>2786</lpage><history><date date-type="received"><day>3</day><month>9</month><year>2011</year></date><date date-type="accepted"><day>7</day><month>12</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv00512002780.pdf"></self-uri><abstract><p>To prepare for influenza pandemics that may be caused by the H2 and H6 subtype influenza viruses, live attenuated influenza virus (LAIV) H2 and H6 vaccines are being developed and evaluated. The H2 and H6 vaccine candidates with different receptor binding preferences specified by amino acid substitutions at residues 226 and 228 were generated and evaluated for their growth in embryonated chicken eggs and their immunogenicity and protection against wild-type virus challenge in the ferret model. The viruses containing Q226 and G228 in the hemagglutinin (HA) protein bound to the avian-like α2,3-sialic acid (SA) receptor and replicated efficiently in chicken eggs. The viruses with L226 and G228 bound preferentially to the human-like α2,6-SA receptor. The viruses containing L226 and S228 displayed dual binding to both α2,3-SA and α2,6-SA receptors and replicated efficiently in eggs. The strains containing L226/G228 or L226/S228 that preferentially bound to α2,6-SA receptors replicated efficiently in the upper respiratory tract of ferrets, induced high levels of neutralizing antibody, and conferred a high level of protection against wild-type virus challenge infection compared to the strain with the Q226/G228 residues. Our data suggest that pandemic vaccines with receptor binding preference to both avian- and human-like receptors might be desired for efficient viral replication in eggs and for inducing protective immune responses in humans.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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