Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential Effects of NS1 Proteins of Human Pandemic H1N1/2009, Avian Highly Pathogenic H5N1, and Low Pathogenic H5N2 Influenza A Viruses on Cellular Pre-mRNA Polyadenylation and mRNA Translation<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Kainov, Denis E" sort="Kainov, Denis E" uniqKey="Kainov D" first="Denis E." last="Kainov">Denis E. Kainov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Muller, Konstantin H" sort="Muller, Konstantin H" uniqKey="Muller K" first="Konstantin H." last="Müller">Konstantin H. Müller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Theisen, Linda L" sort="Theisen, Linda L" uniqKey="Theisen L" first="Linda L." last="Theisen">Linda L. Theisen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Anastasina, Maria" sort="Anastasina, Maria" uniqKey="Anastasina M" first="Maria" last="Anastasina">Maria Anastasina</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kaloinen, Minttu" sort="Kaloinen, Minttu" uniqKey="Kaloinen M" first="Minttu" last="Kaloinen">Minttu Kaloinen</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Muller, Claude P" sort="Muller, Claude P" uniqKey="Muller C" first="Claude P." last="Muller">Claude P. Muller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21163951</idno><idno type="pmc">3044980</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044980</idno><idno type="RBID">PMC:3044980</idno><idno type="doi">10.1074/jbc.M110.203489</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000621</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000621</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differential Effects of NS1 Proteins of Human Pandemic H1N1/2009, Avian Highly Pathogenic H5N1, and Low Pathogenic H5N2 Influenza A Viruses on Cellular Pre-mRNA Polyadenylation and mRNA Translation<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Kainov, Denis E" sort="Kainov, Denis E" uniqKey="Kainov D" first="Denis E." last="Kainov">Denis E. Kainov</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Muller, Konstantin H" sort="Muller, Konstantin H" uniqKey="Muller K" first="Konstantin H." last="Müller">Konstantin H. Müller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Theisen, Linda L" sort="Theisen, Linda L" uniqKey="Theisen L" first="Linda L." last="Theisen">Linda L. Theisen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Anastasina, Maria" sort="Anastasina, Maria" uniqKey="Anastasina M" first="Maria" last="Anastasina">Maria Anastasina</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kaloinen, Minttu" sort="Kaloinen, Minttu" uniqKey="Kaloinen M" first="Minttu" last="Kaloinen">Minttu Kaloinen</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Muller, Claude P" sort="Muller, Claude P" uniqKey="Muller C" first="Claude P." last="Muller">Claude P. Muller</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The nonstructural protein NS1 of influenza A virus blocks the development of host antiviral responses by inhibiting polyadenylation of cellular pre-mRNA. NS1 also promotes the synthesis of viral proteins by stimulating mRNA translation. Here, we show that recombinant NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza strains differentially affected these two cellular processes: NS1 of the two avian strains, in contrast to NS1 of H1N1/2009, stimulated translation of reporter mRNA in cell-free translation system; NS1 of H5N1 was an effective inhibitor of cellular pre-mRNA polyadenylation in A549 cells, unlike NS1 of H5N2 and H1N1/2009. We identified key amino acids in NS1 that contribute to its activity in these two basic cellular processes. Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biol Chem</journal-id><journal-id journal-id-type="hwp">jbc</journal-id><journal-id journal-id-type="pmc">jbc</journal-id><journal-id journal-id-type="publisher-id">JBC</journal-id><journal-title-group><journal-title>The Journal of Biological Chemistry</journal-title></journal-title-group><issn pub-type="ppub">0021-9258</issn><issn pub-type="epub">1083-351X</issn><publisher><publisher-name>American Society for Biochemistry and Molecular Biology</publisher-name><publisher-loc>9650 Rockville Pike, Bethesda, MD 20814, U.S.A.</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21163951</article-id><article-id pub-id-type="pmc">3044980</article-id><article-id pub-id-type="publisher-id">M110.203489</article-id><article-id pub-id-type="doi">10.1074/jbc.M110.203489</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject></subj-group></article-categories><title-group><article-title>Differential Effects of NS1 Proteins of Human Pandemic H1N1/2009, Avian Highly Pathogenic H5N1, and Low Pathogenic H5N2 Influenza A Viruses on Cellular Pre-mRNA Polyadenylation and mRNA Translation<xref ref-type="fn" rid="FN1">*</xref></article-title><alt-title alt-title-type="short">Strain-specific Activities of Influenza A NS1 Proteins</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kainov</surname><given-names>Denis E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Müller</surname><given-names>Konstantin H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="author-notes" rid="FN2"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Theisen</surname><given-names>Linda L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="author-notes" rid="FN2"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Anastasina</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaloinen</surname><given-names>Minttu</given-names></name><xref ref-type="aff" rid="aff2"><sup>§</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Muller</surname><given-names>Claude P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>‡</sup></xref><xref ref-type="corresp" rid="cor1"><sup>2</sup></xref></contrib><aff id="aff1">From the<label>‡</label>Institute of Immunology, Centre de Recherche Public-Santé / Laboratoire National de Santé, L-1011, Luxembourg and</aff><aff id="aff2">the<label>§</label>Institute for Molecular Medicine Finland, University of Helsinki, FI-00014 Helsinki, Finland</aff></contrib-group><author-notes><corresp id="cor1"><label>2</label> To whom correspondence should be addressed. Tel.: <phone>352-490604-220</phone>; Fax: <fax>352-490686</fax>; E-mail: <email>Claude.Muller@lns.etat.lu</email>.</corresp><fn fn-type="equal" id="FN2"><label>1</label><p>Both authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="ppub"><day>4</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2010</year></pub-date><volume>286</volume><issue>9</issue><fpage>7239</fpage><lpage>7247</lpage><history><date date-type="received"><day>19</day><month>11</month><year>2010</year></date><date date-type="rev-recd"><day>15</day><month>12</month><year>2010</year></date></history><permissions><copyright-statement>© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zbc00911007239.pdf"></self-uri><abstract><p>The nonstructural protein NS1 of influenza A virus blocks the development of host antiviral responses by inhibiting polyadenylation of cellular pre-mRNA. NS1 also promotes the synthesis of viral proteins by stimulating mRNA translation. Here, we show that recombinant NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza strains differentially affected these two cellular processes: NS1 of the two avian strains, in contrast to NS1 of H1N1/2009, stimulated translation of reporter mRNA in cell-free translation system; NS1 of H5N1 was an effective inhibitor of cellular pre-mRNA polyadenylation in A549 cells, unlike NS1 of H5N2 and H1N1/2009. We identified key amino acids in NS1 that contribute to its activity in these two basic cellular processes. Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation.</p></abstract><kwd-group><kwd>Protein-Protein Interactions</kwd><kwd>RNA</kwd><kwd>Transcription</kwd><kwd>Translation</kwd><kwd>Viral Protein</kwd><kwd>NS1 Protein</kwd><kwd>Influenza A Virus</kwd><kwd>Virus-Host Interaction</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000621 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000621 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |