Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus
Identifieur interne : 000616 ( Pmc/Corpus ); précédent : 000615; suivant : 000617Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus
Auteurs : Christopher D. O'Donnell ; Amber Wright ; Leatrice Vogel ; Kobporn Boonnak ; John J. Treanor ; Kanta SubbaraoSource :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2014.
Abstract
The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza virus infection governs the antibody response thereafter. Subsequent influenza virus infection results in an antibody response against the original infecting virus and an impaired immune response against the newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans previously infected with H1N1 viruses with various antigenic distances from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1 virus-primed ferrets. Analysis of paired samples of human serum taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater-fold rise in the titer of antibody against the 2009 pH1N1 virus than against H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.
Url:
DOI: 10.1128/CVI.00790-13
PubMed: 24648486
PubMed Central: 4018878
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PMC:4018878Le document en format XML
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<author><name sortKey="O Donnell, Christopher D" sort="O Donnell, Christopher D" uniqKey="O Donnell C" first="Christopher D." last="O'Donnell">Christopher D. O'Donnell</name>
<affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, Bethesda, Maryland, USA</nlm:aff>
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<author><name sortKey="Wright, Amber" sort="Wright, Amber" uniqKey="Wright A" first="Amber" last="Wright">Amber Wright</name>
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<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
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<author><name sortKey="Boonnak, Kobporn" sort="Boonnak, Kobporn" uniqKey="Boonnak K" first="Kobporn" last="Boonnak">Kobporn Boonnak</name>
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<author><name sortKey="Treanor, John J" sort="Treanor, John J" uniqKey="Treanor J" first="John J." last="Treanor">John J. Treanor</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA</nlm:aff>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus</title>
<author><name sortKey="O Donnell, Christopher D" sort="O Donnell, Christopher D" uniqKey="O Donnell C" first="Christopher D." last="O'Donnell">Christopher D. O'Donnell</name>
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<author><name sortKey="Wright, Amber" sort="Wright, Amber" uniqKey="Wright A" first="Amber" last="Wright">Amber Wright</name>
<affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, Bethesda, Maryland, USA</nlm:aff>
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<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
<affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, Bethesda, Maryland, USA</nlm:aff>
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<author><name sortKey="Boonnak, Kobporn" sort="Boonnak, Kobporn" uniqKey="Boonnak K" first="Kobporn" last="Boonnak">Kobporn Boonnak</name>
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<author><name sortKey="Treanor, John J" sort="Treanor, John J" uniqKey="Treanor J" first="John J." last="Treanor">John J. Treanor</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA</nlm:aff>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
<affiliation><nlm:aff id="aff1">Laboratory of Infectious Diseases, NIAID, Bethesda, Maryland, USA</nlm:aff>
</affiliation>
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<series><title level="j">Clinical and Vaccine Immunology : CVI</title>
<idno type="ISSN">1556-6811</idno>
<idno type="eISSN">1556-679X</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza virus infection governs the antibody response thereafter. Subsequent influenza virus infection results in an antibody response against the original infecting virus and an impaired immune response against the newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans previously infected with H1N1 viruses with various antigenic distances from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1 virus-primed ferrets. Analysis of paired samples of human serum taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater-fold rise in the titer of antibody against the 2009 pH1N1 virus than against H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Vaccine Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Clin. Vaccine Immunol</journal-id>
<journal-id journal-id-type="hwp">cdli</journal-id>
<journal-id journal-id-type="pmc">cvi</journal-id>
<journal-id journal-id-type="publisher-id">CVI</journal-id>
<journal-title-group><journal-title>Clinical and Vaccine Immunology : CVI</journal-title>
</journal-title-group>
<issn pub-type="ppub">1556-6811</issn>
<issn pub-type="epub">1556-679X</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24648486</article-id>
<article-id pub-id-type="pmc">4018878</article-id>
<article-id pub-id-type="publisher-id">00790-13</article-id>
<article-id pub-id-type="doi">10.1128/CVI.00790-13</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Vaccines</subject>
</subj-group>
</article-categories>
<title-group><article-title>Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>O'Donnell</surname>
<given-names>Christopher D.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wright</surname>
<given-names>Amber</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vogel</surname>
<given-names>Leatrice</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boonnak</surname>
<given-names>Kobporn</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
<xref ref-type="author-notes" rid="fn1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Treanor</surname>
<given-names>John J.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Subbarao</surname>
<given-names>Kanta</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
</xref>
</contrib>
<aff id="aff1"><label>a</label>
Laboratory of Infectious Diseases, NIAID, Bethesda, Maryland, USA</aff>
<aff id="aff2"><label>b</label>
Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA</aff>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Hodinka</surname>
<given-names>R. L.</given-names>
</name>
<role>Editor</role>
</contrib>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to Kanta Subbarao, <email>ksubbarao@niaid.nih.gov</email>
.</corresp>
<fn id="fn1" fn-type="present-address"><label>*</label>
<p>Present address: Christopher D. O'Donnell, Development, Security and Cooperation Unit, National Academy of Sciences, The National Academies, Washington, DC, USA; Amber Wright, University of Washington Department of Genome Sciences, Seattle, Washington, USA; Kobporn Boonnak, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>2014</year>
</pub-date>
<volume>21</volume>
<issue>5</issue>
<fpage>737</fpage>
<lpage>746</lpage>
<history><date date-type="received"><day>9</day>
<month>12</month>
<year>2013</year>
</date>
<date date-type="rev-request"><day>16</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>13</day>
<month>3</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zcd00514000737.pdf"></self-uri>
<abstract><p>The hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza virus infection governs the antibody response thereafter. Subsequent influenza virus infection results in an antibody response against the original infecting virus and an impaired immune response against the newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans previously infected with H1N1 viruses with various antigenic distances from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1 virus-primed ferrets. Analysis of paired samples of human serum taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater-fold rise in the titer of antibody against the 2009 pH1N1 virus than against H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.</p>
</abstract>
</article-meta>
</front>
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