H2N2V1, Pmc, Corpus, bibRecord, 000607

Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

Identifieur interne : 000607 ( Pmc/Corpus ); précédent : 000606; suivant : 000608

Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

Auteurs : Heather M. Kling ; Gerard J. Nau ; Ted M. Ross ; Thomas G. Evans ; Krishnendu Chakraborty ; Kerry M. Empey ; Joanne L. Flynn

Source :

Annals of the American Thoracic Society [ 2329-6933 ] ; 2014.

RBID : PMC:4200570

Abstract

Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200570

DOI: 10.1513/AnnalsATS.201401-036PL
PubMed: 25148426
PubMed Central: 4200570

Links to Exploration step

PMC:4200570

Le document en format XML

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<author><name sortKey="Kling, Heather M" sort="Kling, Heather M" uniqKey="Kling H" first="Heather M." last="Kling">Heather M. Kling</name>
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<author><name sortKey="Nau, Gerard J" sort="Nau, Gerard J" uniqKey="Nau G" first="Gerard J." last="Nau">Gerard J. Nau</name>
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<author><name sortKey="Chakraborty, Krishnendu" sort="Chakraborty, Krishnendu" uniqKey="Chakraborty K" first="Krishnendu" last="Chakraborty">Krishnendu Chakraborty</name>
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<author><name sortKey="Empey, Kerry M" sort="Empey, Kerry M" uniqKey="Empey K" first="Kerry M." last="Empey">Kerry M. Empey</name>
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<author><name sortKey="Flynn, Joanne L" sort="Flynn, Joanne L" uniqKey="Flynn J" first="Joanne L." last="Flynn">Joanne L. Flynn</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy</title>
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<author><name sortKey="Ross, Ted M" sort="Ross, Ted M" uniqKey="Ross T" first="Ted M." last="Ross">Ted M. Ross</name>
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<author><name sortKey="Evans, Thomas G" sort="Evans, Thomas G" uniqKey="Evans T" first="Thomas G." last="Evans">Thomas G. Evans</name>
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<author><name sortKey="Chakraborty, Krishnendu" sort="Chakraborty, Krishnendu" uniqKey="Chakraborty K" first="Krishnendu" last="Chakraborty">Krishnendu Chakraborty</name>
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<author><name sortKey="Empey, Kerry M" sort="Empey, Kerry M" uniqKey="Empey K" first="Kerry M." last="Empey">Kerry M. Empey</name>
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<author><name sortKey="Flynn, Joanne L" sort="Flynn, Joanne L" uniqKey="Flynn J" first="Joanne L." last="Flynn">Joanne L. Flynn</name>
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<series><title level="j">Annals of the American Thoracic Society</title>
<idno type="ISSN">2329-6933</idno>
<idno type="eISSN">2325-6621</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Am Thorac Soc</journal-id>
<journal-id journal-id-type="iso-abbrev">Ann Am Thorac Soc</journal-id>
<journal-id journal-id-type="publisher-id">AnnalsATS</journal-id>
<journal-title-group><journal-title>Annals of the American Thoracic Society</journal-title>
</journal-title-group>
<issn pub-type="ppub">2329-6933</issn>
<issn pub-type="epub">2325-6621</issn>
<publisher><publisher-name>American Thoracic Society</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25148426</article-id>
<article-id pub-id-type="pmc">4200570</article-id>
<article-id pub-id-type="publisher-manuscript">201401-036PL</article-id>
<article-id pub-id-type="doi">10.1513/AnnalsATS.201401-036PL</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pittsburgh Lung Conference</subject>
</subj-group>
</article-categories>
<title-group><article-title>Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kling</surname>
<given-names>Heather M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nau</surname>
<given-names>Gerard J.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ross</surname>
<given-names>Ted M.</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Evans</surname>
<given-names>Thomas G.</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chakraborty</surname>
<given-names>Krishnendu</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Empey</surname>
<given-names>Kerry M.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flynn</surname>
<given-names>JoAnne L.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Department of Immunology</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
Department of Microbiology and Molecular Genetics, and</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</aff>
<aff id="aff4"><label><sup>4</sup>
</label>
Vaccine and Gene Therapy Institute of Florida, Port Saint Lucie, Florida</aff>
<aff id="aff5"><label><sup>5</sup>
</label>
Aeras Global TB Vaccines Foundation, Rockville, Maryland; and</aff>
<aff id="aff6"><label><sup>6</sup>
</label>
Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania</aff>
</contrib-group>
<author-notes><corresp>Correspondence and requests for reprints should be addressed to Heather M. Kling, Ph.D., Department of Immunology, University of Pittsburgh, 200 Lothrop Street, W1111 BSTWR, Pittsburgh, PA 15261. E-mail: <email xlink:href="hek7@pitt.edu">hek7@pitt.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="epub-ppub"><month>8</month>
<year>2014</year>
<pmc-comment>string-date: August 2014</pmc-comment>
      </pub-date>
<pmc-comment>Fake ppub date generated by PMC from publisher 
 							pub-date/@pub-type='epub-ppub' </pmc-comment>
      <pub-date pub-type="ppub"><month>8</month>
<year>2014</year>
<pmc-comment>string-date: August 2014</pmc-comment>
      </pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 6 months and 0 days and was based on the . </pmc-comment>
      <volume>11</volume>
<issue>Suppl 4</issue>
<fpage>S201</fpage>
<lpage>S210</lpage>
<history><date date-type="received"><day>28</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>12</day>
<month>3</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 by the American Thoracic Society</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:href="AnnalsATS.201401-036PL.pdf"></self-uri>
<abstract><p>Pulmonary diseases and infections are among the top contributors to human morbidity and mortality worldwide, and despite the successful history of vaccines and antimicrobial therapeutics, infectious disease still presents a significant threat to human health. Effective vaccines are frequently unavailable in developing countries, and successful vaccines have yet to be developed for major global maladies, such as tuberculosis. Furthermore, antibiotic resistance poses a growing threat to human health. The “Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy” session of the 2013 Pittsburgh International Lung Conference highlighted several recent and current studies related to treatment and prevention of antibiotic-resistant bacterial infections, highly pathogenic influenza, respiratory syncytial virus, and tuberculosis. Research presented here focused on novel antimicrobial therapies, new vaccines that are either in development or currently in clinical trials, and the potential for immunomodulatory therapies. These studies are making important contributions to the areas of microbiology, virology, and immunology related to pulmonary diseases and infections and are paving the way for improvements in the efficacy of vaccines and antimicrobials.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>antimicrobials</kwd>
<kwd>influenza vaccines</kwd>
<kwd>respiratory syncytial virus</kwd>
<kwd>tuberculosis</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
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</front>
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Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

Challenges and Future in Vaccines, Drug Development, and Immunomodulatory Therapy

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Abstract

Links to Exploration step

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