Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cellular and Humoral Immune Responses to Pandemic Influenza Vaccine in Healthy and in Highly Active Antiretroviral Therapy-Treated HIV Patients</title><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lapa, Daniele" sort="Lapa, Daniele" uniqKey="Lapa D" first="Daniele" last="Lapa">Daniele Lapa</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Berno, Giulia" sort="Berno, Giulia" uniqKey="Berno G" first="Giulia" last="Berno">Giulia Berno</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Puro, Vincenzo" sort="Puro, Vincenzo" uniqKey="Puro V" first="Vincenzo" last="Puro">Vincenzo Puro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Carletti, Fabrizio" sort="Carletti, Fabrizio" uniqKey="Carletti F" first="Fabrizio" last="Carletti">Fabrizio Carletti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cimini, Eleonora" sort="Cimini, Eleonora" uniqKey="Cimini E" first="Eleonora" last="Cimini">Eleonora Cimini</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nisii, Carla" sort="Nisii, Carla" uniqKey="Nisii C" first="Carla" last="Nisii">Carla Nisii</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Castellino, Flora" sort="Castellino, Flora" uniqKey="Castellino F" first="Flora" last="Castellino">Flora Castellino</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Martini, Federico" sort="Martini, Federico" uniqKey="Martini F" first="Federico" last="Martini">Federico Martini</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Capobianchi, Maria R" sort="Capobianchi, Maria R" uniqKey="Capobianchi M" first="Maria R." last="Capobianchi">Maria R. Capobianchi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22439734</idno><idno type="pmc">3505053</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505053</idno><idno type="RBID">PMC:3505053</idno><idno type="doi">10.1089/aid.2011.0371</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000603</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000603</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cellular and Humoral Immune Responses to Pandemic Influenza Vaccine in Healthy and in Highly Active Antiretroviral Therapy-Treated HIV Patients</title><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lapa, Daniele" sort="Lapa, Daniele" uniqKey="Lapa D" first="Daniele" last="Lapa">Daniele Lapa</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Berno, Giulia" sort="Berno, Giulia" uniqKey="Berno G" first="Giulia" last="Berno">Giulia Berno</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Puro, Vincenzo" sort="Puro, Vincenzo" uniqKey="Puro V" first="Vincenzo" last="Puro">Vincenzo Puro</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Carletti, Fabrizio" sort="Carletti, Fabrizio" uniqKey="Carletti F" first="Fabrizio" last="Carletti">Fabrizio Carletti</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Cimini, Eleonora" sort="Cimini, Eleonora" uniqKey="Cimini E" first="Eleonora" last="Cimini">Eleonora Cimini</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nisii, Carla" sort="Nisii, Carla" uniqKey="Nisii C" first="Carla" last="Nisii">Carla Nisii</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Castellino, Flora" sort="Castellino, Flora" uniqKey="Castellino F" first="Flora" last="Castellino">Flora Castellino</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Martini, Federico" sort="Martini, Federico" uniqKey="Martini F" first="Federico" last="Martini">Federico Martini</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Capobianchi, Maria R" sort="Capobianchi, Maria R" uniqKey="Capobianchi M" first="Maria R." last="Capobianchi">Maria R. Capobianchi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">AIDS Research and Human Retroviruses</title><idno type="ISSN">0889-2229</idno><idno type="eISSN">1931-8405</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Influenza vaccination is recommended for HAART-treated HIV patients to prevent influenza illness and complications. Due to the known ability of T cells to mediate a broadly cross-reactive response, vaccination effectiveness in cell-mediated immune (CMI) response induction is a main objective in new influenza vaccination strategies. Nevertheless, data on CMI responses after pandemic vaccination in HIV subjects are still missing. In the present study, the ability of a single dose of adjuvanted pandemic influenza vaccine to induce humoral and CMI responses was compared in HAART-treated HIV patients and in healthcare workers. Healthcare workers (HCW, <italic>n</italic>=65) and HAART-treated HIV patients (HIV, <italic>n</italic>=67) receiving pandemic vaccination were enrolled and analyzed before (t0) and after (t1) vaccination. The analysis of strain-specific humoral response was performed by HAI assay; CMI against pandemic (A/H1N1/Cal/09) and seasonal (A/H1N1/Brisb/07 and A/H3N2/Brisb/07) strains was analyzed by ELISpot and intracellular staining followed by flow cytometry. Pandemic vaccination was effective in inducing both humoral and cell-mediated responses in HAART-treated HIV patients as well as in HCWs. A large fraction of both HCWs and HIV-infected patients showed a T cell response to the pandemic strain before vaccination, suggesting possible previous exposure to A/H1N1/pdm/09 and/or cross-reactive T cells. Notably, pandemic vaccine was also able to boost cross-reactive immune responses to seasonal strains. Finally, a weaker boost of both strain-specific and cross-reactive T cell immunity was found in individuals showing a higher baseline response. These data show the effectiveness of adjuvanted pandemic vaccine to induce both humoral and cellular (strain-specific and cross-reactive) immune responses in HIV patients similar to HCWs.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS Res Hum Retroviruses</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Res. Hum. Retroviruses</journal-id><journal-id journal-id-type="publisher-id">aid</journal-id><journal-title-group><journal-title>AIDS Research and Human Retroviruses</journal-title></journal-title-group><issn pub-type="ppub">0889-2229</issn><issn pub-type="epub">1931-8405</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22439734</article-id><article-id pub-id-type="pmc">3505053</article-id><article-id pub-id-type="publisher-id">10.1089/aid.2011.0371</article-id><article-id pub-id-type="doi">10.1089/aid.2011.0371</article-id><article-categories><subj-group subj-group-type="heading"><subject>Immunology</subject></subj-group></article-categories><title-group><article-title>Cellular and Humoral Immune Responses to Pandemic Influenza Vaccine in Healthy and in Highly Active Antiretroviral Therapy-Treated HIV Patients</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Agrati</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gioia</surname><given-names>Cristiana</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Castilletti</surname><given-names>Concetta</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lapa</surname><given-names>Daniele</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Berno</surname><given-names>Giulia</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Puro</surname><given-names>Vincenzo</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Carletti</surname><given-names>Fabrizio</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cimini</surname><given-names>Eleonora</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nisii</surname><given-names>Carla</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Castellino</surname><given-names>Flora</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martini</surname><given-names>Federico</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Capobianchi</surname><given-names>Maria R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label><institution>National Institute for Infectious Diseases (INMI) Lazzaro Spallanzani</institution>, Rome,<country>Italy</country>.</aff><aff id="aff2"><label><sup>2</sup></label><institution>Novartis Vaccines and Diagnostics Research Center</institution>, Siena,<country>Italy</country>.</aff></contrib-group><author-notes><corresp>Address correspondence to: <italic>Chiara Agrati, INMI L.Spallanzani, Via Portuense 292, 00149 Rome, Italy. E-mail:</italic><email xlink:href="mailto:chiara.agrati@inmi.it">chiara.agrati@inmi.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year><pmc-comment>string-date: December 2012</pmc-comment>
</pub-date><volume>28</volume><issue>12</issue><fpage>1606</fpage><lpage>1616</lpage><permissions><copyright-statement>Copyright 2012, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:type="simple" xlink:href="aid.2011.0371.pdf"></self-uri><abstract><title>Abstract</title><p>Influenza vaccination is recommended for HAART-treated HIV patients to prevent influenza illness and complications. Due to the known ability of T cells to mediate a broadly cross-reactive response, vaccination effectiveness in cell-mediated immune (CMI) response induction is a main objective in new influenza vaccination strategies. Nevertheless, data on CMI responses after pandemic vaccination in HIV subjects are still missing. In the present study, the ability of a single dose of adjuvanted pandemic influenza vaccine to induce humoral and CMI responses was compared in HAART-treated HIV patients and in healthcare workers. Healthcare workers (HCW, <italic>n</italic>=65) and HAART-treated HIV patients (HIV, <italic>n</italic>=67) receiving pandemic vaccination were enrolled and analyzed before (t0) and after (t1) vaccination. The analysis of strain-specific humoral response was performed by HAI assay; CMI against pandemic (A/H1N1/Cal/09) and seasonal (A/H1N1/Brisb/07 and A/H3N2/Brisb/07) strains was analyzed by ELISpot and intracellular staining followed by flow cytometry. Pandemic vaccination was effective in inducing both humoral and cell-mediated responses in HAART-treated HIV patients as well as in HCWs. A large fraction of both HCWs and HIV-infected patients showed a T cell response to the pandemic strain before vaccination, suggesting possible previous exposure to A/H1N1/pdm/09 and/or cross-reactive T cells. Notably, pandemic vaccine was also able to boost cross-reactive immune responses to seasonal strains. Finally, a weaker boost of both strain-specific and cross-reactive T cell immunity was found in individuals showing a higher baseline response. These data show the effectiveness of adjuvanted pandemic vaccine to induce both humoral and cellular (strain-specific and cross-reactive) immune responses in HIV patients similar to HCWs.</p></abstract><counts><fig-count count="6"></fig-count><table-count count="3"></table-count><ref-count count="57"></ref-count><page-count count="11"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0006030 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0006030 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |