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<title xml:lang="en">The pathogenesis of influenza virus infections: the contributions of virus and host factors</title>
<author>
<name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name>
<affiliation>
<nlm:aff id="A1">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
<affiliation>
<nlm:aff id="A1">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A4">International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff>
</affiliation>
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<idno type="pmid">21840185</idno>
<idno type="pmc">3163725</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163725</idno>
<idno type="RBID">PMC:3163725</idno>
<idno type="doi">10.1016/j.coi.2011.07.016</idno>
<date when="2011">2011</date>
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<title xml:lang="en" level="a" type="main">The pathogenesis of influenza virus infections: the contributions of virus and host factors</title>
<author>
<name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name>
<affiliation>
<nlm:aff id="A1">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
<affiliation>
<nlm:aff id="A1">ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A2">Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A4">International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff>
</affiliation>
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<series>
<title level="j">Current opinion in immunology</title>
<idno type="ISSN">0952-7915</idno>
<idno type="eISSN">1879-0372</idno>
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<date when="2011">2011</date>
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<p id="P1">Influenza viruses cause acute respiratory inflammation in humans and symptoms such as high fever, body aches, and fatigue. Usually these symptoms improve after several days; however, the 2009 pandemic H1N1 influenza virus [influenza A(H1N1)2009] is more pathogenic than seasonal influenza viruses and the pathogenicity of highly pathogenic H5N1 viruses is still higher. The 1918 influenza pandemic virus caused severe pneumonia, resulting in an estimated 50 million deaths worldwide. Several virulence factors have been identified in these virus strains, but host factors are also responsible for the pathogenesis of infections caused by virulent viruses. Here, we review the contributions of both virus and host factors to the pathogenesis of these viral infections.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="en">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">8900118</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1461</journal-id>
<journal-id journal-id-type="nlm-ta">Curr Opin Immunol</journal-id>
<journal-title-group>
<journal-title>Current opinion in immunology</journal-title>
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<issn pub-type="ppub">0952-7915</issn>
<issn pub-type="epub">1879-0372</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">21840185</article-id>
<article-id pub-id-type="pmc">3163725</article-id>
<article-id pub-id-type="doi">10.1016/j.coi.2011.07.016</article-id>
<article-id pub-id-type="manuscript">NIHMS318626</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
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<title-group>
<article-title>The pathogenesis of influenza virus infections: the contributions of virus and host factors</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Fukuyama</surname>
<given-names>Satoshi</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kawaoka</surname>
<given-names>Yoshihiro</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
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<aff id="A1">
<label>1</label>
ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan</aff>
<aff id="A2">
<label>2</label>
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI 53711, USA</aff>
<aff id="A3">
<label>3</label>
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</aff>
<aff id="A4">
<label>4</label>
International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</aff>
<author-notes>
<corresp id="cor1">Corresponding authors: Satoshi Fukuyama (
<email>satoshif@ims.u-tokyo</email>
,ac,jp) and Yoshihiro Kawaoka (
<email>kawaoka@ims.u-tokyo.ac.jp</email>
)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>22</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>11</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub">
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>11</day>
<month>8</month>
<year>2012</year>
</pub-date>
<volume>23</volume>
<issue>4</issue>
<fpage>481</fpage>
<lpage>486</lpage>
<permissions>
<copyright-statement>© 2011 Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
</permissions>
<abstract>
<p id="P1">Influenza viruses cause acute respiratory inflammation in humans and symptoms such as high fever, body aches, and fatigue. Usually these symptoms improve after several days; however, the 2009 pandemic H1N1 influenza virus [influenza A(H1N1)2009] is more pathogenic than seasonal influenza viruses and the pathogenicity of highly pathogenic H5N1 viruses is still higher. The 1918 influenza pandemic virus caused severe pneumonia, resulting in an estimated 50 million deaths worldwide. Several virulence factors have been identified in these virus strains, but host factors are also responsible for the pathogenesis of infections caused by virulent viruses. Here, we review the contributions of both virus and host factors to the pathogenesis of these viral infections.</p>
</abstract>
<funding-group>
<award-group>
<funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R01 AI069274-05 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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