Passive immune neutralization strategies for prevention and control of influenza A infections
Identifieur interne : 000578 ( Pmc/Corpus ); précédent : 000577; suivant : 000579Passive immune neutralization strategies for prevention and control of influenza A infections
Auteurs : Jianqiang Ye ; Hongxia Shao ; Daniel R. PerezSource :
- Immunotherapy [ 1750-743X ] ; 2012.
Abstract
Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.
Url:
DOI: 10.2217/imt.11.167
PubMed: 22339460
PubMed Central: 3292042
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PMC:3292042Le document en format XML
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<author><name sortKey="Ye, Jianqiang" sort="Ye, Jianqiang" uniqKey="Ye J" first="Jianqiang" last="Ye">Jianqiang Ye</name>
<affiliation><nlm:aff id="A1">Department of Veterinary Medicine, University of Maryland, College Park & Virginia – Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA</nlm:aff>
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<author><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name>
<affiliation><nlm:aff id="A1">Department of Veterinary Medicine, University of Maryland, College Park & Virginia – Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA</nlm:aff>
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<affiliation><nlm:aff id="A2">Key Laboratory of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, People's Republic of China</nlm:aff>
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<author><name sortKey="Perez, Daniel R" sort="Perez, Daniel R" uniqKey="Perez D" first="Daniel R" last="Perez">Daniel R. Perez</name>
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<series><title level="j">Immunotherapy</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.</p>
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<journal-id journal-id-type="nlm-ta">Immunotherapy</journal-id>
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<title-group><article-title>Passive immune neutralization strategies for prevention and control of influenza A infections</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Ye</surname>
<given-names>Jianqiang</given-names>
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<given-names>Hongxia</given-names>
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<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Perez</surname>
<given-names>Daniel R</given-names>
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<xref ref-type="corresp" rid="CR1">*</xref>
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<aff id="A1"><label>1</label>
Department of Veterinary Medicine, University of Maryland, College Park & Virginia – Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA</aff>
<aff id="A2"><label>2</label>
Key Laboratory of Jiangsu Preventive Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, People's Republic of China</aff>
<author-notes><corresp id="CR1"><label>*</label>
Author for correspondence: Tel.: +1 301 314 6811 Fax: +1 301 314 6855 <email>dperez1@umd.edu</email>
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<pub-date pub-type="nihms-submitted"><day>25</day>
<month>2</month>
<year>2012</year>
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<pub-date pub-type="ppub"><month>2</month>
<year>2012</year>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2012</year>
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<volume>4</volume>
<issue>2</issue>
<fpage>175</fpage>
<lpage>186</lpage>
<permissions><copyright-statement>© 2012 Future Medicine Ltd</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<abstract><p id="P1">Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.</p>
</abstract>
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<kwd>neutralizing antibodies</kwd>
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