Serveur d'exploration H2N2

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<title xml:lang="en">Influenza Virus Evolution, Host Adaptation and Pandemic Formation</title>
<author>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
</author>
<author>
<name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name>
</author>
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<idno type="wicri:source">PMC</idno>
<idno type="pmid">20542248</idno>
<idno type="pmc">2892379</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892379</idno>
<idno type="RBID">PMC:2892379</idno>
<idno type="doi">10.1016/j.chom.2010.05.009</idno>
<date when="2010">2010</date>
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<title xml:lang="en" level="a" type="main">Influenza Virus Evolution, Host Adaptation and Pandemic Formation</title>
<author>
<name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name>
</author>
<author>
<name sortKey="Kash, John C" sort="Kash, John C" uniqKey="Kash J" first="John C." last="Kash">John C. Kash</name>
</author>
</analytic>
<series>
<title level="j">Cell host & microbe</title>
<idno type="ISSN">1931-3128</idno>
<idno type="eISSN">1934-6069</idno>
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<date when="2010">2010</date>
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<div type="abstract" xml:lang="en">
<p id="P1">Newly emerging or `re-emerging' viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and mortality. Influenza viruses can cause zoonotic infections and adapt to humans leading to sustained transmission and emergence of novel viruses. Mechanisms by which viruses evolve in one host, cause zoonotic infection and adapt to a new host species remain unelucidated. Here we review evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans leading to pandemics and the establishment of seasonal viruses.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">101302316</journal-id>
<journal-id journal-id-type="pubmed-jr-id">33345</journal-id>
<journal-id journal-id-type="nlm-ta">Cell Host Microbe</journal-id>
<journal-title>Cell host & microbe</journal-title>
<issn pub-type="ppub">1931-3128</issn>
<issn pub-type="epub">1934-6069</issn>
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<article-id pub-id-type="pmid">20542248</article-id>
<article-id pub-id-type="pmc">2892379</article-id>
<article-id pub-id-type="doi">10.1016/j.chom.2010.05.009</article-id>
<article-id pub-id-type="manuscript">NIHMS213943</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
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<title-group>
<article-title>Influenza Virus Evolution, Host Adaptation and Pandemic Formation</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Taubenberger</surname>
<given-names>Jeffery K.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kash</surname>
<given-names>John C.</given-names>
</name>
</contrib>
<aff id="A1">Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD USA</aff>
</contrib-group>
<author-notes>
<corresp id="CR1">
<label>*</label>
Contact author's
<email>taubenbergerj@niaid.nih.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>21</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<day>25</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>25</day>
<month>6</month>
<year>2011</year>
</pub-date>
<volume>7</volume>
<issue>6</issue>
<fpage>440</fpage>
<lpage>451</lpage>
<abstract>
<p id="P1">Newly emerging or `re-emerging' viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and mortality. Influenza viruses can cause zoonotic infections and adapt to humans leading to sustained transmission and emergence of novel viruses. Mechanisms by which viruses evolve in one host, cause zoonotic infection and adapt to a new host species remain unelucidated. Here we review evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans leading to pandemics and the establishment of seasonal viruses.</p>
</abstract>
<contract-num rid="AI1">ZIA AI001114-01 ||AI</contract-num>
<contract-num rid="AI1">ZIA AI000996-03 ||AI</contract-num>
<contract-num rid="AI1">ZIA AI000986-03 ||AI</contract-num>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

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