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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structures of influenza A proteins and insights into antiviral drug targets</title><author><name sortKey="Das, Kalyan" sort="Das, Kalyan" uniqKey="Das K" first="Kalyan" last="Das">Kalyan Das</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Aramini, James M" sort="Aramini, James M" uniqKey="Aramini J" first="James M" last="Aramini">James M. Aramini</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Ma, Li Chung" sort="Ma, Li Chung" uniqKey="Ma L" first="Li-Chung" last="Ma">Li-Chung Ma</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Krug, Robert M" sort="Krug, Robert M" uniqKey="Krug R" first="Robert M" last="Krug">Robert M. Krug</name><affiliation><nlm:aff id="A4">Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Eddy" sort="Arnold, Eddy" uniqKey="Arnold E" first="Eddy" last="Arnold">Eddy Arnold</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20383144</idno><idno type="pmc">2957899</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957899</idno><idno type="RBID">PMC:2957899</idno><idno type="doi">10.1038/nsmb.1779</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000542</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structures of influenza A proteins and insights into antiviral drug targets</title><author><name sortKey="Das, Kalyan" sort="Das, Kalyan" uniqKey="Das K" first="Kalyan" last="Das">Kalyan Das</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Aramini, James M" sort="Aramini, James M" uniqKey="Aramini J" first="James M" last="Aramini">James M. Aramini</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Ma, Li Chung" sort="Ma, Li Chung" uniqKey="Ma L" first="Li-Chung" last="Ma">Li-Chung Ma</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author><author><name sortKey="Krug, Robert M" sort="Krug, Robert M" uniqKey="Krug R" first="Robert M" last="Krug">Robert M. Krug</name><affiliation><nlm:aff id="A4">Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas, USA</nlm:aff></affiliation></author><author><name sortKey="Arnold, Eddy" sort="Arnold, Eddy" uniqKey="Arnold E" first="Eddy" last="Arnold">Eddy Arnold</name><affiliation><nlm:aff id="A1">Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature structural & molecular biology</title><idno type="ISSN">1545-9993</idno><idno type="eISSN">1545-9985</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called ‘swine flu’. The H5N1 (‘bird flu’) influenza A viruses, now circulating in Asia, Africa and Europe, are extremely virulent in humans, although they have not so far acquired the ability to transfer efficiently from human to human. These health concerns have spurred considerable interest in understanding the molecular biology of influenza A viruses. Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the nonstructural NS1A protein provide opportunities for targeting these proteins to inhibit viral replication.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101186374</journal-id><journal-id journal-id-type="pubmed-jr-id">31761</journal-id><journal-id journal-id-type="nlm-ta">Nat Struct Mol Biol</journal-id><journal-title>Nature structural & molecular biology</journal-title><issn pub-type="ppub">1545-9993</issn><issn pub-type="epub">1545-9985</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20383144</article-id><article-id pub-id-type="pmc">2957899</article-id><article-id pub-id-type="doi">10.1038/nsmb.1779</article-id><article-id pub-id-type="manuscript">NIHMS242629</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Structures of influenza A proteins and insights into antiviral drug targets</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Das</surname><given-names>Kalyan</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Aramini</surname><given-names>James M</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Li-Chung</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Krug</surname><given-names>Robert M</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Arnold</surname><given-names>Eddy</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA</aff><aff id="A2"><label>2</label>Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA</aff><aff id="A3"><label>3</label>Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA</aff><aff id="A4"><label>4</label>Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, University of Texas, Austin, Texas, USA</aff><author-notes><corresp id="CR1">Correspondence should be addressed to K.D. (<email>kalyan@cabm.rutgers.edu</email>).</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>6</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>11</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>5</month><year>2011</year></pub-date><volume>17</volume><issue>5</issue><fpage>530</fpage><lpage>538</lpage><permissions><copyright-statement>© 2010 Nature America, Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">The world is currently undergoing a pandemic caused by an H1N1 influenza A virus, the so-called ‘swine flu’. The H5N1 (‘bird flu’) influenza A viruses, now circulating in Asia, Africa and Europe, are extremely virulent in humans, although they have not so far acquired the ability to transfer efficiently from human to human. These health concerns have spurred considerable interest in understanding the molecular biology of influenza A viruses. Recent structural studies of influenza A virus proteins (or fragments) help enhance our understanding of the molecular mechanisms of the viral proteins and the effects of drug resistance to improve drug design. The structures of domains of the influenza RNA-dependent RNA polymerase and the nonstructural NS1A protein provide opportunities for targeting these proteins to inhibit viral replication.</p></abstract><contract-num rid="AI1">U01 AI074497-03
||AI</contract-num><contract-num rid="AI1">R01 AI011772-36
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