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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target</title><author><name sortKey="Singh, Neetu" sort="Singh, Neetu" uniqKey="Singh N" first="Neetu" last="Singh">Neetu Singh</name></author><author><name sortKey="Pandey, Aseem" sort="Pandey, Aseem" uniqKey="Pandey A" first="Aseem" last="Pandey">Aseem Pandey</name></author><author><name sortKey="Mittal, Suresh K" sort="Mittal, Suresh K" uniqKey="Mittal S" first="Suresh K." last="Mittal">Suresh K. Mittal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20426889</idno><idno type="pmc">2904949</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904949</idno><idno type="RBID">PMC:2904949</idno><idno type="doi">10.1017/S1462399410001432</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000538</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000538</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target</title><author><name sortKey="Singh, Neetu" sort="Singh, Neetu" uniqKey="Singh N" first="Neetu" last="Singh">Neetu Singh</name></author><author><name sortKey="Pandey, Aseem" sort="Pandey, Aseem" uniqKey="Pandey A" first="Aseem" last="Pandey">Aseem Pandey</name></author><author><name sortKey="Mittal, Suresh K" sort="Mittal, Suresh K" uniqKey="Mittal S" first="Suresh K." last="Mittal">Suresh K. Mittal</name></author></analytic><series><title level="j">Expert reviews in molecular medicine</title><idno type="eISSN">1462-3994</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The unprecedented global spread of highly pathogenic avian H5N1 influenza viruses within the past ten years and their extreme lethality to poultry and humans has underscored their potential to cause an influenza pandemic. Combating the threat of an impending H5N1 influenza pandemic will require a combination of pharmaceutical and nonpharmaceutical intervention strategies. The emergence of the H1N1 pandemic in 2009 emphasised the unpredictable nature of a pandemic influenza. Undoubtedly, vaccines offer the most viable means to combat a pandemic threat. Current egg-based influenza vaccine manufacturing strategies are unlikely to be able to cater to the huge, rapid global demand because of the anticipated scarcity of embryonated eggs in an avian influenza pandemic and other factors associated with the vaccine production process. Therefore, alternative, egg-independent vaccine manufacturing strategies should be evaluated to supplement the traditional egg-derived influenza vaccine manufacturing. Furthermore, evaluation of dose-sparing strategies that offer protection with a reduced antigen dose will be critical for pandemic influenza preparedness. Development of new antiviral therapeutics and other, nonpharmaceutical intervention strategies will further supplement pandemic preparedness. This review highlights the current status of egg-dependent and egg-independent strategies against an avian influenza pandemic.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100939725</journal-id><journal-id journal-id-type="pubmed-jr-id">30086</journal-id><journal-id journal-id-type="nlm-ta">Expert Rev Mol Med</journal-id><journal-title>Expert reviews in molecular medicine</journal-title><issn pub-type="epub">1462-3994</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20426889</article-id><article-id pub-id-type="pmc">2904949</article-id><article-id pub-id-type="doi">10.1017/S1462399410001432</article-id><article-id pub-id-type="manuscript">NIHMS218345</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Singh</surname><given-names>Neetu</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pandey</surname><given-names>Aseem</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mittal</surname><given-names>Suresh K.</given-names></name></contrib><aff id="A1">Department of Comparative Pathobiology, School of Veterinary Medicine, and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA</aff></contrib-group><pub-date pub-type="nihms-submitted"><day>7</day><month>7</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>29</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>1</month><year>2011</year></pub-date><volume>12</volume><fpage>e14</fpage><lpage>e14</lpage><abstract><p id="P1">The unprecedented global spread of highly pathogenic avian H5N1 influenza viruses within the past ten years and their extreme lethality to poultry and humans has underscored their potential to cause an influenza pandemic. Combating the threat of an impending H5N1 influenza pandemic will require a combination of pharmaceutical and nonpharmaceutical intervention strategies. The emergence of the H1N1 pandemic in 2009 emphasised the unpredictable nature of a pandemic influenza. Undoubtedly, vaccines offer the most viable means to combat a pandemic threat. Current egg-based influenza vaccine manufacturing strategies are unlikely to be able to cater to the huge, rapid global demand because of the anticipated scarcity of embryonated eggs in an avian influenza pandemic and other factors associated with the vaccine production process. Therefore, alternative, egg-independent vaccine manufacturing strategies should be evaluated to supplement the traditional egg-derived influenza vaccine manufacturing. Furthermore, evaluation of dose-sparing strategies that offer protection with a reduced antigen dose will be critical for pandemic influenza preparedness. Development of new antiviral therapeutics and other, nonpharmaceutical intervention strategies will further supplement pandemic preparedness. This review highlights the current status of egg-dependent and egg-independent strategies against an avian influenza pandemic.</p></abstract><contract-num rid="AI1">R01 AI059374-05
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