Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The genomic and epidemiological dynamics of human influenza A virus</title><author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name><affiliation><nlm:aff id="A1">Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK</nlm:aff></affiliation></author><author><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G." last="Pybus">Oliver G. Pybus</name><affiliation><nlm:aff id="A2">Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK</nlm:aff></affiliation></author><author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, USA</nlm:aff></affiliation></author><author><name sortKey="Viboud, Cecile" sort="Viboud, Cecile" uniqKey="Viboud C" first="Cecile" last="Viboud">Cecile Viboud</name><affiliation><nlm:aff id="A4">Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="A5">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18418375</idno><idno type="pmc">2441973</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441973</idno><idno type="RBID">PMC:2441973</idno><idno type="doi">10.1038/nature06945</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000530</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000530</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The genomic and epidemiological dynamics of human influenza A virus</title><author><name sortKey="Rambaut, Andrew" sort="Rambaut, Andrew" uniqKey="Rambaut A" first="Andrew" last="Rambaut">Andrew Rambaut</name><affiliation><nlm:aff id="A1">Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK</nlm:aff></affiliation></author><author><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G." last="Pybus">Oliver G. Pybus</name><affiliation><nlm:aff id="A2">Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK</nlm:aff></affiliation></author><author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I." last="Nelson">Martha I. Nelson</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, USA</nlm:aff></affiliation></author><author><name sortKey="Viboud, Cecile" sort="Viboud, Cecile" uniqKey="Viboud C" first="Cecile" last="Viboud">Cecile Viboud</name><affiliation><nlm:aff id="A4">Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="A5">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C." last="Holmes">Edward C. Holmes</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecular evolution. However, little is known about the genome-scale evolutionary dynamics of this pathogen. Similarly, how genomic processes relate to global influenza epidemiology, in which the A/H3N2 and A/H1N1 subtypes co-circulate, is poorly understood. Here through an analysis of 1,302 complete viral genomes sampled from temperate populations in both hemispheres, we show that the genomic evolution of influenza A virus is characterized by a complex interplay between frequent reassortment and periodic selective sweeps. The A/H3N2 and A/H1N1 subtypes exhibit different evolutionary dynamics, with diverse lineages circulating in A/H1N1, indicative of weaker antigenic drift. These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-title>Nature</journal-title><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18418375</article-id><article-id pub-id-type="pmc">2441973</article-id><article-id pub-id-type="doi">10.1038/nature06945</article-id><article-id pub-id-type="manuscript">NIHMS54769</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The genomic and epidemiological dynamics of human influenza A virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rambaut</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pybus</surname><given-names>Oliver G.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nelson</surname><given-names>Martha I.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Viboud</surname><given-names>Cecile</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Taubenberger</surname><given-names>Jeffery K.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Holmes</surname><given-names>Edward C.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK</aff><aff id="A2"><label>2</label>Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK</aff><aff id="A3"><label>3</label>Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 16802, USA</aff><aff id="A4"><label>4</label>Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA</aff><aff id="A5"><label>5</label>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA</aff><author-notes><corresp id="CR1">Correspondence and requests for materials should be addressed to A.R. (<email>a.rambaut@ed.ac.uk</email>) and E.C.H. (<email>ech15@psu.edu</email>).</corresp><fn id="FN1"><p id="P1"><bold>Author Contributions</bold> A.R. and E.C.H. conceived the study. A.R. and O.G.P. undertook the genome sequence analyses and development of methods. E.C.H., A.R. and O.G.P. wrote the paper. M.I.N., C.V. and J.K.T. provided epidemiological and virological data. All authors interpreted the results and commented on the paper.</p></fn><fn id="FN2"><p id="P2"><bold>Author Information</bold> Reprints and permissions information is available at <ext-link ext-link-type="uri" xlink:href="http://www.nature.com/reprints">www.nature.com/reprints</ext-link>.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>19</day><month>6</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>16</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>29</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>5</month><year>2009</year></pub-date><volume>453</volume><issue>7195</issue><fpage>615</fpage><lpage>619</lpage><abstract><p id="P3">The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecular evolution. However, little is known about the genome-scale evolutionary dynamics of this pathogen. Similarly, how genomic processes relate to global influenza epidemiology, in which the A/H3N2 and A/H1N1 subtypes co-circulate, is poorly understood. Here through an analysis of 1,302 complete viral genomes sampled from temperate populations in both hemispheres, we show that the genomic evolution of influenza A virus is characterized by a complex interplay between frequent reassortment and periodic selective sweeps. The A/H3N2 and A/H1N1 subtypes exhibit different evolutionary dynamics, with diverse lineages circulating in A/H1N1, indicative of weaker antigenic drift. These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions.</p></abstract><contract-num rid="AI1">Z01 AI000996-01</contract-num><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000530 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000530 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.33. |  |