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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structural basis of pre-existing immunity to the 2009 H1N1 pandemic influenza virus</title><author><name sortKey="Xu, Rui" sort="Xu, Rui" uniqKey="Xu R" first="Rui" last="Xu">Rui Xu</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name><affiliation><nlm:aff id="A2">Dept. of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Hai, Rong" sort="Hai, Rong" uniqKey="Hai R" first="Rong" last="Hai">Rong Hai</name><affiliation><nlm:aff id="A3">Dept. of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name><affiliation><nlm:aff id="A2">Dept. of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20339031</idno><idno type="pmc">2897825</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897825</idno><idno type="RBID">PMC:2897825</idno><idno type="doi">10.1126/science.1186430</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000529</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000529</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structural basis of pre-existing immunity to the 2009 H1N1 pandemic influenza virus</title><author><name sortKey="Xu, Rui" sort="Xu, Rui" uniqKey="Xu R" first="Rui" last="Xu">Rui Xu</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author><author><name sortKey="Krause, Jens C" sort="Krause, Jens C" uniqKey="Krause J" first="Jens C." last="Krause">Jens C. Krause</name><affiliation><nlm:aff id="A2">Dept. of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Hai, Rong" sort="Hai, Rong" uniqKey="Hai R" first="Rong" last="Hai">Rong Hai</name><affiliation><nlm:aff id="A3">Dept. of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA</nlm:aff></affiliation></author><author><name sortKey="Crowe, James E" sort="Crowe, James E" uniqKey="Crowe J" first="James E." last="Crowe">James E. Crowe</name><affiliation><nlm:aff id="A2">Dept. of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation><nlm:aff id="A1">Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to human H1N1 viruses circulating early in the 20<sup>th</sup> century. The co-crystal structure of the 1918 HA with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id><journal-id journal-id-type="pubmed-jr-id">7473</journal-id><journal-id journal-id-type="nlm-ta">Science</journal-id><journal-title>Science (New York, N.Y.)</journal-title><issn pub-type="ppub">0036-8075</issn><issn pub-type="epub">1095-9203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20339031</article-id><article-id pub-id-type="pmc">2897825</article-id><article-id pub-id-type="doi">10.1126/science.1186430</article-id><article-id pub-id-type="manuscript">NIHMS207420</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Structural basis of pre-existing immunity to the 2009 H1N1 pandemic influenza virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Rui</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ekiert</surname><given-names>Damian C.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Krause</surname><given-names>Jens C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hai</surname><given-names>Rong</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Crowe</surname><given-names>James E.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Ian A.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="corresp" rid="cor1">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</aff><aff id="A2"><label>2</label>Dept. of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA</aff><aff id="A3"><label>3</label>Dept. of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA</aff><aff id="A4"><label>4</label>Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA</aff><author-notes><corresp id="cor1"><label>†</label>To whom correspondence should be addressed, <email>wilson@scripps.edu</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>6</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>25</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>16</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>10</month><year>2010</year></pub-date><volume>328</volume><issue>5976</issue><fpage>357</fpage><lpage>360</lpage><abstract><p id="P2">The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to human H1N1 viruses circulating early in the 20<sup>th</sup> century. The co-crystal structure of the 1918 HA with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.</p></abstract><contract-num rid="AI1">U54 AI057157-06
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