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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus</title><author><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Sugimoto, Jonathan D" sort="Sugimoto, Jonathan D" uniqKey="Sugimoto J" first="Jonathan D." last="Sugimoto">Jonathan D. Sugimoto</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Halloran, M Elizabeth" sort="Halloran, M Elizabeth" uniqKey="Halloran M" first="M. Elizabeth" last="Halloran">M. Elizabeth Halloran</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Basta, Nicole E" sort="Basta, Nicole E" uniqKey="Basta N" first="Nicole E." last="Basta">Nicole E. Basta</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Chao, Dennis L" sort="Chao, Dennis L" uniqKey="Chao D" first="Dennis L." last="Chao">Dennis L. Chao</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Matrajt, Laura" sort="Matrajt, Laura" uniqKey="Matrajt L" first="Laura" last="Matrajt">Laura Matrajt</name><affiliation><nlm:aff id="A4">Department of Applied Mathematics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Potter, Gail" sort="Potter, Gail" uniqKey="Potter G" first="Gail" last="Potter">Gail Potter</name><affiliation><nlm:aff id="A5">Department of Statistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Kenah, Eben" sort="Kenah, Eben" uniqKey="Kenah E" first="Eben" last="Kenah">Eben Kenah</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Global Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Longini, Ira M" sort="Longini, Ira M" uniqKey="Longini I" first="Ira M." last="Longini">Ira M. Longini</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19745114</idno><idno type="pmc">2880578</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880578</idno><idno type="RBID">PMC:2880578</idno><idno type="doi">10.1126/science.1177373</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000528</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000528</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus</title><author><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Sugimoto, Jonathan D" sort="Sugimoto, Jonathan D" uniqKey="Sugimoto J" first="Jonathan D." last="Sugimoto">Jonathan D. Sugimoto</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Halloran, M Elizabeth" sort="Halloran, M Elizabeth" uniqKey="Halloran M" first="M. Elizabeth" last="Halloran">M. Elizabeth Halloran</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Basta, Nicole E" sort="Basta, Nicole E" uniqKey="Basta N" first="Nicole E." last="Basta">Nicole E. Basta</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Chao, Dennis L" sort="Chao, Dennis L" uniqKey="Chao D" first="Dennis L." last="Chao">Dennis L. Chao</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Matrajt, Laura" sort="Matrajt, Laura" uniqKey="Matrajt L" first="Laura" last="Matrajt">Laura Matrajt</name><affiliation><nlm:aff id="A4">Department of Applied Mathematics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Potter, Gail" sort="Potter, Gail" uniqKey="Potter G" first="Gail" last="Potter">Gail Potter</name><affiliation><nlm:aff id="A5">Department of Statistics, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Kenah, Eben" sort="Kenah, Eben" uniqKey="Kenah E" first="Eben" last="Kenah">Eben Kenah</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Department of Global Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author><author><name sortKey="Longini, Ira M" sort="Longini, Ira M" uniqKey="Longini I" first="Ira M." last="Longini">Ira M. Longini</name><affiliation><nlm:aff id="A1">Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Pandemic influenza A (H1N1) 2009 (pandemic H1N1) is spreading throughout the planet. It has become the dominant strain in the southern hemisphere, where the influenza season is underway. Here, based on reported case clusters in the USA, we estimate the household secondary attack rate for pandemic H1N1 to be 27.3% (95% CI: 12.2%–50.5%). From a school outbreak, we estimate a school child infects 2.4 (95% CI: 1.8–3.2) other children within the school. We estimate the basic reproductive number, R<sub>0</sub>, to range from 1.3–1.7 and the generation interval to range from 2.6–3.2 days. We use a simulation model to evaluate the effectiveness of vaccination strategies in the USA for the Fall, 2009. If vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high risk and essential workforce groups, could mitigate a severe epidemic.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0404511</journal-id><journal-id journal-id-type="pubmed-jr-id">7473</journal-id><journal-id journal-id-type="nlm-ta">Science</journal-id><journal-title>Science (New York, N.Y.)</journal-title><issn pub-type="ppub">0036-8075</issn><issn pub-type="epub">1095-9203</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19745114</article-id><article-id pub-id-type="pmc">2880578</article-id><article-id pub-id-type="doi">10.1126/science.1177373</article-id><article-id pub-id-type="manuscript">NIHMS193182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sugimoto</surname><given-names>Jonathan D.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Halloran</surname><given-names>M. Elizabeth</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Basta</surname><given-names>Nicole E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chao</surname><given-names>Dennis L.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Matrajt</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Potter</surname><given-names>Gail</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kenah</surname><given-names>Eben</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Longini</surname><given-names>Ira M.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA, USA</aff><aff id="A2"><label>2</label>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA</aff><aff id="A3"><label>3</label>Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</aff><aff id="A4"><label>4</label>Department of Applied Mathematics, University of Washington, Seattle, WA, USA</aff><aff id="A5"><label>5</label>Department of Statistics, University of Washington, Seattle, WA, USA</aff><aff id="A6"><label>6</label>Department of Global Health, University of Washington, Seattle, WA, USA</aff><author-notes><corresp id="CR1"><label>*</label>To whom correspondence should be addressed. <email>longini@scharp.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>9</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>30</day><month>10</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>6</month><year>2010</year></pub-date><volume>326</volume><issue>5953</issue><fpage>729</fpage><lpage>733</lpage><abstract><p id="P1">Pandemic influenza A (H1N1) 2009 (pandemic H1N1) is spreading throughout the planet. It has become the dominant strain in the southern hemisphere, where the influenza season is underway. Here, based on reported case clusters in the USA, we estimate the household secondary attack rate for pandemic H1N1 to be 27.3% (95% CI: 12.2%–50.5%). From a school outbreak, we estimate a school child infects 2.4 (95% CI: 1.8–3.2) other children within the school. We estimate the basic reproductive number, R<sub>0</sub>, to range from 1.3–1.7 and the generation interval to range from 2.6–3.2 days. We use a simulation model to evaluate the effectiveness of vaccination strategies in the USA for the Fall, 2009. If vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high risk and essential workforce groups, could mitigate a severe epidemic.</p></abstract><contract-num rid="GM1">U01 GM070749-07
||GM</contract-num><contract-num rid="AI1">R01 AI032042-16
||AI</contract-num><contract-sponsor id="GM1">National Institute of General Medical Sciences : NIGMS</contract-sponsor><contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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