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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup></xref></title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Lee, Jane Hwei" sort="Lee, Jane Hwei" uniqKey="Lee J" first="Jane-Hwei" last="Lee">Jane-Hwei Lee</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Kaur, Kaval" sort="Kaur, Kaval" uniqKey="Kaur K" first="Kaval" last="Kaur">Kaval Kaur</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21994454</idno><idno type="pmc">3233150</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233150</idno><idno type="RBID">PMC:3233150</idno><idno type="doi">10.1128/JVI.05193-11</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000487</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000487</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup></xref></title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author><author><name sortKey="Lee, Jane Hwei" sort="Lee, Jane Hwei" uniqKey="Lee J" first="Jane-Hwei" last="Lee">Jane-Hwei Lee</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Kaur, Kaval" sort="Kaur, Kaval" uniqKey="Kaur K" first="Kaval" last="Kaur">Kaval Kaur</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff></affiliation></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We characterized human monoclonal antibodies (MAbs) cloned from influenza virus-infected patients and from influenza vaccine recipients by complement-dependent lysis (CDL) assay. Most MAbs active in CDL were neutralizing, but not all neutralizing MAbs can mediate CDL. Two of the three stalk-specific neutralizing MAbs tested were able to mediate CDL and were more cross-reactive to temporally distant H1N1 strains than the conventional hemagglutination-inhibiting and neutralizing MAbs. One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk-specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21994454</article-id><article-id pub-id-type="pmc">3233150</article-id><article-id pub-id-type="publisher-id">5193-11</article-id><article-id pub-id-type="doi">10.1128/JVI.05193-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Terajima</surname><given-names>Masanori</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Cruz</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Co</surname><given-names>Mary Dawn T.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Jane-Hwei</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kaur</surname><given-names>Kaval</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Patrick C.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ennis</surname><given-names>Francis A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1"><label>1</label>Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</aff><aff id="aff2"><label>2</label>Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Mailing address: <addr-line>Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655</addr-line>. Phone: <phone>(508) 856-4182</phone>. Fax: <fax>(508) 856-4890</fax>. E-mail: <email>Masanori.Terajima@umassmed.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2011</year></pub-date><volume>85</volume><issue>24</issue><fpage>13463</fpage><lpage>13467</lpage><history><date date-type="received"><day>23</day><month>5</month><year>2011</year></date><date date-type="accepted"><day>3</day><month>10</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011, American Society for Microbiology. All Rights Reserved.</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv02411013463.pdf"></self-uri><abstract><p>We characterized human monoclonal antibodies (MAbs) cloned from influenza virus-infected patients and from influenza vaccine recipients by complement-dependent lysis (CDL) assay. Most MAbs active in CDL were neutralizing, but not all neutralizing MAbs can mediate CDL. Two of the three stalk-specific neutralizing MAbs tested were able to mediate CDL and were more cross-reactive to temporally distant H1N1 strains than the conventional hemagglutination-inhibiting and neutralizing MAbs. One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk-specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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