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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup>
</xref>
</title>
<author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Jane Hwei" sort="Lee, Jane Hwei" uniqKey="Lee J" first="Jane-Hwei" last="Lee">Jane-Hwei Lee</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaur, Kaval" sort="Kaur, Kaval" uniqKey="Kaur K" first="Kaval" last="Kaur">Kaval Kaur</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21994454</idno>
<idno type="pmc">3233150</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233150</idno>
<idno type="RBID">PMC:3233150</idno>
<idno type="doi">10.1128/JVI.05193-11</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000487</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup>
</xref>
</title>
<author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Jane Hwei" sort="Lee, Jane Hwei" uniqKey="Lee J" first="Jane-Hwei" last="Lee">Jane-Hwei Lee</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kaur, Kaval" sort="Kaur, Kaval" uniqKey="Kaur K" first="Kaval" last="Kaur">Kaval Kaur</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name>
<affiliation><nlm:aff id="aff2">Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name>
<affiliation><nlm:aff id="aff1">Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>We characterized human monoclonal antibodies (MAbs) cloned from influenza virus-infected patients and from influenza vaccine recipients by complement-dependent lysis (CDL) assay. Most MAbs active in CDL were neutralizing, but not all neutralizing MAbs can mediate CDL. Two of the three stalk-specific neutralizing MAbs tested were able to mediate CDL and were more cross-reactive to temporally distant H1N1 strains than the conventional hemagglutination-inhibiting and neutralizing MAbs. One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk-specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.</p>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21994454</article-id>
<article-id pub-id-type="pmc">3233150</article-id>
<article-id pub-id-type="publisher-id">5193-11</article-id>
<article-id pub-id-type="doi">10.1128/JVI.05193-11</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject>
</subj-group>
</article-categories>
<title-group><article-title>Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
<xref ref-type="fn" rid="FN1"><sup>▿</sup>
</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Terajima</surname>
<given-names>Masanori</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cruz</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Co</surname>
<given-names>Mary Dawn T.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Jane-Hwei</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaur</surname>
<given-names>Kaval</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>Patrick C.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ennis</surname>
<given-names>Francis A.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</aff>
<aff id="aff2"><label>2</label>
Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Mailing address: <addr-line>Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655</addr-line>
. Phone: <phone>(508) 856-4182</phone>
. Fax: <fax>(508) 856-4890</fax>
. E-mail: <email>Masanori.Terajima@umassmed.edu</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<volume>85</volume>
<issue>24</issue>
<fpage>13463</fpage>
<lpage>13467</lpage>
<history><date date-type="received"><day>23</day>
<month>5</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>3</day>
<month>10</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2011, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2011</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv02411013463.pdf"></self-uri>
<abstract><p>We characterized human monoclonal antibodies (MAbs) cloned from influenza virus-infected patients and from influenza vaccine recipients by complement-dependent lysis (CDL) assay. Most MAbs active in CDL were neutralizing, but not all neutralizing MAbs can mediate CDL. Two of the three stalk-specific neutralizing MAbs tested were able to mediate CDL and were more cross-reactive to temporally distant H1N1 strains than the conventional hemagglutination-inhibiting and neutralizing MAbs. One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk-specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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