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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies.</title><author><name sortKey="Coelingh, K J" sort="Coelingh, K J" uniqKey="Coelingh K" first="K J" last="Coelingh">K J Coelingh</name></author><author><name sortKey="Winter, C C" sort="Winter, C C" uniqKey="Winter C" first="C C" last="Winter">C C Winter</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author><author><name sortKey="Rice, J M" sort="Rice, J M" uniqKey="Rice J" first="J M" last="Rice">J M Rice</name></author><author><name sortKey="Kimball, P C" sort="Kimball, P C" uniqKey="Kimball P" first="P C" last="Kimball">P C Kimball</name></author><author><name sortKey="Olmsted, R A" sort="Olmsted, R A" uniqKey="Olmsted R" first="R A" last="Olmsted">R A Olmsted</name></author><author><name sortKey="Collins, P L" sort="Collins, P L" uniqKey="Collins P" first="P L" last="Collins">P L Collins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2427750</idno><idno type="pmc">253905</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC253905</idno><idno type="RBID">PMC:253905</idno><date when="1986">1986</date><idno type="wicri:Area/Pmc/Corpus">000396</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000396</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies.</title><author><name sortKey="Coelingh, K J" sort="Coelingh, K J" uniqKey="Coelingh K" first="K J" last="Coelingh">K J Coelingh</name></author><author><name sortKey="Winter, C C" sort="Winter, C C" uniqKey="Winter C" first="C C" last="Winter">C C Winter</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author><author><name sortKey="Rice, J M" sort="Rice, J M" uniqKey="Rice J" first="J M" last="Rice">J M Rice</name></author><author><name sortKey="Kimball, P C" sort="Kimball, P C" uniqKey="Kimball P" first="P C" last="Kimball">P C Kimball</name></author><author><name sortKey="Olmsted, R A" sort="Olmsted, R A" uniqKey="Olmsted R" first="R A" last="Olmsted">R A Olmsted</name></author><author><name sortKey="Collins, P L" sort="Collins, P L" uniqKey="Collins P" first="P L" last="Collins">P L Collins</name></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1986">1986</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have previously identified 11 epitopes located in two topologically nonoverlapping antigenic sites (A and B) and a third bridging site (C) on the human type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) glycoprotein by using monoclonal antibodies (MAbs) which inhibit hemagglutination and virus infectivity (K. L. Coelingh, C. C. Winter, and B. R. Murphy, Virology 143:569-582, 1985). We have identified three additional antigenic sites (D, E, and F) on the HN molecule by competitive-binding assays of anti-HN MAbs which have no known biological activity. Epitopes in sites A, D, and F are conserved on the bovine PIV3 HN glycoprotein and also among a wide range of human isolates. The dideoxy method was used to identify nucleotide substitutions in the HN genes of antigenic variants selected with neutralizing MAbs representing epitopes in site A which are shared by human and bovine PIV3. The deduced amino acid substitutions in the variants were located in separate hydrophilic stretches of HN residues which are conserved in the primary structures of the HN proteins of both human and bovine PIV3 strains.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jvirol00104-0099-a" xlink:role="91"></graphic></fig><fig id="F2"><graphic xlink:href="jvirol00104-0101-a" xlink:role="93"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn></journal-meta><article-meta><article-id pub-id-type="pmid">2427750</article-id><article-id pub-id-type="pmc">253905</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Conserved epitopes on the hemagglutinin-neuraminidase proteins of human and bovine parainfluenza type 3 viruses: nucleotide sequence analysis of variants selected with monoclonal antibodies.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coelingh</surname><given-names>K J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Winter</surname><given-names>C C</given-names></name></contrib><contrib contrib-type="author"><name><surname>Murphy</surname><given-names>B R</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rice</surname><given-names>J M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kimball</surname><given-names>P C</given-names></name></contrib><contrib contrib-type="author"><name><surname>Olmsted</surname><given-names>R A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Collins</surname><given-names>P L</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>10</month><year>1986</year></pub-date><volume>60</volume><issue>1</issue><fpage>90</fpage><lpage>96</lpage><abstract><p>We have previously identified 11 epitopes located in two topologically nonoverlapping antigenic sites (A and B) and a third bridging site (C) on the human type 3 parainfluenza virus (PIV3) hemagglutinin-neuraminidase (HN) glycoprotein by using monoclonal antibodies (MAbs) which inhibit hemagglutination and virus infectivity (K. L. Coelingh, C. C. Winter, and B. R. Murphy, Virology 143:569-582, 1985). We have identified three additional antigenic sites (D, E, and F) on the HN molecule by competitive-binding assays of anti-HN MAbs which have no known biological activity. Epitopes in sites A, D, and F are conserved on the bovine PIV3 HN glycoprotein and also among a wide range of human isolates. The dideoxy method was used to identify nucleotide substitutions in the HN genes of antigenic variants selected with neutralizing MAbs representing epitopes in site A which are shared by human and bovine PIV3. The deduced amino acid substitutions in the variants were located in separate hydrophilic stretches of HN residues which are conserved in the primary structures of the HN proteins of both human and bovine PIV3 strains.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jvirol00104-0099-a" xlink:role="91"></graphic></fig><fig id="F2"><graphic xlink:href="jvirol00104-0101-a" xlink:role="93"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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