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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title>
<author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name>
</author>
<author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name>
</author>
<author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name>
</author>
<author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name>
</author>
<author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">2304147</idno>
<idno type="pmc">249260</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC249260</idno>
<idno type="RBID">PMC:249260</idno>
<date when="1990">1990</date>
<idno type="wicri:Area/Pmc/Corpus">000393</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000393</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title>
<author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name>
</author>
<author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name>
</author>
<author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name>
</author>
<author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name>
</author>
<author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="1990">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-title>Journal of Virology</journal-title>
<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">2304147</article-id>
<article-id pub-id-type="pmc">249260</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Treanor</surname>
<given-names>J J</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tierney</surname>
<given-names>E L</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Zebedee</surname>
<given-names>S L</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lamb</surname>
<given-names>R A</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Murphy</surname>
<given-names>B R</given-names>
</name>
</contrib>
</contrib-group>
<aff>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.</aff>
<pub-date pub-type="ppub"><month>3</month>
<year>1990</year>
</pub-date>
<volume>64</volume>
<issue>3</issue>
<fpage>1375</fpage>
<lpage>1377</lpage>
<abstract><p>The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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