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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title><author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name></author><author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name></author><author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name></author><author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">2304147</idno><idno type="pmc">249260</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC249260</idno><idno type="RBID">PMC:249260</idno><date when="1990">1990</date><idno type="wicri:Area/Pmc/Corpus">000393</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000393</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</title><author><name sortKey="Treanor, J J" sort="Treanor, J J" uniqKey="Treanor J" first="J J" last="Treanor">J J Treanor</name></author><author><name sortKey="Tierney, E L" sort="Tierney, E L" uniqKey="Tierney E" first="E L" last="Tierney">E L Tierney</name></author><author><name sortKey="Zebedee, S L" sort="Zebedee, S L" uniqKey="Zebedee S" first="S L" last="Zebedee">S L Zebedee</name></author><author><name sortKey="Lamb, R A" sort="Lamb, R A" uniqKey="Lamb R" first="R A" last="Lamb">R A Lamb</name></author><author><name sortKey="Murphy, B R" sort="Murphy, B R" uniqKey="Murphy B" first="B R" last="Murphy">B R Murphy</name></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1990">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn></journal-meta><article-meta><article-id pub-id-type="pmid">2304147</article-id><article-id pub-id-type="pmc">249260</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Treanor</surname><given-names>J J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tierney</surname><given-names>E L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zebedee</surname><given-names>S L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lamb</surname><given-names>R A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Murphy</surname><given-names>B R</given-names></name></contrib></contrib-group><aff>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.</aff><pub-date pub-type="ppub"><month>3</month><year>1990</year></pub-date><volume>64</volume><issue>3</issue><fpage>1375</fpage><lpage>1377</lpage><abstract><p>The M2 protein of influenza A virus is expressed on the surfaces of infected cells, and a monoclonal antibody to this protein inhibits plaque enlargement of sensitive influenza A viruses without reducing plaque titer (S.L. Zebedee and R.A. Lamb, J. Virol. 62:2762-2772, 1988). In the current study, passively transferred monoclonal antibody to M2 reduced the level of replication of influenza A virus but not of influenza B virus in the lungs of mice. These experiments demonstrated that antibody to a protein conserved among influenza A virus subtypes inhibits virus growth in vivo.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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