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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza A Virus Matrix Protein 1-Specific Human CD8<sup>+</sup> T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients <xref ref-type="fn" rid="fn2">▿</xref> </title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Leporati, Anita M" sort="Leporati, Anita M" uniqKey="Leporati A" first="Anita M." last="Leporati">Anita M. Leporati</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Orphin, Laura" sort="Orphin, Laura" uniqKey="Orphin L" first="Laura" last="Orphin">Laura Orphin</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Babon, Jenny Aurielle B" sort="Babon, Jenny Aurielle B" uniqKey="Babon J" first="Jenny Aurielle B." last="Babon">Jenny Aurielle B. Babon</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Pazoles, Pamela" sort="Pazoles, Pamela" uniqKey="Pazoles P" first="Pamela" last="Pazoles">Pamela Pazoles</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Jameson, Julie" sort="Jameson, Julie" uniqKey="Jameson J" first="Julie" last="Jameson">Julie Jameson</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18614638</idno><idno type="pmc">2546892</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546892</idno><idno type="RBID">PMC:2546892</idno><idno type="doi">10.1128/JVI.01047-08</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000362</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000362</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Influenza A Virus Matrix Protein 1-Specific Human CD8<sup>+</sup> T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients <xref ref-type="fn" rid="fn2">▿</xref> </title><author><name sortKey="Terajima, Masanori" sort="Terajima, Masanori" uniqKey="Terajima M" first="Masanori" last="Terajima">Masanori Terajima</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Cruz, John" sort="Cruz, John" uniqKey="Cruz J" first="John" last="Cruz">John Cruz</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Leporati, Anita M" sort="Leporati, Anita M" uniqKey="Leporati A" first="Anita M." last="Leporati">Anita M. Leporati</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Orphin, Laura" sort="Orphin, Laura" uniqKey="Orphin L" first="Laura" last="Orphin">Laura Orphin</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Babon, Jenny Aurielle B" sort="Babon, Jenny Aurielle B" uniqKey="Babon J" first="Jenny Aurielle B." last="Babon">Jenny Aurielle B. Babon</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Co, Mary Dawn T" sort="Co, Mary Dawn T" uniqKey="Co M" first="Mary Dawn T." last="Co">Mary Dawn T. Co</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Pazoles, Pamela" sort="Pazoles, Pamela" uniqKey="Pazoles P" first="Pamela" last="Pazoles">Pamela Pazoles</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Jameson, Julie" sort="Jameson, Julie" uniqKey="Jameson J" first="Julie" last="Jameson">Julie Jameson</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><affiliation><nlm:aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Among 17 HLA-A2-positive healthy adults, CD8<sup>+</sup> T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8<sup>+</sup> T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8<sup>+</sup> T-cell responses in some vaccinees.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">jvi</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology (ASM)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18614638</article-id><article-id pub-id-type="pmc">2546892</article-id><article-id pub-id-type="publisher-id">1047-08</article-id><article-id pub-id-type="doi">10.1128/JVI.01047-08</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Influenza A Virus Matrix Protein 1-Specific Human CD8<sup>+</sup> T-Cell Response Induced in Trivalent Inactivated Vaccine Recipients <xref ref-type="fn" rid="fn2">▿</xref> </article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Terajima</surname><given-names>Masanori</given-names></name><xref ref-type="aff" rid="aff0"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Cruz</surname><given-names>John</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Leporati</surname><given-names>Anita M.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Orphin</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Babon</surname><given-names>Jenny Aurielle B.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Co</surname><given-names>Mary Dawn T.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Pazoles</surname><given-names>Pamela</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib><contrib contrib-type="author"><name><surname>Jameson</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="aff0"></xref><xref ref-type="fn" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Ennis</surname><given-names>Francis A.</given-names></name><xref ref-type="aff" rid="aff0"></xref></contrib></contrib-group><aff id="aff0">Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655</aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address: Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655. Phone: (508) 856-4182. Fax: (508) 856-4890. E-mail: <email>masanori.terajima@umassmed.edu</email></p></fn><fn id="fn1"><label>†</label><p>Present address: Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>9</day><month>7</month><year>2008</year></pub-date><volume>82</volume><issue>18</issue><fpage>9283</fpage><lpage>9287</lpage><history><date date-type="received"><day>19</day><month>5</month><year>2008</year></date><date date-type="accepted"><day>3</day><month>7</month><year>2008</year></date></history><permissions><copyright-statement>Copyright © 2008, American Society for Microbiology</copyright-statement></permissions><self-uri xlink:title="pdf" xlink:href="zjv01808009283.pdf"></self-uri><abstract><p>Among 17 HLA-A2-positive healthy adults, CD8<sup>+</sup> T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8<sup>+</sup> T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8<sup>+</sup> T-cell responses in some vaccinees.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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