Clinical review: Update of avian influenza A infections in humans
Identifieur interne : 000226 ( Pmc/Corpus ); précédent : 000225; suivant : 000227Clinical review: Update of avian influenza A infections in humans
Auteurs : Christian Sandrock ; Terra KellySource :
- Critical Care [ 1364-8535 ] ; 2007.
Abstract
Influenza A viruses have a wide host range for infection, from wild waterfowl to poultry to humans. Recently, the cross-species transmission of avian influenza A, particularly subtype H5N1, has highlighted the importance of the non-human subtypes and their incidence in the human population has increased over the past decade. During cross-species transmission, human disease can range from the asymptomatic to mild conjunctivitis to fulminant pneumonia and death. With these cases, however, the risk for genetic change and development of a novel virus increases, heightening the need for public health and hospital measures. This review discusses the epidemiology, host range, human disease, outcome, treatment, and prevention of cross-transmission of avian influenza A into humans.
Url:
DOI: 10.1186/cc5675
PubMed: 17419881
PubMed Central: 2206439
Links to Exploration step
PMC:2206439Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical review: Update of avian influenza A infections in humans</title><author><name sortKey="Sandrock, Christian" sort="Sandrock, Christian" uniqKey="Sandrock C" first="Christian" last="Sandrock">Christian Sandrock</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Terra" sort="Kelly, Terra" uniqKey="Kelly T" first="Terra" last="Kelly">Terra Kelly</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Veterinary Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17419881</idno><idno type="pmc">2206439</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206439</idno><idno type="RBID">PMC:2206439</idno><idno type="doi">10.1186/cc5675</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000226</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical review: Update of avian influenza A infections in humans</title><author><name sortKey="Sandrock, Christian" sort="Sandrock, Christian" uniqKey="Sandrock C" first="Christian" last="Sandrock">Christian Sandrock</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</nlm:aff></affiliation></author><author><name sortKey="Kelly, Terra" sort="Kelly, Terra" uniqKey="Kelly T" first="Terra" last="Kelly">Terra Kelly</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Veterinary Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</nlm:aff></affiliation></author></analytic><series><title level="j">Critical Care</title><idno type="ISSN">1364-8535</idno><idno type="eISSN">1466-609X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza A viruses have a wide host range for infection, from wild waterfowl to poultry to humans. Recently, the cross-species transmission of avian influenza A, particularly subtype H5N1, has highlighted the importance of the non-human subtypes and their incidence in the human population has increased over the past decade. During cross-species transmission, human disease can range from the asymptomatic to mild conjunctivitis to fulminant pneumonia and death. With these cases, however, the risk for genetic change and development of a novel virus increases, heightening the need for public health and hospital measures. This review discusses the epidemiology, host range, human disease, outcome, treatment, and prevention of cross-transmission of avian influenza A into humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author><author><name sortKey="Munster, V" uniqKey="Munster V">V Munster</name></author><author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author><author><name sortKey="Smith, D" uniqKey="Smith D">D Smith</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Olsen, B" uniqKey="Olsen B">B Olsen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kendal, Ap" uniqKey="Kendal A">AP Kendal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gambaryan, As" uniqKey="Gambaryan A">AS Gambaryan</name></author><author><name sortKey="Tuzikov, Ab" uniqKey="Tuzikov A">AB Tuzikov</name></author><author><name sortKey="Bovin, Nv" uniqKey="Bovin N">NV Bovin</name></author><author><name sortKey="Yamnikova, Ss" uniqKey="Yamnikova S">SS Yamnikova</name></author><author><name sortKey="Lvov, Dk" uniqKey="Lvov D">DK Lvov</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author><author><name sortKey="Couceiro, Jnss" uniqKey="Couceiro J">JNSS Couceiro</name></author><author><name sortKey="Kelm, S" uniqKey="Kelm S">S Kelm</name></author><author><name sortKey="Baum, Lg" uniqKey="Baum L">LG Baum</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Castrucci, Mr" uniqKey="Castrucci M">MR Castrucci</name></author><author><name sortKey="Donatelli, I" uniqKey="Donatelli I">I Donatelli</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Couceiro, Jn" uniqKey="Couceiro J">JN Couceiro</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Baum, Lg" uniqKey="Baum L">LG Baum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name></author><author><name sortKey="Matrosovich, Ty" uniqKey="Matrosovich T">TY Matrosovich</name></author><author><name sortKey="Gray, T" uniqKey="Gray T">T Gray</name></author><author><name sortKey="Roberts, Na" uniqKey="Roberts N">NA Roberts</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrosovich, M" uniqKey="Matrosovich M">M Matrosovich</name></author><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Webster, R" uniqKey="Webster R">R Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name></author><author><name sortKey="Ebina, M" uniqKey="Ebina M">M Ebina</name></author><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name></author><author><name sortKey="Ono, M" uniqKey="Ono M">M Ono</name></author><author><name sortKey="Kasai, N" uniqKey="Kasai N">N Kasai</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pensaert, M" uniqKey="Pensaert M">M Pensaert</name></author><author><name sortKey="Ottis, K" uniqKey="Ottis K">K Ottis</name></author><author><name sortKey="Vandeputte, J" uniqKey="Vandeputte J">J Vandeputte</name></author><author><name sortKey="Kaplan, Mm" uniqKey="Kaplan M">MM Kaplan</name></author><author><name sortKey="Bachmann, Pa" uniqKey="Bachmann P">PA Bachmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name></author><author><name sortKey="Burger, H" uniqKey="Burger H">H Burger</name></author><author><name sortKey="Bachmann, Pa" uniqKey="Bachmann P">PA Bachmann</name></author><author><name sortKey="Hannoun, C" uniqKey="Hannoun C">C Hannoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Easterday, Bc" uniqKey="Easterday B">BC Easterday</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D van Riel</name></author><author><name sortKey="Baars, M" uniqKey="Baars M">M Baars</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keawcharoen, J" uniqKey="Keawcharoen J">J Keawcharoen</name></author><author><name sortKey="Oraveerakul, K" uniqKey="Oraveerakul K">K Oraveerakul</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Amonsin, A" uniqKey="Amonsin A">A Amonsin</name></author><author><name sortKey="Payungporn, S" uniqKey="Payungporn S">S Payungporn</name></author><author><name sortKey="Noppornpanth, S" uniqKey="Noppornpanth S">S Noppornpanth</name></author><author><name sortKey="Wattanodorn, S" uniqKey="Wattanodorn S">S Wattanodorn</name></author><author><name sortKey="Theambooniers, A" uniqKey="Theambooniers A">A Theambooniers</name></author><author><name sortKey="Tantilertcharoen, R" uniqKey="Tantilertcharoen R">R Tantilertcharoen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Englund, L" uniqKey="Englund L">L Englund</name></author><author><name sortKey="Klingeborn, B" uniqKey="Klingeborn B">B Klingeborn</name></author><author><name sortKey="Mejerland, T" uniqKey="Mejerland T">T Mejerland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klingeborn, B" uniqKey="Klingeborn B">B Klingeborn</name></author><author><name sortKey="Englund, L" uniqKey="Englund L">L Englund</name></author><author><name sortKey="Rott, R" uniqKey="Rott R">R Rott</name></author><author><name sortKey="Juntti, N" uniqKey="Juntti N">N Juntti</name></author><author><name sortKey="Rockborn, G" uniqKey="Rockborn G">G Rockborn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Geraci, J" uniqKey="Geraci J">J Geraci</name></author><author><name sortKey="Fiorelli, P" uniqKey="Fiorelli P">P Fiorelli</name></author><author><name sortKey="Early, G" uniqKey="Early G">G Early</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Zheng, Gs" uniqKey="Zheng G">GS Zheng</name></author><author><name sortKey="Li, Wk" uniqKey="Li W">WK Li</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Gorman, O" uniqKey="Gorman O">O Gorman</name></author><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Callan, Rj" uniqKey="Callan R">RJ Callan</name></author><author><name sortKey="Early, G" uniqKey="Early G">G Early</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Rehg, Je" uniqKey="Rehg J">JE Rehg</name></author><author><name sortKey="Fiorelli, P" uniqKey="Fiorelli P">P Fiorelli</name></author><author><name sortKey="Early, G" uniqKey="Early G">G Early</name></author><author><name sortKey="Geraci, Jr" uniqKey="Geraci J">JR Geraci</name></author><author><name sortKey="St Aubin, Dj" uniqKey="St Aubin D">DJ St Aubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Van Wyke, Kl" uniqKey="Van Wyke K">KL Van Wyke</name></author><author><name sortKey="Geraci, Jr" uniqKey="Geraci J">JR Geraci</name></author><author><name sortKey="St Aubin, Dj" uniqKey="St Aubin D">DJ St Aubin</name></author><author><name sortKey="Petursson, G" uniqKey="Petursson G">G Petursson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crawford, Pc" uniqKey="Crawford P">PC Crawford</name></author><author><name sortKey="Dubovi, Ej" uniqKey="Dubovi E">EJ Dubovi</name></author><author><name sortKey="Castleman, Wl" uniqKey="Castleman W">WL Castleman</name></author><author><name sortKey="Stephenson, I" uniqKey="Stephenson I">I Stephenson</name></author><author><name sortKey="Gibbs, Ep" uniqKey="Gibbs E">EP Gibbs</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Hill, Rc" uniqKey="Hill R">RC Hill</name></author><author><name sortKey="Ferro, P" uniqKey="Ferro P">P Ferro</name></author><author><name sortKey="Pompey, J" uniqKey="Pompey J">J Pompey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberton, Si" uniqKey="Roberton S">SI Roberton</name></author><author><name sortKey="Bell, Dj" uniqKey="Bell D">DJ Bell</name></author><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Nguyen, Dt" uniqKey="Nguyen D">DT Nguyen</name></author><author><name sortKey="Tran, Pq" uniqKey="Tran P">PQ Tran</name></author><author><name sortKey="Streicher, U" uniqKey="Streicher U">U Streicher</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banks, J" uniqKey="Banks J">J Banks</name></author><author><name sortKey="Speidel, E" uniqKey="Speidel E">E Speidel</name></author><author><name sortKey="Alexander, Dj" uniqKey="Alexander D">DJ Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claas, Ec" uniqKey="Claas E">EC Claas</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Van Beek, R" uniqKey="Van Beek R">R van Beek</name></author><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC De Jong</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Senne, Da" uniqKey="Senne D">DA Senne</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Schneeberger, Pm" uniqKey="Schneeberger P">PM Schneeberger</name></author><author><name sortKey="Rozendaal, Fw" uniqKey="Rozendaal F">FW Rozendaal</name></author><author><name sortKey="Broekman, Jm" uniqKey="Broekman J">JM Broekman</name></author><author><name sortKey="Kemink, Sa" uniqKey="Kemink S">SA Kemink</name></author><author><name sortKey="Munster, V" uniqKey="Munster V">V Munster</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name></author><author><name sortKey="Van Doornum, Gj" uniqKey="Van Doornum G">GJ Van Doornum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A Klimov</name></author><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name></author><author><name sortKey="Regnery, H" uniqKey="Regnery H">H Regnery</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Hall, H" uniqKey="Hall H">H Hall</name></author><author><name sortKey="Perdue, M" uniqKey="Perdue M">M Perdue</name></author><author><name sortKey="Swayne, D" uniqKey="Swayne D">D Swayne</name></author><author><name sortKey="Bender, C" uniqKey="Bender C">C Bender</name></author><author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Air, Gm" uniqKey="Air G">GM Air</name></author><author><name sortKey="Gibbs, Aj" uniqKey="Gibbs A">AJ Gibbs</name></author><author><name sortKey="Graves, L" uniqKey="Graves L">L Graves</name></author><author><name sortKey="Prescott, B" uniqKey="Prescott B">B Prescott</name></author><author><name sortKey="Karunakaran, D" uniqKey="Karunakaran D">D Karunakaran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Yamnikova, S" uniqKey="Yamnikova S">S Yamnikova</name></author><author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name></author><author><name sortKey="Lvov, Dk" uniqKey="Lvov D">DK Lvov</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohm, C" uniqKey="Rohm C">C Rohm</name></author><author><name sortKey="Zhou, N" uniqKey="Zhou N">N Zhou</name></author><author><name sortKey="Suss, J" uniqKey="Suss J">J Suss</name></author><author><name sortKey="Mackenzie, J" uniqKey="Mackenzie J">J Mackenzie</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellis, Tm" uniqKey="Ellis T">TM Ellis</name></author><author><name sortKey="Bousfield, Rb" uniqKey="Bousfield R">RB Bousfield</name></author><author><name sortKey="Bissett, La" uniqKey="Bissett L">LA Bissett</name></author><author><name sortKey="Dyrting, Kc" uniqKey="Dyrting K">KC Dyrting</name></author><author><name sortKey="Luk, Gs" uniqKey="Luk G">GS Luk</name></author><author><name sortKey="Tsim, St" uniqKey="Tsim S">ST Tsim</name></author><author><name sortKey="Sturm Ramirez, K" uniqKey="Sturm Ramirez K">K Sturm-Ramirez</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Malik Peiris, Js" uniqKey="Malik Peiris J">JS Malik Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author><author><name sortKey="Lei, F" uniqKey="Lei F">F Lei</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name></author><author><name sortKey="Zhang, Xw" uniqKey="Zhang X">XW Zhang</name></author><author><name sortKey="Zhang, Xl" uniqKey="Zhang X">XL Zhang</name></author><author><name sortKey="Zhao, D" uniqKey="Zhao D">D Zhao</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sturm Ramirez, Km" uniqKey="Sturm Ramirez K">KM Sturm-Ramirez</name></author><author><name sortKey="Ellis, T" uniqKey="Ellis T">T Ellis</name></author><author><name sortKey="Bousfield, B" uniqKey="Bousfield B">B Bousfield</name></author><author><name sortKey="Bissett, L" uniqKey="Bissett L">L Bissett</name></author><author><name sortKey="Dyrting, K" uniqKey="Dyrting K">K Dyrting</name></author><author><name sortKey="Rehg, Je" uniqKey="Rehg J">JE Rehg</name></author><author><name sortKey="Poon, L" uniqKey="Poon L">L Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Xu, Km" uniqKey="Xu K">KM Xu</name></author><author><name sortKey="Duan, L" uniqKey="Duan L">L Duan</name></author><author><name sortKey="Rahardjo, Ap" uniqKey="Rahardjo A">AP Rahardjo</name></author><author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name></author><author><name sortKey="Buranathai, C" uniqKey="Buranathai C">C Buranathai</name></author><author><name sortKey="Nguyen, Td" uniqKey="Nguyen T">TD Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Lei, Fm" uniqKey="Lei F">FM Lei</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Fan, Zj" uniqKey="Fan Z">ZJ Fan</name></author><author><name sortKey="Yin, Zh" uniqKey="Yin Z">ZH Yin</name></author><author><name sortKey="Jia, Cx" uniqKey="Jia C">CX Jia</name></author><author><name sortKey="Xiong, Kj" uniqKey="Xiong K">KJ Xiong</name></author><author><name sortKey="Sun, Yh" uniqKey="Sun Y">YH Sun</name></author><author><name sortKey="Zhang, Xw" uniqKey="Zhang X">XW Zhang</name></author><author><name sortKey="Wu, Xm" uniqKey="Wu X">XM Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mase, M" uniqKey="Mase M">M Mase</name></author><author><name sortKey="Tsukamoto, K" uniqKey="Tsukamoto K">K Tsukamoto</name></author><author><name sortKey="Imada, T" uniqKey="Imada T">T Imada</name></author><author><name sortKey="Imai, K" uniqKey="Imai K">K Imai</name></author><author><name sortKey="Tanimura, N" uniqKey="Tanimura N">N Tanimura</name></author><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name></author><author><name sortKey="Yamamoto, Y" uniqKey="Yamamoto Y">Y Yamamoto</name></author><author><name sortKey="Hitomi, T" uniqKey="Hitomi T">T Hitomi</name></author><author><name sortKey="Kira, T" uniqKey="Kira T">T Kira</name></author><author><name sortKey="Nakai, T" uniqKey="Nakai T">T Nakai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Borm, S" uniqKey="Van Borm S">S Van Borm</name></author><author><name sortKey="Thomas, I" uniqKey="Thomas I">I Thomas</name></author><author><name sortKey="Hanquet, G" uniqKey="Hanquet G">G Hanquet</name></author><author><name sortKey="Lambrecht, B" uniqKey="Lambrecht B">B Lambrecht</name></author><author><name sortKey="Boschmans, M" uniqKey="Boschmans M">M Boschmans</name></author><author><name sortKey="Dupont, G" uniqKey="Dupont G">G Dupont</name></author><author><name sortKey="Decaestecker, M" uniqKey="Decaestecker M">M Decaestecker</name></author><author><name sortKey="Snacken, R" uniqKey="Snacken R">R Snacken</name></author><author><name sortKey="Van Den Berg, T" uniqKey="Van Den Berg T">T van den Berg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Fan, Xh" uniqKey="Fan X">XH Fan</name></author><author><name sortKey="Rayner, Jm" uniqKey="Rayner J">JM Rayner</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Zhang, Jx" uniqKey="Zhang J">JX Zhang</name></author><author><name sortKey="Zhang, Lj" uniqKey="Zhang L">LJ Zhang</name></author><author><name sortKey="Guo, Ct" uniqKey="Guo C">CT Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulse Post, Dj" uniqKey="Hulse Post D">DJ Hulse-Post</name></author><author><name sortKey="Sturm Ramirez, Km" uniqKey="Sturm Ramirez K">KM Sturm-Ramirez</name></author><author><name sortKey="Humberd, J" uniqKey="Humberd J">J Humberd</name></author><author><name sortKey="Seiler, P" uniqKey="Seiler P">P Seiler</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Scholtissek, C" uniqKey="Scholtissek C">C Scholtissek</name></author><author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name></author><author><name sortKey="Buranathai, C" uniqKey="Buranathai C">C Buranathai</name></author><author><name sortKey="Nguyen, Td" uniqKey="Nguyen T">TD Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Yakhno, M" uniqKey="Yakhno M">M Yakhno</name></author><author><name sortKey="Hinshaw, Vs" uniqKey="Hinshaw V">VS Hinshaw</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Murti, Kg" uniqKey="Murti K">KG Murti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author><author><name sortKey="Okazaki, K" uniqKey="Okazaki K">K Okazaki</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name></author><author><name sortKey="Baas, C" uniqKey="Baas C">C Baas</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name></author><author><name sortKey="Olsen, B" uniqKey="Olsen B">B Olsen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woolhouse, Me" uniqKey="Woolhouse M">ME Woolhouse</name></author><author><name sortKey="Gowtage Sequeria, S" uniqKey="Gowtage Sequeria S">S Gowtage-Sequeria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Geraci, J" uniqKey="Geraci J">J Geraci</name></author><author><name sortKey="Petursson, G" uniqKey="Petursson G">G Petursson</name></author><author><name sortKey="Skirnisson, K" uniqKey="Skirnisson K">K Skirnisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurtz, J" uniqKey="Kurtz J">J Kurtz</name></author><author><name sortKey="Manvell, Rj" uniqKey="Manvell R">RJ Manvell</name></author><author><name sortKey="Banks, J" uniqKey="Banks J">J Banks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Leung, Cw" uniqKey="Leung C">CW Leung</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Ip, Pl" uniqKey="Ip P">PL Ip</name></author><author><name sortKey="Lai, Rw" uniqKey="Lai R">RW Lai</name></author><author><name sortKey="Orr, Wk" uniqKey="Orr W">WK Orr</name></author><author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koopmans, M" uniqKey="Koopmans M">M Koopmans</name></author><author><name sortKey="Wilbrink, B" uniqKey="Wilbrink B">B Wilbrink</name></author><author><name sortKey="Conyn, M" uniqKey="Conyn M">M Conyn</name></author><author><name sortKey="Natrop, G" uniqKey="Natrop G">G Natrop</name></author><author><name sortKey="Van Der Nat, H" uniqKey="Van Der Nat H">H van der Nat</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Meijer, A" uniqKey="Meijer A">A Meijer</name></author><author><name sortKey="Van Steenbergen, J" uniqKey="Van Steenbergen J">J van Steenbergen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Bosman, A" uniqKey="Bosman A">A Bosman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author><author><name sortKey="Tsang, Dn" uniqKey="Tsang D">DN Tsang</name></author><author><name sortKey="Que, Tl" uniqKey="Que T">TL Que</name></author><author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name></author><author><name sortKey="Cheung, Pt" uniqKey="Cheung P">PT Cheung</name></author><author><name sortKey="To, Wk" uniqKey="To W">WK To</name></author><author><name sortKey="Ho, Et" uniqKey="Ho E">ET Ho</name></author><author><name sortKey="Sung, R" uniqKey="Sung R">R Sung</name></author><author><name sortKey="Cheng, Af" uniqKey="Cheng A">AF Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Pks" uniqKey="Chan P">PKS Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Yu, Wc" uniqKey="Yu W">WC Yu</name></author><author><name sortKey="Leung, Cw" uniqKey="Leung C">CW Leung</name></author><author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name></author><author><name sortKey="Ng, Wf" uniqKey="Ng W">WF Ng</name></author><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name></author><author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Lim, Wl" uniqKey="Lim W">WL Lim</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tweed, Sa" uniqKey="Tweed S">SA Tweed</name></author><author><name sortKey="Skowronski, Dm" uniqKey="Skowronski D">DM Skowronski</name></author><author><name sortKey="David, St" uniqKey="David S">ST David</name></author><author><name sortKey="Larder, A" uniqKey="Larder A">A Larder</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M Petric</name></author><author><name sortKey="Lees, W" uniqKey="Lees W">W Lees</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M Krajden</name></author><author><name sortKey="Tellier, R" uniqKey="Tellier R">R Tellier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Hu Primmer, J" uniqKey="Hu Primmer J">J Hu-Primmer</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Abernathy, Ra" uniqKey="Abernathy R">RA Abernathy</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author><author><name sortKey="Conn, L" uniqKey="Conn L">L Conn</name></author><author><name sortKey="Kwong, H" uniqKey="Kwong H">H Kwong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buxton Bridges, C" uniqKey="Buxton Bridges C">C Buxton Bridges</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Seto, Wh" uniqKey="Seto W">WH Seto</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Tsang, D" uniqKey="Tsang D">D Tsang</name></author><author><name sortKey="Ho, W" uniqKey="Ho W">W Ho</name></author><author><name sortKey="Mak, Kh" uniqKey="Mak K">KH Mak</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ungchusak, K" uniqKey="Ungchusak K">K Ungchusak</name></author><author><name sortKey="Auewarakul, P" uniqKey="Auewarakul P">P Auewarakul</name></author><author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name></author><author><name sortKey="Kitphati, R" uniqKey="Kitphati R">R Kitphati</name></author><author><name sortKey="Auwanit, W" uniqKey="Auwanit W">W Auwanit</name></author><author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name></author><author><name sortKey="Uiprasertkul, M" uniqKey="Uiprasertkul M">M Uiprasertkul</name></author><author><name sortKey="Boonnak, K" uniqKey="Boonnak K">K Boonnak</name></author><author><name sortKey="Pittayawonganon, C" uniqKey="Pittayawonganon C">C Pittayawonganon</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liem, Nt" uniqKey="Liem N">NT Liem</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schultsz, C" uniqKey="Schultsz C">C Schultsz</name></author><author><name sortKey="Dong, Vc" uniqKey="Dong V">VC Dong</name></author><author><name sortKey="Chau, Nv" uniqKey="Chau N">NV Chau</name></author><author><name sortKey="Le, Nt" uniqKey="Le N">NT Le</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Thanh, Tt" uniqKey="Thanh T">TT Thanh</name></author><author><name sortKey="Dolecek, C" uniqKey="Dolecek C">C Dolecek</name></author><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Hien, Tt" uniqKey="Hien T">TT Hien</name></author><author><name sortKey="Farrar, J" uniqKey="Farrar J">J Farrar</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tran, Th" uniqKey="Tran T">TH Tran</name></author><author><name sortKey="Nguyen, Tl" uniqKey="Nguyen T">TL Nguyen</name></author><author><name sortKey="Nguyen, Td" uniqKey="Nguyen T">TD Nguyen</name></author><author><name sortKey="Luong, Ts" uniqKey="Luong T">TS Luong</name></author><author><name sortKey="Pham, Pm" uniqKey="Pham P">PM Pham</name></author><author><name sortKey="Nguyen, Vc" uniqKey="Nguyen V">VC Nguyen</name></author><author><name sortKey="Pham, Ts" uniqKey="Pham T">TS Pham</name></author><author><name sortKey="Vo, Cd" uniqKey="Vo C">CD Vo</name></author><author><name sortKey="Le, Tq" uniqKey="Le T">TQ Le</name></author><author><name sortKey="Ngo, Tt" uniqKey="Ngo T">TT Ngo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chotpitayasunondh, T" uniqKey="Chotpitayasunondh T">T Chotpitayasunondh</name></author><author><name sortKey="Ungchusak, K" uniqKey="Ungchusak K">K Ungchusak</name></author><author><name sortKey="Hanshaoworakul, W" uniqKey="Hanshaoworakul W">W Hanshaoworakul</name></author><author><name sortKey="Chunsuthiwat, S" uniqKey="Chunsuthiwat S">S Chunsuthiwat</name></author><author><name sortKey="Sawanpanyalert, P" uniqKey="Sawanpanyalert P">P Sawanpanyalert</name></author><author><name sortKey="Kijphati, R" uniqKey="Kijphati R">R Kijphati</name></author><author><name sortKey="Lochindarat, S" uniqKey="Lochindarat S">S Lochindarat</name></author><author><name sortKey="Srisan, P" uniqKey="Srisan P">P Srisan</name></author><author><name sortKey="Suwan, P" uniqKey="Suwan P">P Suwan</name></author><author><name sortKey="Osotthanakorn, Y" uniqKey="Osotthanakorn Y">Y Osotthanakorn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Bach, Vc" uniqKey="Bach V">VC Bach</name></author><author><name sortKey="Phan, Tq" uniqKey="Phan T">TQ Phan</name></author><author><name sortKey="Vo, Mh" uniqKey="Vo M">MH Vo</name></author><author><name sortKey="Tran, Tt" uniqKey="Tran T">TT Tran</name></author><author><name sortKey="Nguyen, Bh" uniqKey="Nguyen B">BH Nguyen</name></author><author><name sortKey="Beld, M" uniqKey="Beld M">M Beld</name></author><author><name sortKey="Le, Tp" uniqKey="Le T">TP Le</name></author><author><name sortKey="Truong, Hk" uniqKey="Truong H">HK Truong</name></author><author><name sortKey="Nguyen, Vv" uniqKey="Nguyen V">VV Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruber, Pc" uniqKey="Gruber P">PC Gruber</name></author><author><name sortKey="Gomersall, Cd" uniqKey="Gomersall C">CD Gomersall</name></author><author><name sortKey="Joynt, Gm" uniqKey="Joynt G">GM Joynt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, Cy" uniqKey="Cheung C">CY Cheung</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Lau, As" uniqKey="Lau A">AS Lau</name></author><author><name sortKey="Luk, W" uniqKey="Luk W">W Luk</name></author><author><name sortKey="Lau, Yl" uniqKey="Lau Y">YL Lau</name></author><author><name sortKey="Shortridge, Kf" uniqKey="Shortridge K">KF Shortridge</name></author><author><name sortKey="Gordon, S" uniqKey="Gordon S">S Gordon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name></author><author><name sortKey="Lee, Wk" uniqKey="Lee W">WK Lee</name></author><author><name sortKey="Lam, Wy" uniqKey="Lam W">WY Lam</name></author><author><name sortKey="Wong, Kf" uniqKey="Wong K">KF Wong</name></author><author><name sortKey="Tang, Nl" uniqKey="Tang N">NL Tang</name></author><author><name sortKey="Tsang, Dn" uniqKey="Tsang D">DN Tsang</name></author><author><name sortKey="Sung, Ry" uniqKey="Sung R">RY Sung</name></author><author><name sortKey="Buckley, Ta" uniqKey="Buckley T">TA Buckley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Hu Primmer, J" uniqKey="Hu Primmer J">J Hu-Primmer</name></author><author><name sortKey="Sims, L" uniqKey="Sims L">L Sims</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K Fukuda</name></author><author><name sortKey="Mak, Kh" uniqKey="Mak K">KH Mak</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Conn, L" uniqKey="Conn L">L Conn</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spackman, E" uniqKey="Spackman E">E Spackman</name></author><author><name sortKey="Senne, Da" uniqKey="Senne D">DA Senne</name></author><author><name sortKey="Myers, Tj" uniqKey="Myers T">TJ Myers</name></author><author><name sortKey="Bulaga, Ll" uniqKey="Bulaga L">LL Bulaga</name></author><author><name sortKey="Garber, Lp" uniqKey="Garber L">LP Garber</name></author><author><name sortKey="Perdue, Ml" uniqKey="Perdue M">ML Perdue</name></author><author><name sortKey="Lohman, K" uniqKey="Lohman K">K Lohman</name></author><author><name sortKey="Daum, Lt" uniqKey="Daum L">LT Daum</name></author><author><name sortKey="Suarez, Dl" uniqKey="Suarez D">DL Suarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cw" uniqKey="Lee C">CW Lee</name></author><author><name sortKey="Suarez, Dl" uniqKey="Suarez D">DL Suarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Payungporn, S" uniqKey="Payungporn S">S Payungporn</name></author><author><name sortKey="Phakdeewirot, P" uniqKey="Phakdeewirot P">P Phakdeewirot</name></author><author><name sortKey="Chutinimitkul, S" uniqKey="Chutinimitkul S">S Chutinimitkul</name></author><author><name sortKey="Theamboonlers, A" uniqKey="Theamboonlers A">A Theamboonlers</name></author><author><name sortKey="Keawcharoen, J" uniqKey="Keawcharoen J">J Keawcharoen</name></author><author><name sortKey="Oraveerakul, K" uniqKey="Oraveerakul K">K Oraveerakul</name></author><author><name sortKey="Amonsin, A" uniqKey="Amonsin A">A Amonsin</name></author><author><name sortKey="Poovorawan, Y" uniqKey="Poovorawan Y">Y Poovorawan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Regoes, Rr" uniqKey="Regoes R">RR Regoes</name></author><author><name sortKey="Bonhoeffer, S" uniqKey="Bonhoeffer S">S Bonhoeffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammer, Sm" uniqKey="Hammer S">SM Hammer</name></author><author><name sortKey="Inouye, Rt" uniqKey="Inouye R">RT Inouye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, To" uniqKey="Jefferson T">TO Jefferson</name></author><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name></author><author><name sortKey="Di Pietrantonj, C" uniqKey="Di Pietrantonj C">C Di Pietrantonj</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name></author><author><name sortKey="Rivetti, D" uniqKey="Rivetti D">D Rivetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cass, Lm" uniqKey="Cass L">LM Cass</name></author><author><name sortKey="Efthymiopoulos, C" uniqKey="Efthymiopoulos C">C Efthymiopoulos</name></author><author><name sortKey="Bye, A" uniqKey="Bye A">A Bye</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massarella, Jw" uniqKey="Massarella J">JW Massarella</name></author><author><name sortKey="He, Gz" uniqKey="He G">GZ He</name></author><author><name sortKey="Dorr, A" uniqKey="Dorr A">A Dorr</name></author><author><name sortKey="Nieforth, K" uniqKey="Nieforth K">K Nieforth</name></author><author><name sortKey="Ward, P" uniqKey="Ward P">P Ward</name></author><author><name sortKey="Brown, A" uniqKey="Brown A">A Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leneva, Ia" uniqKey="Leneva I">IA Leneva</name></author><author><name sortKey="Roberts, N" uniqKey="Roberts N">N Roberts</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Goloubeva, Og" uniqKey="Goloubeva O">OG Goloubeva</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Fang, Hb" uniqKey="Fang H">HB Fang</name></author><author><name sortKey="Tan, M" uniqKey="Tan M">M Tan</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leneva, Ia" uniqKey="Leneva I">IA Leneva</name></author><author><name sortKey="Goloubeva, O" uniqKey="Goloubeva O">O Goloubeva</name></author><author><name sortKey="Fenton, Rj" uniqKey="Fenton R">RJ Fenton</name></author><author><name sortKey="Tisdale, M" uniqKey="Tisdale M">M Tisdale</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Mitamura, K" uniqKey="Mitamura K">K Mitamura</name></author><author><name sortKey="Sakai Tagawa, Y" uniqKey="Sakai Tagawa Y">Y Sakai-Tagawa</name></author><author><name sortKey="Shiraishi, K" uniqKey="Shiraishi K">K Shiraishi</name></author><author><name sortKey="Kawakami, C" uniqKey="Kawakami C">C Kawakami</name></author><author><name sortKey="Kimura, K" uniqKey="Kimura K">K Kimura</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author><author><name sortKey="Sugaya, N" uniqKey="Sugaya N">N Sugaya</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Tran, Tt" uniqKey="Tran T">TT Tran</name></author><author><name sortKey="Truong, Hk" uniqKey="Truong H">HK Truong</name></author><author><name sortKey="Vo, Mh" uniqKey="Vo M">MH Vo</name></author><author><name sortKey="Smith, Gj" uniqKey="Smith G">GJ Smith</name></author><author><name sortKey="Nguyen, Vc" uniqKey="Nguyen V">VC Nguyen</name></author><author><name sortKey="Bach, Vc" uniqKey="Bach V">VC Bach</name></author><author><name sortKey="Phan, Tq" uniqKey="Phan T">TQ Phan</name></author><author><name sortKey="Do, Qh" uniqKey="Do Q">QH Do</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le, Qm" uniqKey="Le Q">QM Le</name></author><author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name></author><author><name sortKey="Someya, K" uniqKey="Someya K">K Someya</name></author><author><name sortKey="Sakai, Yt" uniqKey="Sakai Y">YT Sakai</name></author><author><name sortKey="Nguyen, Th" uniqKey="Nguyen T">TH Nguyen</name></author><author><name sortKey="Nguyen, Kh" uniqKey="Nguyen K">KH Nguyen</name></author><author><name sortKey="Pham, Nd" uniqKey="Pham N">ND Pham</name></author><author><name sortKey="Ngyen, Hh" uniqKey="Ngyen H">HH Ngyen</name></author><author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name></author><author><name sortKey="Muramoto, Y" uniqKey="Muramoto Y">Y Muramoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sidwell, Rw" uniqKey="Sidwell R">RW Sidwell</name></author><author><name sortKey="Bailey, Kw" uniqKey="Bailey K">KW Bailey</name></author><author><name sortKey="Wong, Mh" uniqKey="Wong M">MH Wong</name></author><author><name sortKey="Barnard, Dl" uniqKey="Barnard D">DL Barnard</name></author><author><name sortKey="Smee, Df" uniqKey="Smee D">DF Smee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name></author><author><name sortKey="Wu, Ak" uniqKey="Wu A">AK Wu</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Colegate, Ae" uniqKey="Colegate A">AE Colegate</name></author><author><name sortKey="Podda, A" uniqKey="Podda A">A Podda</name></author><author><name sortKey="Stephenson, I" uniqKey="Stephenson I">I Stephenson</name></author><author><name sortKey="Wood, J" uniqKey="Wood J">J Wood</name></author><author><name sortKey="Ypma, E" uniqKey="Ypma E">E Ypma</name></author><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephenson, I" uniqKey="Stephenson I">I Stephenson</name></author><author><name sortKey="Bugarini, R" uniqKey="Bugarini R">R Bugarini</name></author><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name></author><author><name sortKey="Podda, A" uniqKey="Podda A">A Podda</name></author><author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name></author><author><name sortKey="Zambon, Mc" uniqKey="Zambon M">MC Zambon</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name></author><author><name sortKey="Wilkinson, Be" uniqKey="Wilkinson B">BE Wilkinson</name></author><author><name sortKey="Masseoud, F" uniqKey="Masseoud F">F Masseoud</name></author><author><name sortKey="Hu Primmer, J" uniqKey="Hu Primmer J">J Hu-Primmer</name></author><author><name sortKey="Battaglia, R" uniqKey="Battaglia R">R Battaglia</name></author><author><name sortKey="O Brien, D" uniqKey="O Brien D">D O'Brien</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name></author><author><name sortKey="Rabinovich, G" uniqKey="Rabinovich G">G Rabinovich</name></author><author><name sortKey="Blackwelder, W" uniqKey="Blackwelder W">W Blackwelder</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipatov, As" uniqKey="Lipatov A">AS Lipatov</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author><author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name></author><author><name sortKey="Campbell, Jd" uniqKey="Campbell J">JD Campbell</name></author><author><name sortKey="Zangwill, Km" uniqKey="Zangwill K">KM Zangwill</name></author><author><name sortKey="Rowe, T" uniqKey="Rowe T">T Rowe</name></author><author><name sortKey="Wolff, M" uniqKey="Wolff M">M Wolff</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yu, It" uniqKey="Yu I">IT Yu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wong, Tw" uniqKey="Wong T">TW Wong</name></author><author><name sortKey="Tam, W" uniqKey="Tam W">W Tam</name></author><author><name sortKey="Chan, At" uniqKey="Chan A">AT Chan</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Leung, Dy" uniqKey="Leung D">DY Leung</name></author><author><name sortKey="Ho, T" uniqKey="Ho T">T Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fowler, Ra" uniqKey="Fowler R">RA Fowler</name></author><author><name sortKey="Lapinsky, Se" uniqKey="Lapinsky S">SE Lapinsky</name></author><author><name sortKey="Hallett, D" uniqKey="Hallett D">D Hallett</name></author><author><name sortKey="Detsky, As" uniqKey="Detsky A">AS Detsky</name></author><author><name sortKey="Sibbald, Wj" uniqKey="Sibbald W">WJ Sibbald</name></author><author><name sortKey="Slutsky, As" uniqKey="Slutsky A">AS Slutsky</name></author><author><name sortKey="Stewart, Te" uniqKey="Stewart T">TE Stewart</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Crit Care</journal-id><journal-title-group><journal-title>Critical Care</journal-title></journal-title-group><issn pub-type="ppub">1364-8535</issn><issn pub-type="epub">1466-609X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17419881</article-id><article-id pub-id-type="pmc">2206439</article-id><article-id pub-id-type="publisher-id">5195</article-id><article-id pub-id-type="doi">10.1186/cc5675</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Clinical review: Update of avian influenza A infections in humans</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Sandrock</surname><given-names>Christian</given-names></name><address><email>cesandrock@ucdavis.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>Terra</given-names></name><address><email>trkelly@ucdavis.edu</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.27860.3b</institution-id><institution-id institution-id-type="ISNI">0000000419369684</institution-id><institution>School of Veterinary Medicine,</institution><institution>University of California, Davis,</institution></institution-wrap>Sacramento, CA 95817 USA</aff></contrib-group><pub-date pub-type="epub"><day>22</day><month>3</month><year>2007</year></pub-date><pub-date pub-type="collection"><year>2007</year></pub-date><volume>11</volume><elocation-id>209</elocation-id><permissions><copyright-statement>© BioMed Central Ltd 2007</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>Influenza A viruses have a wide host range for infection, from wild waterfowl to poultry to humans. Recently, the cross-species transmission of avian influenza A, particularly subtype H5N1, has highlighted the importance of the non-human subtypes and their incidence in the human population has increased over the past decade. During cross-species transmission, human disease can range from the asymptomatic to mild conjunctivitis to fulminant pneumonia and death. With these cases, however, the risk for genetic change and development of a novel virus increases, heightening the need for public health and hospital measures. This review discusses the epidemiology, host range, human disease, outcome, treatment, and prevention of cross-transmission of avian influenza A into humans.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Influenza</kwd><kwd>Acute Respiratory Distress Syndrome</kwd><kwd>Avian Influenza</kwd><kwd>Oseltamivir</kwd><kwd>Avian Influenza Virus</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2007</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Introduction</title><p>Human influenza pandemics over the last 100 years have been caused by H1, H2, and H3 subtypes of influenza A viruses. More recently, avian influenza virus subtypes (that is, H5, H7) have been found to directly infect humans from their avian hosts. The recent emergence, host expansion, and spread of a highly pathogenic avian influenza (HPAI) H5N1 subtype in Asia have heightened concerns globally, both in regards to mortality from HPAI H5N1 infection in humans and the potential of a new pandemic. This paper will review the current human infections with avian influenza and their public health and medical implications.</p></sec><sec id="Sec2"><title>Influenza A viruses</title><p>Influenza A, B and C are the most important genera of the Orthomyxoviridae family, casusing both pandemic and seasonal disease in humans. Influenza A viruses are enveloped, single-stranded RNA viruses with a segmented genome (Table <xref rid="Tab1" ref-type="table">1</xref>) [<xref ref-type="bibr" rid="CR1">1</xref>]. They are classified into subtypes on the basis of the antigenic properties of the hemagglutinin (HA) and neuraminidase (NA) glycoproteins expressed on the surface of the virus [<xref ref-type="bibr" rid="CR1">1</xref>, <xref ref-type="bibr" rid="CR2">2</xref>]. Influenza A viruses are characterized by their pathogenicity, with highly pathogenic avian influenza (HPAI) causing severe disease or death in domestic poultry [<xref ref-type="bibr" rid="CR3">3</xref>]. Molecular changes in the RNA genome occur through two main mechanisms: point mutation (antigenic drift) and RNA segment reassortment (antigenic shift) [<xref ref-type="bibr" rid="CR4">4</xref>, <xref ref-type="bibr" rid="CR5">5</xref>]. Point mutations cause minor changes in the antigenic character of viruses and are the primary reason a vaccination for influenza A is given yearly. Reassortment occurs when a host cell is infected with two or more influenza A viruses, leading to the creation of a novel subtype. The influenza subtypes of the 1957 (H2N2) and 1968 (H3N2) pandemics occurred through reassortment, while the origins of the 1918 (H1N1) pandemic are unclear.<table-wrap id="Tab1"><label>Table 1</label><caption><p>Characteristics of influenza viruses</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="left">Influenza A</th><th align="left">Influenza B</th><th align="left">Influenza C</th></tr></thead><tbody><tr><td align="left">Genetic structure</td><td align="left">8 segments</td><td align="left">8 segments</td><td align="left">7 segments</td></tr><tr><td align="left">Viral proteins</td><td align="left">10 total</td><td align="left">11 total</td><td align="left">9 total</td></tr><tr><td align="left">Unique viral protein</td><td align="left">M2</td><td align="left">NB</td><td align="left">HEF</td></tr><tr><td align="left">Antigenic determinants</td><td align="left">Hemagglutinin and neuroaminidase</td><td align="left">Hemagglutinin and neuroaminidase</td><td align="left">Hemagglutinin and neuroaminidase</td></tr><tr><td align="left">Genetic change</td><td align="left">Antigenic shift and drift</td><td align="left">Antigenic drift</td><td align="left">Antigentic drift</td></tr><tr><td align="left">Host range</td><td align="left">Avians, humans swine, marine mammals, horses</td><td align="left">Humans</td><td align="left">Humans and swine</td></tr><tr><td align="left">Human epidemiology</td><td align="left">Pandemics and seasonal epidemics</td><td align="left">Seasonal epidemics</td><td align="left">No seasonality</td></tr></tbody></table></table-wrap></p><p>The HA glycoprotein mediates attachment and entry of the virus by binding to sialic acid receptors on the cell surface. The binding affinity of the HA to the host sialic acid allows for the host specificity of influenza A [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR7">7</xref>]. Avian influenza subtypes prefer to bind to sialic acid linked to galactose by α-2,3 linkages, which are found in avian intestinal and respiratory epithelium (Table <xref rid="Tab2" ref-type="table">2</xref>) [<xref ref-type="bibr" rid="CR8">8</xref>]. Human virus subtypes bind to α-2,6 linkages found in human respiratory epithelium [<xref ref-type="bibr" rid="CR8">8</xref>, <xref ref-type="bibr" rid="CR9">9</xref>]. Swine contain both α-2,3 and α-2,6 linkages in their respiratory epithelium, allowing for easy co-infection with both human and avian subtypes (thus acting as a 'mixing vessel' for new strains) [<xref ref-type="bibr" rid="CR10">10</xref>]. Humans have been found to contain both α-2,3 and α-2,6 linkages in their lower respiratory tract and conjunctivae, which allows for human infections by avian subtypes [<xref ref-type="bibr" rid="CR9">9</xref>, <xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR12">12</xref>]. The HA glycoprotein is the main target for immunity by neutralizing antibodies.<table-wrap id="Tab2"><label>Table 2</label><caption><p>Characteristics and pathogenicity of influenza A viruses</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="center">Viral features</th></tr></thead><tbody><tr><td align="left">Number of HA subtypes</td><td align="center">16</td></tr><tr><td align="left">Number of NA subtypes</td><td align="center">9</td></tr><tr><td align="left">Predominant human subtypes</td><td align="center">H1, H2, H3</td></tr><tr><td align="left">Avian subtypes</td><td align="center">H1–H16</td></tr><tr><td align="left">HPAI subtypes</td><td align="center">H5 and H7</td></tr><tr><td align="left">Conversion to HPAI</td><td align="center">Basic amino acid insertion in HA</td></tr><tr><td align="left">Avian sialic acid-galactose linkages</td><td align="center">α-2,3 linkages</td></tr><tr><td align="left">Human sialic acid-galactose linkages</td><td align="center">α-2,6 linkages</td></tr></tbody></table><table-wrap-foot><p>HA, hemagglutinin; HPAI, highly pathogenic avian influenza; NA, neuroaminidase.</p></table-wrap-foot></table-wrap></p><p>The NA glycoprotein allows the spread of the virus by cleaving the glycosidic linkages to sialic acid on host cells and the surface of the virus. The virus is then spread in secretions or other bodily fluids. The NA glycoprotein is not the major target site for neutralization of the virus by antibodies.</p></sec><sec id="Sec3"><title>Host range of influenza A viruses</title><p>Influenza A viruses infect a wide range of hosts, including many avian species, and various mammalian species, such as swine, ferrets, felids, mink, whales, horses, seals, dogs, civets, and humans [<xref ref-type="bibr" rid="CR13">13</xref>–<xref ref-type="bibr" rid="CR31">31</xref>]. Wild birds (ducks, geese, swans, and shorebirds) are important natural reservoirs of these viruses, and all of the known 16 HA and 9 NA subtypes have been found in these birds [<xref ref-type="bibr" rid="CR32">32</xref>–<xref ref-type="bibr" rid="CR35">35</xref>]. In most cases, these subtypes are found within the gastrointestinal tract of the birds, are shed in their feces, and rarely cause disease [<xref ref-type="bibr" rid="CR32">32</xref>]. Since 2002, however, HPAI H5N1 viruses originating in Asia have been reported from approximately 960 wild bird species, causing disease in some instances and asymptomatic shedding in others [<xref ref-type="bibr" rid="CR36">36</xref>–<xref ref-type="bibr" rid="CR48">48</xref>]. The virus has now spread across Asia, Europe, the Middle East, and some African countries. Additional species, such as tigers, leopards, cats, stone martens, and humans have also become infected with HPAI H5N1 [<xref ref-type="bibr" rid="CR49">49</xref>]. This spread of H5N1 into a wide range of animal and avian species may enhance the spread of the virus into the human population as it interacts with animals in a number of ways (increased land use, markets, consumption) [<xref ref-type="bibr" rid="CR44">44</xref>]. Thus, the potential contact, transmission, and mutability of HPAI H5N1 worldwide will increase as the number of species and their interactions increase, complicating prevention, surveillance and treatment possibilities.</p></sec><sec id="Sec4"><title>Epidemiology and pathogenicity of avian influenza infections in humans</title><p>The incidence of avian influenza infections in humans has increased over the past decade (Table <xref rid="Tab3" ref-type="table">3</xref>). Initially, cases of avian influenza (H7N7) in humans occurred in association with poultry outbreaks, manifesting as self-limiting conjunctivitis [<xref ref-type="bibr" rid="CR30">30</xref>, <xref ref-type="bibr" rid="CR50">50</xref>–<xref ref-type="bibr" rid="CR53">53</xref>]. Then, in 1997, a large scale HPAI H5N1 outbreak occurred among poultry in Hong Kong, with 18 documented human cases [<xref ref-type="bibr" rid="CR29">29</xref>, <xref ref-type="bibr" rid="CR31">31</xref>, <xref ref-type="bibr" rid="CR54">54</xref>, <xref ref-type="bibr" rid="CR55">55</xref>]. Two subsequent poultry outbreaks in Hong Kong in 1999 and 2003 with HPAI H5N1 occurred without human cases until 2003 when two members of a family in Hong Kong contracted HPAI H5N1 [<xref ref-type="bibr" rid="CR56">56</xref>]. In December of 2003, HPAI H5N1 surfaced in poultry in Korea and China, and from 2003 to 2006 the outbreak stretched worldwide in the largest outbreak in poultry history. Human cases of HPAI H5N1 followed the poultry outbreak, with a total of 256 cases and 151 fatalities thus far [<xref ref-type="bibr" rid="CR57">57</xref>]. Other limited outbreaks have occurred, causing variable human disease (Table <xref rid="Tab3" ref-type="table">3</xref>) [<xref ref-type="bibr" rid="CR52">52</xref>, <xref ref-type="bibr" rid="CR58">58</xref>]. However, HPAI H5N1 remains the largest and most significant poultry and human avian influenza outbreak.<table-wrap id="Tab3"><label>Table 3</label><caption><p>Avian influenza A outbreaks reported in humans</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="center">United Kingdom 1995 [51]</th><th align="center">Hong Kong 1997 [54]</th><th align="center">Hong Kong 1999 [52]</th><th align="center">The Netherlands 2003 [53]</th><th align="center">Canada 2004 [58]</th><th align="center">Worldwide (Southeast Asia, Africa, Middle East) 2003 to present [57,65,66,68]</th></tr></thead><tbody><tr><td align="left">Influenza A subtype</td><td align="center">H7N7</td><td align="center">H5N1</td><td align="center">H9N2</td><td align="center">H7N7</td><td align="center">H7N3</td><td align="center">H5N1</td></tr><tr><td align="left">Source of infection</td><td align="center">Poultry</td><td align="center">Poultry and waterfowl</td><td align="center">Poultry</td><td align="center">Poultry</td><td align="center">Poultry</td><td align="center">Poultry and waterfowl</td></tr><tr><td align="left">Clinical presentation</td><td align="center">Conjunctivitis</td><td align="center">Conjunctivitis and ILI</td><td align="center">ILI</td><td align="center">Conjunctivitis, pneumonia, ILI</td><td align="center">Conjunctivitis, ILI</td><td align="center">Conjunctivitis, ILI, pneumonia, multi-organ failure</td></tr><tr><td align="left">Number of human cases</td><td align="center">1</td><td align="center">18</td><td align="center">2</td><td align="center">89</td><td align="center">2</td><td align="center">256</td></tr><tr><td align="left">Number of fatalities (percent)</td><td align="center">0 (0)</td><td align="center">6 (33)</td><td align="center">0 (0)</td><td align="center">1 (1)</td><td align="center">0 (0)</td><td align="center">151 (59)</td></tr></tbody></table><table-wrap-foot><p>H, hemagglutinin; ILI, influenza like illness; N, neuroaminidase.</p></table-wrap-foot></table-wrap></p><p>Epidemiological investigations of human cases of avian influenza show that the virus was acquired by direct contact with infected birds [<xref ref-type="bibr" rid="CR29">29</xref>–<xref ref-type="bibr" rid="CR31">31</xref>, <xref ref-type="bibr" rid="CR50">50</xref>–<xref ref-type="bibr" rid="CR56">56</xref>]. Influenza A is transmitted through the fecal-oral and respiratory routes among wild birds and poultry [<xref ref-type="bibr" rid="CR32">32</xref>]. Human interaction with these infected secretions and birds was the major mode of transmission, with contact including consumption of undercooked or raw poultry products, handling of sick or dead birds without protection, or food processing at bird cleaning sites. All birds were domesticated (chicken, duck, goose) and no transmission from birds in the wild (migrating) or contaminated waterways has been documented. In a few cases, limited human to human transmission has been reported among health care workers and family members (Table <xref rid="Tab4" ref-type="table">4</xref>) [<xref ref-type="bibr" rid="CR59">59</xref>–<xref ref-type="bibr" rid="CR63">63</xref>]. In each of these cases, no personal protective equipment was used, which is the major factor in transmission between humans [<xref ref-type="bibr" rid="CR60">60</xref>].<table-wrap id="Tab4"><label>Table 4</label><caption><p>Person to person transmission of avian influenza</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="center">Hong Kong 1997 [59]</th><th align="center">Hong Kong 1997 [60]</th><th align="center">Netherlands 2003 [53]</th><th align="center">Thailand 2004 [61]</th><th align="center">Vietnam 2004 [62]</th><th align="center">Indonesia 2006 [64]</th></tr></thead><tbody><tr><td align="left">Influenza subtype</td><td align="center">H5N1</td><td align="center">H5N1</td><td align="center">H7N7</td><td align="center">H5N1</td><td align="center">H5N1</td><td align="center">H5N1</td></tr><tr><td align="left">Location</td><td align="center">Household</td><td align="center">Hospital</td><td align="center">Household</td><td align="center">Hospital</td><td align="center">Hospital</td><td align="center">Household</td></tr><tr><td align="left">Transmission to</td><td align="center">Family member</td><td align="center">Health care worker</td><td align="center">Family member</td><td align="center">Family member</td><td align="center">Health Care worker</td><td align="center">Family member</td></tr><tr><td align="left">Number of cases</td><td align="center">1</td><td align="center">8</td><td align="center">3</td><td align="center">2</td><td align="center">0</td><td align="center">7</td></tr><tr><td align="left">Clinical presentation</td><td align="center">Seropositive</td><td align="center">Seropositive</td><td align="center">Conjunctivitis and ILI</td><td align="center">Pneumonia, death</td><td align="center">N/A</td><td align="center">Pneumonia, death</td></tr></tbody></table><table-wrap-foot><p>ILI, influenza like illness.</p></table-wrap-foot></table-wrap></p></sec><sec id="Sec5"><title>Clinical manifestations of avian influenza in humans</title><p>The clinical manifestations of avian influenza in humans has ranged from mild conjunctivitis to severe pneumonia with multi-organ system failure (Table <xref rid="Tab5" ref-type="table">5</xref>) [<xref ref-type="bibr" rid="CR50">50</xref>, <xref ref-type="bibr" rid="CR51">51</xref>]. The median age of patients was 17.2 years in the 1997 HPAI H5N1 outbreak and 16 years in the 2003 to 2006 Southeast Asian cases (range 2 months to 90 years) [<xref ref-type="bibr" rid="CR17">17</xref>, <xref ref-type="bibr" rid="CR55">55</xref>, <xref ref-type="bibr" rid="CR65">65</xref>–<xref ref-type="bibr" rid="CR68">68</xref>]. The incubation period ranged from two to eight days from contact with sick or dead birds to symptom onset. The predominant clinical findings appear to vary with each influenza A subtype; for example, in 2003 during the Netherlands outbreak (H7N7) 92% (82 of 89) of patients presented with conjunctivitis and a minority with respiratory symptoms [<xref ref-type="bibr" rid="CR53">53</xref>]. However, with HPAI in Hong Kong in 1997 and in Southeast Asia currently, pneumonia progressing to multiorgan failure, acute respiratory distress syndrome (ARDS), and death are the predominant findings [<xref ref-type="bibr" rid="CR17">17</xref>, <xref ref-type="bibr" rid="CR55">55</xref>, <xref ref-type="bibr" rid="CR65">65</xref>–<xref ref-type="bibr" rid="CR68">68</xref>]. Rye syndrome, pulmonary hemorrhage, and predominant nausea, vomiting, and diarrhea complicate these cases [<xref ref-type="bibr" rid="CR68">68</xref>]. Laboratory findings include both thrombocytopenia and lymphopenia [<xref ref-type="bibr" rid="CR65">65</xref>, <xref ref-type="bibr" rid="CR66">66</xref>]. Chest radiographic findings include interstitial infiltrates, lobar consolidation, and air bronchograms. The clinical course of patients with HPAI H5N1 is rapid, with 68% percent of patients developing ARDS and multiorgan failure within 6 days of disease onset [<xref ref-type="bibr" rid="CR69">69</xref>]. The case fatality rate ranges form 67% to 80%, depending on the case series [<xref ref-type="bibr" rid="CR17">17</xref>, <xref ref-type="bibr" rid="CR55">55</xref>, <xref ref-type="bibr" rid="CR65">65</xref>, <xref ref-type="bibr" rid="CR66">66</xref>]. Once the patients reached the critical care unit, however, the mortality rate was 90% [<xref ref-type="bibr" rid="CR69">69</xref>]. The average time of death from disease onset was nine to ten days.<table-wrap id="Tab5"><label>Table 5</label><caption><p>Clinical, laboratory, and radiographic findings of avian influenza in humans</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="left">Clinical presentation</td></tr><tr><td align="left"> Conjunctivitis</td></tr><tr><td align="left"> Influenza-like illness</td></tr><tr><td align="left"> Nausea</td></tr><tr><td align="left"> Emesis</td></tr><tr><td align="left"> Diarrhea</td></tr><tr><td align="left"> Shortness of breath</td></tr><tr><td align="left"> Pneumonia</td></tr><tr><td align="left">Laboratory findings</td></tr><tr><td align="left"> Lymphopenia</td></tr><tr><td align="left"> Thrombocytopenia</td></tr><tr><td align="left"> Elevated creatinine</td></tr><tr><td align="left"> Abnormal transaminases</td></tr><tr><td align="left">Chest radiographic findings</td></tr><tr><td align="left"> Interstitial infiltrates</td></tr><tr><td align="left"> Lobar infiltration</td></tr><tr><td align="left"> Consolidation</td></tr><tr><td align="left"> Pneumothorax (on mechanical ventilation)</td></tr></tbody></table></table-wrap></p><p>Avian influenza A infections in humans differ from seasonal influenza in several ways. The presence of conjunctivitis is more common with avian influenza A infections than with seasonal influenza. Gastrointestinal symptoms, as seen with HPAI H5N1, and reports of primary influenza pneumonia and development of ARDS are also more common with avian influenza A infections [<xref ref-type="bibr" rid="CR65">65</xref>, <xref ref-type="bibr" rid="CR67">67</xref>, <xref ref-type="bibr" rid="CR69">69</xref>]. Finally, the rapid progression to multi-organ failure and eventually death occurs at a much higher rate with avian influenza A infections [<xref ref-type="bibr" rid="CR69">69</xref>].</p><p>Post-mortem studies have illustrated findings consistent with an overwhelming systemic inflammatory response syndrome, including diffuse alveolar damage, acute tubular necrosis and atrophy, disseminated intravascular coagulation, and multi-organ damage [<xref ref-type="bibr" rid="CR70">70</xref>, <xref ref-type="bibr" rid="CR71">71</xref>]. Interestingly, the virus has been isolated from the lungs, intestine, spleen, and brain, suggesting viremia, but active replication of the virus has been limited to the lungs [<xref ref-type="bibr" rid="CR71">71</xref>]. This overwhelming inflammatory response, with acute lung injury and ARDS as the predominant features, coincides with the findings of preferential binding of the avian influenza A viruses to α-2,3 linkages in type II pneumocytes of the lower respiratory tract of humans and a vigorous cytokine response, including increased interleukin-6, interleukin-10, and interferon beta release [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR12">12</xref>, <xref ref-type="bibr" rid="CR70">70</xref>, <xref ref-type="bibr" rid="CR71">71</xref>].</p></sec><sec id="Sec6"><title>Diagnosis</title><p>The clinical diagnosis of avian influenza infection in humans is difficult and relies on the epidemiological link to endemic areas, contact with sick or dead poultry, or contact with a confirmed case of avian influenza (Table <xref rid="Tab6" ref-type="table">6</xref>). Since many infectious diseases present with similar symptoms, the only feature significant to the clinician may be contact in an endemic area, through travel or infected poultry, and the clinician should always elicit a detailed patient history.<table-wrap id="Tab6"><label>Table 6</label><caption><p>Case definition of avian influenza</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left">Suspected H5N1 case</th></tr></thead><tbody><tr><td align="left">Lower respiratory tract infection</td></tr><tr><td align="left">Fever (>38°C)</td></tr><tr><td align="left">Cough</td></tr><tr><td align="left">Shortness of breath</td></tr><tr><td align="left">AND one of the following in the past 7 days</td></tr><tr><td align="left"> Close contact with a known or suspected human case of H5N1 disease</td></tr><tr><td align="left"> Contact with sick or dead birds (handling) or the environment where H5N1 is present</td></tr><tr><td align="left"> Consumption of a sick or dead bird in an H5N1 endemic area</td></tr><tr><td align="left"> Contact or exposure to laboratory specimens of H5N1</td></tr></tbody></table></table-wrap></p><p>The definitive diagnosis is made from isolation of the virus in culture from clinical specimens. This method not only provides the definitive diagnosis, but the viral isolate is now available for further testing, including pathogenicity, antiviral resistance, and DNA sequencing and analysis. Alternatively, antibody testing can be performed, with a standard four-fold titer increase to the specific subtype of avian influenza virus. Neutralizing antibody titer assays for H5, H7 and H9 are performed by the micorneutralization technique [<xref ref-type="bibr" rid="CR72">72</xref>]. Western blot analysis with recombinant H5 is the confirmatory test for any positive microneutralization assay [<xref ref-type="bibr" rid="CR59">59</xref>, <xref ref-type="bibr" rid="CR60">60</xref>, <xref ref-type="bibr" rid="CR72">72</xref>]. More recently, rapid diagnosis can be performed with reverse transcription-PCR on clinical samples with primers specific for the viral subtype [<xref ref-type="bibr" rid="CR73">73</xref>–<xref ref-type="bibr" rid="CR75">75</xref>]. This test should be performed only on patients meeting the case definition of possible avian influenza A infection.</p><p>Any suspected case of avian influenza in a human should be investigated by the public health officials in the province or country of origin [<xref ref-type="bibr" rid="CR39">39</xref>, <xref ref-type="bibr" rid="CR76">76</xref>]. Additionally, governmental labs are often equipped with the appropriate biolevel safety 3 laboratories, primer libraries, and associated expertise to confirm the diagnosis quickly and efficiently. Any clinical specimens should be submitted with the assistance of the public health experts.</p></sec><sec id="Sec7"><title>Treatment</title><p>Treatment of avian influenza infections in humans includes antiviral therapy and supportive care. Controlled clinical trials on the efficacy of antivirals (NA inhibitors), supportive therapy, or adjuvant care have never been performed, so current recommendations stem from the experiences of past avian influenza outbreaks and animal models.</p><p>The adamantanes (rimantadine and amantadine) and NA inhibitors (oseltamivir and zanamivir) are the antivirals used for treatment and prophylaxis of influenza infections in humans. In avian influenza virus infections, adamantanes have no role due to widespread resistance through a M2 protein alteration. In addition, over 90% of isolates of H1 and H3 human subtypes during seasonal influenza have had resistance to the adamantanes [<xref ref-type="bibr" rid="CR77">77</xref>]. Their role has now been limited to prophylaxis in the community when the circulation strain is know to be susceptible to the adamantanes [<xref ref-type="bibr" rid="CR78">78</xref>–<xref ref-type="bibr" rid="CR80">80</xref>].</p><p>NA inhibitors (oseltamivir and zanamivir) have been studied for both treatment and prophylaxis with the human influenza A subtypes H1, H2, and H3 as well as influenza B (Table <xref rid="Tab7" ref-type="table">7</xref>) [<xref ref-type="bibr" rid="CR80">80</xref>–<xref ref-type="bibr" rid="CR82">82</xref>]. In animal models with HPAI H5N1, their efficacy has been well documented, with improved survival rates seen after infection [<xref ref-type="bibr" rid="CR83">83</xref>–<xref ref-type="bibr" rid="CR85">85</xref>]. Oseltamivir has been used in avian influenza outbreaks involving H7N7 and HPAI H5N1, and therapy with oseltamivir has been shown to decrease the viral load in nasal secretions in patients infected with HPAI H5N1 [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR86">86</xref>, <xref ref-type="bibr" rid="CR87">87</xref>]. Resistance to oseltamivir has been documented in a HPAI H5N1 subtype in a Vietnamese girl treated with 75 mg daily for 4 days as post-exposure prophylaxis [<xref ref-type="bibr" rid="CR68">68</xref>]. The NA glycoprotein had a histidine to tyrosine substitution at position 274, conveying a markedly higher IC50 for oseltamivir [<xref ref-type="bibr" rid="CR68">68</xref>, <xref ref-type="bibr" rid="CR88">88</xref>]. In one study, the viral count of HPAI H5N1 in nasal secretions did not decrease with the administration of oseltamivir when the H5N1 isolate carried this resistance mutation [<xref ref-type="bibr" rid="CR68">68</xref>]. However, resistance produced by this change may be overcome with higher doses of oseltamivir <italic>in vitro</italic>, and this change has not been documented to confer resistance to zanamivir [<xref ref-type="bibr" rid="CR88">88</xref>].<table-wrap id="Tab7"><label>Table 7</label><caption><p>Neuroaminidase inhibitors</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="center">Oseltamivir</th><th align="center">Zanamivir</th></tr></thead><tbody><tr><td align="left">Spectrum of activity</td><td align="center">Influenza A and B</td><td align="center">Influenza A and B</td></tr><tr><td align="left">Administration</td><td align="center">Oral</td><td align="center">Inhalation</td></tr><tr><td align="left">Prophylaxis</td><td align="center">≥ 13 years; 75 mg daily</td><td align="center">>13 years; 10 mg daily</td></tr><tr><td align="left">Treatment</td><td align="center">≥ 1 year; 75 BID × 5 to 10 days</td><td align="center">≥ 7 years; 10 mg BID × 5 to 10 days</td></tr><tr><td align="left">Select adverse effects</td><td align="center">GI symptoms: N/V, abdominal pain</td><td align="center">Bronchospasm, cough</td></tr><tr><td align="left">Resistance potential</td><td align="center">Drug-resistant strain of H5N1 reported</td><td align="center">None yet</td></tr><tr><td align="left">Efficacy</td><td align="center">Estimated efficacy: 30 to 70 percent</td><td align="center">Not well studied</td></tr><tr><td align="left">Generic available</td><td align="center">No</td><td align="center">No</td></tr></tbody></table><table-wrap-foot><p>Data are from [80-82]. BID, twice a day; GI, gastrointestinal; N/V, nausea and vomiting.</p></table-wrap-foot></table-wrap></p><p>The timing of treatment with NA inhibitors is paramount, as early therapy is directly related to improved survival [<xref ref-type="bibr" rid="CR66">66</xref>, <xref ref-type="bibr" rid="CR83">83</xref>–<xref ref-type="bibr" rid="CR85">85</xref>]. The greatest level of protection was seen if the NA inhibitors were started within 48 hours of infection, and protection rapidly dropped after 60 hours [<xref ref-type="bibr" rid="CR78">78</xref>, <xref ref-type="bibr" rid="CR79">79</xref>]. These initial studies, however, were performed with seasonal human influenza A and B, where the period of viral shedding is approximately 48 to 72 hours. In HPAI H5N1 cases from Southeast Asia, survival appeared to be improved in patients who received oseltamavir earlier (4.5 days versus 9 days after onset of symptoms) [<xref ref-type="bibr" rid="CR66">66</xref>]. Both of these time periods are much longer than documented in animal models, so the window of optimal therapy is still unknown, particularly if viral shedding exceeds the average 48 to 72 hour period seen in seasonal influenza A and B infections.</p><p>Combination therapy with influenza A viruses has not been studied [<xref ref-type="bibr" rid="CR84">84</xref>]. Ribaviron by inhalation has been evaluated <italic>in vitro</italic> with some avian influenza A subtypes and has been found to reduce mortality from influenza B in a mouse model [<xref ref-type="bibr" rid="CR89">89</xref>]. Further animal model studies are indicated to determine if there is a role for ribaviron or combination therapy with avian influenza A viruses.</p><p>Supportive care with intravenous rehydration, mechanical ventilation, vasopressor therapy, and renal replacement therapy are required if multiorgan failure and ARDS are a feature of disease [<xref ref-type="bibr" rid="CR69">69</xref>, <xref ref-type="bibr" rid="CR90">90</xref>]. Due to the progression of pneumonia to ARDS, non-invasive ventilation is not recommended, and early intubation may be beneficial before overt respiratory failure ensues. Corticosteroids have been used in some patients with HPAI H5N1, but no definitive role for steroids has been determined. Other immunomodulatory therapy has not been reported [<xref ref-type="bibr" rid="CR91">91</xref>].</p></sec><sec id="Sec8"><title>Vaccination</title><p>Human vaccination for avian influenza viruses has not been widely used, although multiple vaccination trials are underway. Prior avian vaccines in humans have been poorly immunogenic and thus have limited use. An inactivated H5N3 has been tested and was tolerated but with limited immunogenicity [<xref ref-type="bibr" rid="CR91">91</xref>, <xref ref-type="bibr" rid="CR92">92</xref>]. Other H5 vaccines have resulted in the development of neutralizing antibodies, but to a limited degree [<xref ref-type="bibr" rid="CR93">93</xref>, <xref ref-type="bibr" rid="CR94">94</xref>]. Recently, a large randomized trial looked at an H5N1 attenuated vaccine from the Vietnam strain [<xref ref-type="bibr" rid="CR95">95</xref>]. Only a modest immune response was seen, with micro-neutralization antibodies being developed at 12 times the dose used in the seasonal influenza vaccine. The side effects were minimal. A number of other industry trials with adjuvant vaccines are currently ongoing. Although promising, human vaccination against avian influenza viruses is still under development. Underscoring this development is the uncertainty of a pandemic strain, which may have vastly different antigenic properties from any developed H5 vaccine.</p></sec><sec id="Sec9"><title>Infection control</title><p>Health care infection control is a crucial component in the management of avian influenza infection or a new pandemic strain. Experience from the severe ARDS outbreak in 2002 has illustrated that appropriate infection control measures are paramount to reduce spread to health care workers and, possibly, the community [<xref ref-type="bibr" rid="CR96">96</xref>–<xref ref-type="bibr" rid="CR98">98</xref>]. Therefore, the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recommend contact and airborne precautions for any initial suspected case of avian influenza in a human [<xref ref-type="bibr" rid="CR99">99</xref>]. In late October 2006, the CDC released updated interim guidance on the use of masks and respirators in the health care setting (Table <xref rid="Tab8" ref-type="table">8</xref>) [<xref ref-type="bibr" rid="CR99">99</xref>]. In certain high risk procedures, additional protection may be considered given the likelihood of generating aerosol particles that may enhance transmission (Table <xref rid="Tab9" ref-type="table">9</xref>) [<xref ref-type="bibr" rid="CR99">99</xref>]. Respiratory protection should be worn along with an impermeable gown, face shield, and gloves. Initial cases should be placed in a negative pressure isolation room with 6 to 12 air changes per hour. Hand hygiene with antibacterial soap or alcohol based washless gel should be standard, with appropriate basins at each patient room. Seasonal vaccination of all health care workers should be preformed and further emphasized in order to reduce the likelihood of co-infection with two stains of influenza. Visitors and family members should be strictly monitored and their access to the patient limited to reduce the likelihood of spread. Finally, antiviral chemoprophylaxis should be available to any health care workers exposed to an infected individual. Any symptomatic worker should be taken off duty and workplace surveillance should occur. With these aggressive measures, risk to health care workers, patients, and family members will be reduced.<table-wrap id="Tab8"><label>Table 8</label><caption><p>Masks and respirators for health care workers</p></caption><table frame="hsides" rules="groups"><thead><tr><th></th><th align="center">Surgical mask</th><th align="center">N-95 respirator</th><th align="center">N-95 cartridge mask</th><th align="center">Powered air purifying respirator</th></tr></thead><tbody><tr><td align="left">Protection</td><td align="center">Droplet</td><td align="center">Aerosol</td><td align="center">Aerosol</td><td align="center">Aerosol</td></tr><tr><td align="left">Disposable</td><td align="center">Yes</td><td align="center">Yes</td><td align="center">Filter only</td><td align="center">No</td></tr><tr><td align="left">Fit testing</td><td align="center">No</td><td align="center">Yearly</td><td align="center">Yearly</td><td align="center">Yearly</td></tr><tr><td align="left">Power source</td><td align="center">No</td><td align="center">No</td><td align="center">No</td><td align="center">Battery</td></tr><tr><td align="left">Stockpiling</td><td align="center">Yes</td><td align="center">Yes</td><td align="center">No</td><td align="center">No</td></tr><tr><td align="left">Cost</td><td align="center">Very low</td><td align="center">Low</td><td align="center">High</td><td align="center">Very high</td></tr></tbody></table></table-wrap><table-wrap id="Tab9"><label>Table 9</label><caption><p>High risk aerosol procedures in avian influenza</p></caption><table frame="hsides" rules="groups"><tbody><tr><td align="left">Nebulization of medication</td></tr><tr><td align="left">Endotrachial intubation</td></tr><tr><td align="left">Non-invasive mechanical ventilation</td></tr><tr><td align="left">Bronchoscopy</td></tr><tr><td align="left">Humidified oxygen delivery</td></tr><tr><td align="left">Non-rebreather mask without expiratory filter</td></tr></tbody></table></table-wrap></p></sec><sec id="Sec10"><title>Conclusion</title><p>Avian influenza viruses have occurred with increased incidence within the human population, reflecting the delicate and tangled interaction between wildlife, domesticated animals, and humans. Disease in humans can be limited to conjunctivitis or an influenza-like illness, but HPAI H5N1 causes mainly severe pneumonia, respiratory failure, and death. Most cases have occurred through direct transmission from infected poultry or waterfowl, with only a few limited cases of human to human transmission. Treatment has been successful with the NA inhibitors if started early, and vaccine development is underway with a more immunogenic attenuated H5N1 virus preparation. Infection control measures are the mainstay for prevention and disease reduction. Avian influenza viruses may constitute part of the next pandemic, so appropriate knowledge, prevention, and treatment will reduce the likelihood of this occurrence.</p></sec><sec id="Sec11"><title>Note</title><p>This article is part of a thematic series on <italic>Disaster management</italic> edited by J Christopher Farmer.</p><p>Other articles in this series can be found online at <ext-link ext-link-type="uri" xlink:href="http://ccforum.com/articles/theme-series.asp?series=CC_Disaster">http://ccforum.com/articles/theme-series.asp?series=CC_Disaster</ext-link></p></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>ARDS</term><def><p>acute respiratory distress syndrome</p></def></def-item><def-item><term>CDC</term><def><p>Centers for Disease Control and Prevention</p></def></def-item><def-item><term>HA</term><def><p>hemagglutinin</p></def></def-item><def-item><term>HPAI</term><def><p>highly pathogenic avian influenza</p></def></def-item><def-item><term>NA</term><def><p>neuroaminidase</p></def></def-item><def-item><term>WHO</term><def><p>World Health Organization.</p></def></def-item></def-list></glossary><fn-group><fn><p><bold>Competing interests</bold></p><p>The authors declare that they have no competing interests.</p></fn></fn-group><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><element-citation publication-type="journal"><person-group person-group-type="author"><collab>World Health Organization Expert Committee</collab></person-group><article-title>A revision of the system of nomenclature for influenza viruses: a WHO Memorandum</article-title><source>Bull WHO</source><year>1980</year><volume>58</volume><fpage>585</fpage><lpage>591</lpage><pub-id pub-id-type="pmid">6969132</pub-id></element-citation></ref><ref id="CR2"><label>2.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fouchier</surname><given-names>RAM</given-names></name><name><surname>Munster</surname><given-names>V</given-names></name><name><surname>Wallensten</surname><given-names>A</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>Herfst</surname><given-names>S</given-names></name><name><surname>Smith</surname><given-names>D</given-names></name><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>Olsen</surname><given-names>B</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls</article-title><source>J Virol</source><year>2005</year><volume>79</volume><fpage>2814</fpage><lpage>2822</lpage><pub-id pub-id-type="doi">10.1128/JVI.79.5.2814-2822.2005</pub-id><pub-id pub-id-type="pmid">15709000</pub-id></element-citation></ref><ref id="CR3"><label>3.</label><mixed-citation publication-type="other"><bold>Highly Pathogenic Avian Influenza: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals</bold>[<ext-link ext-link-type="uri" xlink:href="http://www.oie.int/eng/normes/mmanual/A_00037.htm">http://www.oie.int/eng/normes/mmanual/A_00037.htm</ext-link>]</mixed-citation></ref><ref id="CR4"><label>4.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Molecular mechanism of acquisition of virulence in influenza virus in nature</article-title><source>Microb Pathog</source><year>1988</year><volume>5</volume><fpage>311</fpage><lpage>318</lpage><pub-id pub-id-type="doi">10.1016/0882-4010(88)90032-0</pub-id><pub-id pub-id-type="pmid">3070264</pub-id></element-citation></ref><ref id="CR5"><label>5.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kendal</surname><given-names>AP</given-names></name></person-group><article-title>Epidemiologic implications of changes in the influenza virus genome</article-title><source>Am J Med</source><year>1987</year><volume>82</volume><fpage>4</fpage><lpage>14</lpage><pub-id pub-id-type="doi">10.1016/0002-9343(87)90554-7</pub-id><pub-id pub-id-type="pmid">3591816</pub-id></element-citation></ref><ref id="CR6"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gambaryan</surname><given-names>AS</given-names></name><name><surname>Tuzikov</surname><given-names>AB</given-names></name><name><surname>Bovin</surname><given-names>NV</given-names></name><name><surname>Yamnikova</surname><given-names>SS</given-names></name><name><surname>Lvov</surname><given-names>DK</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Matrosovich</surname><given-names>MN</given-names></name></person-group><article-title>Differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 H5N1 chicken and human influenza viruses from Hong Kong</article-title><source>Avian Dis</source><year>2003</year><volume>47</volume><fpage>1154</fpage><lpage>1160</lpage><pub-id pub-id-type="doi">10.1637/0005-2086-47.s3.1154</pub-id><pub-id pub-id-type="pmid">14575133</pub-id></element-citation></ref><ref id="CR7"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ito</surname><given-names>T</given-names></name><name><surname>Couceiro</surname><given-names>JNSS</given-names></name><name><surname>Kelm</surname><given-names>S</given-names></name><name><surname>Baum</surname><given-names>LG</given-names></name><name><surname>Krauss</surname><given-names>S</given-names></name><name><surname>Castrucci</surname><given-names>MR</given-names></name><name><surname>Donatelli</surname><given-names>I</given-names></name><name><surname>Kida</surname><given-names>H</given-names></name><name><surname>Paulson</surname><given-names>JC</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name></person-group><article-title>Molecular basis for the generation in pigs of influenza A viruses with pandemic potential</article-title><source>J Virol</source><year>1998</year><volume>72</volume><fpage>7367</fpage><lpage>7373</lpage><pub-id pub-id-type="pmid">9696833</pub-id></element-citation></ref><ref id="CR8"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Couceiro</surname><given-names>JN</given-names></name><name><surname>Paulson</surname><given-names>JC</given-names></name><name><surname>Baum</surname><given-names>LG</given-names></name></person-group><article-title>Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium: the role of the host cell in selection of hemagglutinin receptor specificity</article-title><source>Virus Res</source><year>1993</year><volume>29</volume><fpage>155</fpage><lpage>165</lpage><pub-id pub-id-type="doi">10.1016/0168-1702(93)90056-S</pub-id><pub-id pub-id-type="pmid">8212857</pub-id></element-citation></ref><ref id="CR9"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matrosovich</surname><given-names>MN</given-names></name><name><surname>Matrosovich</surname><given-names>TY</given-names></name><name><surname>Gray</surname><given-names>T</given-names></name><name><surname>Roberts</surname><given-names>NA</given-names></name><name><surname>Klenk</surname><given-names>HD</given-names></name></person-group><article-title>Human and avian influenza (AI) viruses target different cell types in cultures of human airway epithelium</article-title><source>Proc Natl Acad Sci USA</source><year>2004</year><volume>101</volume><fpage>4620</fpage><lpage>4624</lpage><pub-id pub-id-type="doi">10.1073/pnas.0308001101</pub-id><pub-id pub-id-type="pmid">15070767</pub-id></element-citation></ref><ref id="CR10"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Matrosovich</surname><given-names>M</given-names></name><name><surname>Zhou</surname><given-names>N</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Webster</surname><given-names>R</given-names></name></person-group><article-title>The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties</article-title><source>J Virol</source><year>1999</year><volume>73</volume><fpage>1146</fpage><lpage>1155</lpage><pub-id pub-id-type="pmid">9882316</pub-id></element-citation></ref><ref id="CR11"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shinya</surname><given-names>K</given-names></name><name><surname>Ebina</surname><given-names>M</given-names></name><name><surname>Yamada</surname><given-names>S</given-names></name><name><surname>Ono</surname><given-names>M</given-names></name><name><surname>Kasai</surname><given-names>N</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name></person-group><article-title>Avian flu: influenza virus receptors in the human airway</article-title><source>Nature</source><year>2006</year><volume>440</volume><fpage>435</fpage><lpage>436</lpage><pub-id pub-id-type="doi">10.1038/440435a</pub-id><pub-id pub-id-type="pmid">16554799</pub-id></element-citation></ref><ref id="CR12"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Riel</surname><given-names>D</given-names></name><name><surname>Munster</surname><given-names>VJ</given-names></name><name><surname>de Wit</surname><given-names>E</given-names></name><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name></person-group><article-title>H5N1 virus attachment to lower respiratory tract</article-title><source>Science</source><year>2006</year><volume>312</volume><fpage>399</fpage><pub-id pub-id-type="doi">10.1126/science.1125548</pub-id><pub-id pub-id-type="pmid">16556800</pub-id></element-citation></ref><ref id="CR13"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pensaert</surname><given-names>M</given-names></name><name><surname>Ottis</surname><given-names>K</given-names></name><name><surname>Vandeputte</surname><given-names>J</given-names></name><name><surname>Kaplan</surname><given-names>MM</given-names></name><name><surname>Bachmann</surname><given-names>PA</given-names></name></person-group><article-title>Evidence for the natural transmission of influenza A virus from wild ducks to swine and its potential importance for man</article-title><source>Bull WHO</source><year>1981</year><volume>59</volume><fpage>75</fpage><lpage>78</lpage><pub-id pub-id-type="pmid">6973418</pub-id></element-citation></ref><ref id="CR14"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scholtissek</surname><given-names>C</given-names></name><name><surname>Burger</surname><given-names>H</given-names></name><name><surname>Bachmann</surname><given-names>PA</given-names></name><name><surname>Hannoun</surname><given-names>C</given-names></name></person-group><article-title>Genetic relatedness of hemagglutinins of the H1 subtype of influenza A viruses isolated from swine and birds</article-title><source>Virology</source><year>1983</year><volume>129</volume><fpage>521</fpage><lpage>523</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(83)90194-0</pub-id><pub-id pub-id-type="pmid">6623931</pub-id></element-citation></ref><ref id="CR15"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Easterday</surname><given-names>BC</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names><suffix>Jr</suffix></name></person-group><article-title>Replication of avian influenza A viruses in mammals</article-title><source>Infect Immun</source><year>1981</year><volume>34</volume><fpage>354</fpage><lpage>361</lpage><pub-id pub-id-type="pmid">7309229</pub-id></element-citation></ref><ref id="CR16"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>van Riel</surname><given-names>D</given-names></name><name><surname>Baars</surname><given-names>M</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>van Amerongen</surname><given-names>G</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name></person-group><article-title>Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts</article-title><source>Am J Pathol</source><year>2006</year><volume>168</volume><fpage>176</fpage><lpage>183</lpage><pub-id pub-id-type="doi">10.2353/ajpath.2006.050466</pub-id><pub-id pub-id-type="pmid">16400021</pub-id></element-citation></ref><ref id="CR17"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Keawcharoen</surname><given-names>J</given-names></name><name><surname>Oraveerakul</surname><given-names>K</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Amonsin</surname><given-names>A</given-names></name><name><surname>Payungporn</surname><given-names>S</given-names></name><name><surname>Noppornpanth</surname><given-names>S</given-names></name><name><surname>Wattanodorn</surname><given-names>S</given-names></name><name><surname>Theambooniers</surname><given-names>A</given-names></name><name><surname>Tantilertcharoen</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>Avian influenza H5N1 in tigers and leopards</article-title><source>Emerg Infect Dis</source><year>2004</year><volume>10</volume><fpage>2189</fpage><lpage>2191</lpage><pub-id pub-id-type="doi">10.3201/eid1012.040759</pub-id><pub-id pub-id-type="pmid">15663858</pub-id></element-citation></ref><ref id="CR18"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Englund</surname><given-names>L</given-names></name><name><surname>Klingeborn</surname><given-names>B</given-names></name><name><surname>Mejerland</surname><given-names>T</given-names></name></person-group><article-title>Avian influenza A virus causing an outbreak of contagious interstitial pneumonia in mink</article-title><source>Acta Vet Scand</source><year>1986</year><volume>27</volume><fpage>497</fpage><lpage>504</lpage><pub-id pub-id-type="pmid">3604824</pub-id></element-citation></ref><ref id="CR19"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klingeborn</surname><given-names>B</given-names></name><name><surname>Englund</surname><given-names>L</given-names></name><name><surname>Rott</surname><given-names>R</given-names></name><name><surname>Juntti</surname><given-names>N</given-names></name><name><surname>Rockborn</surname><given-names>G</given-names></name></person-group><article-title>An avian influenza A virus killing a mammalian species – the mink. Brief report</article-title><source>Arch Virol</source><year>1985</year><volume>86</volume><fpage>347</fpage><lpage>351</lpage><pub-id pub-id-type="doi">10.1007/BF01309839</pub-id><pub-id pub-id-type="pmid">4062564</pub-id></element-citation></ref><ref id="CR20"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names></name><name><surname>Geraci</surname><given-names>J</given-names></name><name><surname>Fiorelli</surname><given-names>P</given-names></name><name><surname>Early</surname><given-names>G</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Characterization of two influenza A viruses from a pilot whale</article-title><source>J Virol</source><year>1986</year><volume>58</volume><fpage>655</fpage><lpage>656</lpage><pub-id pub-id-type="pmid">3701925</pub-id></element-citation></ref><ref id="CR21"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guo</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>M</given-names></name><name><surname>Zheng</surname><given-names>GS</given-names></name><name><surname>Li</surname><given-names>WK</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Seroepidemiological and molecular evidence for the presence of two H3N8 equine influenza viruses in China in 1993–94</article-title><source>J Gen Virol</source><year>1995</year><volume>76</volume><fpage>2009</fpage><lpage>2014</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-76-8-2009</pub-id><pub-id pub-id-type="pmid">7636481</pub-id></element-citation></ref><ref id="CR22"><label>22.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guo</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>M</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Gorman</surname><given-names>O</given-names></name><name><surname>Ito</surname><given-names>T</given-names></name><name><surname>Saito</surname><given-names>T</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Characterization of a new avian-like influenza A virus from horses in China</article-title><source>Virology</source><year>1992</year><volume>188</volume><fpage>245</fpage><lpage>255</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(92)90754-D</pub-id><pub-id pub-id-type="pmid">1314452</pub-id></element-citation></ref><ref id="CR23"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Callan</surname><given-names>RJ</given-names></name><name><surname>Early</surname><given-names>G</given-names></name><name><surname>Kida</surname><given-names>H</given-names></name><name><surname>Hinshaw</surname><given-names>VS</given-names></name></person-group><article-title>The appearance of H3 influenza viruses in seals</article-title><source>J Gen Virol</source><year>1995</year><volume>76</volume><fpage>199</fpage><lpage>203</lpage><pub-id pub-id-type="doi">10.1099/0022-1317-76-1-199</pub-id><pub-id pub-id-type="pmid">7844533</pub-id></element-citation></ref><ref id="CR24"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Rehg</surname><given-names>JE</given-names></name><name><surname>Fiorelli</surname><given-names>P</given-names></name><name><surname>Early</surname><given-names>G</given-names></name><name><surname>Geraci</surname><given-names>JR</given-names></name><name><surname>St Aubin</surname><given-names>DJ</given-names></name></person-group><article-title>Are seals frequently infected with avian influenza viruses?</article-title><source>J Virol</source><year>1984</year><volume>51</volume><fpage>863</fpage><lpage>865</lpage><pub-id pub-id-type="pmid">6471169</pub-id></element-citation></ref><ref id="CR25"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names></name><name><surname>Van Wyke</surname><given-names>KL</given-names></name><name><surname>Geraci</surname><given-names>JR</given-names></name><name><surname>St Aubin</surname><given-names>DJ</given-names></name><name><surname>Petursson</surname><given-names>G</given-names></name></person-group><article-title>Characterization of an influenza A virus from seals</article-title><source>Virology</source><year>1981</year><volume>113</volume><fpage>712</fpage><lpage>724</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(81)90200-2</pub-id><pub-id pub-id-type="pmid">6267805</pub-id></element-citation></ref><ref id="CR26"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Crawford</surname><given-names>PC</given-names></name><name><surname>Dubovi</surname><given-names>EJ</given-names></name><name><surname>Castleman</surname><given-names>WL</given-names></name><name><surname>Stephenson</surname><given-names>I</given-names></name><name><surname>Gibbs</surname><given-names>EP</given-names></name><name><surname>Chen</surname><given-names>L</given-names></name><name><surname>Smith</surname><given-names>C</given-names></name><name><surname>Hill</surname><given-names>RC</given-names></name><name><surname>Ferro</surname><given-names>P</given-names></name><name><surname>Pompey</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Transmission of equine influenza virus to dogs</article-title><source>Science</source><year>2005</year><volume>310</volume><fpage>482</fpage><lpage>485</lpage><pub-id pub-id-type="doi">10.1126/science.1117950</pub-id><pub-id pub-id-type="pmid">16186182</pub-id></element-citation></ref><ref id="CR27"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Roberton</surname><given-names>SI</given-names></name><name><surname>Bell</surname><given-names>DJ</given-names></name><name><surname>Smith</surname><given-names>GJ</given-names></name><name><surname>Nicholls</surname><given-names>JM</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Nguyen</surname><given-names>DT</given-names></name><name><surname>Tran</surname><given-names>PQ</given-names></name><name><surname>Streicher</surname><given-names>U</given-names></name><name><surname>Poon</surname><given-names>LL</given-names></name><name><surname>Chen</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Avian influenza H5N1 in viverrids: implications for wildlife health and conservation</article-title><source>Proc R Soc B</source><year>2006</year><volume>273</volume><fpage>1729</fpage><lpage>1732</lpage><pub-id pub-id-type="doi">10.1098/rspb.2006.3549</pub-id><pub-id pub-id-type="pmid">16790404</pub-id></element-citation></ref><ref id="CR28"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Banks</surname><given-names>J</given-names></name><name><surname>Speidel</surname><given-names>E</given-names></name><name><surname>Alexander</surname><given-names>DJ</given-names></name></person-group><article-title>Characterization of an avian influenza A virus isolated from a human – is an intermediate host necessary for the emergence of pandemic influenza viruses?</article-title><source>Arch Virol</source><year>1998</year><volume>143</volume><fpage>781</fpage><lpage>787</lpage><pub-id pub-id-type="doi">10.1007/s007050050329</pub-id><pub-id pub-id-type="pmid">9638147</pub-id></element-citation></ref><ref id="CR29"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Claas</surname><given-names>EC</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>van Beek</surname><given-names>R</given-names></name><name><surname>De Jong</surname><given-names>JC</given-names></name><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>Senne</surname><given-names>DA</given-names></name><name><surname>Krauss</surname><given-names>S</given-names></name><name><surname>Shortridge</surname><given-names>KF</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus</article-title><source>Lancet</source><year>1998</year><volume>351</volume><fpage>472</fpage><lpage>477</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(97)11212-0</pub-id><pub-id pub-id-type="pmid">9482438</pub-id></element-citation></ref><ref id="CR30"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Schneeberger</surname><given-names>PM</given-names></name><name><surname>Rozendaal</surname><given-names>FW</given-names></name><name><surname>Broekman</surname><given-names>JM</given-names></name><name><surname>Kemink</surname><given-names>SA</given-names></name><name><surname>Munster</surname><given-names>V</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>Schutten</surname><given-names>M</given-names></name><name><surname>Van Doornum</surname><given-names>GJ</given-names></name><etal></etal></person-group><article-title>Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome</article-title><source>Proc Natl Acad Sci USA</source><year>2004</year><volume>101</volume><fpage>1356</fpage><lpage>1361</lpage><pub-id pub-id-type="doi">10.1073/pnas.0308352100</pub-id><pub-id pub-id-type="pmid">14745020</pub-id></element-citation></ref><ref id="CR31"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Subbarao</surname><given-names>K</given-names></name><name><surname>Klimov</surname><given-names>A</given-names></name><name><surname>Katz</surname><given-names>J</given-names></name><name><surname>Regnery</surname><given-names>H</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Hall</surname><given-names>H</given-names></name><name><surname>Perdue</surname><given-names>M</given-names></name><name><surname>Swayne</surname><given-names>D</given-names></name><name><surname>Bender</surname><given-names>C</given-names></name><name><surname>Huang</surname><given-names>J</given-names></name><etal></etal></person-group><article-title>Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness</article-title><source>Science</source><year>1998</year><volume>279</volume><fpage>393</fpage><lpage>396</lpage><pub-id pub-id-type="doi">10.1126/science.279.5349.393</pub-id><pub-id pub-id-type="pmid">9430591</pub-id></element-citation></ref><ref id="CR32"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names></name><name><surname>Gorman</surname><given-names>OT</given-names></name><name><surname>Chambers</surname><given-names>TM</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name></person-group><article-title>Evolution and ecology of influenza A viruses</article-title><source>Microbiol Rev</source><year>1992</year><volume>56</volume><fpage>152</fpage><lpage>179</lpage><pub-id pub-id-type="pmid">1579108</pub-id></element-citation></ref><ref id="CR33"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Air</surname><given-names>GM</given-names></name><name><surname>Gibbs</surname><given-names>AJ</given-names></name><name><surname>Graves</surname><given-names>L</given-names></name><name><surname>Prescott</surname><given-names>B</given-names></name><name><surname>Karunakaran</surname><given-names>D</given-names></name></person-group><article-title>Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls</article-title><source>J Virol</source><year>1982</year><volume>42</volume><fpage>865</fpage><lpage>872</lpage><pub-id pub-id-type="pmid">7097861</pub-id></element-citation></ref><ref id="CR34"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Yamnikova</surname><given-names>S</given-names></name><name><surname>Chambers</surname><given-names>TM</given-names></name><name><surname>Lvov</surname><given-names>DK</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus</article-title><source>Virology</source><year>1990</year><volume>179</volume><fpage>759</fpage><lpage>767</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(90)90143-F</pub-id><pub-id pub-id-type="pmid">2238469</pub-id></element-citation></ref><ref id="CR35"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rohm</surname><given-names>C</given-names></name><name><surname>Zhou</surname><given-names>N</given-names></name><name><surname>Suss</surname><given-names>J</given-names></name><name><surname>Mackenzie</surname><given-names>J</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes</article-title><source>Virology</source><year>1996</year><volume>217</volume><fpage>508</fpage><lpage>516</lpage><pub-id pub-id-type="doi">10.1006/viro.1996.0145</pub-id><pub-id pub-id-type="pmid">8610442</pub-id></element-citation></ref><ref id="CR36"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ellis</surname><given-names>TM</given-names></name><name><surname>Bousfield</surname><given-names>RB</given-names></name><name><surname>Bissett</surname><given-names>LA</given-names></name><name><surname>Dyrting</surname><given-names>KC</given-names></name><name><surname>Luk</surname><given-names>GS</given-names></name><name><surname>Tsim</surname><given-names>ST</given-names></name><name><surname>Sturm-Ramirez</surname><given-names>K</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Malik Peiris</surname><given-names>JS</given-names></name></person-group><article-title>Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002</article-title><source>Avian Pathol</source><year>2004</year><volume>33</volume><fpage>492</fpage><lpage>505</lpage><pub-id pub-id-type="doi">10.1080/03079450400003601</pub-id><pub-id pub-id-type="pmid">15545029</pub-id></element-citation></ref><ref id="CR37"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>J</given-names></name><name><surname>Xiao</surname><given-names>H</given-names></name><name><surname>Lei</surname><given-names>F</given-names></name><name><surname>Zhu</surname><given-names>Q</given-names></name><name><surname>Qin</surname><given-names>K</given-names></name><name><surname>Zhang</surname><given-names>XW</given-names></name><name><surname>Zhang</surname><given-names>XL</given-names></name><name><surname>Zhao</surname><given-names>D</given-names></name><name><surname>Wang</surname><given-names>G</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Highly pathogenic H5N1 influenza virus infection in migratory birds</article-title><source>Science</source><year>2005</year><volume>309</volume><fpage>1206</fpage><pub-id pub-id-type="doi">10.1126/science.1115273</pub-id><pub-id pub-id-type="pmid">16000410</pub-id></element-citation></ref><ref id="CR38"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sturm-Ramirez</surname><given-names>KM</given-names></name><name><surname>Ellis</surname><given-names>T</given-names></name><name><surname>Bousfield</surname><given-names>B</given-names></name><name><surname>Bissett</surname><given-names>L</given-names></name><name><surname>Dyrting</surname><given-names>K</given-names></name><name><surname>Rehg</surname><given-names>JE</given-names></name><name><surname>Poon</surname><given-names>L</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Peiris</surname><given-names>M</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Reemerging H5N1 viruses in Hong Kong in 2002 are highly pathogenic to ducks</article-title><source>J Virol</source><year>2004</year><volume>78</volume><fpage>4892</fpage><lpage>4901</lpage><pub-id pub-id-type="doi">10.1128/JVI.78.9.4892-4901.2004</pub-id><pub-id pub-id-type="pmid">15078970</pub-id></element-citation></ref><ref id="CR39"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Li</surname><given-names>KS</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Smith</surname><given-names>GJ</given-names></name><name><surname>Xu</surname><given-names>KM</given-names></name><name><surname>Duan</surname><given-names>L</given-names></name><name><surname>Rahardjo</surname><given-names>AP</given-names></name><name><surname>Puthavathana</surname><given-names>P</given-names></name><name><surname>Buranathai</surname><given-names>C</given-names></name><name><surname>Nguyen</surname><given-names>TD</given-names></name><etal></etal></person-group><article-title>Genesis of a highly pathogenic and potentially pandemic H5N1 virus in eastern Asia</article-title><source>Nature</source><year>2004</year><volume>430</volume><fpage>209</fpage><lpage>213</lpage><pub-id pub-id-type="doi">10.1038/nature02746</pub-id><pub-id pub-id-type="pmid">15241415</pub-id></element-citation></ref><ref id="CR40"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kou</surname><given-names>Z</given-names></name><name><surname>Lei</surname><given-names>FM</given-names></name><name><surname>Yu</surname><given-names>J</given-names></name><name><surname>Fan</surname><given-names>ZJ</given-names></name><name><surname>Yin</surname><given-names>ZH</given-names></name><name><surname>Jia</surname><given-names>CX</given-names></name><name><surname>Xiong</surname><given-names>KJ</given-names></name><name><surname>Sun</surname><given-names>YH</given-names></name><name><surname>Zhang</surname><given-names>XW</given-names></name><name><surname>Wu</surname><given-names>XM</given-names></name><etal></etal></person-group><article-title>New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China</article-title><source>J Virol</source><year>2005</year><volume>79</volume><fpage>15460</fpage><lpage>15466</lpage><pub-id pub-id-type="doi">10.1128/JVI.79.24.15460-15466.2005</pub-id><pub-id pub-id-type="pmid">16306617</pub-id></element-citation></ref><ref id="CR41"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mase</surname><given-names>M</given-names></name><name><surname>Tsukamoto</surname><given-names>K</given-names></name><name><surname>Imada</surname><given-names>T</given-names></name><name><surname>Imai</surname><given-names>K</given-names></name><name><surname>Tanimura</surname><given-names>N</given-names></name><name><surname>Nakamura</surname><given-names>K</given-names></name><name><surname>Yamamoto</surname><given-names>Y</given-names></name><name><surname>Hitomi</surname><given-names>T</given-names></name><name><surname>Kira</surname><given-names>T</given-names></name><name><surname>Nakai</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Characterization of H5N1 influenza A viruses isolated during the 2003–2004 influenza outbreaks in Japan</article-title><source>Virology</source><year>2005</year><volume>332</volume><fpage>167</fpage><lpage>176</lpage><pub-id pub-id-type="doi">10.1016/j.virol.2004.11.016</pub-id><pub-id pub-id-type="pmid">15661149</pub-id></element-citation></ref><ref id="CR42"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Van Borm</surname><given-names>S</given-names></name><name><surname>Thomas</surname><given-names>I</given-names></name><name><surname>Hanquet</surname><given-names>G</given-names></name><name><surname>Lambrecht</surname><given-names>B</given-names></name><name><surname>Boschmans</surname><given-names>M</given-names></name><name><surname>Dupont</surname><given-names>G</given-names></name><name><surname>Decaestecker</surname><given-names>M</given-names></name><name><surname>Snacken</surname><given-names>R</given-names></name><name><surname>van den Berg</surname><given-names>T</given-names></name></person-group><article-title>Highly pathogenic H5N1 influenza virus in smuggled Thai Eagles, Belgium</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>702</fpage><lpage>705</lpage><pub-id pub-id-type="doi">10.3201/eid1105.050211</pub-id><pub-id pub-id-type="pmid">15890123</pub-id></element-citation></ref><ref id="CR43"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>H</given-names></name><name><surname>Smith</surname><given-names>GJ</given-names></name><name><surname>Li</surname><given-names>KS</given-names></name><name><surname>Wang</surname><given-names>J</given-names></name><name><surname>Fan</surname><given-names>XH</given-names></name><name><surname>Rayner</surname><given-names>JM</given-names></name><name><surname>Vijaykrishna</surname><given-names>D</given-names></name><name><surname>Zhang</surname><given-names>JX</given-names></name><name><surname>Zhang</surname><given-names>LJ</given-names></name><name><surname>Guo</surname><given-names>CT</given-names></name><etal></etal></person-group><article-title>Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control</article-title><source>Proc Natl Acad Sci USA</source><year>2006</year><volume>103</volume><fpage>2845</fpage><lpage>2850</lpage><pub-id pub-id-type="doi">10.1073/pnas.0511120103</pub-id><pub-id pub-id-type="pmid">16473931</pub-id></element-citation></ref><ref id="CR44"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hulse-Post</surname><given-names>DJ</given-names></name><name><surname>Sturm-Ramirez</surname><given-names>KM</given-names></name><name><surname>Humberd</surname><given-names>J</given-names></name><name><surname>Seiler</surname><given-names>P</given-names></name><name><surname>Govorkova</surname><given-names>EA</given-names></name><name><surname>Krauss</surname><given-names>S</given-names></name><name><surname>Scholtissek</surname><given-names>C</given-names></name><name><surname>Puthavathana</surname><given-names>P</given-names></name><name><surname>Buranathai</surname><given-names>C</given-names></name><name><surname>Nguyen</surname><given-names>TD</given-names></name><etal></etal></person-group><article-title>Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia</article-title><source>Proc Natl Acad Sci USA</source><year>2005</year><volume>102</volume><fpage>10682</fpage><lpage>10687</lpage><pub-id pub-id-type="doi">10.1073/pnas.0504662102</pub-id><pub-id pub-id-type="pmid">16030144</pub-id></element-citation></ref><ref id="CR45"><label>45.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Yakhno</surname><given-names>M</given-names></name><name><surname>Hinshaw</surname><given-names>VS</given-names></name><name><surname>Bean</surname><given-names>WJ</given-names></name><name><surname>Murti</surname><given-names>KG</given-names></name></person-group><article-title>Intestinal influenza: replication and characterization of influenza viruses in ducks</article-title><source>Virology</source><year>1978</year><volume>84</volume><fpage>268</fpage><lpage>278</lpage><pub-id pub-id-type="doi">10.1016/0042-6822(78)90247-7</pub-id><pub-id pub-id-type="pmid">23604</pub-id></element-citation></ref><ref id="CR46"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ito</surname><given-names>T</given-names></name><name><surname>Okazaki</surname><given-names>K</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name><name><surname>Takada</surname><given-names>A</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Kida</surname><given-names>H</given-names></name></person-group><article-title>Perpetuation of influenza A viruses in Alaskan waterfowl reservoirs</article-title><source>Arch Virol</source><year>1995</year><volume>140</volume><fpage>1163</fpage><lpage>1172</lpage><pub-id pub-id-type="doi">10.1007/BF01322743</pub-id><pub-id pub-id-type="pmid">7646350</pub-id></element-citation></ref><ref id="CR47"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morse</surname><given-names>SS</given-names></name></person-group><article-title>Factors in the emergence of infectious diseases</article-title><source>Emerg Infect Dis</source><year>1995</year><volume>1</volume><fpage>7</fpage><lpage>15</lpage><pub-id pub-id-type="doi">10.3201/eid0101.950102</pub-id><pub-id pub-id-type="pmid">8903148</pub-id></element-citation></ref><ref id="CR48"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Munster</surname><given-names>VJ</given-names></name><name><surname>Wallensten</surname><given-names>A</given-names></name><name><surname>Baas</surname><given-names>C</given-names></name><name><surname>Rimmelzwaan</surname><given-names>GF</given-names></name><name><surname>Schutten</surname><given-names>M</given-names></name><name><surname>Olsen</surname><given-names>B</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name></person-group><article-title>Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>1545</fpage><lpage>1551</lpage><pub-id pub-id-type="doi">10.3201/eid1110.050546</pub-id><pub-id pub-id-type="pmid">16318694</pub-id></element-citation></ref><ref id="CR49"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Woolhouse</surname><given-names>ME</given-names></name><name><surname>Gowtage-Sequeria</surname><given-names>S</given-names></name></person-group><article-title>Host range and emerging and reemerging pathogens</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>1842</fpage><lpage>1847</lpage><pub-id pub-id-type="doi">10.3201/eid1112.050997</pub-id><pub-id pub-id-type="pmid">16485468</pub-id></element-citation></ref><ref id="CR50"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Webster</surname><given-names>RG</given-names></name><name><surname>Geraci</surname><given-names>J</given-names></name><name><surname>Petursson</surname><given-names>G</given-names></name><name><surname>Skirnisson</surname><given-names>K</given-names></name></person-group><article-title>Conjunctivitis in human beings caused by influenza A virus of seals</article-title><source>N Engl J Med</source><year>1981</year><volume>304</volume><fpage>911</fpage><pub-id pub-id-type="pmid">7207529</pub-id></element-citation></ref><ref id="CR51"><label>51.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kurtz</surname><given-names>J</given-names></name><name><surname>Manvell</surname><given-names>RJ</given-names></name><name><surname>Banks</surname><given-names>J</given-names></name></person-group><article-title>Avian influenza virus isolated from a woman with conjunctivitis</article-title><source>Lancet</source><year>1996</year><volume>348</volume><fpage>901</fpage><lpage>902</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(05)64783-6</pub-id><pub-id pub-id-type="pmid">8826845</pub-id></element-citation></ref><ref id="CR52"><label>52.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peiris</surname><given-names>M</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Leung</surname><given-names>CW</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Ip</surname><given-names>PL</given-names></name><name><surname>Lai</surname><given-names>RW</given-names></name><name><surname>Orr</surname><given-names>WK</given-names></name><name><surname>Shortridge</surname><given-names>KF</given-names></name></person-group><article-title>Human infection with influenza H9N2</article-title><source>Lancet</source><year>1999</year><volume>354</volume><fpage>916</fpage><lpage>917</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(99)03311-5</pub-id><pub-id pub-id-type="pmid">10489954</pub-id></element-citation></ref><ref id="CR53"><label>53.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Koopmans</surname><given-names>M</given-names></name><name><surname>Wilbrink</surname><given-names>B</given-names></name><name><surname>Conyn</surname><given-names>M</given-names></name><name><surname>Natrop</surname><given-names>G</given-names></name><name><surname>van der Nat</surname><given-names>H</given-names></name><name><surname>Vennema</surname><given-names>H</given-names></name><name><surname>Meijer</surname><given-names>A</given-names></name><name><surname>van Steenbergen</surname><given-names>J</given-names></name><name><surname>Fouchier</surname><given-names>R</given-names></name><name><surname>Osterhaus</surname><given-names>A</given-names></name><name><surname>Bosman</surname><given-names>A</given-names></name></person-group><article-title>Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands</article-title><source>Lancet</source><year>2004</year><volume>363</volume><fpage>587</fpage><lpage>593</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(04)15589-X</pub-id><pub-id pub-id-type="pmid">14987882</pub-id></element-citation></ref><ref id="CR54"><label>54.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Chan</surname><given-names>PK</given-names></name><name><surname>Peiris</surname><given-names>M</given-names></name><name><surname>Tsang</surname><given-names>DN</given-names></name><name><surname>Que</surname><given-names>TL</given-names></name><name><surname>Shortridge</surname><given-names>KF</given-names></name><name><surname>Cheung</surname><given-names>PT</given-names></name><name><surname>To</surname><given-names>WK</given-names></name><name><surname>Ho</surname><given-names>ET</given-names></name><name><surname>Sung</surname><given-names>R</given-names></name><name><surname>Cheng</surname><given-names>AF</given-names></name></person-group><article-title>Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus</article-title><source>Lancet</source><year>1998</year><volume>351</volume><fpage>467</fpage><lpage>471</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(98)01182-9</pub-id><pub-id pub-id-type="pmid">9482437</pub-id></element-citation></ref><ref id="CR55"><label>55.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>PKS</given-names></name></person-group><article-title>Outbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997</article-title><source>Clin Infect Dis</source><year>2002</year><volume>34</volume><issue>Suppl 2</issue><fpage>S58</fpage><lpage>S64</lpage><pub-id pub-id-type="doi">10.1086/338820</pub-id><pub-id pub-id-type="pmid">11938498</pub-id></element-citation></ref><ref id="CR56"><label>56.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Peiris</surname><given-names>JS</given-names></name><name><surname>Yu</surname><given-names>WC</given-names></name><name><surname>Leung</surname><given-names>CW</given-names></name><name><surname>Cheung</surname><given-names>CY</given-names></name><name><surname>Ng</surname><given-names>WF</given-names></name><name><surname>Nicholls</surname><given-names>JM</given-names></name><name><surname>Ng</surname><given-names>TK</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Lai</surname><given-names>ST</given-names></name><name><surname>Lim</surname><given-names>WL</given-names></name><etal></etal></person-group><article-title>Re-emergence of fatal human influenza A subtype H5N1 disease</article-title><source>Lancet</source><year>2004</year><volume>363</volume><fpage>617</fpage><lpage>619</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(04)15595-5</pub-id><pub-id pub-id-type="pmid">14987888</pub-id></element-citation></ref><ref id="CR57"><label>57.</label><mixed-citation publication-type="other"><bold>World Health Organization: Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO</bold>[<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/disease/avian_influenza/country/cases_table_2006_10_16/en/index.html">http://www.who.int/csr/disease/avian_influenza/country/cases_table_2006_10_16/en/index.html</ext-link>]</mixed-citation></ref><ref id="CR58"><label>58.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tweed</surname><given-names>SA</given-names></name><name><surname>Skowronski</surname><given-names>DM</given-names></name><name><surname>David</surname><given-names>ST</given-names></name><name><surname>Larder</surname><given-names>A</given-names></name><name><surname>Petric</surname><given-names>M</given-names></name><name><surname>Lees</surname><given-names>W</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Katz</surname><given-names>J</given-names></name><name><surname>Krajden</surname><given-names>M</given-names></name><name><surname>Tellier</surname><given-names>R</given-names></name><etal></etal></person-group><article-title>Human illness from avian influenza H7N3, British Columbia</article-title><source>Emerg Infect Dis</source><year>2004</year><volume>10</volume><fpage>2196</fpage><lpage>2199</lpage><pub-id pub-id-type="doi">10.3201/eid1012.040961</pub-id><pub-id pub-id-type="pmid">15663860</pub-id></element-citation></ref><ref id="CR59"><label>59.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Katz</surname><given-names>JM</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Bridges</surname><given-names>CB</given-names></name><name><surname>Rowe</surname><given-names>T</given-names></name><name><surname>Hu-Primmer</surname><given-names>J</given-names></name><name><surname>Lu</surname><given-names>X</given-names></name><name><surname>Abernathy</surname><given-names>RA</given-names></name><name><surname>Clarke</surname><given-names>M</given-names></name><name><surname>Conn</surname><given-names>L</given-names></name><name><surname>Kwong</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts</article-title><source>J Infect Dis</source><year>1999</year><volume>180</volume><fpage>1763</fpage><lpage>1770</lpage><pub-id pub-id-type="doi">10.1086/315137</pub-id><pub-id pub-id-type="pmid">10558929</pub-id></element-citation></ref><ref id="CR60"><label>60.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Buxton Bridges</surname><given-names>C</given-names></name><name><surname>Katz</surname><given-names>JM</given-names></name><name><surname>Seto</surname><given-names>WH</given-names></name><name><surname>Chan</surname><given-names>PK</given-names></name><name><surname>Tsang</surname><given-names>D</given-names></name><name><surname>Ho</surname><given-names>W</given-names></name><name><surname>Mak</surname><given-names>KH</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Tam</surname><given-names>JS</given-names></name><name><surname>Clarke</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong</article-title><source>J Infect Dis</source><year>2000</year><volume>181</volume><fpage>344</fpage><lpage>348</lpage><pub-id pub-id-type="doi">10.1086/315213</pub-id><pub-id pub-id-type="pmid">10608786</pub-id></element-citation></ref><ref id="CR61"><label>61.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ungchusak</surname><given-names>K</given-names></name><name><surname>Auewarakul</surname><given-names>P</given-names></name><name><surname>Dowell</surname><given-names>SF</given-names></name><name><surname>Kitphati</surname><given-names>R</given-names></name><name><surname>Auwanit</surname><given-names>W</given-names></name><name><surname>Puthavathana</surname><given-names>P</given-names></name><name><surname>Uiprasertkul</surname><given-names>M</given-names></name><name><surname>Boonnak</surname><given-names>K</given-names></name><name><surname>Pittayawonganon</surname><given-names>C</given-names></name><name><surname>Cox</surname><given-names>NJ</given-names></name><etal></etal></person-group><article-title>Probable person-to-person transmission of avian influenza A (H5N1)</article-title><source>N Engl J Med</source><year>2005</year><volume>352</volume><fpage>333</fpage><lpage>340</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa044021</pub-id><pub-id pub-id-type="pmid">15668219</pub-id></element-citation></ref><ref id="CR62"><label>62.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liem</surname><given-names>NT</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><collab>World Health Organization International Avian Influenza Investigation Team, Vietnam</collab></person-group><article-title>Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>210</fpage><lpage>215</lpage><pub-id pub-id-type="doi">10.3201/eid1102.041075</pub-id><pub-id pub-id-type="pmid">15752437</pub-id></element-citation></ref><ref id="CR63"><label>63.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schultsz</surname><given-names>C</given-names></name><name><surname>Dong</surname><given-names>VC</given-names></name><name><surname>Chau</surname><given-names>NV</given-names></name><name><surname>Le</surname><given-names>NT</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Thanh</surname><given-names>TT</given-names></name><name><surname>Dolecek</surname><given-names>C</given-names></name><name><surname>de Jong</surname><given-names>MD</given-names></name><name><surname>Hien</surname><given-names>TT</given-names></name><name><surname>Farrar</surname><given-names>J</given-names></name></person-group><article-title>Avian influenza H5N1 and healthcare workers</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>1158</fpage><lpage>1159</lpage><pub-id pub-id-type="doi">10.3201/eid1107.050070</pub-id><pub-id pub-id-type="pmid">16032802</pub-id></element-citation></ref><ref id="CR64"><label>64.</label><mixed-citation publication-type="other"><bold>Avian Influenza, human (09): Indonesia, Archive number 20070111.0133</bold>[<ext-link ext-link-type="uri" xlink:href="http://www.promedmail.org/pls/promed">http://www.promedmail.org/pls/promed</ext-link>]</mixed-citation></ref><ref id="CR65"><label>65.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tran</surname><given-names>TH</given-names></name><name><surname>Nguyen</surname><given-names>TL</given-names></name><name><surname>Nguyen</surname><given-names>TD</given-names></name><name><surname>Luong</surname><given-names>TS</given-names></name><name><surname>Pham</surname><given-names>PM</given-names></name><name><surname>Nguyen</surname><given-names>VC</given-names></name><name><surname>Pham</surname><given-names>TS</given-names></name><name><surname>Vo</surname><given-names>CD</given-names></name><name><surname>Le</surname><given-names>TQ</given-names></name><name><surname>Ngo</surname><given-names>TT</given-names></name><etal></etal></person-group><article-title>Avian influenza A (H5N1) in 10 patients in Vietnam</article-title><source>N Engl J Med</source><year>2004</year><volume>350</volume><fpage>1179</fpage><lpage>1188</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa040419</pub-id><pub-id pub-id-type="pmid">14985470</pub-id></element-citation></ref><ref id="CR66"><label>66.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chotpitayasunondh</surname><given-names>T</given-names></name><name><surname>Ungchusak</surname><given-names>K</given-names></name><name><surname>Hanshaoworakul</surname><given-names>W</given-names></name><name><surname>Chunsuthiwat</surname><given-names>S</given-names></name><name><surname>Sawanpanyalert</surname><given-names>P</given-names></name><name><surname>Kijphati</surname><given-names>R</given-names></name><name><surname>Lochindarat</surname><given-names>S</given-names></name><name><surname>Srisan</surname><given-names>P</given-names></name><name><surname>Suwan</surname><given-names>P</given-names></name><name><surname>Osotthanakorn</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Human disease from influenza A (H5N1), Thailand, 2004</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>201</fpage><lpage>209</lpage><pub-id pub-id-type="doi">10.3201/eid1102.041061</pub-id><pub-id pub-id-type="pmid">15752436</pub-id></element-citation></ref><ref id="CR67"><label>67.</label><element-citation publication-type="journal"><person-group person-group-type="author"><collab>The Writing Committee of the World Health Organization (WHO) Consultation on human influenza A/H5</collab></person-group><article-title>Avian influenza A (H5N1) infection in humans</article-title><source>N Engl J Med</source><year>2005</year><volume>353</volume><fpage>1374</fpage><lpage>1385</lpage><pub-id pub-id-type="doi">10.1056/NEJMra052211</pub-id><pub-id pub-id-type="pmid">16192482</pub-id></element-citation></ref><ref id="CR68"><label>68.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Jong</surname><given-names>MD</given-names></name><name><surname>Bach</surname><given-names>VC</given-names></name><name><surname>Phan</surname><given-names>TQ</given-names></name><name><surname>Vo</surname><given-names>MH</given-names></name><name><surname>Tran</surname><given-names>TT</given-names></name><name><surname>Nguyen</surname><given-names>BH</given-names></name><name><surname>Beld</surname><given-names>M</given-names></name><name><surname>Le</surname><given-names>TP</given-names></name><name><surname>Truong</surname><given-names>HK</given-names></name><name><surname>Nguyen</surname><given-names>VV</given-names></name><etal></etal></person-group><article-title>Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma</article-title><source>N Engl J Med</source><year>2005</year><volume>352</volume><fpage>686</fpage><lpage>691</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa044307</pub-id><pub-id pub-id-type="pmid">15716562</pub-id></element-citation></ref><ref id="CR69"><label>69.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gruber</surname><given-names>PC</given-names></name><name><surname>Gomersall</surname><given-names>CD</given-names></name><name><surname>Joynt</surname><given-names>GM</given-names></name></person-group><article-title>Avian influenza (H5N1): implications for intensive care</article-title><source>Intensive Care Med</source><year>2006</year><volume>32</volume><fpage>823</fpage><lpage>829</lpage><pub-id pub-id-type="doi">10.1007/s00134-006-0148-z</pub-id><pub-id pub-id-type="pmid">16568274</pub-id></element-citation></ref><ref id="CR70"><label>70.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheung</surname><given-names>CY</given-names></name><name><surname>Poon</surname><given-names>LL</given-names></name><name><surname>Lau</surname><given-names>AS</given-names></name><name><surname>Luk</surname><given-names>W</given-names></name><name><surname>Lau</surname><given-names>YL</given-names></name><name><surname>Shortridge</surname><given-names>KF</given-names></name><name><surname>Gordon</surname><given-names>S</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><name><surname>Peiris</surname><given-names>JS</given-names></name></person-group><article-title>Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?</article-title><source>Lancet</source><year>2002</year><volume>360</volume><fpage>1831</fpage><lpage>1837</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(02)11772-7</pub-id><pub-id pub-id-type="pmid">12480361</pub-id></element-citation></ref><ref id="CR71"><label>71.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>To</surname><given-names>KF</given-names></name><name><surname>Chan</surname><given-names>PK</given-names></name><name><surname>Chan</surname><given-names>KF</given-names></name><name><surname>Lee</surname><given-names>WK</given-names></name><name><surname>Lam</surname><given-names>WY</given-names></name><name><surname>Wong</surname><given-names>KF</given-names></name><name><surname>Tang</surname><given-names>NL</given-names></name><name><surname>Tsang</surname><given-names>DN</given-names></name><name><surname>Sung</surname><given-names>RY</given-names></name><name><surname>Buckley</surname><given-names>TA</given-names></name><etal></etal></person-group><article-title>Pathology of fatal human infection associated with avian influenza A H5N1 virus</article-title><source>J Med Virol</source><year>2001</year><volume>63</volume><fpage>242</fpage><lpage>246</lpage><pub-id pub-id-type="doi">10.1002/1096-9071(200103)63:3<242::AID-JMV1007>3.0.CO;2-N</pub-id><pub-id pub-id-type="pmid">11170064</pub-id></element-citation></ref><ref id="CR72"><label>72.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bridges</surname><given-names>CB</given-names></name><name><surname>Lim</surname><given-names>W</given-names></name><name><surname>Hu-Primmer</surname><given-names>J</given-names></name><name><surname>Sims</surname><given-names>L</given-names></name><name><surname>Fukuda</surname><given-names>K</given-names></name><name><surname>Mak</surname><given-names>KH</given-names></name><name><surname>Rowe</surname><given-names>T</given-names></name><name><surname>Thompson</surname><given-names>WW</given-names></name><name><surname>Conn</surname><given-names>L</given-names></name><name><surname>Lu</surname><given-names>X</given-names></name><etal></etal></person-group><article-title>Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997–1998</article-title><source>J Infect Dis</source><year>2002</year><volume>185</volume><fpage>1005</fpage><lpage>1010</lpage><pub-id pub-id-type="doi">10.1086/340044</pub-id><pub-id pub-id-type="pmid">11930308</pub-id></element-citation></ref><ref id="CR73"><label>73.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Spackman</surname><given-names>E</given-names></name><name><surname>Senne</surname><given-names>DA</given-names></name><name><surname>Myers</surname><given-names>TJ</given-names></name><name><surname>Bulaga</surname><given-names>LL</given-names></name><name><surname>Garber</surname><given-names>LP</given-names></name><name><surname>Perdue</surname><given-names>ML</given-names></name><name><surname>Lohman</surname><given-names>K</given-names></name><name><surname>Daum</surname><given-names>LT</given-names></name><name><surname>Suarez</surname><given-names>DL</given-names></name></person-group><article-title>Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes</article-title><source>J Clin Microbiol</source><year>2002</year><volume>40</volume><fpage>3256</fpage><lpage>3260</lpage><pub-id pub-id-type="doi">10.1128/JCM.40.9.3256-3260.2002</pub-id><pub-id pub-id-type="pmid">12202562</pub-id></element-citation></ref><ref id="CR74"><label>74.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lee</surname><given-names>CW</given-names></name><name><surname>Suarez</surname><given-names>DL</given-names></name></person-group><article-title>Application of real-time RT-PCR for the quantitation and competitive replication study of H5 and H7 subtype avian influenza virus</article-title><source>J Virol Methods</source><year>2004</year><volume>119</volume><fpage>151</fpage><lpage>158</lpage><pub-id pub-id-type="doi">10.1016/j.jviromet.2004.03.014</pub-id><pub-id pub-id-type="pmid">15158597</pub-id></element-citation></ref><ref id="CR75"><label>75.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Payungporn</surname><given-names>S</given-names></name><name><surname>Phakdeewirot</surname><given-names>P</given-names></name><name><surname>Chutinimitkul</surname><given-names>S</given-names></name><name><surname>Theamboonlers</surname><given-names>A</given-names></name><name><surname>Keawcharoen</surname><given-names>J</given-names></name><name><surname>Oraveerakul</surname><given-names>K</given-names></name><name><surname>Amonsin</surname><given-names>A</given-names></name><name><surname>Poovorawan</surname><given-names>Y</given-names></name></person-group><article-title>Single-step multiplex reverse transcription-polymerase chain reaction (RT-PCR) for influenza A virus subtype H5N1 detection</article-title><source>Viral Immunol</source><year>2004</year><volume>17</volume><fpage>588</fpage><lpage>593</lpage><pub-id pub-id-type="doi">10.1089/vim.2004.17.588</pub-id><pub-id pub-id-type="pmid">15671756</pub-id></element-citation></ref><ref id="CR76"><label>76.</label><element-citation publication-type="journal"><person-group person-group-type="author"><collab>The World Health Organization Global Influenza Program Surveillance Network</collab></person-group><article-title>Evolution of H5N1 avian influenza viruses in Asia</article-title><source>Emerg Infect Dis</source><year>2005</year><volume>11</volume><fpage>1515</fpage><lpage>1521</lpage><pub-id pub-id-type="doi">10.3201/eid1110.050644</pub-id><pub-id pub-id-type="pmid">16318689</pub-id></element-citation></ref><ref id="CR77"><label>77.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Regoes</surname><given-names>RR</given-names></name><name><surname>Bonhoeffer</surname><given-names>S</given-names></name></person-group><article-title>Emergence of drug-resistant influenza virus: population dynamical considerations</article-title><source>Science</source><year>2006</year><volume>312</volume><fpage>389</fpage><lpage>391</lpage><pub-id pub-id-type="doi">10.1126/science.1122947</pub-id><pub-id pub-id-type="pmid">16627735</pub-id></element-citation></ref><ref id="CR78"><label>78.</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Hammer</surname><given-names>SM</given-names></name><name><surname>Inouye</surname><given-names>RT</given-names></name></person-group><person-group person-group-type="editor"><name><surname>Richman</surname><given-names>DD</given-names></name><name><surname>Whitley</surname><given-names>RJ</given-names></name><name><surname>Hayden</surname><given-names>FG</given-names></name></person-group><article-title>Antiviral agents</article-title><source>Clinical Virology</source><year>2002</year><edition>2</edition><publisher-loc>Washington DC</publisher-loc><publisher-name>ASM Press</publisher-name><fpage>171</fpage><lpage>242</lpage></element-citation></ref><ref id="CR79"><label>79.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Clercq</surname><given-names>E</given-names></name></person-group><article-title>Antiviral agents active against influenza A viruses</article-title><source>Nat Rev Drug Discov</source><year>2006</year><volume>5</volume><fpage>1015</fpage><lpage>1025</lpage><pub-id pub-id-type="doi">10.1038/nrd2175</pub-id><pub-id pub-id-type="pmid">17139286</pub-id></element-citation></ref><ref id="CR80"><label>80.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jefferson</surname><given-names>TO</given-names></name><name><surname>Demicheli</surname><given-names>V</given-names></name><name><surname>Di Pietrantonj</surname><given-names>C</given-names></name><name><surname>Jones</surname><given-names>M</given-names></name><name><surname>Rivetti</surname><given-names>D</given-names></name></person-group><article-title>Neuraminidase inhibitors for preventing and treating influenza in healthy adults</article-title><source>Cochrane Databse Syst Rev</source><year>2006</year><volume>3</volume><fpage>CD001265</fpage></element-citation></ref><ref id="CR81"><label>81.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cass</surname><given-names>LM</given-names></name><name><surname>Efthymiopoulos</surname><given-names>C</given-names></name><name><surname>Bye</surname><given-names>A</given-names></name></person-group><article-title>Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers</article-title><source>Clin Pharmacokinet</source><year>1999</year><volume>36</volume><issue>Suppl 1</issue><fpage>1</fpage><lpage>11</lpage><pub-id pub-id-type="doi">10.2165/00003088-199936001-00001</pub-id><pub-id pub-id-type="pmid">10429835</pub-id></element-citation></ref><ref id="CR82"><label>82.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Massarella</surname><given-names>JW</given-names></name><name><surname>He</surname><given-names>GZ</given-names></name><name><surname>Dorr</surname><given-names>A</given-names></name><name><surname>Nieforth</surname><given-names>K</given-names></name><name><surname>Ward</surname><given-names>P</given-names></name><name><surname>Brown</surname><given-names>A</given-names></name></person-group><article-title>The pharmacokinetics and tolerability of the oral neuraminidase inhibitor oseltamivir (Ro 64-0796/GS4104) in healthy adult and elderly volunteers</article-title><source>J Clin Pharmacol</source><year>2000</year><volume>40</volume><fpage>836</fpage><lpage>843</lpage><pub-id pub-id-type="doi">10.1177/00912700022009567</pub-id><pub-id pub-id-type="pmid">10934667</pub-id></element-citation></ref><ref id="CR83"><label>83.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leneva</surname><given-names>IA</given-names></name><name><surname>Roberts</surname><given-names>N</given-names></name><name><surname>Govorkova</surname><given-names>EA</given-names></name><name><surname>Goloubeva</surname><given-names>OG</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses</article-title><source>Antiviral Res</source><year>2000</year><volume>48</volume><fpage>101</fpage><lpage>115</lpage><pub-id pub-id-type="doi">10.1016/S0166-3542(00)00123-6</pub-id><pub-id pub-id-type="pmid">11114412</pub-id></element-citation></ref><ref id="CR84"><label>84.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Govorkova</surname><given-names>EA</given-names></name><name><surname>Fang</surname><given-names>HB</given-names></name><name><surname>Tan</surname><given-names>M</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Neuraminidase inhibitorrimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells</article-title><source>Antimicrob Agents Chemother</source><year>2004</year><volume>48</volume><fpage>4855</fpage><lpage>4863</lpage><pub-id pub-id-type="doi">10.1128/AAC.48.12.4855-4863.2004</pub-id><pub-id pub-id-type="pmid">15561867</pub-id></element-citation></ref><ref id="CR85"><label>85.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leneva</surname><given-names>IA</given-names></name><name><surname>Goloubeva</surname><given-names>O</given-names></name><name><surname>Fenton</surname><given-names>RJ</given-names></name><name><surname>Tisdale</surname><given-names>M</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals</article-title><source>Antimicrob Agents Chemother</source><year>2001</year><volume>45</volume><fpage>1216</fpage><lpage>1224</lpage><pub-id pub-id-type="doi">10.1128/AAC.45.4.1216-1224.2001</pub-id><pub-id pub-id-type="pmid">11257037</pub-id></element-citation></ref><ref id="CR86"><label>86.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kiso</surname><given-names>M</given-names></name><name><surname>Mitamura</surname><given-names>K</given-names></name><name><surname>Sakai-Tagawa</surname><given-names>Y</given-names></name><name><surname>Shiraishi</surname><given-names>K</given-names></name><name><surname>Kawakami</surname><given-names>C</given-names></name><name><surname>Kimura</surname><given-names>K</given-names></name><name><surname>Hayden</surname><given-names>FG</given-names></name><name><surname>Sugaya</surname><given-names>N</given-names></name><name><surname>Kawaoka</surname><given-names>Y</given-names></name></person-group><article-title>Resistant influenza A viruses in children treated with oseltamivir: descriptive study</article-title><source>Lancet</source><year>2004</year><volume>364</volume><fpage>759</fpage><lpage>765</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(04)16934-1</pub-id><pub-id pub-id-type="pmid">15337401</pub-id></element-citation></ref><ref id="CR87"><label>87.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Jong</surname><given-names>MD</given-names></name><name><surname>Tran</surname><given-names>TT</given-names></name><name><surname>Truong</surname><given-names>HK</given-names></name><name><surname>Vo</surname><given-names>MH</given-names></name><name><surname>Smith</surname><given-names>GJ</given-names></name><name><surname>Nguyen</surname><given-names>VC</given-names></name><name><surname>Bach</surname><given-names>VC</given-names></name><name><surname>Phan</surname><given-names>TQ</given-names></name><name><surname>Do</surname><given-names>QH</given-names></name><name><surname>Guan</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Oseltamivir resistance during treatment of influenza A (H5N1) infection</article-title><source>New Engl J Med</source><year>2005</year><volume>353</volume><fpage>2667</fpage><pub-id pub-id-type="doi">10.1056/NEJMoa054512</pub-id><pub-id pub-id-type="pmid">16371632</pub-id></element-citation></ref><ref id="CR88"><label>88.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Le</surname><given-names>QM</given-names></name><name><surname>Kiso</surname><given-names>M</given-names></name><name><surname>Someya</surname><given-names>K</given-names></name><name><surname>Sakai</surname><given-names>YT</given-names></name><name><surname>Nguyen</surname><given-names>TH</given-names></name><name><surname>Nguyen</surname><given-names>KH</given-names></name><name><surname>Pham</surname><given-names>ND</given-names></name><name><surname>Ngyen</surname><given-names>HH</given-names></name><name><surname>Yamada</surname><given-names>S</given-names></name><name><surname>Muramoto</surname><given-names>Y</given-names></name><etal></etal></person-group><article-title>Avian flu: isolation of drug-resistant H5N1 virus</article-title><source>Nature</source><year>2005</year><volume>437</volume><fpage>1108</fpage><pub-id pub-id-type="doi">10.1038/4371108a</pub-id><pub-id pub-id-type="pmid">16228009</pub-id></element-citation></ref><ref id="CR89"><label>89.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sidwell</surname><given-names>RW</given-names></name><name><surname>Bailey</surname><given-names>KW</given-names></name><name><surname>Wong</surname><given-names>MH</given-names></name><name><surname>Barnard</surname><given-names>DL</given-names></name><name><surname>Smee</surname><given-names>DF</given-names></name></person-group><article-title><italic>In vitro</italic> and <italic>in vivo</italic> influenza virus inhibitory effects of viramidine</article-title><source>Antiviral Res</source><year>2005</year><volume>68</volume><fpage>10</fpage><lpage>17</lpage><pub-id pub-id-type="doi">10.1016/j.antiviral.2005.06.003</pub-id><pub-id pub-id-type="pmid">16087250</pub-id></element-citation></ref><ref id="CR90"><label>90.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cheng</surname><given-names>VC</given-names></name><name><surname>Tang</surname><given-names>BS</given-names></name><name><surname>Wu</surname><given-names>AK</given-names></name><name><surname>Chu</surname><given-names>CM</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name></person-group><article-title>Medical treatment of viral pneumonia including SARS in immunocompetent adult</article-title><source>J Infect</source><year>2004</year><volume>49</volume><fpage>262</fpage><lpage>273</lpage><pub-id pub-id-type="doi">10.1016/j.jinf.2004.07.010</pub-id><pub-id pub-id-type="pmid">15474623</pub-id></element-citation></ref><ref id="CR91"><label>91.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nicholson</surname><given-names>KG</given-names></name><name><surname>Colegate</surname><given-names>AE</given-names></name><name><surname>Podda</surname><given-names>A</given-names></name><name><surname>Stephenson</surname><given-names>I</given-names></name><name><surname>Wood</surname><given-names>J</given-names></name><name><surname>Ypma</surname><given-names>E</given-names></name><name><surname>Zambon</surname><given-names>MC</given-names></name></person-group><article-title>Safety and antigenicity of non-adjuvanted and F59-adjuvanted influenza A/Duck/Singapore/97 (h5N3) vaccine: a randomized trial of two potential vaccines against H5N1 influenza</article-title><source>Lancet</source><year>2001</year><volume>357</volume><fpage>1937</fpage><lpage>1943</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(00)05066-2</pub-id><pub-id pub-id-type="pmid">11425416</pub-id></element-citation></ref><ref id="CR92"><label>92.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stephenson</surname><given-names>I</given-names></name><name><surname>Bugarini</surname><given-names>R</given-names></name><name><surname>Nicholson</surname><given-names>KG</given-names></name><name><surname>Podda</surname><given-names>A</given-names></name><name><surname>Wood</surname><given-names>JM</given-names></name><name><surname>Zambon</surname><given-names>MC</given-names></name><name><surname>Katz</surname><given-names>JM</given-names></name></person-group><article-title>Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy</article-title><source>J Infect Dis</source><year>2005</year><volume>191</volume><fpage>1210</fpage><lpage>1215</lpage><pub-id pub-id-type="doi">10.1086/428948</pub-id><pub-id pub-id-type="pmid">15776364</pub-id></element-citation></ref><ref id="CR93"><label>93.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Treanor</surname><given-names>JJ</given-names></name><name><surname>Wilkinson</surname><given-names>BE</given-names></name><name><surname>Masseoud</surname><given-names>F</given-names></name><name><surname>Hu-Primmer</surname><given-names>J</given-names></name><name><surname>Battaglia</surname><given-names>R</given-names></name><name><surname>O'Brien</surname><given-names>D</given-names></name><name><surname>Wolff</surname><given-names>M</given-names></name><name><surname>Rabinovich</surname><given-names>G</given-names></name><name><surname>Blackwelder</surname><given-names>W</given-names></name><name><surname>Katz</surname><given-names>JM</given-names></name></person-group><article-title>Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans</article-title><source>Vaccine</source><year>2001</year><volume>19</volume><fpage>1732</fpage><lpage>1737</lpage><pub-id pub-id-type="doi">10.1016/S0264-410X(00)00395-9</pub-id><pub-id pub-id-type="pmid">11166898</pub-id></element-citation></ref><ref id="CR94"><label>94.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lipatov</surname><given-names>AS</given-names></name><name><surname>Webby</surname><given-names>RJ</given-names></name><name><surname>Govorkova</surname><given-names>EA</given-names></name><name><surname>Krauss</surname><given-names>S</given-names></name><name><surname>Webster</surname><given-names>RG</given-names></name></person-group><article-title>Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model</article-title><source>J Infect Dis</source><year>2005</year><volume>191</volume><fpage>1216</fpage><lpage>1220</lpage><pub-id pub-id-type="doi">10.1086/428951</pub-id><pub-id pub-id-type="pmid">15776365</pub-id></element-citation></ref><ref id="CR95"><label>95.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Treanor</surname><given-names>JJ</given-names></name><name><surname>Campbell</surname><given-names>JD</given-names></name><name><surname>Zangwill</surname><given-names>KM</given-names></name><name><surname>Rowe</surname><given-names>T</given-names></name><name><surname>Wolff</surname><given-names>M</given-names></name></person-group><article-title>Saftey and immunogenicity of an inactivated subviron influenza A (H5N1) vaccine</article-title><source>New Engl J Med</source><year>2006</year><volume>354</volume><fpage>1343</fpage><lpage>1351</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa055778</pub-id><pub-id pub-id-type="pmid">16571878</pub-id></element-citation></ref><ref id="CR96"><label>96.</label><mixed-citation publication-type="other"><bold>World Health Organization: Summary of Probable SARS Cases with Onset of Illness from 1 November 2002 to 31 July 2003</bold>[<ext-link ext-link-type="uri" xlink:href="http://www.who.int/csr/sars/country/table2004_04_21/en/index.html">http://www.who.int/csr/sars/country/table2004_04_21/en/index.html</ext-link>]</mixed-citation></ref><ref id="CR97"><label>97.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yu</surname><given-names>IT</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Wong</surname><given-names>TW</given-names></name><name><surname>Tam</surname><given-names>W</given-names></name><name><surname>Chan</surname><given-names>AT</given-names></name><name><surname>Lee</surname><given-names>JH</given-names></name><name><surname>Leung</surname><given-names>DY</given-names></name><name><surname>Ho</surname><given-names>T</given-names></name></person-group><article-title>Evidence of airborne transmission of the severe acute respiratory syndrome virus</article-title><source>N Engl J Med</source><year>2004</year><volume>350</volume><fpage>1731</fpage><lpage>1739</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa032867</pub-id><pub-id pub-id-type="pmid">15102999</pub-id></element-citation></ref><ref id="CR98"><label>98.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fowler</surname><given-names>RA</given-names></name><name><surname>Lapinsky</surname><given-names>SE</given-names></name><name><surname>Hallett</surname><given-names>D</given-names></name><name><surname>Detsky</surname><given-names>AS</given-names></name><name><surname>Sibbald</surname><given-names>WJ</given-names></name><name><surname>Slutsky</surname><given-names>AS</given-names></name><name><surname>Stewart</surname><given-names>TE</given-names></name><collab>Toronto SARS Critical Care Group</collab></person-group><article-title>Critically ill patients with severe acute respiratory distress syndrome</article-title><source>JAMA</source><year>2003</year><volume>290</volume><fpage>367</fpage><lpage>373</lpage><pub-id pub-id-type="doi">10.1001/jama.290.3.367</pub-id><pub-id pub-id-type="pmid">12865378</pub-id></element-citation></ref><ref id="CR99"><label>99.</label><mixed-citation publication-type="other"><bold>PandemicFlu.Gov: Interim Guidance On The Planning For The Use Of Surgical Masks And Respirators In Health Care Settings During An Influenza Pandemic</bold>[<ext-link ext-link-type="uri" xlink:href="http://www.pandemicflu.gov/plan/healthcare/maskguidancehc.html">http://www.pandemicflu.gov/plan/healthcare/maskguidancehc.html</ext-link>]</mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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